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Updated 08 Jul 2026 · ClinicalTrials.gov

Clinical Trials in Massachusetts

← All US trials

The most recently updated industry-sponsored clinical trials recruiting across the United States — searchable by condition, sponsor, phase and state. Refreshed daily from the ClinicalTrials.gov registry.

25
Recruiting now
36
Studies tracked
Massachusetts
Selected state
Recruiting Phase 3
A Long-term Extension Study of PCI-32765 (Ibrutinib)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma
Janssen Research & Development, LLC · started 2013-09-09
📍 California · Connecticut · Georgia · Illinois · Indiana · Kansas · Kentucky · Massachusetts
NCT01804686 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
Alzheimers Disease
Hoffmann-La Roche · started 2025-11-12
📍 Arizona · California · Connecticut · Florida · Georgia · Illinois · Massachusetts · Michigan
NCT07170150 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease
Respiratory Syncytial Virus Infections
Shionogi · started 2025-12-11
📍 California · Florida · Georgia · Massachusetts · Missouri · New York · North Carolina · Ohio
NCT07214571 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma
Genentech, Inc. · started 2022-10-20
📍 California · Colorado · Florida · Georgia · Massachusetts · Michigan · Missouri · New Jersey
NCT05581004 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of NNZ-2591 in Pediatric Participants With Phelan-McDermid Syndrome
Phelan-McDermid Syndrome
Neuren Pharmaceuticals Limited · started 2025-11-12
📍 California · Illinois · Maryland · Massachusetts · New York · Ohio · Texas
NCT07281079 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Brenipatide in Participants With Alcohol Use Disorder
Alcohol Use Disorder
Eli Lilly and Company · started 2025-10-16
📍 Arizona · Arkansas · California · Florida · Illinois · Maryland · Massachusetts · New York
NCT07219953 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
Durvalumab and Tremelimumab for Pediatric Malignancies
Pediatric Cancer, Solid Tumor Pediatric, Hematological Malignancies
AstraZeneca · started 2019-03-07
📍 Maryland · Massachusetts · New York · Oklahoma · South Carolina
NCT03837899 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
Eli Lilly and Company · started 2024-07-01
📍 California · Colorado · Florida · Illinois · Indiana · Massachusetts · Michigan · Missouri
NCT06465069 on ClinicalTrials.gov ↗
Active Phase 2
A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
Prostatic Cancer, Castration-Resistant
Novartis Pharmaceuticals · started 2025-07-03
📍 California · Colorado · Connecticut · Indiana · Massachusetts · Nebraska · New York · Pennsylvania
NCT07047118 on ClinicalTrials.gov ↗
Recruiting
GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections
Aortic Dissection
W.L.Gore & Associates · started 2025-09-22
📍 Alabama · California · Florida · Georgia · Illinois · Indiana · Massachusetts · Michigan
NCT06827990 on ClinicalTrials.gov ↗
Recruiting
Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions
Coronary Artery Disease
Teleflex · started 2025-07-18
📍 California · Kansas · Massachusetts · Missouri · New York · Texas · West Virginia
NCT06779630 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
Alzheimer Disease
Karuna Therapeutics, Inc., a Bristol Myers Squibb company · started 2024-09-26
📍 Arizona · California · Connecticut · Florida · Georgia · Massachusetts · Michigan · Mississippi
NCT06585787 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)
Diffuse Large B-Cell Lymphoma, Follicular Lymphoma
Genmab · started 2020-11-03
📍 Alabama · California · Massachusetts · Michigan · New Jersey · New York · North Carolina · Texas
NCT04663347 on ClinicalTrials.gov ↗
Recruiting
AERA Pediatrics Registry
Dysfunction of Eustachian Tube
Integra LifeSciences Corporation · started 2025-06-17
📍 California · Massachusetts · Michigan · Minnesota · Ohio · Pennsylvania · Texas · Utah
NCT07071298 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide in Adult Participants With Schizophrenia
Schizophrenia
Eli Lilly and Company · started 2026-02-10
📍 Arkansas · California · Connecticut · Florida · Georgia · Illinois · Maryland · Massachusetts
NCT07410507 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)
Immunoglobulin A Nephropathy (IgAN)
Biogen · started 2025-05-08
📍 Arkansas · California · Florida · Georgia · Massachusetts · Michigan · Mississippi · Missouri
NCT06935357 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
Multiple Myeloma
AbbVie · started 2025-07-23
📍 California · Connecticut · Massachusetts · Michigan · New York · North Carolina · Oregon · Texas
NCT06953960 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)
LMNA-Related Dilated Cardiomyopathy
Nuevocor Pte. Ltd. · started 2026-06-16
📍 Alabama · California · Massachusetts · Minnesota · Ohio · Texas
NCT07606274 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome
Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Treatment-naïve High Risk Chronic Lymphocytic Leukemia
Genmab · started 2020-11-25
📍 Alabama · California · Florida · Maryland · Massachusetts · Michigan · New Jersey · New York
NCT04623541 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma
Asthma
Eli Lilly and Company · started 2025-10-22
📍 Arizona · California · Colorado · Florida · Illinois · Kentucky · Massachusetts · Nevada
NCT07219173 on ClinicalTrials.gov ↗
Starting soon Phase 3
DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy
Extrapulmonary Neuroendocrine Cancer
Boehringer Ingelheim · started 2026-07-07
📍 Arizona · California · Florida · Georgia · Maryland · Massachusetts · Minnesota · Missouri
NCT07544654 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy
Urothelial Cancer
Bristol-Myers Squibb · started 2025-09-30
📍 Arizona · California · Colorado · District of Columbia · Florida · Kentucky · Maryland · Massachusetts
NCT07106762 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
Adenocarcinoma, Pancreatic Ductal
Genentech, Inc. · started 2023-10-18
📍 California · Connecticut · Illinois · Indiana · Kentucky · Massachusetts · Michigan · Nebraska
NCT05968326 on ClinicalTrials.gov ↗
Active Phase 2
An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
Tisento Therapeutics · started 2025-08-18
📍 California · Colorado · Georgia · Massachusetts · New York · Ohio · Pennsylvania · Texas
NCT06961344 on ClinicalTrials.gov ↗
Active Phase 2
A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS)
Novartis Pharmaceuticals · started 2024-10-17
📍 California · Florida · Georgia · Kansas · Massachusetts · Nebraska · New York · North Carolina
NCT06643481 on ClinicalTrials.gov ↗
Recruiting
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
Parkinson's Disease
Boston Scientific Corporation · started 2014-03-04
📍 California · Colorado · Florida · Idaho · Illinois · Indiana · Massachusetts · Missouri
NCT02071134 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Depressive Disorder, Major
Eli Lilly and Company · started 2026-02-09
📍 California · Connecticut · Florida · Georgia · Indiana · Iowa · Maryland · Massachusetts
NCT07412756 on ClinicalTrials.gov ↗
Recruiting Phase 3
Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder in Pediatric Patients
Irritability Associated With Autism Spectrum Disorder
Intra-Cellular Therapies, Inc. · started 2024-11-22
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Illinois · Massachusetts
NCT06690398 on ClinicalTrials.gov ↗
Recruiting Phase 2
INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes
Type 1 Diabetes Mellitus
Mannkind Corporation · started 2026-02-04
📍 California · Colorado · Connecticut · Florida · Indiana · Massachusetts · Oklahoma · Texas
NCT07224321 on ClinicalTrials.gov ↗
Recruiting Phase 2
Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma
Low Grade Upper Tract Urothelial Carcinoma
Tyra Biosciences, Inc · started 2025-12-22
📍 Georgia · Illinois · Indiana · Massachusetts · New Jersey · New York · Ohio · Tennessee
NCT07265947 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies
Advanced Solid Malignancies
AstraZeneca · started 2022-06-24
📍 California · Illinois · Massachusetts · New York · Oregon · Texas · Virginia
NCT05417594 on ClinicalTrials.gov ↗
Active Phase 3
A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Diffuse Large B-cell Lymphoma
Hoffmann-La Roche · started 2021-02-23
📍 Alabama · California · Florida · Maryland · Massachusetts · Mississippi · New Jersey · New York
NCT04408638 on ClinicalTrials.gov ↗
Active Phase 2
Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer
Breast Cancer
AstraZeneca · started 2022-11-07
📍 Colorado · Massachusetts · Oregon · Pennsylvania
NCT05498155 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
Biochemically Recurrent Prostate Cancer
Bayer · started 2023-04-03
📍 Arizona · California · Colorado · Illinois · Maryland · Massachusetts · Michigan · Minnesota
NCT05794906 on ClinicalTrials.gov ↗
Active Phase 3
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)
Rett Syndrome
Taysha Gene Therapies, Inc. · started 2023-03-06
📍 California · Illinois · Maryland · Massachusetts · Missouri · Texas
NCT05606614 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Osteoarthritis
Eli Lilly and Company · started 2025-09-15
📍 Arizona · California · Colorado · Connecticut · Georgia · Illinois · Kansas · Massachusetts
NCT07153471 on ClinicalTrials.gov ↗
No trials match your search.

Browse by state

California · 125 Florida · 104 Georgia · 66 Illinois · 58 Arizona · 57 Colorado · 55 Connecticut · 41 Michigan · 38 Indiana · 37 Alabama · 37 Massachusetts · 36 Texas · 35 New York · 32 Maryland · 27 Ohio · 24 Arkansas · 22

Browse by condition

Obesity · 7 Overweight · 6 Advanced Solid Tumors · 5 Neoplasm Metastasis · 4 Colitis, Ulcerative · 4 Melanoma · 3 Non-small Cell Lung Cancer · 3 Alzheimer Disease · 3 Crohn Disease · 3 Schizophrenia · 3 Small Lymphocytic Lymphoma · 2 Follicular Lymphoma · 2 Osteoarthritis · 2 Overweight or Obesity · 2 Alzheimers Disease · 2 Diabetes Mellitus, Type 1 · 2
Cite this page

Priya Life Science (2026). Clinical Trials in the USA Tracker. Available at: https://priyalifescience.com/clinical-trials-usa/state/massachusetts (Accessed: 8 July 2026).

Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one US site, most recently updated first, refreshed daily. This is a curated slice of the full registry, not every US trial. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish and EU sites, see our Ireland and EU trackers.