A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

NCT07501702 · tracked via the Priya Life Science UK tracker

Sponsor

Vertex Pharmaceuticals Incorporated

Phase

Phase 2

Started

2026-05-13

Last updated

2026-09-11

Condition(s) studied

Myasthenia Gravis, Generalized

Investigational drug(s) / intervention(s)

PovetaciceptPlacebo

Povetacicept: Solution for Subcutaneous Injection.

Placebo: Solution for Subcutaneous Injection.

Study summary

The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Key Inclusion Criteria: * Age greater than or equal to (\>=) 18 years * Diagnosis of generalized myasthenia gravis with generalized muscle weakness and fitting MGFA clinical classification II-IV * Additional inclusion criteria are defined in the protocol Key Exclusion Criteria: * History of thymic surgery within 6 months of screening * History of malignancy within the last 5 years * Additional exclusion criteria are defined in the protocol Other protocol defined Inclusion/Exclusion criteria will apply.

Primary outcome measure(s)

Percent change in Total Immunoglobulin G (IgG) — Baseline and At Week 12
Safety and Tolerability as Assessed by Number of Participants with Adverse Events (AEs) and Serious Adverse Events (SAEs) — From Baseline Up to Week 116

Trial sites (28)

Facility	City	Region	Status
Tri Valley Neurology Medical Associates Inc.	Mission Hills	California	Recruiting
Neurology Offices	Boca Raton	Florida	Recruiting
SFM Clinical Reseach, LLC	Boca Raton	Florida	Recruiting
Homestead Associates in Research	Homestead	Florida	Recruiting
UF Health Jacksonville Respiratory Therapy (PFT and DLCO)	Jacksonville	Florida	Recruiting
Y & L Advance Health Care, Inc D/B/A Elite Clinical Research - Neurology	Miami	Florida	Recruiting
Quantix Research	Miami	Florida	Recruiting
Hawaii Pacific Neuroscience	Honolulu	Hawaii	Recruiting
HSHS Medical Group - St. Elizabeth's Hospital	O'Fallon	Illinois	Recruiting
Las Vegas Neurology Center	Las Vegas	Nevada	Recruiting
Clinical Trials of South Carolina - Neurology	Charleston	South Carolina	Recruiting
Ut Erlanger Neurology	Chattanooga	Tennessee	Recruiting
Nerve and Muscle Center of Texas - Neurology	Houston	Texas	Recruiting
Texas Institute for Neurological Disorders	Sherman	Texas	Recruiting
Neurology Care Clinic	Waxahachie	Texas	Recruiting
Eastern Health - Box Hill Hospital	Box Hill	Australia	Recruiting
MICS Centrum Medyczne Bydgoszcz	Bydgoszcz	Poland	Recruiting
Neurologia Slaska Centrum Medyczne	Katowice	Poland	Recruiting
Clinical Research Center Sp. z o.o., Medic-R Sp. K.	Poznan	Poland	Recruiting
NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partnerska Lekarzy	Poznan	Poland	Recruiting
Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o. o.	Poznan	Poland	Recruiting
Centrum Medyczne Neuroprotect	Warsaw	Poland	Recruiting
ETG Neuroscience	Warsaw	Poland	Recruiting
Istanbul University Medical Faculty	Fatih	Turkey (Türkiye)	Recruiting
Kocaeli University Medical Faculty	Kocaeli	Turkey (Türkiye)	Recruiting
University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital	Birmingham	United Kingdom	Recruiting
St. George's University Hospital	London	United Kingdom	Recruiting
Northern Care Alliance NHS Foundation Trust - Salford Royal Hospital	Salford	United Kingdom	Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07501702 on ClinicalTrials.gov ↗ ← All trials in the UK