Ireland
--:--IST
Priya Life Science Compound trial record
Compound · clinical trials

Almonertinib clinical trials

Also listed in trial records as HS-10296, Aumolertinib, Ameile
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 20 trials in our China and Taiwan registers that name Almonertinib as an intervention. Synced 9 Nov 2026
20Current trials
10Recruiting now
15Lead sponsors
2Country registers
At a glance

Almonertinib is named as an intervention in 20 current clinical trials in our China and Taiwan registers. 10 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Jiangsu Hansoh Pharmaceutical Co., Ltd (3). The most-studied condition is Non-small Cell Lung Cancer.

How Almonertinib works

All drug targets →
  • Epidermal growth factor receptor erbB1 inhibitor Inhibitor
    Target: EGFR epidermal growth factor receptor
    ✓ In ChEMBL and the Guide to Pharmacology
Diseases it has been tested for in clinical trials, by furthest phase
  • Lung cancerPhase 2/3
  • Leptomeningeal metastasisPhase 2
  • Squamous cell carcinomaPhase 2
  • CancerPhase 1

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL4761468, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 11136, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Almonertinib

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting1050%
  • Not yet open315%
  • Active, closed630%
  • By invitation15%

Trials by phase

  • Phase 3945%
  • Phase 2735%
  • Phase 2/315%
  • Phase 1/215%
  • Not applicable15%
  • Phase 115%
01

Clinical trials of Almonertinib

20 trials
StudyPhaseStatusLead sponsorRegisters
A Phase III Study to Assess the Effects of Almonertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer
NCT04951635 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 3 Recruiting Jiangsu Hansoh Pharmaceutical Co., Ltd China
Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases
NCT05768490 · ClinicalTrials.gov ↗ · Brain Metastases, Radiotherapy, EGFR Activating Mutation
Phase 3 Recruiting Sun Yat-sen University China
Armatinib Alone or in Combination With SRT for Brain Metastases EGFR-mutated Non-small Cell Lung Cancer
NCT05800223 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer Metastatic
Phase 3 Recruiting Shanghai Cancer Hospital, China China
Almonertinib Combined With Anlotinib as First-line Treatment for Advanced Non-small Cell Lung Cance
NCT06043973 · ClinicalTrials.gov ↗ · Advanced Non-small Cell Lung Cancer
Phase 3 Recruiting Qianfoshan Hospital China
A Study of HS-20117 Combined With Aumolertinib in Participants With Advanced Non-Squamous Non-Small Cell Lung Cancer
NCT06417008 · ClinicalTrials.gov ↗ · Non-Squamous Non-Small Cell Lung Cancer
Phase 2/3 Recruiting Hansoh BioMedical R&D Company China
PLATFORM Study of Precision Medicine for Rare Tumors
NCT04423185 · ClinicalTrials.gov ↗ · Rare Tumor
Phase 2 Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences China
A Study of BL-B01D1 and Almonertinib in Patients With Resectable EGFR+ Stage II-IIIB NSCLC
NCT06951464 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 2 Recruiting Sichuan University China
Aumolertinib Combined With Phased Chemotherapy for EGFR L858R Lung Adenocarcinoma
NCT07624487 · ClinicalTrials.gov ↗ · Lung Adenocarcinoma Metastatic
Phase 2 Recruiting Taipei Medical University Hospital Taiwan
A Study of Almonertinib Combined With Palbociclib in Patients With Advanced Solid Tumors Harboring KRAS Mutations
NCT06947811 · ClinicalTrials.gov ↗ · EGFR Tyrosine Kinase Inhibitors Plus Cyclin-dependent Kinase 4/6 Inhibitor
Phase 1/2 Recruiting Sun Yat-sen University China
PHASE 1b STUDY OF HS-20122 COMBINED THERAPY IN NSCLC
NCT07645222 · ClinicalTrials.gov ↗ · Lung Cancer
Phase 1 Recruiting Hansoh BioMedical R&D Company China
Aumolertinib Versus Osimertinib As First-line Therapy for Patients with EGFR Mutated Locally Advanced or Metastatic Non-small-cell Lung Cancer
NCT06752408 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
Phase 2 Not yet open Peking Union Medical College Hospital China
An Open, Multicenter Phase II Clinical Trial of SHR-A2009 Combined With Other Anti-tumor Therapies for Perioperative Treatment of Resectable Non-small Cell Lung Cancer.
NCT07863167 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Not yet open Suzhou Suncadia Biopharmaceuticals Co., Ltd China
MRD-Guided Aumolertinib-Based Adjuvant Therapy for Resected EGFR-Mutant NSCLC
NCT07873086 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Not applicable Not yet open Peking University People's Hospital China
Efficacy and Safety of Almonertinib Combined With or Without Chemotherapy as an Adjuvant Treatment for Stage II-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection
NCT04762459 · ClinicalTrials.gov ↗ · Non-small Cell Lung Carcinoma
Phase 3 By invitation Chinese Academy of Medical Sciences China
Almonertinib Versus Placebo as Adjuvant Therapy in Resected Stage II-IIIB Non-Small Cell Lung Cancer With EGFR-sensitive Mutations
NCT04687241 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 3 Active, closed Jiangsu Hansoh Pharmaceutical Co., Ltd China
MDT-bridged Radical Therapy After Aumolertinib With MRD-guided Maintenance in EGFRm+ Unresectable Stage III NSCLC (APPROACH)
NCT04841811 · ClinicalTrials.gov ↗ · Lung Cancer
Phase 3 Active, closed Guangdong Association of Clinical Trials China
Aumolertinib with or Without Chemotherapy As 1st Line Treatment in Locally Advanced or Metastatic Non-Small Cell Lung Cancer with Sensitizing EGFR Mutations
NCT04923906 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 3 Active, closed Jiangsu Hansoh Pharmaceutical Co., Ltd China
A Study of SHR-A2009 Combined With Aumolertinib Versus Aumolertinib for First-line Treatment in EGFR-mutated, Advanced or Metastatic NSCLC
NCT07183189 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 3 Active, closed Suzhou Suncadia Biopharmaceuticals Co., Ltd China
Neoadjuvant HS-10296 (Almonertinib) Therapy for Potential Resectable Stage III EGFR Mutation-Positive Non-small Cell Lung Cancer
NCT04685070 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer Stage III
Phase 2 Active, closed Shanghai Pulmonary Hospital, Shanghai, China China
Neoadjuvant Almonertinib Followed by Chemo-immunotherapy in II-IIIB EGFR-mutant NSCLC
NCT06300424 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, EGFR Gene Mutation
Phase 2 Active, closed Guangdong Provincial People's Hospital China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Almonertinib

16 conditions
Non-small Cell Lung Cancer5Non Small Cell Lung Cancer2Non-Small Cell Lung Cancer2Lung Cancer2EGFR Gene Mutation1Advanced Non-small Cell Lung Cancer1Non-small Cell Lung Carcinoma1Non-Squamous Non-Small Cell Lung Cancer1Non-small Cell Lung Cancer Stage III1Non-small Cell Lung Cancer Metastatic1Rare Tumor1EGFR Tyrosine Kinase Inhibitors Plus Cyclin-dependent Kinase 4/6 Inhibitor1
All 16 conditions
Condition (as registered)Trials
Non-small Cell Lung Cancer5
Non Small Cell Lung Cancer2
Non-Small Cell Lung Cancer2
Lung Cancer2
EGFR Gene Mutation1
Advanced Non-small Cell Lung Cancer1
Non-small Cell Lung Carcinoma1
Non-Squamous Non-Small Cell Lung Cancer1
Non-small Cell Lung Cancer Stage III1
Non-small Cell Lung Cancer Metastatic1
Rare Tumor1
EGFR Tyrosine Kinase Inhibitors Plus Cyclin-dependent Kinase 4/6 Inhibitor1
Brain Metastases1
Radiotherapy1
EGFR Activating Mutation1
Lung Adenocarcinoma Metastatic1
05

Related compounds

06

Questions about Almonertinib trials

How many clinical trials are testing Almonertinib?

20 current trials in our China and Taiwan registers name Almonertinib (also registered as HS-10296) as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are Almonertinib trials recruiting patients?

Yes. 10 of the 20 trials are recruiting: 9 with sites in China and 1 with sites in Taiwan. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Almonertinib clinical trials?

Jiangsu Hansoh Pharmaceutical Co., Ltd (3), Hansoh BioMedical R&D Company (2), Sun Yat-sen University (2) and Suzhou Suncadia Biopharmaceuticals Co., Ltd (2), among 15 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Almonertinib works or whether it is effective, and it is not medical advice.

Approvals, shortages and trials, every Friday

One email a week with new EMA and FDA approvals, EU and US medicine shortages, how many trials are recruiting in Ireland, and the week's Irish pharma news.

Free. Unsubscribe from any email with one click. See our privacy policy.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Almonertinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Almonertinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.