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Updated 21 Aug 2026 · ClinicalTrials.gov

Clinical Trials in Massachusetts

← All US trials

The most recently updated industry-sponsored clinical trials recruiting across the United States — searchable by condition, sponsor, phase and state. Refreshed daily from the ClinicalTrials.gov registry.

28
Recruiting now
41
Studies tracked
Massachusetts
Selected state
Recruiting Phase 3
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Non-Small Cell Lung Cancer (NSCLC)
Amgen · started 2023-11-16
📍 California · Delaware · Florida · Illinois · Kentucky · Massachusetts · New Mexico · New York
NCT05920356 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Acute Stroke, Ischemic Stroke, Stroke
DiaMedica Therapeutics Inc · started 2021-11-07
📍 Alabama · California · Florida · Georgia · Illinois · Kansas · Louisiana · Massachusetts
NCT05065216 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Systemic Lupus Erythematosus, Active Refractory Rheumatoid Arthritis
Amgen · started 2025-07-16
📍 Arizona · Colorado · Florida · Louisiana · Massachusetts · Minnesota · New York · Ohio
NCT06570798 on ClinicalTrials.gov ↗
Active Phase 3
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Merz Pharmaceuticals GmbH · started 2019-09-16
📍 Alabama · Arkansas · California · Connecticut · Florida · Massachusetts · Missouri · New York
NCT03992404 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
First-in-human Study of 7MW4911 in GI Cancer
GI Cancers
Mabwell (Shanghai) Bioscience Co., Ltd. · started 2026-01-13
📍 Florida · Massachusetts · New York · Utah · Washington
NCT07216560 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Evaluate the Safety and Efficacy of Zilganersen (ION373) in Patients With Alexander Disease (AxD)
Alexander Disease
Ionis Pharmaceuticals, Inc. · started 2021-06-01
📍 California · Georgia · Massachusetts · Pennsylvania
NCT04849741 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
Ovarian Cancer
AbbVie · started 2025-11-13
📍 California · Florida · Kentucky · Louisiana · Maine · Massachusetts · Michigan · Montana
NCT07059845 on ClinicalTrials.gov ↗
Active Phase 3
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa
Hidradenitis Suppurativa
Novartis Pharmaceuticals · started 2025-03-20
📍 Alabama · Arizona · California · Florida · Georgia · Illinois · Indiana · Massachusetts
NCT06840392 on ClinicalTrials.gov ↗
Active Phase 2
An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Metastatic Hormone-sensitive Prostate Cancer
Novartis Pharmaceuticals · started 2025-07-07
📍 California · Colorado · Connecticut · Florida · Georgia · Illinois · Massachusetts · Michigan
NCT06991556 on ClinicalTrials.gov ↗
Recruiting
A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk
Relapsing Multiple Sclerosis
TG Therapeutics, Inc. · started 2024-03-26
📍 California · Georgia · Massachusetts · North Carolina · Tennessee
NCT06143514 on ClinicalTrials.gov ↗
By invitation
Observational Study of VYKAT™ XR in Patients With Prader-Willi Syndrome
Prader-Willi Syndrome
Soleno Therapeutics, Inc. · started 2025-11-26
📍 Arizona · California · Colorado · Georgia · Illinois · Indiana · Massachusetts · Michigan
NCT07450664 on ClinicalTrials.gov ↗
Active Phase 3
A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids
Primary Immune Thrombocytopenia
Novartis Pharmaceuticals · started 2023-02-02
📍 Arizona · Colorado · Illinois · Massachusetts · Michigan · Montana · New York
NCT05653219 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
Idiopathic Inflammatory Myopathy, Dermatomyositis, Anti-Synthetase Syndrome, Immune-Mediated Necrotizing Myopathy
Cabaletta Bio · started 2023-12-20
📍 California · Colorado · Florida · Georgia · Illinois · Kansas · Maryland · Massachusetts
NCT06154252 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma
Asthma
Eli Lilly and Company · started 2025-10-22
📍 Arizona · California · Colorado · Florida · Illinois · Kentucky · Massachusetts · Nevada
NCT07219173 on ClinicalTrials.gov ↗
Recruiting Phase 2
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
Glioblastoma (GBM), Newly Diagnosed Glioblastoma, GBM, Glioblastoma Multiforme (GBM)
Black Diamond Therapeutics, Inc. · started 2026-05-05
📍 Alabama · Arkansas · California · Connecticut · District of Columbia · Florida · Maryland · Massachusetts
NCT07326566 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease
X-Linked Chronic Granulomatous Disease
Ensoma · started 2025-08-05
📍 California · Florida · Massachusetts · Minnesota · New York · North Carolina · Utah
NCT06876363 on ClinicalTrials.gov ↗
Recruiting
A Multicenter, Prospective Blood Collection Study in a Kidney Transplant Population
Kidney Disease, Kidney Transplant, Transplant Recipient, Renal Function
Devyser Inc. · started 2025-11-14
📍 California · Georgia · Maryland · Massachusetts · Utah
NCT07006831 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Breast Cancer, Endometrial Cancer, Ovarian Cancer, Lung Squamous Cell Carcinoma
Terremoto Biosciences Inc. · started 2025-09-23
📍 California · Florida · Illinois · Massachusetts · Minnesota · Missouri · Nebraska · North Carolina
NCT07109726 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
Ovarian Cancer, Breast Cancer, Endometrial Cancer, Biliary Tract Cancer
NextCure, Inc. · started 2025-01-07
📍 California · Kentucky · Massachusetts · Missouri · New Jersey · New York · Ohio · Pennsylvania
NCT06774963 on ClinicalTrials.gov ↗
Recruiting
ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis
Myasthenia Gravis, MG, gMG, Generalized Myasthenia Gravis
argenx · started 2025-12-19
📍 California · Florida · Massachusetts · Michigan · New York · North Carolina · Ohio · Tennessee
NCT07294170 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)
Progressive Metastatic Castrate Resistant Prostate Cancer
Novartis Pharmaceuticals · started 2025-10-15
📍 Colorado · Florida · Georgia · Kansas · Massachusetts · North Carolina · Ohio · Washington
NCT07206056 on ClinicalTrials.gov ↗
Recruiting Phase 2
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
Non-small Cell Lung Cancer
AstraZeneca · started 2022-04-14
📍 Arkansas · California · Connecticut · Florida · Georgia · Illinois · Maryland · Massachusetts
NCT05061550 on ClinicalTrials.gov ↗
By invitation Phase 2/Phase 3
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
Erythropoietic Protoporphyria
Disc Medicine, Inc · started 2023-08-31
📍 Alabama · California · Florida · Massachusetts · New York · North Carolina · Ohio · Pennsylvania
NCT05883748 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Dravet Syndrome
Encoded Therapeutics · started 2024-05-14
📍 California · Colorado · Florida · Illinois · Massachusetts · Michigan · Minnesota · North Carolina
NCT05419492 on ClinicalTrials.gov ↗
By invitation Phase 3
An Extension Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE)
Biogen · started 2022-06-10
📍 Arizona · California · Colorado · District of Columbia · Florida · Georgia · Massachusetts · Michigan
NCT05352919 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Brenipatide in Participants With Alcohol Use Disorder
Alcohol Use Disorder
Eli Lilly and Company · started 2025-10-16
📍 Arizona · Arkansas · California · Florida · Illinois · Maryland · Massachusetts · New York
NCT07219953 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Heart Failure, Left Ventricular Systolic Dysfunction
Merck Sharp & Dohme LLC · started 2023-05-31
📍 California · Colorado · District of Columbia · Florida · Georgia · Massachusetts · Michigan · Missouri
NCT05714085 on ClinicalTrials.gov ↗
Active Phase 1
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
Neuroblastoma
Eli Lilly and Company · started 2020-06-11
📍 California · Colorado · Illinois · Massachusetts · Ohio · Pennsylvania · Texas
NCT04106219 on ClinicalTrials.gov ↗
Recruiting
Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area
Anastomotic Leaks, Hartmanns Stump Leakage
Boston Scientific Corporation · started 2026-09
📍 California · Florida · Massachusetts · New York · Ohio · Pennsylvania · Washington · West Virginia
NCT07035431 on ClinicalTrials.gov ↗
Recruiting Phase 1
A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma
T-cell NHL (PTCL or CTCL)
Kyowa Kirin, Inc. · started 2026-09
📍 California · Florida · Georgia · Iowa · Massachusetts · Missouri · New Jersey · New York
NCT07192471 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)
Alpha-1 Antitrypsin Deficiency (AATD)
Tessera Therapeutics, Inc. · started 2026-04-21
📍 Massachusetts · South Carolina · Washington
NCT07227207 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
Bipolar Disorder
Eli Lilly and Company · started 2025-11-24
📍 California · Connecticut · Florida · Georgia · Iowa · Maryland · Massachusetts · Pennsylvania
NCT07286175 on ClinicalTrials.gov ↗
Active Phase 2
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
Merck Sharp & Dohme LLC · started 2022-07-21
📍 Alaska · Arizona · Colorado · Illinois · Kansas · Kentucky · Maryland · Massachusetts
NCT05458297 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
Heterozygous Familial Hypercholesterolemia (HeFH)
Merck Sharp & Dohme LLC · started 2025-08-21
📍 Delaware · District of Columbia · Florida · Georgia · Massachusetts · Ohio · West Virginia
NCT07058077 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
Atherosclerosis, Cardiovascular Diseases, Lipoprotein(a)
Eli Lilly and Company · started 2026-06-01
📍 California · Florida · Idaho · Massachusetts · Michigan · Nevada · Pennsylvania · Utah
NCT07613294 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Breast Neoplasms, Colorectal Neoplasms, Prostate Neoplasm, Endometrial Neoplasms
Eli Lilly and Company · started 2025-08-06
📍 California · Florida · Georgia · Massachusetts · Michigan · Missouri · New York · Pennsylvania
NCT07114601 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
Lymphoma, Non-Hodgkin, B-cell Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular
Eli Lilly and Company · started 2026-05-28
📍 California · Colorado · Connecticut · Illinois · Iowa · Kansas · Massachusetts · Michigan
NCT07101328 on ClinicalTrials.gov ↗
Active Phase 4
Pediatric Long-Term Follow-up and Rollover Study
Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood
Novartis Pharmaceuticals · started 2019-11-04
📍 Arizona · District of Columbia · Florida · Indiana · Maryland · Massachusetts · Minnesota · New York
NCT03975829 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase 3 Trial of VMX-C001 vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.
Blood Loss, Surgical, Coagulation Disorder
VarmX B.V. · started 2026-08-18
📍 Arizona · California · Colorado · Delaware · Florida · Iowa · Massachusetts · Michigan
NCT07288489 on ClinicalTrials.gov ↗
Recruiting Phase 1
Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)
Ewing Sarcoma
Amgen · started 2026-04-08
📍 California · Massachusetts · New York · Pennsylvania · Texas
NCT07297979 on ClinicalTrials.gov ↗
Active Phase 2
BIVV020 (SAR445088) in Prevention and Treatment of Antibody-mediated Rejection (AMR)
Transplant Rejection
Sanofi · started 2022-06-09
📍 California · Massachusetts · New York · Wisconsin
NCT05156710 on ClinicalTrials.gov ↗
No trials match your search.

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Prostate Cancer · 5 Ovarian Cancer · 4 Overweight · 4 Obesity · 4 Systemic Lupus Erythematosus · 3 Ulcerative Colitis · 3 Follicular Lymphoma · 3 Heart Failure · 3 Non-small Cell Lung Cancer · 3 Lymphoma, Large B-Cell, Diffuse · 2 Diabetes Mellitus, Type 1 · 2 Breast Neoplasms · 2 B-cell Malignancy · 2 Hidradenitis Suppurativa · 2 Acute Myeloid Leukemia · 2 Ovarian Neoplasms · 2
Cite this page

Priya Life Science (2026). Clinical Trials in the USA Tracker. Available at: https://priyalifescience.com/clinical-trials-usa/state/massachusetts (Accessed: 22 August 2026).

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Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one US site, most recently updated first, refreshed daily. This is a curated slice of the full registry, not every US trial. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish and EU sites, see our Ireland and EU trackers.