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Clinical trial register · China

Leptomeningeal Metastasis Trials in China, 2026

Every study on the ClinicalTrials.gov registry that lists a site in China and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 19282 matching records held by the registry are in this view. Synced 14 Nov 2026, 03:17 UTC
19282
Studies in scope
all four open statuses
11840
Recruiting now
open to new participants
2032
Lead sponsors
across recruiting studies
Top sites
Shanghai 7 Huizhou 6 Beijing 4 Guangzhou 2 Nanjing 1

Leptomeningeal Metastasis trials in China

20 of 19282 studies
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Status
Study
Lead sponsor
Phase
Enrol
Chinese sites
Start
Not yet open
Tianjin Medical University Cancer Institute and Hospital
Phase 2
50
Tianjin
2026-09
Not yet open
Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI
NCT07551414NSCLC (Non-small Cell Lung Carcinoma), Leptomeningeal Metastasis, EGFR-TKI Sensitizing Mutation, Zorifertinib
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Phase 2
38
Beijing
2026-05-30
Recruiting
Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis
NCT07348965NSCLC (Advanced Non-small Cell Lung Cancer), Leptomeningeal Metastasis, Furmonertinib, EGFR Activating Mutation
Guangzhou University of Traditional Chinese Medicine
Not applicable
42
Guangzhou
2026-03-01
Recruiting
Second Affiliated Hospital of Nanchang University
Not applicable
30
Nanchang
2026-02-15
Recruiting
Guangzhou Medical University
Phase 2
36
Huizhou
2025-09-01
Not yet open
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Observational
142
Nanjing
2025-07-01
Recruiting
Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases
NCT07092202Leptomeningeal Metastasis, NSCLC, Intrathecal Chemotherapy, Tyrosine Kinase Inhibitor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Phase 4
40
Wuhan
2025-04-15
Recruiting
Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis
NCT06809517Leptomeningeal Metastasis, Intrathecal Drug Delivery
Guangzhou Medical University
Phase 1/2
34
Huizhou
2025-03-18
Active, closed
Guangzhou Medical University
Phase 1/2
39
Beijing, Huizhou, Shanghai
2025-03-17
Recruiting
Guangzhou Medical University
Phase 1/2
39
Huizhou, Beijing, Shanghai
2025-03-07
Recruiting
Shanghai Chest Hospital
Phase 1
19
Shanghai
2024-12-09
By invitation
Shanghai Zhongshan Hospital
Observational
107
Shanghai
2024-10-01
Active, closed
Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases
NCT06282874Carcinoma, Non-Small-Cell Lung, Brain Metastases, Leptomeningeal Metastasis
Guangdong Association of Clinical Trials
Phase 4
41
Dongguan, Foshan, Guangzhou
2024-08-01
Active, closed
Guangzhou Medical University
Phase 1/2
45
Huizhou, Beijing, Shanghai
2024-06-30
Recruiting
Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
NCT06431685NSCLC, Low Dose Radiotherapy, PD-1 Inhibitor, Leptomeningeal Metastasis
Sichuan University
Phase 1
10
Chengdu
2024-04-25
Recruiting
Fudan University
Phase 4
37
Shanghai
2024-01-05
Recruiting
Xiangya Hospital of Central South University
Observational
64
Changsha
2023-10-30
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Chinese investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 15 November 2026. https://priyalifescience.com/clinical-trials-china/condition/leptomeningeal-metastasis

Query this register directly
GET /api/trials?country=cn&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in China and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 19,282 studies in total at the last sync on 14 Nov 2026, 03:17 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 20 of those studies listing the condition Leptomeningeal Metastasis.

How many Leptomeningeal Metastasis trials are recruiting in China?

12 of the 20 studies on this page are recruiting new participants as of the 14 Nov 2026, 03:17 UTC sync. A further 4 have not yet opened recruitment, 3 are active but closed to new participants, and 1 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Leptomeningeal Metastasis), 20 studies
PhaseStudiesRecruitingShare
Phase 25225%
Phase 1/24220%
Not applicable3315%
Observational3115%
Phase 43215%
Phase 12210%

Most active sponsors

Lead sponsors with the most studies (Leptomeningeal Metastasis)
Lead sponsorStudiesRecruiting
Guangzhou Medical University64
Cancer Institute and Hospital, Chinese Academy of Medical Sciences10
Fudan University11
Fujian Cancer Hospital10
Guangdong Association of Clinical Trials10
Guangzhou University of Traditional Chinese Medicine11
Second Affiliated Hospital of Nanchang University11
Shanghai Cancer Hospital, China11
Shanghai Chest Hospital11
Shanghai Zhongshan Hospital10
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and India registers.