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Clinical Trials in the UK / NCT07258511
Recruiting Phase 3

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

NCT07258511 · tracked via the Priya Life Science UK tracker
Sponsor
Janssen Research & Development, LLC
Phase
Phase 3
Started
2026-02-04
Last updated
2026-08-28

Condition(s) studied

Multiple Myeloma

Investigational drug(s) / intervention(s)

JNJ-79635322Teclistamab

JNJ-79635322: JNJ-79635322 will be administered as SC injection.

Teclistamab: Teclistamab will be administered as SC injection.

Study summary

The purpose of this study is to evaluate how well JNJ-79635322 works when compared with an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion: * Documented diagnosis of multiple myeloma (MM) as defined by the criteria below: 1. MM diagnosis according to the international myeloma working group (IMWG) diagnostic criteria 2. Measurable disease at screening as assessed by central laboratory * Received at least 3 prior lines of antimyeloma therapy including a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and an anti-cluster of differentiation (CD)38 antibody * Documented evidence of progressive disease (PD) or failure to achieve a response to the last line of therapy based on investigator's determination of response by IMWG criteria * Toxicity related to previous anticancer therapy must have resolved to Grade 1 or better * Have an eastern cooperative oncology group (ECOG) performance status of 0 to 2 at screening and immediately before the start of study treatment administration Exclusion: * Active hepatitis of infectious origin * Known active or prior central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of MM * Suspected or known allergies, hypersensitivity, or intolerance to the excipients of JNJ-79635322 and Teclistamab * Major surgery, (example, requiring general anesthesia) within 2 weeks before first dose, or will not have fully recovered from surgery, or has surgery planned during the time the participant is expected to participate in the study * Received or plans to receive any live, attenuated vaccine within 4 weeks before the first dose of study treatment, or during study treatment

Primary outcome measure(s)

Trial sites (144)

FacilityCityRegionStatus
Mayo Clinic Phoenix Phoenix Arizona Recruiting
UAMS Little Rock Arkansas Recruiting
City of Hope Duarte Duarte California Recruiting
City of Hope Orange County Lennar Foundation Cancer Center Irvine California Recruiting
USC Norris Comprehensive Cancer Center Los Angeles California Recruiting
University of California San Francisco San Francisco California Recruiting
Colorado Blood Cancer Institute Denver Colorado Recruiting
University of Connecticut Health Center Farmington Connecticut Recruiting
Yale Cancer Center New Haven Connecticut Recruiting
Florida Cancer Specialists & Research Institute Fort Myers Florida Recruiting
Mayo Clinic Jacksonville Jacksonville Florida Recruiting
Moffit Cancer center Tampa Florida Recruiting
Emory University Atlanta Georgia Recruiting
City of Hope Chicago Zion Illinois Recruiting
University of Iowa Hospital and Clinics Iowa City Iowa Recruiting
Mission Cancer Blood Waukee Iowa Recruiting
University of Kansas Cancer Center Kansas City Kansas Recruiting
Norton Cancer Institute Louisville Kentucky Recruiting
University of Maryland School of Medicine Baltimore Maryland Recruiting
Mayo Clinic Rochester Rochester Minnesota Recruiting
Mount Sinai Brooklyn Brooklyn New York Recruiting
NYU Winthrop Mineola New York Recruiting
Mount Sinai Chelsea New York New York Recruiting
Laura and Isaac Perlmutter Cancer Center NYU ACC New York New York Recruiting
Icahn School of Medicine at Mount Sinai New York New York Recruiting
Memorial Sloan Kettering Cancer Center New York New York Recruiting
University of North Carolina Chapel Hill North Carolina Recruiting
Durham VAMC Durham North Carolina Recruiting
Oregon Health And Science University Portland Oregon Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania Recruiting
Fox Chase Cancer Center Philadelphia Pennsylvania Recruiting
SCRI Oncology Partners Nashville Tennessee Recruiting
Vanderbilt University Medical Center Nashville Tennessee Recruiting
St. David's South Austin Medical Center Austin Texas Recruiting
Baylor University Medical Center Dallas Texas Recruiting
UT Southwestern Medical Center Dallas Texas Recruiting
Texas Transplant Institute San Antonio Texas Recruiting
Huntsman Cancer Institute Salt Lake City Utah Recruiting
Medical College Of Wisconsin Milwaukee Wisconsin Recruiting
Box Hill Hospital Box Hill Australia Recruiting

+ 104 more sites — see the full list on the official registry below.

More Janssen Research & Development, LLC trials in the UK

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07258511 on ClinicalTrials.gov ↗ ← All trials in the UK