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Updated 21 Aug 2026 · ClinicalTrials.gov

Clinical Trials in California

← All US trials

The most recently updated industry-sponsored clinical trials recruiting across the United States — searchable by condition, sponsor, phase and state. Refreshed daily from the ClinicalTrials.gov registry.

86
Recruiting now
112
Studies tracked
California
Selected state
Recruiting Phase 2
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Lymphoma, Large B-Cell, Diffuse
Merck Sharp & Dohme LLC · started 2025-04-11
📍 Alabama · Arizona · Arkansas · California · Colorado · Delaware · District of Columbia · Florida
NCT06890884 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Non-Small Cell Lung Cancer (NSCLC)
Amgen · started 2023-11-16
📍 California · Delaware · Florida · Illinois · Kentucky · Massachusetts · New Mexico · New York
NCT05920356 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Acute Stroke, Ischemic Stroke, Stroke
DiaMedica Therapeutics Inc · started 2021-11-07
📍 Alabama · California · Florida · Georgia · Illinois · Kansas · Louisiana · Massachusetts
NCT05065216 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
Atopic Dermatitis
Apogee Therapeutics, Inc. · started 2025-05-14
📍 California · Florida · Georgia · Illinois · Kentucky · Michigan · New York · North Carolina
NCT07003425 on ClinicalTrials.gov ↗
Active Phase 3
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Merz Pharmaceuticals GmbH · started 2019-09-16
📍 Alabama · Arkansas · California · Connecticut · Florida · Massachusetts · Missouri · New York
NCT03992404 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Prostate Cancer, Prostatic Neoplasms
Merck Sharp & Dohme LLC · started 2025-05-13
📍 Arizona · California · Colorado · Connecticut · District of Columbia · Florida · Georgia · Illinois
NCT06925737 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Evaluate the Safety and Efficacy of Zilganersen (ION373) in Patients With Alexander Disease (AxD)
Alexander Disease
Ionis Pharmaceuticals, Inc. · started 2021-06-01
📍 California · Georgia · Massachusetts · Pennsylvania
NCT04849741 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
Ovarian Cancer
AbbVie · started 2025-11-13
📍 California · Florida · Kentucky · Louisiana · Maine · Massachusetts · Michigan · Montana
NCT07059845 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
Colitis Ulcerative, Ulcerative Colitis
Merck Sharp & Dohme LLC · started 2026-03-24
📍 California · Colorado · Florida · Georgia · Kansas · Louisiana · Missouri
NCT07463183 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)
Small Cell Lung Cancer Extensive Stage
Merck Sharp & Dohme LLC · started 2026-01-29
📍 California · Colorado · Florida · Kentucky · Missouri · New Jersey · Oregon · South Dakota
NCT07227597 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
Breast Neoplasms
Eli Lilly and Company · started 2026-05-13
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Indiana · Kentucky
NCT07287098 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTO
Diabetic Macular Edema (DME)
Kodiak Sciences Inc · started 2026-08-03
📍 California · Florida · Maryland · Minnesota · South Carolina
NCT07734844 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma
BeOne Medicines · started 2021-09-13
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Illinois · Iowa
NCT05006716 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency
Growth Hormone Deficiency (GHD)
Lumos Pharma · started 2026-05-20
📍 Alabama · California · Colorado · District of Columbia · Florida · Indiana · Iowa · Louisiana
NCT06948214 on ClinicalTrials.gov ↗
Recruiting Phase 2
Caring Recharge Project for Caregivers of Individuals With Alzheimer's Disease
Caregiver Stress
Photozig, Inc. · started 2026-08-14
📍 California
NCT07764185 on ClinicalTrials.gov ↗
Active Phase 3
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa
Hidradenitis Suppurativa
Novartis Pharmaceuticals · started 2025-03-20
📍 Alabama · Arizona · California · Florida · Georgia · Illinois · Indiana · Massachusetts
NCT06840392 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study of ZL-1310 in Participants With Selected Solid Tumors
Solid Tumors
Zai Lab (Shanghai) Co., Ltd. · started 2025-05-12
📍 California · Illinois · Michigan · New York · Ohio · Pennsylvania · Tennessee · Texas
NCT06885281 on ClinicalTrials.gov ↗
Active Phase 2
An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Metastatic Hormone-sensitive Prostate Cancer
Novartis Pharmaceuticals · started 2025-07-07
📍 California · Colorado · Connecticut · Florida · Georgia · Illinois · Massachusetts · Michigan
NCT06991556 on ClinicalTrials.gov ↗
Recruiting
A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk
Relapsing Multiple Sclerosis
TG Therapeutics, Inc. · started 2024-03-26
📍 California · Georgia · Massachusetts · North Carolina · Tennessee
NCT06143514 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema
Macular Edema
Boehringer Ingelheim · started 2025-06-05
📍 Arizona · California · Colorado · Florida · Indiana · Kansas · Maryland · Nevada
NCT06962839 on ClinicalTrials.gov ↗
Recruiting Phase 1
CER-1236 in Patients With Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), and Myelofibrosis (MF)
AML, Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
CERo Therapeutics Holdings, Inc. · started 2025-04-07
📍 California · Colorado · Tennessee · Texas
NCT06834282 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
A Study to Assess Adverse Events and Change in Disease Activity When Intravenous (IV) Pivekimab Sunirine is Given in Combination With Oral Venetoclax and IV or Subcutaneous Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia
AbbVie · started 2026-06-30
📍 California · New York
NCT07581002 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Assess the Safety and Efficacy of AGN-151586 Injections for the Treatment of Moderate to Severe Forehead Lines (FHL) in Adult Participants
Forehead Lines
AbbVie · started 2026-07-22
📍 California · New York · North Carolina · Texas
NCT07730554 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
argenx · started 2025-09-16
📍 Alabama · California · Colorado · District of Columbia · Florida · Louisiana · Pennsylvania · Texas
NCT07091630 on ClinicalTrials.gov ↗
By invitation
Observational Study of VYKAT™ XR in Patients With Prader-Willi Syndrome
Prader-Willi Syndrome
Soleno Therapeutics, Inc. · started 2025-11-26
📍 Arizona · California · Colorado · Georgia · Illinois · Indiana · Massachusetts · Michigan
NCT07450664 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
Radiographic Axial Spondyloarthritis
Merck Sharp & Dohme LLC · started 2025-09-26
📍 Arizona · California · Florida · Illinois · Maryland · Missouri · Montana · Nebraska
NCT07133633 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
Eli Lilly and Company · started 2025-10-22
📍 Alabama · Arizona · California · Colorado · Connecticut · Florida · Georgia · Hawaii
NCT07213804 on ClinicalTrials.gov ↗
Recruiting Phase 3
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
Kidney Disease, Chronic
Boehringer Ingelheim · started 2024-08-30
📍 Alabama · Arizona · California · Florida · Georgia · Idaho · Illinois · Kansas
NCT06531824 on ClinicalTrials.gov ↗
Recruiting Phase 3
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
Crohn's Disease, Obesity or Overweight
Eli Lilly and Company · started 2025-06-26
📍 Alabama · California · Florida · Idaho · Illinois · Indiana · Kentucky · Louisiana
NCT06937099 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
Idiopathic Inflammatory Myopathy, Dermatomyositis, Anti-Synthetase Syndrome, Immune-Mediated Necrotizing Myopathy
Cabaletta Bio · started 2023-12-20
📍 California · Colorado · Florida · Georgia · Illinois · Kansas · Maryland · Massachusetts
NCT06154252 on ClinicalTrials.gov ↗
Recruiting Phase 3
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
Elevated Lp(a), Atherosclerotic Cardiovascular Disease (ASCVD)
Eli Lilly and Company · started 2025-09-02
📍 Alabama · Arizona · California · Colorado · Connecticut · Florida · Georgia · Idaho
NCT07157774 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Relapsed or Refractory Multiple Myeloma
Celgene · started 2022-09-20
📍 California · Colorado · Connecticut · Florida · Georgia · Kansas · Louisiana · Maryland
NCT05519085 on ClinicalTrials.gov ↗
Active Phase 2
Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)
Overweight, Type 2 Diabetes, Obesity
Zealand Pharma · started 2025-04-22
📍 Alabama · Arizona · Arkansas · California · Connecticut · District of Columbia · Florida · Georgia
NCT06926842 on ClinicalTrials.gov ↗
Active Phase 3
A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort
In-Stent Restenosis
Boston Scientific Corporation · started 2024-10-07
📍 Arizona · California · Georgia · Michigan · New York · Ohio · Pennsylvania · Rhode Island
NCT06492174 on ClinicalTrials.gov ↗
Active Phase 3
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
Hidradenitis Suppurativa
AbbVie · started 2024-06-27
📍 Alabama · Arizona · Arkansas · California · Connecticut · Florida · Georgia · Idaho
NCT06468228 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma
Asthma
Eli Lilly and Company · started 2025-10-22
📍 Arizona · California · Colorado · Florida · Illinois · Kentucky · Massachusetts · Nevada
NCT07219173 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer
Daiichi Sankyo · started 2024-02-26
📍 California · Connecticut · Florida · Illinois · Maryland · Minnesota · Missouri · New York
NCT06172478 on ClinicalTrials.gov ↗
Active Phase 3
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
Tuberous Sclerosis Complex
Novartis Pharmaceuticals · started 2017-08-23
📍 Arizona · California · Colorado · Connecticut · Illinois · Minnesota · New Jersey · Ohio
NCT02962414 on ClinicalTrials.gov ↗
Recruiting Phase 2
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
Glioblastoma (GBM), Newly Diagnosed Glioblastoma, GBM, Glioblastoma Multiforme (GBM)
Black Diamond Therapeutics, Inc. · started 2026-05-05
📍 Alabama · Arkansas · California · Connecticut · District of Columbia · Florida · Maryland · Massachusetts
NCT07326566 on ClinicalTrials.gov ↗
Recruiting Phase 2
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
Merck Sharp & Dohme LLC · started 2021-04-05
📍 Arkansas · California · Colorado · Kentucky · Minnesota · New Jersey · North Dakota · Texas
NCT04728893 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
Peripheral Arterial Disease
Eli Lilly and Company · started 2025-10-31
📍 Alabama · Arizona · California · Colorado · Florida · Indiana · Maryland · Michigan
NCT07223593 on ClinicalTrials.gov ↗
Recruiting Phase 3
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
Lennox Gastaut Syndrome
Epygenix · started 2025-04-09
📍 Arkansas · California · Florida · Illinois · Kentucky · Michigan · Minnesota · Nebraska
NCT05066217 on ClinicalTrials.gov ↗
Active Phase 1/Phase 2
Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease
X-Linked Chronic Granulomatous Disease
Ensoma · started 2025-08-05
📍 California · Florida · Massachusetts · Minnesota · New York · North Carolina · Utah
NCT06876363 on ClinicalTrials.gov ↗
Recruiting
A Multicenter, Prospective Blood Collection Study in a Kidney Transplant Population
Kidney Disease, Kidney Transplant, Transplant Recipient, Renal Function
Devyser Inc. · started 2025-11-14
📍 California · Georgia · Maryland · Massachusetts · Utah
NCT07006831 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
Episodic Migraine
AbbVie · started 2023-05-01
📍 Alabama · Arkansas · California · Colorado · Florida · Georgia · Indiana · Kansas
NCT05711394 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain
Chronic Pain, Low Back Pain
Eli Lilly and Company · started 2026-08-12
📍 Alabama · Arizona · California · Connecticut · Florida · Georgia · Illinois · Louisiana
NCT07641504 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Metabolic Dysfunction-Associated Steatotic Liver Disease
Eli Lilly and Company · started 2025-10-15
📍 Alabama · Arizona · Arkansas · California · Colorado · Connecticut · Florida · Georgia
NCT07165028 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Breast Cancer, Endometrial Cancer, Ovarian Cancer, Lung Squamous Cell Carcinoma
Terremoto Biosciences Inc. · started 2025-09-23
📍 California · Florida · Illinois · Massachusetts · Minnesota · Missouri · Nebraska · North Carolina
NCT07109726 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
Ovarian Cancer, Breast Cancer, Endometrial Cancer, Biliary Tract Cancer
NextCure, Inc. · started 2025-01-07
📍 California · Kentucky · Massachusetts · Missouri · New Jersey · New York · Ohio · Pennsylvania
NCT06774963 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
Early Breast Cancer
Novartis Pharmaceuticals · started 2024-02-28
📍 Alabama · Alaska · Arizona · Arkansas · California · Colorado · District of Columbia · Florida
NCT05827081 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer
Nausea, Vomiting, Drug-Related Side Effects and Adverse Reactions, Neoplasms
Eli Lilly and Company · started 2025-11-28
📍 California · Colorado · Florida · Georgia · Illinois · Indiana · Mississippi · New York
NCT07169851 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia
Schizophrenia
Leal Therapeutics, Inc · started 2026-08
📍 Arkansas · California · Florida · Georgia · Maryland · New Jersey · Texas
NCT07734493 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
Obesity, Overweight
Eli Lilly and Company · started 2026-02-06
📍 Alabama · Arizona · California · Connecticut · Florida · Georgia · Hawaii · Iowa
NCT07321886 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies
B-cell Malignancy, Relapsed Cancer, Refractory Cancer, B-cell Lymphoma
BeOne Medicines · started 2024-11-27
📍 Arizona · California · Florida · Kansas · Minnesota · Missouri · New Jersey · New York
NCT06634589 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)
Myelodysplastic Syndromes, Cytopenia
Takeda · started 2020-08-19
📍 Arkansas · California · Florida · Maryland · Michigan · New Jersey · New York · Pennsylvania
NCT04419649 on ClinicalTrials.gov ↗
Recruiting
ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis
Myasthenia Gravis, MG, gMG, Generalized Myasthenia Gravis
argenx · started 2025-12-19
📍 California · Florida · Massachusetts · Michigan · New York · North Carolina · Ohio · Tennessee
NCT07294170 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
Prostate Cancer
AstraZeneca · started 2025-08-06
📍 Arizona · California · Colorado · Florida · Georgia · Illinois · Indiana · Maryland
NCT06952803 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of ZL-1310 in Subjects With Small Cell Lung Cancer
SCLC
Zai Lab (Shanghai) Co., Ltd. · started 2024-01-23
📍 California · Connecticut · Florida · Michigan · New Jersey · New York · North Carolina · Ohio
NCT06179069 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer
Astellas Pharma Global Development, Inc. · started 2025-08-19
📍 Alabama · California · Florida · Illinois · Louisiana · New Mexico · Ohio · South Carolina
NCT07005154 on ClinicalTrials.gov ↗
Recruiting Phase 2
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
Non-small Cell Lung Cancer
AstraZeneca · started 2022-04-14
📍 Arkansas · California · Connecticut · Florida · Georgia · Illinois · Maryland · Massachusetts
NCT05061550 on ClinicalTrials.gov ↗
By invitation Phase 2/Phase 3
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
Erythropoietic Protoporphyria
Disc Medicine, Inc · started 2023-08-31
📍 Alabama · California · Florida · Massachusetts · New York · North Carolina · Ohio · Pennsylvania
NCT05883748 on ClinicalTrials.gov ↗
Active Phase 3
Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis
Lupus Nephritis
Novartis Pharmaceuticals · started 2022-07-14
📍 Alabama · California · Florida · Georgia · Louisiana · Michigan · Nevada · New York
NCT05126277 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Dravet Syndrome
Encoded Therapeutics · started 2024-05-14
📍 California · Colorado · Florida · Illinois · Massachusetts · Michigan · Minnesota · North Carolina
NCT05419492 on ClinicalTrials.gov ↗
By invitation Phase 3
An Extension Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE)
Biogen · started 2022-06-10
📍 Arizona · California · Colorado · District of Columbia · Florida · Georgia · Massachusetts · Michigan
NCT05352919 on ClinicalTrials.gov ↗
Starting soon
Wearable Sensor for Early Detection and Monitoring of Cognitive Decline
Mild Cognitive Impairment (MCI), Older Adults With Cognitive Decline, Older Adults
BioSensics · started 2026-12-15
📍 California
NCT07780162 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study to Test How Well Different Doses of BI 3820768 Are Tolerated by People With Advanced Cancer (Solid Tumours)
Advanced Relapsed or Refractory Germ Cell Tumours, Advanced Relapsed or Refractory Endometrial Cancer, Advanced Relapsed or Refractory Ovarian Cancer
Boehringer Ingelheim · started 2026-02-27
📍 California · Indiana · Texas
NCT07306559 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Brenipatide in Participants With Alcohol Use Disorder
Alcohol Use Disorder
Eli Lilly and Company · started 2025-10-16
📍 Arizona · Arkansas · California · Florida · Illinois · Maryland · Massachusetts · New York
NCT07219953 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide in Participants With Opioid Use Disorder
Opioid Use Disorder
Eli Lilly and Company · started 2026-02-13
📍 Arizona · Arkansas · California · Florida · Illinois · Indiana · Kentucky · Maryland
NCT07420283 on ClinicalTrials.gov ↗
Recruiting Phase 3
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis
Boehringer Ingelheim · started 2024-10-14
📍 Alabama · Arizona · California · Colorado · Connecticut · Florida · Georgia · Indiana
NCT06632444 on ClinicalTrials.gov ↗
Recruiting Phase 2/Phase 3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Heart Failure, Left Ventricular Systolic Dysfunction
Merck Sharp & Dohme LLC · started 2023-05-31
📍 California · Colorado · District of Columbia · Florida · Georgia · Massachusetts · Michigan · Missouri
NCT05714085 on ClinicalTrials.gov ↗
Active Phase 2
A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression
Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive
AbbVie · started 2024-07-29
📍 California · Kentucky · Maryland · Missouri · Nevada · New Jersey · New York · North Carolina
NCT06365853 on ClinicalTrials.gov ↗
Active Phase 3
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
Systemic Lupus Erythematosus
Novartis Pharmaceuticals · started 2023-04-21
📍 Alabama · California · Florida · Georgia · Illinois · Kentucky · Louisiana · Maryland
NCT05624749 on ClinicalTrials.gov ↗
Recruiting Phase 1
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
Prostate Cancer
Amgen · started 2020-03-04
📍 California · Colorado · Connecticut · Georgia · Indiana · Kansas · Louisiana · Missouri
NCT04221542 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Pulmonary Arterial Hypertension
Merck Sharp & Dohme LLC · started 2021-05-12
📍 Arizona · California · Colorado · District of Columbia · Florida · Kansas · Kentucky · Maryland
NCT07218029 on ClinicalTrials.gov ↗
Active Phase 1
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
Neuroblastoma
Eli Lilly and Company · started 2020-06-11
📍 California · Colorado · Illinois · Massachusetts · Ohio · Pennsylvania · Texas
NCT04106219 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Heart Failure
Boehringer Ingelheim · started 2024-06-17
📍 Alabama · California · Connecticut · Florida · Georgia · Idaho · Illinois · Indiana
NCT06424288 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Acne
Sanofi Pasteur, a Sanofi Company · started 2024-04-05
📍 Arizona · California · Florida · Georgia · Illinois · Indiana · Iowa · Kentucky
NCT06316297 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
Ovarian Neoplasms, Ovarian Cancer
Merck Sharp & Dohme LLC · started 2026-02-16
📍 Alabama · California · Florida · Georgia · Illinois · Indiana · Louisiana · Maine
NCT07318558 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis
Eli Lilly and Company · started 2025-12-12
📍 Alabama · Arizona · Arkansas · California · Colorado · Connecticut · District of Columbia · Florida
NCT07218380 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma
Endometrial Adenocarcinoma
Acrivon Therapeutics · started 2022-08-29
📍 Alabama · Alaska · Arizona · Arkansas · California · Colorado · Connecticut · Florida
NCT05548296 on ClinicalTrials.gov ↗
Recruiting Phase 3
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
Cardiovascular Disease
Amgen · started 2025-08-22
📍 Alabama · Arizona · Arkansas · California · Colorado · Connecticut · Florida · Georgia
NCT07136012 on ClinicalTrials.gov ↗
Active Phase 2
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms
Seagen, a wholly owned subsidiary of Pfizer · started 2021-01-11
📍 Arizona · California · Colorado · Florida · Minnesota · Missouri · Nebraska · New York
NCT04579380 on ClinicalTrials.gov ↗
Recruiting
Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area
Anastomotic Leaks, Hartmanns Stump Leakage
Boston Scientific Corporation · started 2026-09
📍 California · Florida · Massachusetts · New York · Ohio · Pennsylvania · Washington · West Virginia
NCT07035431 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Non Small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2024-04-03
📍 Arkansas · California · Connecticut · Florida · Georgia · Illinois · Indiana · Kentucky
NCT06312137 on ClinicalTrials.gov ↗
Recruiting Phase 1
A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma
T-cell NHL (PTCL or CTCL)
Kyowa Kirin, Inc. · started 2026-09
📍 California · Florida · Georgia · Iowa · Massachusetts · Missouri · New Jersey · New York
NCT07192471 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis
Atherosclerosis, Coronary Artery Disease
Beijing Inno Medicine Co., Ltd. · started 2026-07-31
📍 Alabama · California · Florida · Illinois · Kansas · Missouri · North Carolina · Ohio
NCT07521007 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative Colitis
AbbVie · started 2025-07-28
📍 Arizona · California · Florida · Georgia · Illinois · New Jersey · Ohio · Pennsylvania
NCT07071519 on ClinicalTrials.gov ↗
By invitation Phase 3
A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
UCB Biopharma SRL · started 2021-07-27
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Idaho · Illinois
NCT04976322 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Metastatic Colorectal Cancer
Amgen · started 2024-07-17
📍 Arizona · California · Connecticut · Florida · Georgia · Illinois · Kentucky · Michigan
NCT06252649 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
Bipolar Disorder
Eli Lilly and Company · started 2025-11-24
📍 California · Connecticut · Florida · Georgia · Iowa · Maryland · Massachusetts · Pennsylvania
NCT07286175 on ClinicalTrials.gov ↗
Active Phase 3
Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
Polymyalgia Rheumatica
Novartis Pharmaceuticals · started 2024-06-28
📍 Arizona · California · Florida · Maryland · Michigan · New Hampshire · Ohio · Texas
NCT06331312 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
Atherosclerosis, Cardiovascular Diseases, Lipoprotein(a)
Eli Lilly and Company · started 2026-06-01
📍 California · Florida · Idaho · Massachusetts · Michigan · Nevada · Pennsylvania · Utah
NCT07613294 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Breast Neoplasms, Colorectal Neoplasms, Prostate Neoplasm, Endometrial Neoplasms
Eli Lilly and Company · started 2025-08-06
📍 California · Florida · Georgia · Massachusetts · Michigan · Missouri · New York · Pennsylvania
NCT07114601 on ClinicalTrials.gov ↗
Recruiting Phase 1
A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
Lymphoma, Non-Hodgkin, B-cell Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular
Eli Lilly and Company · started 2026-05-28
📍 California · Colorado · Connecticut · Illinois · Iowa · Kansas · Massachusetts · Michigan
NCT07101328 on ClinicalTrials.gov ↗
Active Phase 2
Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine
Bronchiectasis
Boehringer Ingelheim · started 2023-09-08
📍 California · Florida · Kansas · New York · Ohio · South Carolina · Texas
NCT05846230 on ClinicalTrials.gov ↗
Recruiting Phase 1
Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation
Acute Leukemia, Myelodysplastic Syndrome
Laguna Biotherapeutics, Inc. · started 2026-08
📍 California
NCT07573111 on ClinicalTrials.gov ↗
Recruiting Phase 2
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
Type 2 Diabetes
Eli Lilly and Company · started 2025-03-28
📍 Arizona · California · Florida · Georgia · Idaho · Indiana · New Jersey · New York
NCT06897475 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Chronic Lymphocytic, Small-Cell Lymphoma, Lymphoma, Small Lymphocytic
Merck Sharp & Dohme LLC · started 2023-08-08
📍 Arkansas · California · Florida · Indiana · Maryland · Mississippi · Missouri · Montana
NCT05947851 on ClinicalTrials.gov ↗
Recruiting Phase 1/Phase 2
A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated
Diabetic Macular Edema
Boehringer Ingelheim · started 2026-05-14
📍 Arizona · California · Connecticut · Florida · New York · North Carolina · North Dakota · Ohio
NCT07553429 on ClinicalTrials.gov ↗
Recruiting Phase 3
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Migraine
AbbVie · started 2022-01-13
📍 Alabama · Arizona · Arkansas · California · Colorado · Connecticut · District of Columbia · Florida
NCT05125302 on ClinicalTrials.gov ↗
Recruiting Phase 3
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Osteoarthritis, Overweight or Obesity
Eli Lilly and Company · started 2026-02-09
📍 Alabama · Arizona · California · Colorado · Florida · Georgia · Idaho · Illinois
NCT07353931 on ClinicalTrials.gov ↗
Recruiting Phase 1
Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).
Juvenile Psoriatic Arthritis
Novartis Pharmaceuticals · started 2025-09-24
📍 California · Florida · Illinois · New York · North Carolina · Ohio · Oregon · Pennsylvania
NCT06751238 on ClinicalTrials.gov ↗
Recruiting Phase 3
Phase 3 Trial of VMX-C001 vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.
Blood Loss, Surgical, Coagulation Disorder
VarmX B.V. · started 2026-08-18
📍 Arizona · California · Colorado · Delaware · Florida · Iowa · Massachusetts · Michigan
NCT07288489 on ClinicalTrials.gov ↗
Starting soon Phase 1
A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early Alzheimer's Disease After Multiple Dose Administration
Alzheimer's Disease, Healthy Participants
Bristol-Myers Squibb · started 2026-08-21
📍 California
NCT07780383 on ClinicalTrials.gov ↗
Recruiting Phase 3
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
Overweight, Obesity
Eli Lilly and Company · started 2025-12-15
📍 Alabama · Arizona · California · Colorado · Connecticut · Florida · Georgia · Hawaii
NCT07282600 on ClinicalTrials.gov ↗
Active Phase 2
A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis
Moderate to Severe Atopic Dermatitis
Nektar Therapeutics · started 2023-11-15
📍 Arkansas · California · Florida · Georgia · Indiana · Kentucky · Michigan · Nevada
NCT06136741 on ClinicalTrials.gov ↗
Recruiting Phase 3
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Metabolic Dysfunction Associated Steatohepatitis
Boehringer Ingelheim · started 2024-11-12
📍 Arizona · California · Colorado · Connecticut · Florida · Georgia · Indiana · Iowa
NCT06632457 on ClinicalTrials.gov ↗
Recruiting Phase 2
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe
Eli Lilly and Company · started 2026-03-26
📍 Arizona · California · Colorado · Connecticut · Florida · Idaho · Illinois · Indiana
NCT07415044 on ClinicalTrials.gov ↗
Active Phase 1
A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or Pancreas
Colorectal Carcinoma, Gastric Carcinoma, Pancreatic Ductal Adenocarcinoma
Boehringer Ingelheim · started 2025-03-28
📍 California · Connecticut · Georgia · New Jersey
NCT06882746 on ClinicalTrials.gov ↗
Recruiting Phase 1
Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)
Ewing Sarcoma
Amgen · started 2026-04-08
📍 California · Massachusetts · New York · Pennsylvania · Texas
NCT07297979 on ClinicalTrials.gov ↗
Active Phase 3
Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients
HIV Infections
ViiV Healthcare · started 2015-02-23
📍 California · Colorado · Connecticut · District of Columbia · Florida · Georgia · Illinois · Indiana
NCT02362503 on ClinicalTrials.gov ↗
Active Phase 2
BIVV020 (SAR445088) in Prevention and Treatment of Antibody-mediated Rejection (AMR)
Transplant Rejection
Sanofi · started 2022-06-09
📍 California · Massachusetts · New York · Wisconsin
NCT05156710 on ClinicalTrials.gov ↗
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Priya Life Science (2026). Clinical Trials in the USA Tracker. Available at: https://priyalifescience.com/clinical-trials-usa/state/california (Accessed: 22 August 2026).

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Source: ClinicalTrials.gov, U.S. National Library of Medicine — industry-sponsored studies in a recruiting status with at least one US site, most recently updated first, refreshed daily. This is a curated slice of the full registry, not every US trial. Listing here is informational and not medical advice; eligibility is determined by each study team. Patients should discuss participation with their clinician. Compare pay for the teams running these studies in our US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish and EU sites, see our Ireland and EU trackers.