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Clinical Trials in the USA / NCT07668414
Recruiting Phase 3

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

NCT07668414 · tracked via the Priya Life Science USA tracker
Sponsor
Novo Nordisk A/S
Phase
Phase 3
Started
2026-09-22
Last updated
2026-09-28

Condition(s) studied

OverweightObesity

Investigational drug(s) / intervention(s)

Zenagamtide →Semaglutide →Placebo (matched to semaglutide)Placebo (matched to zenagamtide)

Zenagamtide: Zenagamtide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Semaglutide: Semaglutide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Placebo (matched to semaglutide): Placebo matched to semaglutide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Placebo (matched to zenagamtide): Placebo matched to zenagamtide will be administered subcutaneously using pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Study summary

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.

Primary outcome measure(s)

  • Relative change in body weight — From week 0 to week 84
    Measured as percentage (%) change in body weight.

Trial sites (45)

FacilityCityRegionStatus
First Valley Medical Group Lancaster California Recruiting
Desert Oasis Healthcare Palm Springs California Recruiting
Western University of Health Sciences Pomona California Recruiting
Artemis Insitute for Clin Res San Diego California Recruiting
Med Home Development Grp Washington D.C. District of Columbia Recruiting
Encore Medical Research LLC Hollywood Florida Recruiting
NextPhase Research Hollywood Florida Recruiting
Jacksonville Ctr Clin Res Jacksonville Florida Not Yet Recruiting
PharmaDev Clinical Research Institute LLC Miami Florida Recruiting
South Broward Research LLC Miramar Florida Recruiting
Essence MD Research Naples Florida Not Yet Recruiting
Florida Inst For Clin Res LLC Orlando Florida Recruiting
Oviedo Medical Research, LLC Oviedo Florida Recruiting
Palm Beach Research Center West Palm Beach Florida Recruiting
Encore Medical Research of Weston Weston Florida Recruiting
Conquest Research Atlanta Georgia Recruiting
Eastside Bariatric and Gen Surg Snellville Georgia Recruiting
Chicago Research Center, Inc Chicago Illinois Not Yet Recruiting
Endeavor Health Skokie Illinois Recruiting
Midwest Inst For Clin Res Indianapolis Indiana Recruiting
Southern Clin Research Zachary Louisiana Not Yet Recruiting
Amicis Centers of Clinical Research St Louis Missouri Recruiting
Ichor Research Syracuse New York Recruiting
Southgate Medical Group, LLP West Seneca New York Recruiting
PharmQuest Life Sciences LLC Greensboro North Carolina Not Yet Recruiting
Piedmont Healthcare/Research Statesville North Carolina Recruiting
Lillestol Research LLC Fargo North Dakota Recruiting
Geisinger Clinic Danville Pennsylvania Recruiting
Medical University Of South Carolina Charleston South Carolina Recruiting
Hillcrest Clinical Research Simpsonville South Carolina Recruiting
Spartanburg Medical Research Spartanburg South Carolina Recruiting
Amarillo Med Spec LLP Amarillo Texas Recruiting
Texas Diabetes & Endocrinology Austin Texas Recruiting
Pinnacle Clinical Research Brownsville Texas Recruiting
Osvaldo A. Brusco MD Corpus Christi Texas Recruiting
UT Southwestern Med Center Dallas Texas Not Yet Recruiting
Epic Medical Research DeSoto Texas Not Yet Recruiting
Houston Research Institute Houston Texas Not Yet Recruiting
The Endocrine Center Houston Texas Not Yet Recruiting
Sleep Therapy Research Center San Antonio Texas Not Yet Recruiting

+ 5 more sites — see the full list on the official registry below.

On this site

📄 Ozempic (semaglutide) drug profile →

More Novo Nordisk A/S trials in the USA

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes Recruiting
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity Active, not recruiting
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight Recruiting
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity Recruiting
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea Recruiting

Other trials for the same condition

A Study to Evaluate the Effects of a Dietary Supplement on Weight Management and Appetite Control Active, not recruiting
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes Active, not recruiting
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION) Recruiting
SYNCHRONIZE®-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose Weight Starting soon
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07668414 on ClinicalTrials.gov ↗ ← All trials in the USA