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Updated 21 Aug 2026 · ClinicalTrials.gov

Clinical Trials in Illinois

← All US trials

The most recently updated industry-sponsored clinical trials recruiting across the United States — searchable by condition, sponsor, phase and state. Refreshed daily from the ClinicalTrials.gov registry.

37
Recruiting now
48
Studies tracked
Illinois
Selected state
Recruiting Phase 3
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Non-Small Cell Lung Cancer (NSCLC)
Amgen · started 2023-11-16
📍 California · Delaware · Florida · Illinois · Kentucky · Massachusetts · New Mexico · New York
NCT05920356 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Acute Stroke, Ischemic Stroke, Stroke
DiaMedica Therapeutics Inc · started 2021-11-07
📍 Alabama · California · Florida · Georgia · Illinois · Kansas · Louisiana · Massachusetts
NCT05065216 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
Atopic Dermatitis
Apogee Therapeutics, Inc. · started 2025-05-14
📍 California · Florida · Georgia · Illinois · Kentucky · Michigan · New York · North Carolina
NCT07003425 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Prostate Cancer, Prostatic Neoplasms
Merck Sharp & Dohme LLC · started 2025-05-13
📍 Arizona · California · Colorado · Connecticut · District of Columbia · Florida · Georgia · Illinois
NCT06925737 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma
BeOne Medicines · started 2021-09-13
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Illinois · Iowa
NCT05006716 on ClinicalTrials.gov ↗
Active Phase 3
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa
Hidradenitis Suppurativa
Novartis Pharmaceuticals · started 2025-03-20
📍 Alabama · Arizona · California · Florida · Georgia · Illinois · Indiana · Massachusetts
NCT06840392 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of ZL-1310 in Participants With Selected Solid Tumors
Solid Tumors
Zai Lab (Shanghai) Co., Ltd. · started 2025-05-12
📍 California · Illinois · Michigan · New York · Ohio · Pennsylvania · Tennessee · Texas
NCT06885281 on ClinicalTrials.gov ↗
Active Phase 2
An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Metastatic Hormone-sensitive Prostate Cancer
Novartis Pharmaceuticals · started 2025-07-07
📍 California · Colorado · Connecticut · Florida · Georgia · Illinois · Massachusetts · Michigan
NCT06991556 on ClinicalTrials.gov ↗
By invitation
Observational Study of VYKAT™ XR in Patients With Prader-Willi Syndrome
Prader-Willi Syndrome
Soleno Therapeutics, Inc. · started 2025-11-26
📍 Arizona · California · Colorado · Georgia · Illinois · Indiana · Massachusetts · Michigan
NCT07450664 on ClinicalTrials.gov ↗
Active Phase 3
A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids
Primary Immune Thrombocytopenia
Novartis Pharmaceuticals · started 2023-02-02
📍 Arizona · Colorado · Illinois · Massachusetts · Michigan · Montana · New York
NCT05653219 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
Radiographic Axial Spondyloarthritis
Merck Sharp & Dohme LLC · started 2025-09-26
📍 Arizona · California · Florida · Illinois · Maryland · Missouri · Montana · Nebraska
NCT07133633 on ClinicalTrials.gov ↗
Recruiting Phase 3
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
Kidney Disease, Chronic
Boehringer Ingelheim · started 2024-08-30
📍 Alabama · Arizona · California · Florida · Georgia · Idaho · Illinois · Kansas
NCT06531824 on ClinicalTrials.gov ↗
Recruiting Phase 3
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
Crohn's Disease, Obesity or Overweight
Eli Lilly and Company · started 2025-06-26
📍 Alabama · California · Florida · Idaho · Illinois · Indiana · Kentucky · Louisiana
NCT06937099 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
Idiopathic Inflammatory Myopathy, Dermatomyositis, Anti-Synthetase Syndrome, Immune-Mediated Necrotizing Myopathy
Cabaletta Bio · started 2023-12-20
📍 California · Colorado · Florida · Georgia · Illinois · Kansas · Maryland · Massachusetts
NCT06154252 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma
Asthma
Eli Lilly and Company · started 2025-10-22
📍 Arizona · California · Colorado · Florida · Illinois · Kentucky · Massachusetts · Nevada
NCT07219173 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer
Daiichi Sankyo · started 2024-02-26
📍 California · Connecticut · Florida · Illinois · Maryland · Minnesota · Missouri · New York
NCT06172478 on ClinicalTrials.gov ↗
Active Phase 3
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
Tuberous Sclerosis Complex
Novartis Pharmaceuticals · started 2017-08-23
📍 Arizona · California · Colorado · Connecticut · Illinois · Minnesota · New Jersey · Ohio
NCT02962414 on ClinicalTrials.gov ↗
Recruiting Phase 3
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
Lennox Gastaut Syndrome
Epygenix · started 2025-04-09
📍 Arkansas · California · Florida · Illinois · Kentucky · Michigan · Minnesota · Nebraska
NCT05066217 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain
Chronic Pain, Low Back Pain
Eli Lilly and Company · started 2026-08-12
📍 Alabama · Arizona · California · Connecticut · Florida · Georgia · Illinois · Louisiana
NCT07641504 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Diabetes Mellitus, Type 1, Hypoglycemia, Islet Cell Transplantation, Type 1 Diabetes
Otsuka Pharmaceutical Factory, Inc. · started 2025-06-10
📍 Illinois
NCT06575426 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Breast Cancer, Endometrial Cancer, Ovarian Cancer, Lung Squamous Cell Carcinoma
Terremoto Biosciences Inc. · started 2025-09-23
📍 California · Florida · Illinois · Massachusetts · Minnesota · Missouri · Nebraska · North Carolina
NCT07109726 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )
Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
Revolution Medicines, Inc. · started 2026-05-22
📍 Arizona · Florida · Georgia · Illinois · Maryland · New Jersey
NCT07621718 on ClinicalTrials.gov ↗
Recruiting Phase 1
Study of Tarlatamab + ZL-1310 +/- Anti-programmed Death Ligand 1 (Anti-PD-L1) in Small Cell Lung Cancer (SCLC)
Small Cell Lung Cancer
Amgen · started 2026-04-21
📍 Arizona · Florida · Illinois · Minnesota · New York · Tennessee · Virginia
NCT07531095 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer
Nausea, Vomiting, Drug-Related Side Effects and Adverse Reactions, Neoplasms
Eli Lilly and Company · started 2025-11-28
📍 California · Colorado · Florida · Georgia · Illinois · Indiana · Mississippi · New York
NCT07169851 on ClinicalTrials.gov ↗
Active Phase 2
An Open-label Extension Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
Pulmonary Sarcoidosis
Xentria, Inc. · started 2024-03-01
📍 Colorado · Illinois · North Carolina · Ohio · Pennsylvania
NCT06169397 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
Prostate Cancer
AstraZeneca · started 2025-08-06
📍 Arizona · California · Colorado · Florida · Georgia · Illinois · Indiana · Maryland
NCT06952803 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer
Astellas Pharma Global Development, Inc. · started 2025-08-19
📍 Alabama · California · Florida · Illinois · Louisiana · New Mexico · Ohio · South Carolina
NCT07005154 on ClinicalTrials.gov ↗
Recruiting Phase 2
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
Non-small Cell Lung Cancer
AstraZeneca · started 2022-04-14
📍 Arkansas · California · Connecticut · Florida · Georgia · Illinois · Maryland · Massachusetts
NCT05061550 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Dravet Syndrome
Encoded Therapeutics · started 2024-05-14
📍 California · Colorado · Florida · Illinois · Massachusetts · Michigan · Minnesota · North Carolina
NCT05419492 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis
Ulcerative Colitis
Boehringer Ingelheim · started 2024-12-11
📍 Arizona · Colorado · Florida · Illinois · Kansas · New York · North Carolina · Texas
NCT06636656 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Brenipatide in Participants With Alcohol Use Disorder
Alcohol Use Disorder
Eli Lilly and Company · started 2025-10-16
📍 Arizona · Arkansas · California · Florida · Illinois · Maryland · Massachusetts · New York
NCT07219953 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide in Participants With Opioid Use Disorder
Opioid Use Disorder
Eli Lilly and Company · started 2026-02-13
📍 Arizona · Arkansas · California · Florida · Illinois · Indiana · Kentucky · Maryland
NCT07420283 on ClinicalTrials.gov ↗
Active Phase 3
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
Systemic Lupus Erythematosus
Novartis Pharmaceuticals · started 2023-04-21
📍 Alabama · California · Florida · Georgia · Illinois · Kentucky · Louisiana · Maryland
NCT05624749 on ClinicalTrials.gov ↗
Active Phase 1
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
Neuroblastoma
Eli Lilly and Company · started 2020-06-11
📍 California · Colorado · Illinois · Massachusetts · Ohio · Pennsylvania · Texas
NCT04106219 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Heart Failure
Boehringer Ingelheim · started 2024-06-17
📍 Alabama · California · Connecticut · Florida · Georgia · Idaho · Illinois · Indiana
NCT06424288 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Acne
Sanofi Pasteur, a Sanofi Company · started 2024-04-05
📍 Arizona · California · Florida · Georgia · Illinois · Indiana · Iowa · Kentucky
NCT06316297 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
Ovarian Neoplasms, Ovarian Cancer
Merck Sharp & Dohme LLC · started 2026-02-16
📍 Alabama · California · Florida · Georgia · Illinois · Indiana · Louisiana · Maine
NCT07318558 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Non Small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2024-04-03
📍 Arkansas · California · Connecticut · Florida · Georgia · Illinois · Indiana · Kentucky
NCT06312137 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis
Atherosclerosis, Coronary Artery Disease
Beijing Inno Medicine Co., Ltd. · started 2026-07-31
📍 Alabama · California · Florida · Illinois · Kansas · Missouri · North Carolina · Ohio
NCT07521007 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative Colitis
AbbVie · started 2025-07-28
📍 Arizona · California · Florida · Georgia · Illinois · New Jersey · Ohio · Pennsylvania
NCT07071519 on ClinicalTrials.gov ↗
By invitation Phase 3
A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
UCB Biopharma SRL · started 2021-07-27
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Idaho · Illinois
NCT04976322 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Metastatic Colorectal Cancer
Amgen · started 2024-07-17
📍 Arizona · California · Connecticut · Florida · Georgia · Illinois · Kentucky · Michigan
NCT06252649 on ClinicalTrials.gov ↗
Active Phase 2
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
Merck Sharp & Dohme LLC · started 2022-07-21
📍 Alaska · Arizona · Colorado · Illinois · Kansas · Kentucky · Maryland · Massachusetts
NCT05458297 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
Lymphoma, Non-Hodgkin, B-cell Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular
Eli Lilly and Company · started 2026-05-28
📍 California · Colorado · Connecticut · Illinois · Iowa · Kansas · Massachusetts · Michigan
NCT07101328 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Osteoarthritis, Overweight or Obesity
Eli Lilly and Company · started 2026-02-09
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Idaho · Illinois
NCT07353931 on ClinicalTrials.gov ↗
Recruiting Phase 1
Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).
Juvenile Psoriatic Arthritis
Novartis Pharmaceuticals · started 2025-09-24
📍 California · Florida · Illinois · New York · North Carolina · Ohio · Oregon · Pennsylvania
NCT06751238 on ClinicalTrials.gov ↗
Recruiting Phase 2
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe
Eli Lilly and Company · started 2026-03-26
📍 Arizona · California · Colorado · Connecticut · Florida · Idaho · Illinois · Indiana
NCT07415044 on ClinicalTrials.gov ↗
Active Phase 3
Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients
HIV Infections
ViiV Healthcare · started 2015-02-23
📍 California · Colorado · Connecticut · District of Columbia · Florida · Georgia · Illinois · Indiana
NCT02362503 on ClinicalTrials.gov ↗
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Prostate Cancer · 5 Ovarian Cancer · 4 Overweight · 4 Obesity · 4 Systemic Lupus Erythematosus · 3 Ulcerative Colitis · 3 Follicular Lymphoma · 3 Heart Failure · 3 Non-small Cell Lung Cancer · 3 Lymphoma, Large B-Cell, Diffuse · 2 Diabetes Mellitus, Type 1 · 2 Breast Neoplasms · 2 B-cell Malignancy · 2 Hidradenitis Suppurativa · 2 Acute Myeloid Leukemia · 2 Ovarian Neoplasms · 2
Cite this page

Priya Life Science (2026). Clinical Trials in the USA Tracker. Available at: https://priyalifescience.com/clinical-trials-usa/state/illinois (Accessed: 22 August 2026).

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Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one US site, most recently updated first, refreshed daily. This is a curated slice of the full registry, not every US trial. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish and EU sites, see our Ireland and EU trackers.