Setmelanotide is named as a drug or biological intervention in 3 clinical trials in our USA and UK trial registers, 1 of which is recruiting. The lead sponsor is Rhythm Pharmaceuticals, Inc.. Registered phases: Phase 3 and Phase 2. Conditions studied include Hypothalamic Obesity; Multiple Pituitary Hormone Deficiency Genetic Form; Septo-Optic Dysplasia.
| NCT ID | Study | Phase | Status |
|---|---|---|---|
| NCT06760546 | A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756) (ClinicalTrials.gov ↗) Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form, Septo-Optic Dysplasia |
Phase 3 | Recruiting |
| NCT05774756 | A Trial of Setmelanotide in Acquired Hypothalamic Obesity (ClinicalTrials.gov ↗) Hypothalamic Obesity |
Phase 3 | Active, closed |
| NCT06772597 | A Study of Setmelanotide in Patients With Prader-Willi Syndrome (ClinicalTrials.gov ↗) Prader-Willi Syndrome, Obesity, Hyperphagia |
Phase 2 | Active, closed |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
| Condition (as registered) | Trials |
|---|---|
| Hypothalamic Obesity | 2 |
| Multiple Pituitary Hormone Deficiency Genetic Form | 1 |
| Septo-Optic Dysplasia | 1 |
| Optic Nerve Hypoplasia | 1 |
| Prader-Willi Syndrome | 1 |
| Obesity | 1 |
| Hyperphagia | 1 |
| Lead sponsor | Trials |
|---|---|
| Rhythm Pharmaceuticals, Inc. | 3 |
| Register | Setmelanotide trials |
|---|---|
| Clinical trials in USA | 3 |
| Clinical trials in UK | 2 |
A trial with sites in more than one country appears in each of those registers.
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Setmelanotide works or whether it is effective. Each trial links to its own record so you can check it yourself.
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Setmelanotide (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.