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Tyra Biosciences clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, UK and EU (CTIS) registers with Tyra Biosciences as lead sponsor. Synced 26 Sep 2026
8Current trials
4Recruiting now
1Drug in these trials
3Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

Tyra Biosciences is the lead sponsor of 8 current clinical trials in our USA, UK and EU (CTIS) registers. 4 are recruiting patients now. The most common phase is Phase 2. The drugs named most often in its trials are TYRA-300. The most-studied condition is FGFR Gene Amplification.

ClinicalTrials.gov trials by status

  • Recruiting467%
  • Active, closed233%

Trials by phase

  • Phase 2350%
  • Phase 1233%
  • Phase 1/2117%
01

Clinical trials sponsored by Tyra Biosciences

6 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
A Study of TYRA-300 in Children With Achondroplasia: BEACH301
NCT06842355 · ClinicalTrials.gov ↗ · Achondroplasia
Drug: TYRA-300
Phase 2 Recruiting 2025-03 UK, USA
Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma
NCT07265947 · ClinicalTrials.gov ↗ · Low Grade Upper Tract Urothelial Carcinoma
Drug: TYRA-300
Phase 2 Recruiting 2025-12 USA
Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations
NCT06915753 · ClinicalTrials.gov ↗ · Metastatic Hepatocellular Carcinoma, Solid Tumors, Solid Tumor, Adult
Phase 1 Recruiting 2025-04 USA
Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer
NCT06995677 · ClinicalTrials.gov ↗ · Low-grade NMIBC, FGFR Gene Amplification, FGFR Gene Alterations
Drug: TYRA-300
Phase 2 Recruiting 2025-06 USA
Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations
NCT05544552 · ClinicalTrials.gov ↗ · Locally Advanced Urothelial Carcinoma, Metastatic Urothelial Carcinoma, Solid Tumor
Drug: TYRA-300
Phase 1/2 Active, closed 2022-11 USA
Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations
NCT06160752 · ClinicalTrials.gov ↗ · Locally Advanced Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma, Solid Tumor
Phase 1 Active, closed 2023-11 USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

Tyra Biosciences in the EU trials register (CTIS)

2 trials

Authorised or ongoing trials in the EU Clinical Trials Information System with Tyra Biosciences as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
A Phase 2A/B, Multi-center, Open-Label Study Evaluating the Efficacy and Safety of Dabogratinib (TYRA-300) in Participants with Low Grade Upper Tract Urothelial Carcinoma (SURF303)
2025-523539-20-00 · CTIS ↗ · Neoplasms
Phase 2 Ongoing Bulgaria, France, Spain
A Phase 2 Multicenter, Open-Label Study Evaluating the Efficacy and Safety of TYRA-300 in Participants with FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer (SURF302)
2025-521277-14-00 · CTIS ↗ · Neoplasms
Phase 2 Ongoing Italy, Spain, France
03

Drugs in Tyra Biosciences trials

1 compound

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

04

Conditions in Tyra Biosciences trials

16 conditions
FGFR Gene Amplification2Solid Tumor2Achondroplasia1Low Grade Upper Tract Urothelial Carcinoma1Metastatic Hepatocellular Carcinoma1Solid Tumors1Solid Tumor, Adult1Locally Advanced Urothelial Carcinoma1Metastatic Urothelial Carcinoma1Urothelial Carcinoma1Low-grade NMIBC1FGFR Gene Alterations1FGFR3 Gene Alteration1Locally Advanced Cholangiocarcinoma1Intrahepatic Cholangiocarcinoma1Metastatic Cholangiocarcinoma1
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA64
Clinical trials in UK11
EU register (CTIS)2—

A trial with sites in more than one country appears in each of those registers.

06

Questions about Tyra Biosciences trials

How many clinical trials does Tyra Biosciences sponsor?

Tyra Biosciences is the lead sponsor of 6 current trials on ClinicalTrials.gov in our USA and UK registers, and 2 authorised or ongoing trials in the EU register (CTIS), as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Tyra Biosciences trials recruiting?

Yes. 4 of its 6 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is Tyra Biosciences testing?

Its current trials name 1 drug or biological as interventions. The most frequent are TYRA-300 (4). The number in brackets is how many of its trials name each drug.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.