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Compound · clinical trials

) Berahyaluronidase alfa clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 6 trials in our USA, UK, China and Ireland registers that name ) Berahyaluronidase alfa as an intervention. Synced 25 Sep 2026
6Current trials
3Recruiting now
2Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

) Berahyaluronidase alfa is named as an intervention in 6 current clinical trials in our USA, UK, China and Ireland registers. 3 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Merck Sharp & Dohme LLC (5). The most-studied condition is Non-Small Cell Lung Cancer.

Trials by status

  • Recruiting350%
  • Active, closed350%

Trials by phase

  • Phase 3467%
  • Phase 2233%
01

Clinical trials of ) Berahyaluronidase alfa

6 trials
StudyPhaseStatusLead sponsorRegisters
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
NCT03486873 · Solid Tumors, Hematologic Malignancies
Phase 3 Recruiting Merck Sharp & Dohme LLC Ireland, UK, USA, China
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
NCT07190248 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 3 Recruiting Merck Sharp & Dohme LLC UK, USA, China
Zanzalintinib Alone or in Combination With Pembrolizumab and Berahyaluronidase Alfa in Participants With Colorectal Cancer With Molecular Residual Disease
NCT07750158 · ClinicalTrials.gov ↗ · Colorectal Cancer
Phase 3 Recruiting Exelixis USA
A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)
NCT06698042 · Lung Cancer, Non-Small Cell Lung Cancer
Phase 3 Active, closed Merck Sharp & Dohme LLC UK, USA, China
A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)
NCT06099782 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, Renal Cell Carcinoma, Melanoma
Phase 2 Active, closed Merck Sharp & Dohme LLC USA
A Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) Coformulated With Berahyaluronidase Alfa (MK-3475A) in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL)(MK-3475A-F65)
NCT06504394 · ClinicalTrials.gov ↗ · Classical Hodgkin Lymphoma Recurrent, Classical Hodgkin Lymphoma Refractory, Primary Mediastinal Large B-cell Lymphoma Recurrent
Phase 2 Active, closed Merck Sharp & Dohme LLC UK, USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with ) Berahyaluronidase alfa

12 conditions
Non-Small Cell Lung Cancer2Solid Tumors1Hematologic Malignancies1Lung Cancer1Non-small Cell Lung Cancer1Classical Hodgkin Lymphoma Recurrent1Classical Hodgkin Lymphoma Refractory1Primary Mediastinal Large B-cell Lymphoma Recurrent1Primary Mediastinal Large B-cell Lymphoma Refractory1Colorectal Cancer1Renal Cell Carcinoma1Melanoma1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Merck Sharp & Dohme LLC5
Exelixis1
04

By country register

RegisterTrialsRecruiting
Clinical trials in USA63
Clinical trials in UK42
Clinical trials in China32
Clinical trials in Ireland11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about ) Berahyaluronidase alfa trials

How many clinical trials are testing ) Berahyaluronidase alfa?

6 current trials in our USA, UK, China and Ireland registers name ) Berahyaluronidase alfa as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are ) Berahyaluronidase alfa trials recruiting patients?

Yes. 3 of the 6 trials are recruiting: 3 with sites in USA, 2 with sites in UK, 2 with sites in China and 1 with sites in Ireland. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors ) Berahyaluronidase alfa clinical trials?

Merck Sharp & Dohme LLC (5) and Exelixis (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how ) Berahyaluronidase alfa works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how ) Berahyaluronidase alfa works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists ) Berahyaluronidase alfa (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.