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Compound · clinical trials

Patritumab deruxtecan clinical trials

Also listed in trial records as U3-1402, HER3-DXd, Up-Titration, Fl-Dp, CTM-1 Lyo-DP, CTM-3 Lyo-DP
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 15 trials in our USA, China and UK registers that name Patritumab deruxtecan as an intervention. Synced 25 Sep 2026
15Current trials
11Recruiting now
2Lead sponsors
3Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Patritumab deruxtecan is named as an intervention in 15 current clinical trials in our USA, China and UK registers. 11 are recruiting patients now. The most common phase is Phase 1/2. The sponsor with the most trials is Merck Sharp & Dohme LLC (10). The most-studied condition is Breast Neoplasms.

Trials by status

  • Recruiting1173%
  • Active, closed427%

Trials by phase

  • Phase 1/2747%
  • Phase 2427%
  • Phase 3213%
  • Phase 1213%
01

Clinical trials of Patritumab deruxtecan

15 trials
StudyPhaseStatusLead sponsorRegisters
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
NCT07060807 · Breast Neoplasms
Phase 3 Recruiting Merck Sharp & Dohme LLC UK, USA, China
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
NCT06172478 · ClinicalTrials.gov ↗ · Advanced Solid Tumor, Melanoma, Head and Neck Cancer
Phase 2 Recruiting Daiichi Sankyo UK, USA, China
A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
NCT06731907 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Recruiting Merck Sharp & Dohme LLC USA
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)
NCT06797635 · ClinicalTrials.gov ↗ · Breast Neoplasms, Breast Cancer
Phase 2 Recruiting Merck Sharp & Dohme LLC USA
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naรฏve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
NCT04165070 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
Phase 1/2 Recruiting Merck Sharp & Dohme LLC USA
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
NCT06445972 · ClinicalTrials.gov ↗ · Gastroesophageal Junction, Gastroesophageal Adenocarcinoma, Esophageal Neoplasms
Phase 1/2 Recruiting Merck Sharp & Dohme LLC USA, China
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
NCT06469944 · ClinicalTrials.gov ↗ · Gastroesophageal Junction, Gastroesophageal Adenocarcinoma, Esophageal Neoplasms
Phase 1/2 Recruiting Merck Sharp & Dohme LLC USA, China
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
NCT06596694 · Gastrointestinal Cancer
Phase 1/2 Recruiting Merck Sharp & Dohme LLC USA, China
Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)
NCT06686394 · ClinicalTrials.gov ↗ · Breast Neoplasms, Breast Cancer
Phase 1/2 Recruiting Merck Sharp & Dohme LLC UK, USA
A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)
NCT06941272 · ClinicalTrials.gov ↗ · Malignant Neoplasm
Phase 1/2 Recruiting Merck Sharp & Dohme LLC UK, USA
A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)
NCT07286149 · ClinicalTrials.gov ↗ · Lung Neoplasm Malignant
Phase 1/2 Recruiting Merck Sharp & Dohme LLC USA, China
HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy
NCT05338970 · ClinicalTrials.gov ↗ · Nonsquamous Non-small Cell Lung Cancer, EGFR L858R, EGFR Exon 19 Deletion
Phase 3 Active, closed Daiichi Sankyo UK, USA, China
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
NCT04619004 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
Phase 2 Active, closed Daiichi Sankyo UK, USA, China
U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
NCT03260491 · Non-Small Cell Lung Cancer (NSCLC)
Phase 1 Active, closed Daiichi Sankyo USA
HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer
NCT04676477 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer (NSCLC)
Phase 1 Active, closed Daiichi Sankyo USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Patritumab deruxtecan

21 conditions
Breast Neoplasms3Breast Cancer2Gastroesophageal Junction2Gastroesophageal Adenocarcinoma2Esophageal Neoplasms2Esophageal Cancer2Non-Small Cell Lung Cancer (NSCLC)2Non-Small Cell Lung Cancer Metastatic1Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor1Malignant Neoplasm1Nonsquamous Non-small Cell Lung Cancer1EGFR L858R1
All 21 conditions
Condition (as registered)Trials
Breast Neoplasms3
Breast Cancer2
Gastroesophageal Junction2
Gastroesophageal Adenocarcinoma2
Esophageal Neoplasms2
Esophageal Cancer2
Non-Small Cell Lung Cancer (NSCLC)2
Non-Small Cell Lung Cancer Metastatic1
Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor1
Malignant Neoplasm1
Nonsquamous Non-small Cell Lung Cancer1
EGFR L858R1
EGFR Exon 19 Deletion1
Gastrointestinal Cancer1
Lung Neoplasm Malignant1
Advanced Solid Tumor1
Melanoma1
Head and Neck Cancer1
Gastric Cancer1
Non-small Cell Lung Cancer1
Carcinoma, Non-Small-Cell Lung1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Merck Sharp & Dohme LLC10
Daiichi Sankyo5
04

By country register

RegisterTrialsRecruiting
Clinical trials in USA1511
Clinical trials in China86
Clinical trials in UK64

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Patritumab deruxtecan trials

How many clinical trials are testing Patritumab deruxtecan?

15 current trials in our USA, China and UK registers name Patritumab deruxtecan (also registered as U3-1402) as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Patritumab deruxtecan trials recruiting patients?

Yes. 11 of the 15 trials are recruiting: 11 with sites in USA, 6 with sites in China and 4 with sites in UK. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Patritumab deruxtecan clinical trials?

Merck Sharp & Dohme LLC (10) and Daiichi Sankyo (5). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Patritumab deruxtecan works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Patritumab deruxtecan works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Patritumab deruxtecan (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.