A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

NCT07589608 · tracked via the Priya Life Science USA tracker

Sponsor

Eli Lilly and Company

Phase

Phase 2

Started

2026-05-15

Last updated

2026-08-06

Condition(s) studied

OverweightObesity

Investigational drug(s) / intervention(s)

Macupatide →Eloralintide →Placebo

Macupatide: Administered SC

Eloralintide: Administered SC

Placebo: Administered SC

Study summary

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Eligibility

Sex

ALL

Min age

18 Years

Max age

75 Years

Healthy volunteers

Inclusion Criteria: * See Master Protocol CWMM (NCT06143956) for inclusion criteria Exclusion Criteria: In addition to exclusion criteria in Master Protocol CWMM (NCT06143956): * Have type 1 diabetes or type 2 diabetes * Have an ongoing history of bradyarrhythmia and/or sinus bradycardia * Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm) * Have a history of acute or chronic pancreatitis * All concomitant medications should be at a stable dose for at least 3 months prior to screening

Primary outcome measure(s)

Percent Change from Baseline in Body Weight — Baseline, Week 36

Trial sites (40)

Facility	City	Region	Status
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa	Chandler	Arizona	Recruiting
Headlands Research - Scottsdale	Scottsdale	Arizona	Recruiting
The Institute for Liver Health II dba Arizona Liver Health-Tucson	Tucson	Arizona	Recruiting
NorCal Medical Research, Inc	Greenbrae	California	Recruiting
Velocity Clinical Research, Huntington Park	Huntington Park	California	Recruiting
Peninsula Research Associates	Rolling Hills Estates	California	Recruiting
Diablo Clinical Research, Inc.	Walnut Creek	California	Recruiting
Stamford Therapeutics Consortium	Stamford	Connecticut	Recruiting
New Horizon Research Center	Miami	Florida	Recruiting
Indago Research & Health Center, Inc	Miami Lakes	Florida	Recruiting
Suncoast Clinical Research, Inc.	New Port Richey	Florida	Recruiting
Charter Research - Winter Park	Orlando	Florida	Recruiting
Charter Research - Lady Lake	The Villages	Florida	Recruiting
Medical Research Partners	Ammon	Idaho	Recruiting
Great Lakes Clinical Trials - Ravenswood	Chicago	Illinois	Recruiting
Cotton O'Neil Diabetes & Endocrinology	Topeka	Kansas	Recruiting
Monroe Biomedical Research - Louisville	Louisville	Kentucky	Recruiting
Knownwell	Needham	Massachusetts	Recruiting
Lucida Clinical Trials	New Bedford	Massachusetts	Recruiting
Headlands Research - Detroit	Southfield	Michigan	Recruiting
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division	Troy	Michigan	Recruiting
StudyMetrix Research	City of Saint Peters	Missouri	Recruiting
Clinvest Headlands Llc	Springfield	Missouri	Recruiting
Las Vegas Medical Research	Las Vegas	Nevada	Recruiting
Dent Neurologic Institute	Amherst	New York	Recruiting
Rochester Clinical Research, LLC	Rochester	New York	Recruiting
Medication Management	Greensboro	North Carolina	Recruiting
Monroe Biomedical Research	Monroe	North Carolina	Recruiting
Lucas Research, Inc	Morehead City	North Carolina	Recruiting
Lucas Research, Inc.	New Bern	North Carolina	Recruiting
CTI Clinical Research Center	Cincinnati	Ohio	Recruiting
Tribe Clinical Research, LLC	Greenville	South Carolina	Recruiting
Quality Medical Research	Nashville	Tennessee	Recruiting
IMA Clinical Research Austin	Austin	Texas	Recruiting
FutureSearch Trials of Dallas	Dallas	Texas	Recruiting
PlanIt Research, PLLC	Houston	Texas	Recruiting
Endeavor Clinical Trials	San Antonio	Texas	Recruiting
Texas Valley Clinical Research	Weslaco	Texas	Recruiting
Sovah Clinical Research-River District	Danville	Virginia	Recruiting
Central Washington Health Services Association d/b/a Confluence Health	Wenatchee	Washington	Recruiting

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Other trials for the same condition

Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide Active, not recruiting

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity Recruiting

A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event Recruiting

A Phase 2b Study to Evaluate the Efficacy and Safety of Once-Monthly MET097 in Adults With Obesity or Overweight Active, not recruiting

A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07589608 on ClinicalTrials.gov ↗ ← All trials in the USA