Rimegepant for acute migraine treatment: Rimegepant for acute migraine treatment
Study summary
This is a non-interventional, prospective study that will enroll participants with migraine in the United Kingdom currently in use of rimegepant to acutely treat migraine attacks. Participants will be followed up for up to 12 weeks and will complete a daily questionnaire to self-report the consistency of response to rimegepant in acute treatment of migraine.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion criteria
1. UK resident.
2. At least 18 years of age.
3. Migraine diagnosis confirmed by healthcare professional.
4. Current prescription of rimegepant for acute treatment of migraine.
5. Experienced at least 4 migraine attacks per month prior to study enrolment.
6. In the case of participants receiving preventive migraine treatment:
* For oral preventives, the treatment must be "stable" i.e., final dosing regimen has been found.
* For migraine preventives administered monthly, the participant must have had their most recent treatment within the 3 weeks prior to study enrolment.
* For migraine preventives administered quarterly, the participant must have had their most recent treatment within the 2 months prior to study enrolment.
* If the last treatment is not within the stipulated period, participants will be asked to provide the date of the next scheduled treatment, after which the participant may be invited back to enrol into the study.
7. Evidence of a personally signed (or acknowledged if obtained electronically or online) and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the study.
Exclusion criteria
1. Current use of rimegepant as a preventive migraine medication.
2. Current diagnosis of any of the following conditions:
* new daily persistent headache
* chronic daily headache
* cluster headache
* post-traumatic headache
* hemicrania continua
* major depression
* pain syndromes other than migraine (e.g. fibromyalgia)
* psychiatric conditions (e.g., schizophrenia)
* dementia
* significant neurological disorders other than migraine.
3. Current prescription of any of the following medications:
* Strong inhibitors of CYP3A4
* Strong or moderate inducers of CYP3A4
4. Patients participating in a migraine-related clinical trial.
Primary outcome measure(s)
Time to Meaninful Pain Relief (MPR) post-dosing — Daily (within 24hs post dose) Proportion of rimegepant-treated attacks with reported MPR: within 1 hour post dose; 1-2 hours post dose; Over 2 hours up to 4 hours post dose; More than 4 hours post dose; who have not achieved MPR and took the medication more than 2 hours before completing the survey; who have not achieved MPR and took the medication less than 2 hours before completing the survey
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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