AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

NCT07503210 · tracked via the Priya Life Science UK tracker

Sponsor

Novo Nordisk A/S

Phase

Phase 3

Started

2026-04-21

Last updated

2026-09-11

Condition(s) studied

Obesity

Investigational drug(s) / intervention(s)

NNC0487-0111Placebo (matched to NNC0487-0111)

NNC0487-0111: NNC0487-0111 will be administered subcutaneously.

Placebo (matched to NNC0487-0111): Placebo will be administered subcutaneously.

Study summary

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) greater than or equal to ≥ 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP 1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.

Primary outcome measure(s)

Relative change in body weight — From week 40 to week 92
Measured as percentage (%) of body weight.

Trial sites (72)

Facility	City	Region
Pinnacle Research Group LLC	Anniston	Alabama
Diablo Clinical Research, Inc.	Walnut Creek	California
Florida Inst For Clin Res LLC	Orlando	Florida
Endeavor Health	Skokie	Illinois
Midwest Inst For Clin Res	Indianapolis	Indiana
Medication Mgmnt, LLC_Grnsboro	Greensboro	North Carolina
PMG Research of Wilmington LLC	Wilmington	North Carolina
UPA Ctr Weight and Eating Dis	Philadelphia	Pennsylvania
Clinical Res Collaborative	Cumberland	Rhode Island
North Texas Endocrine Center	Dallas	Texas
UT Southwestern Med Cntr	Dallas	Texas
Selma Medical Associates	Winchester	Virginia
Rainier Clin Res Ctr Inc	Renton	Washington
Conexa	Ciudad Autonoma de Buenos Aires	Buenos Aires
CICEMO- Consultorio (Av Directorio)	Ciudad Autónoma de Buenos Aires	Buenos Aires
Instituto de Investigaciones Clinicas Mar Del Plata	Mar del Plata	Buenos Aires
CIPREC Pueyrredon	Buenos Aires	Argentina
Sydney Clinical Trials	Campbelltown	New South Wales
Sydney Cardiometabolic Centre	Liverpool	New South Wales
Hunter Diabetes Centre	Merewether	New South Wales
Nightingale Research Adelaide	Adelaide	South Australia
Anima Research Center	Diepenbeek	Belgium
AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie	Kortrijk	Belgium
Centre hospitalier universitaire de Liège (CHU de Liège)	Liège	Belgium
AZ OOSTENDE (Campus DAMIAAN)	Ostend	Belgium
DCC 1 - Lom EOOD	Lom	Bulgaria
MHAT Med Line Clinic	Plovdiv	Bulgaria
UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic	Plovdiv	Bulgaria
AIPSOMCEMD ENDO MED CONSULT 2020 - Dr. Aleksander Botushanov EOOD	Plovdiv	Bulgaria
SGHAT Dr. Shterev EOOD	Sofia	Bulgaria
UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases	Sofia	Bulgaria
Medical Center Maraya Med EOOD	Sofia	Bulgaria
AIPSMC Dr. Traykovska EOOD	Sofia	Bulgaria
Sjællands Universitetshospital, Køge - Medicinsk Afdeling	Køge	Region Sjælland
Sydvestjysk Sygehus Esbjerg - Medicinsk Endokrinologisk Ambulatorium, Forskningsenheden	Esbjerg	Region Syddanmark
Sanos Clinic - Vejle	Vejle	Region Syddanmark
CHU DE CLERMONT-FERRAND-HOPITAL GABRIEL MONTPIED_Service de Nutrition	Clermont-Ferrand	France
CHU GRENOBLE ALPES-SITE NORD MICHALLON_Endocrinologie,diabétologie,maladies de la nutrition	La Tronche	France
GROUPE SOS SANTE-HOPITAL LE CREUSOT-HOTEL DIEU_ Service de Diabétologie	Le Creusot	France
CHU LILLE-HOPITAL CLAUDE HURIEZ_Service de Chirurgie Générale et Endocrinienne	Lille	France

+ 32 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07503210 on ClinicalTrials.gov ↗ ← All trials in the UK