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Clinical Trials in the UK / NCT06543914
Active, not recruiting Observational

Observational Study of Oral Atogepant to Evaluate Real-World Effectiveness in Adult Participants With Migraine

NCT06543914 · tracked via the Priya Life Science UK tracker
Sponsor
AbbVie
Phase
Observational
Started
2024-11-26
Last updated
2026-06-01

Condition(s) studied

Migraine

Study summary

Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will evaluate the effectiveness of atogepant in treating adult participants with migraine in a real-world setting.

Atogepant is an approved drug for preventive treatment of migraine in adults. Approximately 1000 adult participants who are prescribed atogepant by their doctors will be enrolled in this study across the world.

Participants will receive atogepant oral tablets as prescribed per standard clinical practice and will be followed for 2 years.

There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * At least 1-year history of migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders (ICHD)-3, 2018. * Prescribed atogepant according to the relevant approved local label. * For participants who initiate atogepant at the prescribing physician or treating health care provider (HCP) discretion as part of their routine clinical care, the decision to administer atogepant must be made prior to and independent of recruitment into the study. * Willing and able to comply with the requirements of the study. * Not on concomitant preventive medication for migraine or have been on a stable preventive medication for migraine for at least 3 months prior to enrollment in the study. If on a stable preventive medication, the prescribing physician or treating HCP and participant must confirm that there is no plan to change concomitant preventive medication during the first 12 weeks of the study. Exclusion Criteria: * Previously exposed to atogepant as routine therapy or from clinical trials experience prior to entry. * Contraindications to atogepant as per local labeling. * Pregnant or planning to be pregnant or women of childbearing potential not using contraception. * Enrolled in any interventional studies that may include investigational compounds for migraine, or non-AbbVie observational studies. * In the opinion of the prescribing physician or treating HCP, the participant has a history or current evidence of any condition that might interfere with patient's ability to comply with the study requirements.

Primary outcome measure(s)

Trial sites (112)

FacilityCityRegionStatus
Neurology and Neurodiagnostics of Alabama /ID# 267614 Hoover Alabama
Rehabilitation & Neurological Services /ID# 267612 Huntsville Alabama
Barrow Neurological Institute - Dignity Health St. Joseph's Hosp and Medical Ctr /ID# 267610 Phoenix Arizona
Kenneth Martinez MD, A Medical Corp /ID# 267834 Aliso Viejo California
BNL Health - Los Angeles Headache Center /ID# 267570 Los Angeles California
Alcanza Clinical Research, LLC /ID# 267838 Lake Mary Florida
Norton Cancer Institute - St. Matthews /ID# 267605 Louisville Kentucky
Dent Neurologic Institute - Amherst /ID# 267606 Amherst New York
Northwell Health - Great Neck /ID# 280705 Great Neck New York
Northwell Health /ID# 267596 New York New York
Thomas Jefferson University Hospital /ID# 267572 Philadelphia Pennsylvania
Inova Health Care System /ID# 267615 Falls Church Virginia
Neuroscience Group /ID# 267571 Neenah Wisconsin
Cliniques Universitaires UCL Saint-Luc /ID# 270545 Brussels Brussels Capital
Universitair Ziekenhuis Brussel /ID# 269799 Jette Brussels Capital
Chu Tivoli /ID# 271254 La Louvière Hainaut
Centre Hospitalier Régional de la Citadelle /ID# 270539 Liège Liege
Groupe Sante CHC - Clinique du MontLegia /ID# 270218 Liège Liege
OLV Ziekenhuis Aalst /ID# 270284 Aalst Oost-Vlaanderen
Algemeen Ziekenhuis Sint-Jan Brugge /ID# 270540 Bruges West-Vlaanderen
AZ Groeninge /ID# 272772 Kortrijk West-Vlaanderen
Calgary Headache Assessment and Management Program /ID# 270266 Calgary Alberta
Burrard Health Center /ID# 270268 Vancouver British Columbia
Dr. Renju Kuriakose Prof. Corp. /ID# 273178 Saint John New Brunswick
Maritime Neurology /ID# 270270 Halifax Nova Scotia
Centricity /ID# 271478 London Ontario
London Health Sciences Centre - Victoria Hospital & Children's Hospital /ID# 270943 London Ontario
Bayshore Neurology /ID# 270673 Ottawa Ontario
Sunnybrook Health Sciences Centre /ID# 273207 Toronto Ontario
Centre de Recherche St-Louis /ID# 270957 Lévis Quebec
Genge Partners /ID# 270267 Montreal Quebec
Universitaetsklinikum Heidelberg /ID# 278134 Heidelberg Baden-Wurttemberg
Universitaetsklinikum Tuebingen /ID# 275762 Tübingen Baden-Wurttemberg
Praxis fur Neurologie Dr. med. Martin Delf /ID# 275918 Hoppegarten Brandenburg
Zentrum Für Klinische Forschung Dr. Irma Schöll /ID# 275642 Bad Homburg Hesse
Evangelisches Krankenhaus Oldenburg /ID# 275823 Oldenburg Lower Saxony
Universitaetsmedizin Greifswald /ID# 276678 Greifswald Mecklenburg-Vorpommern
ZNS Siegen /ID# 275660 Siegen North Rhine-Westphalia
Dres. Huhn-Doll/Siquet/Vocke /ID# 279583 Velbert North Rhine-Westphalia
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 275759 Dresden Saxony

+ 72 more sites — see the full list on the official registry below.

More AbbVie trials in the UK

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06543914 on ClinicalTrials.gov ↗ ← All trials in the UK