A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Condition(s) studied
Investigational drug(s) / intervention(s)
Amivantamab: Amivantamab will be administered.
Lazertinib: Lazertinib tablet will be administered.
Chemotherapy: Pemetrexed: Pemetrexed will be administered.
Chemotherapy: Carboplatin: Carboplatin will be administered.
Study summary
The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).
Eligibility
Primary outcome measure(s)
- Progression Free Survival (PFS) — Up to 4 Years and 6 months
PFS is defined as the time from the date of first dose of any study treatment until the date of objective disease progression or death, whichever occurs first according to response evaluation criteria in solid tumors (RECIST) version (v) 1.1 as assessed by the investigator.
Trial sites (205)
| Facility | City | Region | Status |
|---|---|---|---|
| Southern Cancer Center, PC | Daphne | Alabama | Active Not Recruiting |
| Clearview Cancer Institute | Huntsville | Alabama | Completed |
| City of Hope Phoenix | Goodyear | Arizona | Active Not Recruiting |
| The Oncology Institute of Hope and Innovation | Cerritos | California | Active Not Recruiting |
| City of Hope Corona | Corona | California | Active Not Recruiting |
| City of Hope | Duarte | California | Active Not Recruiting |
| Oncology Physicians Network Healthcare | Glendale | California | Completed |
| Los Angeles Cancer Network | Glendale | California | Active Not Recruiting |
| Glendale Adventist Medical Center | Glendale | California | Completed |
| Marin Cancer Center | Greenbrae | California | Completed |
| City of Hope Seacliff | Huntington Beach | California | Active Not Recruiting |
| City of Hope Orange County Lennar Foundation Cancer Center | Irvine | California | Active Not Recruiting |
| University of California San Diego Health | La Jolla | California | Active Not Recruiting |
| City of Hope Antelope Valley | Lancaster | California | Recruiting |
| City of Hope Long Beach Elm | Long Beach | California | Recruiting |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | Active Not Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | Active Not Recruiting |
| Cedars Sinai Medical Center | Los Angeles | California | Active Not Recruiting |
| Valkyrie Clinical Trials | Los Angeles | California | Active Not Recruiting |
| Providence Medical Foundation | Mission Viejo | California | Active Not Recruiting |
| Valkyrie Clinical Trials Murrieta | Murrieta | California | Active Not Recruiting |
| Kaiser Permanente Oakland Medical Center | Oakland | California | Completed |
| St. Joseph Hospital Center for Cancer Prevention and Treatment | Orange | California | Completed |
| University of California Irvine | Orange | California | Active Not Recruiting |
| Sutter Health Palo Alto Medical Foundation | Palo Alto | California | Completed |
| Kaiser Permanente Roseville Medical Center | Roseville | California | Completed |
| UC Davis Comprehensive Cancer Center | Sacramento | California | Active Not Recruiting |
| Sutter Institute for Medical Research | Sacramento | California | Completed |
| California Pacific Medical Center | San Francisco | California | Completed |
| Kaiser Permanente San Francisco Medical Center | San Francisco | California | Completed |
| UCSF Zuckerberg San Francisco General Hospital | San Francisco | California | Active Not Recruiting |
| Sansum Clinic | Santa Barbara | California | Active Not Recruiting |
| Kaiser Permanente Santa Clara Medical Center | Santa Clara | California | Active Not Recruiting |
| Providence Medical Foundation 1 | Santa Rosa | California | Active Not Recruiting |
| City of Hope South Pasadena | South Pasadena | California | Recruiting |
| City of Hope Upland | Upland | California | Recruiting |
| Kaiser Permanente Northern California | Vallejo | California | Active Not Recruiting |
| Kaiser Permanente Walnut Creek Medical Center | Walnut Creek | California | Active Not Recruiting |
| John Muir Health Clinical Research Center | Walnut Creek | California | Active Not Recruiting |
| National Jewish Health | Denver | Colorado | Completed |
+ 165 more sites — see the full list on the official registry below.
More Janssen Research & Development, LLC trials in the UK
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06667076 on ClinicalTrials.gov ↗ ← All trials in the UK