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Clinical Trials in the USA / NCT07730554
Recruiting Phase 2

A Study to Assess the Safety and Efficacy of AGN-151586 Injections for the Treatment of Moderate to Severe Forehead Lines (FHL) in Adult Participants

NCT07730554 · tracked via the Priya Life Science USA tracker
Sponsor
AbbVie
Phase
Phase 2
Started
2026-07-22
Last updated
2026-08-21

Condition(s) studied

Forehead Lines

Investigational drug(s) / intervention(s)

AGN-151586 →

AGN-151586: Injection

Study summary

The objective of this study is to evaluate the safety and efficacy of AGN-151586 for the treatment of moderate to severe forehead lines (FHL) in adult participants.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Participant must have moderate (Grade 2) or severe (Grade 3) forehead lines (FHL) at maximum eyebrow elevation as assessed by the subject and investigator using Forehead Lines Severity Scale (FHLSS) at Screening visit and Baseline Day 1 visit. * Participant must have moderate (Grade 2) or severe (Grade 3) glabellar lines (GL) at maximum frown as assessed by the subject and investigator using Allergan Glabellar Lines Severity Scale (AGLSS) at Screening visit and Baseline Day 1 visit. * Sufficient visual acuity without the use of eyeglasses (contact lens use is acceptable) to accurately assess their FHL and GL in investigator's opinion. Exclusion Criteria: * Clinically relevant or significant ECG abnormalities. * Active infection or dermatological condition at any of the treatment injection sites.

Primary outcome measure(s)

Trial sites (5)

FacilityCityRegionStatus
Eye Research Foundation /ID# 282193 Newport Beach California Recruiting
Private Practice - Dr. Steven G. Yoelin /ID# 282334 Newport Beach California Recruiting
Luxurgery /ID# 282336 New York New York Recruiting
Wilmington Dermatology Center /ID# 282192 Wilmington North Carolina Recruiting
Austin Institute for Clinical Research - Pflugerville /ID# 282195 Pflugerville Texas Recruiting

More AbbVie trials in the USA

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07730554 on ClinicalTrials.gov ↗ ← All trials in the USA