Clinical Trials in the USA / NCT07616128
Recruiting
Phase 2
Study of EVO756 in Adults With Migraine
NCT07616128 · tracked via the Priya Life Science USA tracker
Condition(s) studied
Migraine
Investigational drug(s) / intervention(s)
EVO756, Dose 1EVO756, Dose 2Placebo
EVO756, Dose 1: Orally administered EVO756, Dose 1 (Daily)
EVO756, Dose 2: Orally administered EVO756, Dose 2 (Daily)
Placebo: Placebo Control (Daily)
Study summary
This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.
Eligibility
Key Inclusion Criteria:
* Adults aged 18 to \<65 years
* Migraine with or without aura, per ICHD-3 criteria
* History of failure with prior preventive migraine treatments
* Not currently using migraine preventive therapy
Key Exclusion Criteria:
* Difficulty distinguishing migraine from other headache types or presence of other primary headache disorders
* Use of certain medications
* Any clinically significant medical, psychiatric, neurological, cardiovascular, or laboratory abnormalities
Primary outcome measure(s)
- Mean change from baseline in the number of monthly migraine days (MMD) — Last month of the 12-week treatment period
Trial sites (35)
| Facility | City | Region | Status |
|---|---|---|---|
| Trialsphere Corp | Chandler | Arizona | Recruiting |
| Buena Park Research Center | Buena Park | California | Recruiting |
| Neuro Pain Research Center | Fresno | California | Recruiting |
| CA Medical Clinic for Headache | Los Angeles | California | Recruiting |
| Diablo Clinical Research dba Flourish Research | Walnut Creek | California | Recruiting |
| Hasbani Neurology | New Haven | Connecticut | Recruiting |
| New England Institute for Neurology and Headache | Stamford | Connecticut | Recruiting |
| Clinical Neuroscience Solutions, Inc. | Jacksonville | Florida | Recruiting |
| Apple Medical Research Group, Inc | Miami | Florida | Recruiting |
| Blessed Healthcase & Research | Miami | Florida | Recruiting |
| Florida Research Center, Inc. | Miami | Florida | Recruiting |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | Recruiting |
| Vantage Clinical Trials | Tampa | Florida | Recruiting |
| Premiere Research Institute at Palm Beach Neurology | West Palm Beach | Florida | Recruiting |
| Clinical Integrative Research Center of Atlanta | Atlanta | Georgia | Recruiting |
| Accel Research Site-Decatur-Alcanza | Decatur | Georgia | Recruiting |
| Neurology Center of New England P.C. | Foxborough | Massachusetts | Recruiting |
| Mass Institute of Clinical Research | Westborough | Massachusetts | Recruiting |
| Michigan Headache and Neurological Institute | Ann Arbor | Michigan | Recruiting |
| Quest Research Institute-Alcanza | Farmington Hills | Michigan | Recruiting |
| Bio Behavoural health | Toms River | New Jersey | Recruiting |
| Clinosis - Dent Neurologic Instite | Amherst | New York | Recruiting |
| Asheville Neurology Specialists, Pa | Asheville | North Carolina | Recruiting |
| Eximia Research NC | Raleigh | North Carolina | Recruiting |
| NeuroScience Research Center | Canton | Ohio | Recruiting |
| Clinical Trials of South Carolina | Charleston | South Carolina | Recruiting |
| Campbell Clinical Research | Franklin | Tennessee | Recruiting |
| FutureSearch Trials of Neurology | Austin | Texas | Recruiting |
| FutureSearch Trials of Dallas | Dallas | Texas | Recruiting |
| SFF Medical Research Group LLC | Houston | Texas | Recruiting |
| Mercury Clinical Research Inc. - Houston Neurology Associates | Houston | Texas | Recruiting |
| MedStar Health: Headache Center at McLean | McLean | Virginia | Recruiting |
| Vaught Neurological Services | Crab Orchard | West Virginia | Recruiting |
| Centre de Recherche St-Louis | Québec | Quebec | Recruiting |
| Momentum Clinical Research - Wellington | Wellington | New Zealand | Recruiting |
Other trials for the same condition
Long-term Extension Study to Assess Safety and Tolerability of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Pediatric Participants (Ages 6-17)
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Efficacy of Rimegepant 75 mg for the Acute Treatment of Migraine: a Bayesian Individual Participant Data Meta-analysis Standardized to Defined Target Populations
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A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine
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A Comprehensive Digital Care Program for Migraine Management
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Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07616128 on ClinicalTrials.gov ↗ ← All trials in the USA