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Clinical Trials in the UK / NCT07680764
Recruiting Phase 2

A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT07680764 · tracked via the Priya Life Science UK tracker
Sponsor
Bristol-Myers Squibb
Phase
Phase 2
Started
2026-08-31
Last updated
2026-09-16

Condition(s) studied

Locally Advanced Non-Small Cell Lung Cancer (NSCLC)Metastatic Non-Small Cell Lung Cancer (NSCLC)

Investigational drug(s) / intervention(s)

PumitamigImzokitugPemetrexedCisplatinCarboplatinPaclitaxelInfliximabVedolizumab

Pumitamig: Specified dose on specified days

Imzokitug: Specified dose on specified days

Pemetrexed: Specified dose on specified days

Cisplatin: Specified dose on specified days

Carboplatin: Specified dose on specified days

Paclitaxel: Specified dose on specified days

Infliximab: Specified dose on specified days

Vedolizumab: Specified dose on specified days

Study summary

The purpose of this study is to assess the safety, tolerability, and efficacy of Imzokitug in combination with Pumitamig and Platinum-Doublet Chemotherapy (PDCT) versus Pumitamig and PDCT as first-line treatment for participants with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria * Participants must have histologically confirmed diagnosis of stage IV non-small cell lung cancer (NSCLC) (squamous or non-squamous) or recurrent unresectable disease per the American joint committee on cancer (AJCC) Staging System 9th edition. * Participants must have no prior systemic anti-cancer therapy given as primary therapy for advanced or metastatic disease. * Tumor tissue (fresh or archival) obtained within 5 months of enrollment (signing of informed consent) for each participant must be submitted by the site. * Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1. * Participants must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Exclusion Criteria * Participants must not have any documented actionable genomic alterations (AGAs) for which first line approved targeted therapies are indicated. * Participants must not have prior treatment with immuno-oncology therapies. * Participants must not have untreated central nervous system (CNS) metastases. * Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcome measure(s)

Trial sites (71)

FacilityCityRegionStatus
Local Institution - 0170 Athens Georgia Not Yet Recruiting
Local Institution - 0034 Lexington Kentucky Not Yet Recruiting
Local Institution - 0171 Lexington Kentucky Not Yet Recruiting
Local Institution - 0123 Baltimore Maryland Not Yet Recruiting
Local Institution - 0180 Hattiesburg Mississippi Not Yet Recruiting
Nebraska Cancer Specialists Grand Island Nebraska Recruiting
Oncology Hematology West PC Omaha Nebraska Recruiting
Local Institution - 0080 New York New York Not Yet Recruiting
Local Institution - 0095 Houston Texas Not Yet Recruiting
Local Institution - 0135 Madison Wisconsin Not Yet Recruiting
Local Institution - 0082 Rosario Santa Fe Province Not Yet Recruiting
Local Institution - 0094 Buenos Aires Argentina Not Yet Recruiting
Local Institution - 0092 Viedma Argentina Not Yet Recruiting
Local Institution - 0074 Gosford New South Wales Not Yet Recruiting
Local Institution - 0134 Westmead New South Wales Not Yet Recruiting
Local Institution - 0167 Greenslopes Queensland Not Yet Recruiting
Local Institution - 0100 Heidelberg Victoria Not Yet Recruiting
Local Institution - 0048 Perth Western Australia Not Yet Recruiting
Local Institution - 0003 Natal/RN Rio Grande do Norte Not Yet Recruiting
Local Institution - 0006 Porto Alegre Rio Grande do Sul Not Yet Recruiting
Local Institution - 0005 Barretos São Paulo Not Yet Recruiting
Local Institution - 0001 São Paulo Brazil Not Yet Recruiting
Local Institution - 0081 Santiago Santiago Metropolitan Not Yet Recruiting
Local Institution - 0149 Santiago Santiago Metropolitan Not Yet Recruiting
Local Institution - 0084 Viña del Mar Valparaiso Not Yet Recruiting
Local Institution - 0038 Beijing Beijing Municipality Not Yet Recruiting
Local Institution - 0138 Fuzhou Fujian Not Yet Recruiting
Local Institution - 0050 Wuhan Hubei Not Yet Recruiting
Local Institution - 0147 Nanjing Jiangsu Not Yet Recruiting
Local Institution - 0140 Shanghai Shanghai Municipality Not Yet Recruiting
Local Institution - 0169 Shanghai Shanghai Municipality Not Yet Recruiting
Local Institution - 0144 Chengdu Sichuan Not Yet Recruiting
Local Institution - 0137 Hangzhou Zhejiang Not Yet Recruiting
Local Institution - 0131 Nice Alpes-Maritimes Not Yet Recruiting
Local Institution - 0110 Marseille Bouches-du-Rhône Not Yet Recruiting
Local Institution - 0087 Montpellier Languedoc-Roussillon Not Yet Recruiting
Local Institution - 0119 Villejuif Val-de-Marne Not Yet Recruiting
Local Institution - 0047 Grenoble France Not Yet Recruiting
Local Institution - 0109 Paris France Not Yet Recruiting
Local Institution - 0085 Saint-Herblain France Not Yet Recruiting

+ 31 more sites — see the full list on the official registry below.

On this site

📄 Remicade (infliximab) drug profile → 📄 Entyvio (vedolizumab) drug profile →

More Bristol-Myers Squibb trials in the UK

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07680764 on ClinicalTrials.gov ↗ ← All trials in the UK