Study of EVO756 in Adults With Migraine

NCT07616128 · tracked via the Priya Life Science USA tracker

Sponsor

Evommune, Inc.

Phase

Phase 2

Started

2026-07-29

Last updated

2026-09-03

Condition(s) studied

Migraine

Investigational drug(s) / intervention(s)

EVO756, Dose 1EVO756, Dose 2Placebo

EVO756, Dose 1: Orally administered EVO756, Dose 1 (Daily)

EVO756, Dose 2: Orally administered EVO756, Dose 2 (Daily)

Placebo: Placebo Control (Daily)

Study summary

This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.

Eligibility

Sex

ALL

Min age

18 Years

Max age

64 Years

Healthy volunteers

Key Inclusion Criteria: * Adults aged 18 to \<65 years * Migraine with or without aura, per ICHD-3 criteria * History of failure with prior preventive migraine treatments * Not currently using migraine preventive therapy Key Exclusion Criteria: * Difficulty distinguishing migraine from other headache types or presence of other primary headache disorders * Use of certain medications * Any clinically significant medical, psychiatric, neurological, cardiovascular, or laboratory abnormalities

Primary outcome measure(s)

Mean change from baseline in the number of monthly migraine days (MMD) — Last month of the 12-week treatment period

Trial sites (26)

Facility	City	Region	Status
Trialsphere Corp	Chandler	Arizona	Recruiting
Buena Park Research Center	Buena Park	California	Recruiting
Neuro Pain Research Center	Fresno	California	Recruiting
CA Medical Clinic for Headache	Los Angeles	California	Recruiting
Diablo Clinical Research dba Flourish Research	Walnut Creek	California	Recruiting
New England Institute for Neurology and Headache	Stamford	Connecticut	Recruiting
Clinical Neuroscience Solutions, Inc.	Jacksonville	Florida	Recruiting
Apple Medical Research Group, Inc	Miami	Florida	Recruiting
Blessed Healthcase & Research	Miami	Florida	Recruiting
Florida Research Center, Inc.	Miami	Florida	Recruiting
Clinical Neuroscience Solutions, Inc.	Orlando	Florida	Recruiting
Vantage Clinical Trials	Tampa	Florida	Recruiting
Premiere Research Institute at Palm Beach Neurology	West Palm Beach	Florida	Recruiting
Accel Research Site-Decatur-Alcanza	Decatur	Georgia	Recruiting
Mass Institute of Clinical Research	Westborough	Massachusetts	Recruiting
Michigan Headache and Neurological Institute	Ann Arbor	Michigan	Recruiting
Quest Research Institute-Alcanza	Farmington Hills	Michigan	Recruiting
Bio Behavoural health	Toms River	New Jersey	Recruiting
Clinosis - Dent Neurologic Instite	Amherst	New York	Recruiting
Asheville Neurology Specialists, Pa	Asheville	North Carolina	Recruiting
Eximia Research NC	Raleigh	North Carolina	Recruiting
Clinical Trials of South Carolina	Charleston	South Carolina	Recruiting
FutureSearch Trials of Neurology	Austin	Texas	Recruiting
FutureSearch Trials of Dallas	Dallas	Texas	Recruiting
SFF Medical Research Group LLC	Houston	Texas	Recruiting
Vaught Neurological Services	Crab Orchard	West Virginia	Recruiting

More Evommune, Inc. trials in the USA

Phase 2b Study of EVO756 in Adults With Atopic Dermatitis Active, not recruiting

Other trials for the same condition

A Comprehensive Digital Care Program for Migraine Management Enrolling by invitation

Observational Study of Oral Atogepant to Evaluate Real-World Effectiveness in Adult Participants With Migraine Active, not recruiting

Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine Active, not recruiting

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine Active, not recruiting

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17) Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07616128 on ClinicalTrials.gov ↗ ← All trials in the USA