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Compound · clinical trials

Lazertinib clinical trials

Also listed in trial records as JNJ-73841937, YH25448
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 10 trials in our USA, China, UK and India registers that name Lazertinib as an intervention. Synced 25 Sep 2026
10Current trials
3Recruiting now
1Lead sponsor
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Lazertinib is named as an intervention in 10 current clinical trials in our USA, China, UK and India registers. 3 are recruiting patients now. The most common phase is Phase 2. The lead sponsor is Janssen Research & Development, LLC. The most-studied condition is Carcinoma, Non-Small-Cell Lung.

Trials by status

  • Recruiting330%
  • Active, closed770%

Trials by phase

  • Phase 2550%
  • Phase 3330%
  • Phase 1220%
01

Clinical trials of Lazertinib

10 trials
StudyPhaseStatusLead sponsorRegisters
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
NCT05498428 · ClinicalTrials.gov ↗ · Carcinoma, Non-small-Cell Lung
Phase 2 Recruiting Janssen Research & Development, LLC UK, USA, China
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT06667076 · Carcinoma, Non-Small-Cell Lung
Phase 2 Recruiting Janssen Research & Development, LLC UK, USA
A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC
NCT07586202 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
Phase 2 Recruiting Janssen Research & Development, LLC USA, China
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04487080 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
Phase 3 Active, closed Janssen Research & Development, LLC UK, USA, India, China
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
NCT04988295 · Carcinoma, Non-Small-Cell Lung
Phase 3 Active, closed Janssen Research & Development, LLC UK, USA, India, China
A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer
NCT05388669 · ClinicalTrials.gov ↗ · Advanced or Metastatic Non-small Cell Lung Cancer
Phase 3 Active, closed Janssen Research & Development, LLC UK, USA, China
Premedication to Reduce Amivantamab Associated Infusion Related Reactions
NCT05663866 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
Phase 2 Active, closed Janssen Research & Development, LLC USA
Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
NCT06120140 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
Phase 2 Active, closed Janssen Research & Development, LLC USA, China
Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer
NCT02609776 · ClinicalTrials.gov ↗ · Non-Small-Cell Lung Cancer
Phase 1 Active, closed Janssen Research & Development, LLC UK, USA, China
A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer
NCT04077463 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
Phase 1 Active, closed Janssen Research & Development, LLC USA, China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Lazertinib

4 conditions
Carcinoma, Non-Small-Cell Lung7Carcinoma, Non-small-Cell Lung1Non-Small-Cell Lung Cancer1Advanced or Metastatic Non-small Cell Lung Cancer1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Janssen Research & Development, LLC10
04

By country register

RegisterTrialsRecruiting
Clinical trials in USA103
Clinical trials in China82
Clinical trials in UK62
Clinical trials in India20

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Lazertinib trials

How many clinical trials are testing Lazertinib?

10 current trials in our USA, China, UK and India registers name Lazertinib (also registered as JNJ-73841937) as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Lazertinib trials recruiting patients?

Yes. 3 of the 10 trials are recruiting: 3 with sites in USA, 2 with sites in China and 2 with sites in UK. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Lazertinib clinical trials?

The lead sponsor is Janssen Research & Development, LLC. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Lazertinib works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Lazertinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Lazertinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.