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Clinical Trials in the UK / NCT07428499
Recruiting Phase 3

Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)

NCT07428499 · tracked via the Priya Life Science UK tracker
Sponsor
ADARx Pharmaceuticals, Inc.
Phase
Phase 3
Started
2026-04-02
Last updated
2026-09-04

Condition(s) studied

Hereditary Angioedema (HAE)Hereditary Angioedema - Type 1Hereditary Angioedema - Type 2HAE

Investigational drug(s) / intervention(s)

ADX-324 Dose Level 1ADX-324 Dose Level 2

ADX-324 Dose Level 1: siRNA duplex oligonucleotide

ADX-324 Dose Level 2: siRNA duplex oligonucleotide

Study summary

Study ADX-324-302 is an extension study for participants who complete the Phase 3 ADX-324-301 trial. The extension study will provide information about the safety and efficacy of additional dosing of ADX-324 in participants with Type I and Type II hereditary angioedema (HAE). The study will also include pharmacodynamic (PD), pharmacokinetic (PK), and health-related quality of life (HRQoL) measurements.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Have a documented diagnosis of HAE (Type I or II) * Completed Study ADX-324-301 * Have access to an acute therapy to treat HAE attacks (such as plasma derived or recombinant C1-INH concentrate or a BK2-receptor antagonist) Exclusion Criteria: * A negative reaction to study drug in ADX-324-301

Primary outcome measure(s)

Trial sites (48)

FacilityCityRegionStatus
ADARx Clinical Site Litchfield Park Arizona Not Yet Recruiting
ADARx Clinical Site Little Rock Arkansas Not Yet Recruiting
ADARx Clinical Site San Diego California Not Yet Recruiting
ADARx Clinical Site Walnut Creek California Not Yet Recruiting
ADARx Clinical Site Orlando Florida Not Yet Recruiting
ADARx Clinical Site Chevy Chase Maryland Not Yet Recruiting
ADARx Clinical Site Wheaton Maryland Not Yet Recruiting
ADARx Clinical Site Detroit Michigan Not Yet Recruiting
ADARx Clinical Site St Louis Missouri Not Yet Recruiting
ADARx Clinical Site Las Vegas Nevada Recruiting
ADARx Clinical Site New York New York Recruiting
ADARx Clinical Site Cincinnati Ohio Not Yet Recruiting
ADARx Clinical Site Columbus Ohio Not Yet Recruiting
ADARx Clinical Site Toledo Ohio Not Yet Recruiting
ADARx Clinical Site Hershey Pennsylvania Not Yet Recruiting
ADARx Clinical Site Capital Federal Buenos Aires Not Yet Recruiting
ADARx Clinical Site Buenos Aires Buenos Aires F.D. Not Yet Recruiting
ADARx Clinical Site Adelaide South Australia Not Yet Recruiting
ADARx Clinical Site Vienna Austria Not Yet Recruiting
ADARx Clinical Site Edegem Antwerpen Not Yet Recruiting
ADARx Clinical Site Sofia Bulgaria Not Yet Recruiting
ADARx Clinical Site Edmonton Alberta Not Yet Recruiting
ADARx Clinical Site Ottawa Ontario Not Yet Recruiting
ADARx Clinical Site Montreal Quebec Not Yet Recruiting
ADARx Clinical Site Beijing China Not Yet Recruiting
ADARx Clinical Site Harbin China Not Yet Recruiting
ADARx Clinical Site Zhengzhou China Not Yet Recruiting
ADARx Clinical Site Split Croatia Not Yet Recruiting
ADARx Clinical Site Zagreb Croatia Not Yet Recruiting
ADARx Clinical Site Hradec Králové Czechia Recruiting
ADARx Clinical Site Prague Czechia Not Yet Recruiting
ADARx Clinical Site Nice Alpes-Maritimes Not Yet Recruiting
ADARx Clinical Site Tours Indre-et-Loire Not Yet Recruiting
ADARx Clinical Site Montpellier France Not Yet Recruiting
ADARx Clinical Site Paris France Not Yet Recruiting
ADARx Clinical Site Tübingen Baden-Wurttemberg Not Yet Recruiting
ADARx Clinical Site Hong Kong Hong Kong Not Yet Recruiting
ADARx Clinical Site Budapest Hungary Not Yet Recruiting
ADARx Clinical Site Ashkelon Israel Not Yet Recruiting
ADARx Clinical Site Tel Aviv Israel Not Yet Recruiting

+ 8 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07428499 on ClinicalTrials.gov ↗ ← All trials in the UK