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Compound · clinical trials

Luxdegalutamide clinical trials

Also listed in trial records as JSB462 1, JSB462 2, JSB462
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 4 trials in our USA, China, Germany, France, Spain, Italy, Canada, Singapore, Australia, Poland, Netherlands, Czechia, South Korea, Taiwan, UK, Denmark, Mexico, Austria, Israel, Brazil and Japan registers that name Luxdegalutamide as an intervention. Synced 27 Sep 2026
4Current trials
1Recruiting now
1Lead sponsor
21Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Luxdegalutamide is named as an intervention in 4 current clinical trials in our USA, China, Germany, France, Spain, Italy, Canada, Singapore, Australia, Poland, Netherlands, Czechia, South Korea, Taiwan, UK, Denmark, Mexico, Austria, Israel, Brazil and Japan registers. 1 is recruiting patients now. The most common phase is Phase 2. The lead sponsor is Novartis Pharmaceuticals. The most-studied condition is Progressive Metastatic Castrate Resistant Prostate Cancer.

Trials by status

  • Recruiting125%
  • Active, closed375%

Trials by phase

  • Phase 2250%
  • Phase 1/2125%
  • Phase 1125%
01

Clinical trials of Luxdegalutamide

4 trials
StudyPhaseStatusLead sponsorRegisters
An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)
NCT07206056 · ClinicalTrials.gov ↗ · Progressive Metastatic Castrate Resistant Prostate Cancer
Phase 1/2 Recruiting Novartis Pharmaceuticals UK, USA, China, Germany, France, Spain, Italy, Denmark, Poland, Canada, Mexico, Singapore, Australia
An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
NCT06991556 · ClinicalTrials.gov ↗ · Metastatic Hormone-sensitive Prostate Cancer
Phase 2 Active, closed Novartis Pharmaceuticals USA, China, Germany, France, Spain, Italy, Netherlands, Poland, Czechia, Canada, Brazil, South Korea, Taiwan, Singapore, Australia
A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
NCT07047118 · ClinicalTrials.gov ↗ · Prostatic Cancer, Castration-Resistant
Phase 2 Active, closed Novartis Pharmaceuticals USA, China, Germany, France, Spain, Italy, Netherlands, Austria, Czechia, Canada, South Korea, Taiwan, Singapore, Australia, Israel
A Phase I Study of JSB462 (Luxdegalutamide) in Japanese Patients With Metastatic Prostate Cancer
NCT07174063 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer (mCRPC)
Phase 1 Active, closed Novartis Pharmaceuticals Japan

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Luxdegalutamide

4 conditions
Progressive Metastatic Castrate Resistant Prostate Cancer1Prostatic Cancer, Castration-Resistant1Metastatic Hormone-sensitive Prostate Cancer1Metastatic Prostate Cancer (mCRPC)1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Novartis Pharmaceuticals4
04

By country register

RegisterTrialsRecruiting
Clinical trials in USA31
Clinical trials in China31
Clinical trials in Germany31
Clinical trials in France31
Clinical trials in Spain31
Clinical trials in Italy31
Clinical trials in Canada31
Clinical trials in Singapore31
Clinical trials in Australia31
Clinical trials in Poland21
Clinical trials in Netherlands20
Clinical trials in Czechia20
Clinical trials in South Korea20
Clinical trials in Taiwan20
Clinical trials in UK11
Clinical trials in Denmark11
Clinical trials in Mexico11
Clinical trials in Austria10
Clinical trials in Israel10
Clinical trials in Brazil10
Clinical trials in Japan10

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Luxdegalutamide trials

How many clinical trials are testing Luxdegalutamide?

4 current trials in our USA, China, Germany, France, Spain, Italy, Canada, Singapore, Australia, Poland, Netherlands, Czechia, South Korea, Taiwan, UK, Denmark, Mexico, Austria, Israel, Brazil and Japan registers name Luxdegalutamide (also registered as JSB462 1) as a drug or biological intervention, as of the registry sync on 27 September 2026. Completed and withdrawn studies are not counted.

Are Luxdegalutamide trials recruiting patients?

Yes. 1 of the 4 trials is recruiting: 1 with sites in USA, 1 with sites in China, 1 with sites in Germany, 1 with sites in France, 1 with sites in Spain, 1 with sites in Italy, 1 with sites in Canada, 1 with sites in Singapore, 1 with sites in Australia, 1 with sites in Poland, 1 with sites in UK, 1 with sites in Denmark and 1 with sites in Mexico. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Luxdegalutamide clinical trials?

The lead sponsor is Novartis Pharmaceuticals. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Luxdegalutamide works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Luxdegalutamide works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Luxdegalutamide (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 27 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.