A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

NCT07153471 · tracked via the Priya Life Science USA tracker

Sponsor

Eli Lilly and Company

Phase

Phase 3

Started

2025-09-15

Last updated

2026-09-08

Condition(s) studied

Osteoarthritis

Investigational drug(s) / intervention(s)

OrforglipronPlacebo

Orforglipron: Administered orally

Placebo: Administered orally

Study summary

The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening * Have tried at least once to lose weight through diet but were unsuccessful * Have osteoarthritis of the knee and at least one of the following conditions: * Be over 50 years old * Have morning knee stiffness that lasts about 30 minutes * Have a crackling or grinding sound or feeling in the knee Exclusion Criteria: * Have gained or lost more than 11 pounds within 90 days prior to screening * Have had a surgery for obesity or plan to have one in the next 18 months * Have an active knee infection * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure * Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening

Primary outcome measure(s)

Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score — Baseline, Week 72

Trial sites (88)

Facility	City	Region	Status
Arizona Research Center	Phoenix	Arizona	Recruiting
AMR Clinical	Tempe	Arizona	Recruiting
Care Access - Huntington Beach	Huntington Beach	California	Recruiting
Care Access - Thousand Oaks	Thousand Oaks	California	Recruiting
Legacy Clinical Trials	Colorado Springs	Colorado	Recruiting
Chase Medical Research, LLC	Waterbury	Connecticut	Recruiting
Care Access - Decatur	Decatur	Georgia	Recruiting
North Georgia Clinical Research	Woodstock	Georgia	Recruiting
Northwestern University	Chicago	Illinois	Recruiting
AMR Clinical	Newton	Kansas	Recruiting
MedVadis Research Corporation	Waltham	Massachusetts	Recruiting
StudyMetrix Research	City of Saint Peters	Missouri	Recruiting
AMR Clinical	Kansas City	Missouri	Recruiting
Cardio Metabolic Institute	Somerset	New Jersey	Recruiting
Carolina Research Center	Shelby	North Carolina	Recruiting
University Orthopedics Center	Altoona	Pennsylvania	Recruiting
Care Access - Rapid City	Rapid City	South Dakota	Recruiting
AMR Clinical	Knoxville	Tennessee	Recruiting
Mercy Family Clinic	Dallas	Texas	Recruiting
Juno Research	Houston	Texas	Recruiting
Biopharma Informatic, LLC	Houston	Texas	Recruiting
Activian Clinical Research	Kingwood	Texas	Recruiting
Advanced Rheumatology of Houston - Woodlands	The Woodlands	Texas	Recruiting
Charlottesville Medical Research	Charlottesville	Virginia	Recruiting
Gershon Pain Specialists	Virginia Beach	Virginia	Recruiting
Northwest Clinical Research Center	Bellevue	Washington	Recruiting
Aggarwal and Associates Limited	Brampton	Canada	Recruiting
Diex Recherche Inc. Division Joliette	Joliette	Canada	Recruiting
Your Research Network	Niagara Falls	Canada	Recruiting
G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.	Québec	Canada	Recruiting
Alpha Recherche Clinique	Québec	Canada	Recruiting
ALPHA Recherche Clinique	Québec	Canada	Recruiting
Bluewater Clinical Research Group Inc.	Sarnia	Canada	Recruiting
Winterberry Research Inc.	Stoney Creek	Canada	Recruiting
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T	Baotou	China	Recruiting
Xuanwu Hospital Capital Medical University	Beijing	China	Recruiting
The Second Affiliated Hospital Chongqing Medical University	Chongqing	China	Recruiting
The Fourth Affiliated Hospital of Harbin Medical University	Harbin	China	Recruiting
The Second People's Hospital of Hefei	Hefei	China	Recruiting
Jinan Central Hospital	Jinan	China	Recruiting

+ 48 more sites — see the full list on the official registry below.

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07153471 on ClinicalTrials.gov ↗ ← All trials in the USA