A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
Condition(s) studied
Investigational drug(s) / intervention(s)
LY4152199 - IV: Administered by IV infusion
Study summary
The purpose of this study is to find the best dose of the drug and measure the safety and efficacy of LY4152199 in participants with previously treated B-cell malignancies. Participants will have the option to continue taking LY4152199 until the study ends.
Eligibility
Primary outcome measure(s)
- Phase 1 - Number of Participants with Dose Limiting Toxicities (DLT) of LY4152199 — Cycle 1 Day 1 through Cycle 2 Day 8 (35 days)
Trial sites (51)
| Facility | City | Region | Status |
|---|---|---|---|
| City of Hope | Duarte | California | Recruiting |
| University of Colorado Denver - School of Medicine - Anschutz Medical Campus | Aurora | Colorado | Recruiting |
| Colorado Blood Cancer Institute | Denver | Colorado | Recruiting |
| Yale University School of Medicine - Yale Cancer Center | New Haven | Connecticut | Recruiting |
| The University of Chicago Medical Center (UCMC) | Chicago | Illinois | Recruiting |
| University of Iowa | Iowa City | Iowa | Recruiting |
| University of Kansas Cancer Center | Kansas City | Kansas | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | Recruiting |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | Recruiting |
| Mayo Clinic - Rochester | Rochester | Minnesota | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | Not Yet Recruiting |
| New York University (NYU) Clinical Cancer Center | New York | New York | Recruiting |
| Weill Cornell Medicine | New York | New York | Recruiting |
| David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center | New York | New York | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | Recruiting |
| University of Pennsylvania Abramson Cancer Center | Philadelphia | Pennsylvania | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | Recruiting |
| University of Texas Southwestern | Dallas | Texas | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | Recruiting |
| Intermountain Healthcare | Salt Lake City | Utah | Not Yet Recruiting |
| Swedish Cancer Institute (SCI) | Seattle | Washington | Recruiting |
| Froedtert Hospital and the Medical College of Wisconsin | Milwaukee | Wisconsin | Recruiting |
| The Alfred Hospital | Melbourne, VIC | Australia | Not Yet Recruiting |
| Linear Clinical Research | Nedlands | Australia | Recruiting |
| Lady Davis Institute for Medical Research Jewish General Hospital | Montreal | Canada | Not Yet Recruiting |
| University Health Network (UHN) - Princess Margaret Cancer Centre | Toronto | Canada | Not Yet Recruiting |
| BC Cancer - Vancouver | Vancouver | Canada | Not Yet Recruiting |
| Aarhus University Hospital | Aarhus | Denmark | Not Yet Recruiting |
| Center for Cancer and Organ Diseases - Rigshospitalet | Copenhagen | Denmark | Not Yet Recruiting |
| CHU de Lille - Hopital Claude Huriez | Lille | France | Not Yet Recruiting |
| AP-HP Hopital Saint-Louis | Paris | France | Not Yet Recruiting |
| Charite Universitaetsmedizin Berlin | Berlin | Germany | Not Yet Recruiting |
| LMU Klinikum Muenchen-Campus Grosshadern | München | Germany | Not Yet Recruiting |
| Universitaetsklinikum Muenster | Münster | Germany | Not Yet Recruiting |
| IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola | Bologna | Italy | Not Yet Recruiting |
| Istituto Nazionale Tumori IRCCS Fondazione G. Pascale | Naples | Italy | Not Yet Recruiting |
| Istituto Clinico Humanitas | Rozzano | Italy | Not Yet Recruiting |
| National Cancer Center Hospital East | Chiba | Japan | Not Yet Recruiting |
| Okayama University Hospital | Okayama | Japan | Recruiting |
+ 11 more sites — see the full list on the official registry below.
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07101328 on ClinicalTrials.gov ↗ ← All trials in the USA