A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or Obese
Condition(s) studied
Investigational drug(s) / intervention(s)
Glucose-dependent Insulinotropic Polypeptide (GIP): Participants will receive GIP subcutaneously.
Cagrilintide: Participants will receive Cagrilintide subcutaneously.
Placebo GIP: Participants will receive placebo matched to GIP subcutaneously.
Study summary
This trial is being done to look at the safety and effect of combining cagrilintide and NNC0480-0389 in people living with overweight and obesity compared to taking cagrilintide alone. In one period participants will get two medicines: cagrilintide and NNC0480-0389. In the other period, participants will get cagrilintide together with a placebo version of NNC0480-0389.The placebo looks like the real treatment but does not have any active medicine in it. Cagrilintide and NNC0480-0389 is a new medicine being tested to help people with type 2 diabetes and/or overweight or obesity. The trial medicines is not yet approved for use outside of clinical trials. Participants will receive the trial medicines the way the trial doctor has described. The study will last for about 4.5 months.
Eligibility
Primary outcome measure(s)
- Number of Treatment Emergent Adverse Events (TEAEs) nausea, vomiting and diarrhoea — From first investigational medicinal products (IMP) administration (visit 2, day 1 or visit 9, day 74) to the end of treatment visit (Visit 2, day 16 or Visit 9, day 89)
Measured as number of events.
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Parexel Research Unit | Harrow | Middlesex | Recruiting |
More Novo Nordisk A/S trials in the UK
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07411560 on ClinicalTrials.gov ↗ ← All trials in the UK