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Priya Life Science Compound trial record
Compound · clinical trials

Furmonertinib clinical trials

Also listed in trial records as Firmonertinib, AST2818, Ivesa, Furmonertinib(AST2818)
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 31 trials in our China, UK, USA, France, Spain, Italy, Canada, Japan, South Korea, Australia, Taiwan, Singapore, Netherlands, Turkey, Brazil, Mexico and Israel registers that name Furmonertinib as an intervention. Synced 9 Nov 2026
31Current trials
22Recruiting now
22Lead sponsors
17Country registers
At a glance

Furmonertinib is named as an intervention in 31 current clinical trials in our China, UK, USA, France, Spain, Italy, Canada, Japan, South Korea, Australia, Taiwan, Singapore, Netherlands, Turkey, Brazil, Mexico and Israel registers. 22 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is ArriVent BioPharma, Inc (3). The most-studied condition is NSCLC.

How Furmonertinib works

All drug targets →
  • Epidermal growth factor receptor erbB1 inhibitor Inhibitor
    Target: EGFR epidermal growth factor receptor
    ✓ In ChEMBL and the Guide to Pharmacology
Diseases it has been tested for in clinical trials, by furthest phase
  • Non-small cell lung carcinomaPhase 3
  • Leptomeningeal metastasisPhase 2
  • Lung adenocarcinomaPhase 2
  • Lung cancerPhase 2
  • Non-small cell lung adenocarcinomaPhase 2

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL4297258, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 10477, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Furmonertinib

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Reference identifiers for Furmonertinib

ChEMBL
CHEMBL4297258
DrugBank
DB16087
PubChem CID
118861389
CAS number
1869057-83-9
FDA UNII
A49A7A5YN4
Wikidata
Q140641519
Wikipedia
Firmonertinib

Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.

Trials by status

  • Recruiting2271%
  • Not yet open516%
  • Active, closed413%

Trials by phase

  • Phase 22065%
  • Phase 3516%
  • Phase 1/2413%
  • Phase 413%
  • Phase 113%
01

Clinical trials of Furmonertinib

31 trials
StudyPhaseStatusLead sponsorRegisters
Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases
NCT07092202 · ClinicalTrials.gov ↗ · Leptomeningeal Metastasis, NSCLC, Intrathecal Chemotherapy
Phase 4 Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology China
To Assess the Efficacy and Safety of Furmonertinib Versus Placebo, in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy
NCT04853342 · ClinicalTrials.gov ↗ · Non-small Cell Lung Carcinoma
Phase 3 Recruiting Allist Pharmaceuticals, Inc China
Furmonertinib 160mg as First-line Treatment in Locally Advanced or Metastatic NSCLC With EGFR Classical Mutations
NCT06674343 · ClinicalTrials.gov ↗ · Advanced or Metastatic Non-small Cell Lung Cancer
Phase 3 Recruiting Peking Union Medical College Hospital China
A Study to Assess the Efficacy and Safety of Firmonertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB - IIIB NSCLC With Uncommon Epidermal Growth Factor Receptor (EGFR) Mutations, Following Complete Surgical Resection With or Without Adjuvant Chemotherapy(FIRMOST)
NCT07010419 · ClinicalTrials.gov ↗ · NSCLC, Adjuvant Treatment
Phase 3 Recruiting Allist Pharmaceuticals, Inc China
Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations
NCT07185997 · Non-Small-Cell Lung Cancer, Metastatic Non-Small-Cell Lung Cancer, Advanced Non-Small-Cell Lung Cancer
Phase 3 Recruiting ArriVent BioPharma, Inc UK, USA, China, France, Spain, Italy, Turkey, Canada, Japan, South Korea, Taiwan, Singapore, Australia
Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation
NCT04322890 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, EGFR Gene Mutation, ALK Gene Mutation
Phase 2 Recruiting Hunan Province Tumor Hospital China
Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA
NCT05334277 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Recruiting Sun Yat-sen University China
Neoadjuvant Furmonertinib Plus Bevacizumab or Furmonertinib Monotherapy for Resectable and Potentially Resectable Stage III-IVA EGFR Mutation-Positive Lung Adenocarcinoma
NCT05503667 · ClinicalTrials.gov ↗ · Lung Adenocarcinoma Stage III, Lung Adenocarcinoma Stage IV, EGFR Gene Mutation
Phase 2 Recruiting Shanghai Pulmonary Hospital, Shanghai, China China
Study of Furmonertinib as Neoadjuvant Therapy for Resectable Stage Ⅱ-ⅢB EGFR Sensitive Mutant NSCLC
NCT05987826 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 2 Recruiting Shanghai Zhongshan Hospital China
To Assess the Efficacy and Safety of Furmonertinib in Patients With Epidermal Growth Factor Receptor 20ins Mutation Positive Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy
NCT06192849 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, EGFR Exon 20 Insertion Mutation
Phase 2 Recruiting Juan LI, MD China
High-dose Furmonertinib or Combined With Chemotherapy in EGFR-mutant Advanced NSCLC After Disease Progression on Third-generation EGFR-TKI
NCT06652048 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 2 Recruiting Jialei Wang China
A Phase 2 Clinical Study of Combination Therapy With ABSK043 and Firmonertinib
NCT06668103 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer With EGFR Mutation
Phase 2 Recruiting Abbisko Therapeutics Co, Ltd China
A Clinical Trial of Furmonertinib Combined With Anlotinib as First-line Treatment for Advanced NSCLC With EGFR-sensitive Mutations and Brain Metastasis
NCT06945705 · ClinicalTrials.gov ↗ · NSCLC
Phase 2 Recruiting Henan Cancer Hospital China
A Phase Ⅱ Study of RC108 in Combination With Furmonertinib for the First-line Treatment of EGFR-Mutated Combined MET-Positive Unresectable Locally Advanced or Recurrent Metastatic NSCLC
NCT06962865 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 2 Recruiting RemeGen Co., Ltd China
Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases
NCT07304739 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
Phase 2 Recruiting Tianjin Medical University Cancer Institute and Hospital China
Firmonertinib Combined With Definitive Radiotherapy in Stage III Unresectable EGFR Uncommon Mutant Pulmonary Adenocarcinoma
NCT07314216 · ClinicalTrials.gov ↗ · NSCLC (Non-small Cell Lung Carcinoma), Stage III, EGFR Uncommon Mutations
Phase 2 Recruiting Hunan Cancer Hospital China
A Phase II Study of Sacituzumab Tirumotecan in Combination With Furmonertinib in Patients With Non-squamous Non-Small Cell Lung Cancer Who Have Progressed After EGFR-TKI and Platinum-Based Chemotherapy
NCT07548060 · ClinicalTrials.gov ↗ · NSCLC Stage IV, EGFR Gene Mutation
Phase 2 Recruiting Tianjin Medical University Cancer Institute and Hospital China
A Study of SKB571 Combination Therapy in Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT07622186 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 2 Recruiting Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd China
IN10018 Combination Therapy in Advanced EGFR Mutation-positive NSCLC
NCT05994131 · ClinicalTrials.gov ↗ · NSCLC
Phase 1/2 Recruiting InxMed (Shanghai) Co., Ltd China
Phase Ib/II Study of Vebreltinib With Furmonertinib in NSCLC Patients With c-Met Amplification After EGFR-TKI Failure
NCT07087223 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer NSCLC
Phase 1/2 Recruiting Peking University Cancer Hospital & Institute China
A Study of MHB036C Combined With Anti-tumor Therapies in Patients With Advanced Lung Cancer
NCT07229599 · ClinicalTrials.gov ↗ · Advanced Lung Cancer
Phase 1/2 Recruiting Minghui Pharmaceutical (Hangzhou) Ltd China
Vebreltinib Plus Furmonertinib in Patients With EGFR-mutated Advanced Non-small Cell Lung Cancer and High PD-L1 Expression
NCT07655622 · ClinicalTrials.gov ↗ · Non-Small-Cell Lung Cancer
Phase 1/2 Recruiting Second Affiliated Hospital of Nanchang University China
A Clinical Trial of Furmonertinib Combination Therapy As Neoadjuvant Treatment in Resectable EGFR-Mutated NSCLC
NCT06585644 · ClinicalTrials.gov ↗ · Lung Cancer (NSCLC)
Phase 2 Not yet open Shanghai Pulmonary Hospital, Shanghai, China China
Furmonertinib 160mg vs 80mg + Chemotherapy in EGFR-Mutated NSCLC With Brain Metastases: Efficacy and Safety Study
NCT07365410 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer (NSCLC), Brain Metastases, Furmonertinib
Phase 2 Not yet open Tianjin Medical University Cancer Institute and Hospital China
Combining Furmonertinib With Local Therapy for Inoperable Early-stage Lung Cancer: A Phase II Trial
NCT07517640 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Not yet open Shanghai Pulmonary Hospital, Shanghai, China China
A Prospective Study of Firmonertinib as First-line Adaptive Therapy Guided by Dynamic ctDNA (MRD) Changes in Locally Advanced or Metastatic EGFR-mutated Non-small Cell Lung Cancer
NCT07661173 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
Phase 2 Not yet open Anhui Provincial Cancer Hospital China
Firmonertinib Plus Chemotherapy for Unresectable EGFR PACC-Mutant Stage III Lung Cancer: A Phase II Study
NCT07878871 · ClinicalTrials.gov ↗ · Lung Adenocarcinoma, Stage III Lung Cancer, EGFR Positive Non-small Cell Lung Cancer
Phase 2 Not yet open Hunan Province Tumor Hospital China
Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
NCT05607550 · Metastatic Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, EGFR Exon 20 Mutations
Phase 3 Active, closed ArriVent BioPharma, Inc UK, USA, China, France, Spain, Italy, Netherlands, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore, Australia, Israel
Neoadjuvant Furmonertinib and Cisplatin/Pemetrexed as in EGFR Mutated Stage IIA-IIIB Resectable NSCLC (FORESEE)
NCT05430802 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Active, closed Tang-Du Hospital China
Efficacy and Safety of Furmonertinib in Patients With Locally Advanced or Metastatic NSCLC With EGFR Exon 20 Insertion
NCT05466149 · ClinicalTrials.gov ↗ · NSCLC
Phase 2 Active, closed Allist Pharmaceuticals, Inc China
Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations
NCT05364073 · Non-Small Cell Lung Cancer (NSCLC), Metastatic Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer
Phase 1 Active, closed ArriVent BioPharma, Inc UK, USA, China, France, Spain, Italy, Netherlands, Canada, Japan, South Korea, Australia

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Furmonertinib

40 conditions
All 40 conditions
Condition (as registered)Trials
NSCLC5
Non Small Cell Lung Cancer4
Non-Small Cell Lung Cancer4
Non-small Cell Lung Cancer3
EGFR Gene Mutation3
Non-Small-Cell Lung Cancer2
Metastatic Non-Small Cell Lung Cancer2
Advanced Non-Small Cell Lung Cancer2
Metastatic Non-Small-Cell Lung Cancer1
Advanced Non-Small-Cell Lung Cancer1
EGFR P-Loop and Alpha C-Helix Compressing1
Adjuvant Treatment1
NSCLC (Non-small Cell Lung Carcinoma)1
Stage III1
EGFR Uncommon Mutations1
Non-Small Cell Lung Cancer With EGFR Mutation1
Leptomeningeal Metastasis1
Intrathecal Chemotherapy1
Tyrosine Kinase Inhibitor1
Lung Adenocarcinoma1
Stage III Lung Cancer1
EGFR Positive Non-small Cell Lung Cancer1
EGFR Exon 20 Mutations1
Non-Small Cell Lung Cancer (NSCLC)1
HER2 Exon 20 Mutations1
NSCLC Stage IV1
Lung Adenocarcinoma Stage III1
Lung Adenocarcinoma Stage IV1
Non-small Cell Lung Cancer (NSCLC)1
Brain Metastases1
Furmonertinib1
EGFR Mutation1
Advanced Lung Cancer1
Non-small Cell Lung Carcinoma1
EGFR Exon 20 Insertion Mutation1
Lung Cancer (NSCLC)1
ALK Gene Mutation1
ROS1 Gene Mutation1
Non Small Cell Lung Cancer NSCLC1
Advanced or Metastatic Non-small Cell Lung Cancer1
05

Related compounds

06

Questions about Furmonertinib trials

How many clinical trials are testing Furmonertinib?

31 current trials in our China, UK, USA, France, Spain, Italy, Canada, Japan, South Korea, Australia, Taiwan, Singapore, Netherlands, Turkey, Brazil, Mexico and Israel registers name Furmonertinib (also registered as AST2818) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are Furmonertinib trials recruiting patients?

Yes. 22 of the 31 trials are recruiting: 22 with sites in China, 1 with sites in UK, 1 with sites in USA, 1 with sites in France, 1 with sites in Spain, 1 with sites in Italy, 1 with sites in Canada, 1 with sites in Japan, 1 with sites in South Korea, 1 with sites in Australia, 1 with sites in Taiwan, 1 with sites in Singapore and 1 with sites in Turkey. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Furmonertinib clinical trials?

ArriVent BioPharma, Inc (3), Allist Pharmaceuticals, Inc (3), Tianjin Medical University Cancer Institute and Hospital (3) and Shanghai Pulmonary Hospital, Shanghai, China (3), among 22 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Furmonertinib works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Furmonertinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Furmonertinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.