Dextromethorphan clinical trials
Dextromethorphan is named as an intervention in 4 current clinical trials in our USA, UK, Germany, Belgium, Poland, Canada and Australia registers. 2 are recruiting patients now. The most common phase is Phase 1. The sponsor with the most trials is Hoffmann-La Roche (1). The most-studied condition is Active Ulcerative Colitis.
What health systems spend on Dextromethorphan
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
How Dextromethorphan works
All drug targets →- Sigma opioid receptor agonist AgonistTarget: SIGMAR1 sigma non-opioid intracellular receptor 1✓ In ChEMBL and the Guide to Pharmacology
- Glutamate [NMDA] receptor subunit epsilon 1 antagonist AntagonistTarget: GRIN2A glutamate ionotropic receptor NMDA type subunit 2AChEMBL only
- AgitationPhase 3
- Alzheimer diseasePhase 3
- IrritabilityPhase 3
- Rett syndromePhase 3
- Amyotrophic lateral sclerosisPhase 3
- Bipolar disorderPhase 3
- Chronic kidney diseasePhase 3
- Depressive disorderPhase 3
- Major depressive disorderPhase 3
- Opiate dependencePhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL52440, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 6953, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Dextromethorphan
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 2 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Dextromethorphan
- ATC code
- R05DA09
- ChEMBL
- CHEMBL52440
- DrugBank
- DB00514
- PubChem CID
- 5360696
- CAS number
- 125-71-3
- FDA UNII
- 7355X3ROTS
- Wikidata
- Q407781
- Wikipedia
- Dextromethorphan
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Dextromethorphan
4 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Dextromethorphan across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
2 single-substance products containing Dextromethorphan on the HPRA medicines list.
- Benylin Non-Drowsy Dry Coughs, Syrup Dextromethorphan hydrobromide 7.5 mg/5 mlJNTL Consumer Health (Ireland) Limited · PA23490/010/001 · Marketed
- Robitussin Dry Cough 7.5mg/5ml Oral SolutionHaleon Ireland Limited · PA0678/155/001 · Marketed
Supply shortages
No entry for Dextromethorphan in the EMA, FDA or German BfArM shortage lists we track.
Conditions studied with Dextromethorphan
5 conditionsSponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| Hoffmann-La Roche | 1 |
| Allyx Therapeutics | 1 |
| University Health Network, Toronto | 1 |
| Murdoch Childrens Research Institute | 1 |
By country register
| Register | Trials | Recruiting |
|---|---|---|
| Clinical trials in USA | 2 | 1 |
| Clinical trials in UK | 1 | 1 |
| Clinical trials in Germany | 1 | 1 |
| Clinical trials in Belgium | 1 | 1 |
| Clinical trials in Poland | 1 | 1 |
| Clinical trials in Canada | 1 | 0 |
| Clinical trials in Australia | 1 | 1 |
A trial with sites in more than one country appears in each of those registers.
Related compounds
Questions about Dextromethorphan trials
How many clinical trials are testing Dextromethorphan?
4 current trials in our USA, UK, Germany, Belgium, Poland, Canada and Australia registers name Dextromethorphan as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.
Are Dextromethorphan trials recruiting patients?
Yes. 2 of the 4 trials are recruiting: 1 with sites in USA, 1 with sites in UK, 1 with sites in Germany, 1 with sites in Belgium, 1 with sites in Poland and 1 with sites in Australia. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Dextromethorphan clinical trials?
Hoffmann-La Roche (1), Allyx Therapeutics (1), University Health Network, Toronto (1) and Murdoch Childrens Research Institute (1). The number in brackets is how many trials each organisation leads.
Is Dextromethorphan licensed in Ireland?
Yes. The HPRA medicines list includes 2 single-substance products containing Dextromethorphan, for example Benylin Non-Drowsy Dry Coughs, Syrup Dextromethorphan hydrobromide 7.5 mg/5 ml (JNTL Consumer Health (Ireland) Limited). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Dextromethorphan shortage?
Not in the lists we track: Dextromethorphan has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Dextromethorphan works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Dextromethorphan works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Dextromethorphan (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.