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Priya Life Science Compound trial record
Compound · clinical trials

IN10018 clinical trials

Also listed in trial records as BI 853520, BI853520, IN10018(Ifebemtinib)
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 13 trials in our China register that name IN10018 as an intervention. Synced 9 Nov 2026
13Current trials
10Recruiting now
6Lead sponsors
1Country register
At a glance

IN10018 is named as an intervention in 13 current clinical trials in our China register. 10 are recruiting patients now. The most common phase is Phase 1/2. The sponsor with the most trials is InxMed (Shanghai) Co., Ltd (8). The most-studied condition is NSCLC.

How IN10018 works

All drug targets →
  • Focal adhesion kinase 1 inhibitor Inhibitor
    Target: PTK2 protein tyrosine kinase 2
    ChEMBL only
Other medicines acting on PTK2
Diseases it has been tested for in clinical trials, by furthest phase
  • Non-small cell lung carcinomaPhase 3
  • Fallopian tube cancerPhase 2
  • Ovarian cancerPhase 2
  • Primary peritoneal carcinomaPhase 2
  • Colorectal cancerPhase 1/2
  • Exocrine pancreatic carcinomaPhase 1/2
  • MelanomaPhase 1/2
  • NeoplasmPhase 1/2
  • Pancreatic ductal adenocarcinomaPhase 1/2
  • Small cell lung carcinomaPhase 1/2
13 diseases in all

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL3657311, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 12369, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for IN10018

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting1077%
  • Not yet open18%
  • Active, closed215%

Trials by phase

  • Phase 1/2862%
  • Phase 2215%
  • Phase 3215%
  • Phase 118%
01

Clinical trials of IN10018

13 trials
StudyPhaseStatusLead sponsorRegisters
A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation
NCT07174908 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 3 Recruiting InxMed (Shanghai) Co., Ltd China
IN10018 in Combination With Pegylated Liposomal Doxorubicin (PLD) vs. Placebo in Combination With PLD for the Treatment of Platinum-resistant Recurrent Ovarian Cancer
NCT06014528 · ClinicalTrials.gov ↗ · Ovarian Cancer Recurrent
Phase 2 Recruiting InxMed (Shanghai) Co., Ltd China
IN10018 With Nab-Paclitaxel and Cadonilimab for Metastatic or Recurrent Gastric-Type Cervical Adenocarcinoma: Phase 2 Trial
NCT06654011 · ClinicalTrials.gov ↗ · Cervical Adenocarcinoma, Gastric-type Endocervical Adenocarcinoma
Phase 2 Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology China
IN10018 in Combination With Standard Chemotherapy in High-grade Serous Epithelial Ovarian Cancer
NCT05551507 · ClinicalTrials.gov ↗ · Platinum-resistant Ovarian Cancer
Phase 1/2 Recruiting InxMed (Shanghai) Co., Ltd China
IN10018+ Standard Chemotherapy (+KN046) in Subjects With Advanced Pancreatic Cancer
NCT05827796 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 1/2 Recruiting InxMed (Shanghai) Co., Ltd China
IN10018 Combination Therapy in Advanced EGFR Mutation-positive NSCLC
NCT05994131 · ClinicalTrials.gov ↗ · NSCLC
Phase 1/2 Recruiting InxMed (Shanghai) Co., Ltd China
IN10018 Combination Therapy in Treatment-naïve ES-SCLC
NCT06030258 · ClinicalTrials.gov ↗ · Small Cell Lung Cancer Extensive Stage
Phase 1/2 Recruiting InxMed (Shanghai) Co., Ltd China
HX009+ IN10018 With or Without Standard Chemotherapy for Advanced Solid Tumours
NCT06708663 · ClinicalTrials.gov ↗ · Biliary Tract Cancer, Melanoma
Phase 1/2 Recruiting Hangzhou Hanx Biopharmaceuticals, Ltd China
IN10018 in Combination With RNK08954 for the Treatment of KRASG12D Mutation-Positive Locally Advanced or Metastatic Solid Tumors
NCT07441174 · ClinicalTrials.gov ↗ · Solid Tumor Cancer, PDAC
Phase 1/2 Recruiting InxMed (Shanghai) Co., Ltd China
A Phase Ib Study of JMKX001899 in Combination With Other Therapies in Advanced NSCLC Harboring KRAS G12C Mutation
NCT06946927 · ClinicalTrials.gov ↗ · NSCLC (Advanced Non-small Cell Lung Cancer)
Phase 1 Recruiting Jemincare China
A Phase 3 Study of Sosimerasib in Combination With IN10018 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation
NCT07833202 · ClinicalTrials.gov ↗ · NSCLC
Phase 3 Not yet open Shanghai Jeyou Pharmaceutical Co., Ltd China
Study to Evaluate D-1553 in Combination With IN10018 in Subjects With Solid Tumors
NCT05379946 · ClinicalTrials.gov ↗ · Solid Tumor
Phase 1/2 Active, closed InventisBio Co., Ltd China
a Study to Evaluate the Safety and Efficacy of D-1553 Combined With IN10018 in KRAS G12C Mutant Solid Tumors
NCT06166836 · ClinicalTrials.gov ↗ · Solid Tumor
Phase 1/2 Active, closed InxMed (Shanghai) Co., Ltd China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with IN10018

14 conditions
All 14 conditions
Condition (as registered)Trials
NSCLC2
Solid Tumor2
Pancreatic Cancer1
NSCLC (Advanced Non-small Cell Lung Cancer)1
Platinum-resistant Ovarian Cancer1
Solid Tumor Cancer1
PDAC1
Ovarian Cancer Recurrent1
Cervical Adenocarcinoma1
Gastric-type Endocervical Adenocarcinoma1
Non-Small Cell Lung Cancer1
Biliary Tract Cancer1
Melanoma1
Small Cell Lung Cancer Extensive Stage1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
InxMed (Shanghai) Co., Ltd8
Jemincare1
InventisBio Co., Ltd1
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology1
Shanghai Jeyou Pharmaceutical Co., Ltd1
Hangzhou Hanx Biopharmaceuticals, Ltd1
04

By country register

RegisterTrialsRecruiting
Clinical trials in China1310

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about IN10018 trials

How many clinical trials are testing IN10018?

13 current trials in our China register name IN10018 (also registered as BI 853520) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are IN10018 trials recruiting patients?

Yes. 10 of the 13 trials are recruiting: 10 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors IN10018 clinical trials?

InxMed (Shanghai) Co., Ltd (8), Jemincare (1), InventisBio Co., Ltd (1) and Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1), among 6 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how IN10018 works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how IN10018 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists IN10018 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.