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Compound · clinical trials

Memantine clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 7 trials in our Egypt, India, Denmark, Switzerland and Canada registers that name Memantine as an intervention. Synced 26 Sep 2026
7Current trials
5Recruiting now
7Lead sponsors
5Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Memantine is named as an intervention in 7 current clinical trials in our Egypt, India, Denmark, Switzerland and Canada registers. 5 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Tata Memorial Centre (1). The most-studied condition is Neurocognitive Dysfunction.

Memantine also has an approved-drug profile on this site (FDA label data): Namenda (Memantine) →

Trials by status

  • Recruiting571%
  • Not yet open229%

Trials by phase

  • Phase 3229%
  • Phase 2/3229%
  • Phase 1114%
  • Phase 1/2114%
  • Phase 2114%
01

Clinical trials of Memantine

7 trials
StudyPhaseStatusLead sponsorRegisters
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
NCT03550391 · ClinicalTrials.gov ↗ · Brain Metastases
Phase 3 Recruiting Canadian Cancer Trials Group Canada
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
NCT06275035 · ClinicalTrials.gov ↗ · Neurocognitive Dysfunction
Phase 3 Recruiting Tata Memorial Centre India
"The Effect of Memantine on the Prevention and Amelioration of Paclitaxel-induced Toxicity in Breast Cancer Patients"
NCT06679387 · ClinicalTrials.gov ↗ · Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Phase 2 Recruiting Ain Shams University Egypt
Glutamate Inhibitors in Glioblastoma
NCT05664464 · ClinicalTrials.gov ↗ · Glioblastoma
Phase 1/2 Recruiting University of Zurich Switzerland
Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis
NCT04789915 · ClinicalTrials.gov ↗ · Psychosis, Negative Symptoms With Primary Psychotic Disorder
Phase 1 Recruiting Bjorn H. Ebdrup Denmark
Memantine as an Additive Therapy in Patients With Traumatic Brain Injury
NCT06914310 · ClinicalTrials.gov ↗ · Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI)
Phase 2/3 Not yet open Mansoura University Egypt
Neuroprotection of Memantine and Rosuvastatin
NCT07504198 · ClinicalTrials.gov ↗ · Peripheral Nerve Disease
Phase 2/3 Not yet open Tanta University Egypt

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Memantine across our data

Ireland · EU · US

The same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.

Licensed in Ireland (HPRA)

29 single-substance products containing Memantine on the HPRA medicines list.

All 29 Irish products →

Supply shortages

No entry for Memantine in the EMA, FDA or German BfArM shortage lists we track.

03

Conditions studied with Memantine

9 conditions
Neurocognitive Dysfunction1Psychosis1Negative Symptoms With Primary Psychotic Disorder1Glioblastoma1Brain Metastases1Mild Traumatic Brain Injury1Moderate Traumatic Brain Injury (TBI)1Breast Cancer Early Stage Breast Cancer (Stage 1-3)1Peripheral Nerve Disease1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Tata Memorial Centre1
Bjorn H. Ebdrup1
University of Zurich1
Canadian Cancer Trials Group1
Mansoura University1
Ain Shams University1
Tanta University1
05

By country register

RegisterTrialsRecruiting
Clinical trials in Egypt31
Clinical trials in India11
Clinical trials in Denmark11
Clinical trials in Switzerland11
Clinical trials in Canada11

A trial with sites in more than one country appears in each of those registers.

06

Related compounds

07

Questions about Memantine trials

How many clinical trials are testing Memantine?

7 current trials in our Egypt, India, Denmark, Switzerland and Canada registers name Memantine as a drug or biological intervention, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Memantine trials recruiting patients?

Yes. 5 of the 7 trials are recruiting: 1 with sites in Egypt, 1 with sites in India, 1 with sites in Denmark, 1 with sites in Switzerland and 1 with sites in Canada. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Memantine clinical trials?

Tata Memorial Centre (1), Bjorn H. Ebdrup (1), University of Zurich (1) and Canadian Cancer Trials Group (1), among 7 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Is Memantine licensed in Ireland?

Yes. The HPRA medicines list includes 29 single-substance products containing Memantine, for example Memantine Clonmel 10mg Film-coated Tablet (Clonmel Healthcare Ltd). A licence does not mean a product is currently marketed or reimbursed; see each product's record.

Is there a Memantine shortage?

Not in the lists we track: Memantine has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Memantine works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Memantine works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Memantine (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.