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Clinical Trials in the USA / NCT07720271
Recruiting Phase 3

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

NCT07720271 · tracked via the Priya Life Science USA tracker
Sponsor
Novo Nordisk A/S
Phase
Phase 3
Started
2026-08-31
Last updated
2026-09-28

Condition(s) studied

OverweightObesity

Investigational drug(s) / intervention(s)

zenagamtide →Placebo

zenagamtide: zenagamtide will be taken orally.

Placebo: Placebo matched to zenagamtide will be taken orally.

Study summary

The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Male or female (sex at birth). * Age 18 and older (both inclusive) at time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.

Primary outcome measure(s)

  • Relative change in body weight — From baseline (week 0) to (week 76)
    Measured as percentage (%) change in body weight.

Trial sites (41)

FacilityCityRegionStatus
Pinnacle Research Group LLC Anniston Alabama Recruiting
Univ of Alabama Birmingham Birmingham Alabama Recruiting
Chambliss Clinical Trials LLC Montgomery Alabama Recruiting
Providence Medical Foundation Fullerton California Recruiting
Torrance Clinical Research Institute, Inc. Lomita California Recruiting
Diablo Clinical Research, Inc. Walnut Creek California Recruiting
Univ of Colorado at Denver Aurora Colorado Recruiting
Brain Matters Research Delray Beach Florida Recruiting
Northeast Research Institute Fleming Island Florida Recruiting
Miguel Rebollar PA Hialeah Florida Recruiting
Jacksonville Ctr Clin Res Jacksonville Florida Recruiting
South Broward Research LLC Miramar Florida Recruiting
Clinical Neuroscience Solution Orlando Florida Recruiting
Florida Institute for Clinical Research, LLC Orlando Florida Recruiting
Oviedo Medical Research, LLC Oviedo Florida Recruiting
Hope Clin Res & Wellness Conyers Georgia Recruiting
East West Medical Research Institute_Honolulu Honolulu Hawaii Recruiting
Great Lakes Clinical Trials Chicago Illinois Recruiting
Clinical Investigation Spec Gurnee Gurnee Illinois Recruiting
Endeavor Health Skokie Illinois Recruiting
Evanston Premier Hlthcr Res Skokie Illinois Recruiting
Midwest Inst For Clin Res Indianapolis Indiana Not Yet Recruiting
Northern Pines Hlth Ctr, PC Buckley Michigan Recruiting
StudyMetrix Research LLC City of Saint Peters Missouri Recruiting
Palm Research Center Inc. Las Vegas Nevada Recruiting
Comprehensive Weight Ctrl Prog New York New York Recruiting
Medication Mgmnt, LLC_Grnsboro Greensboro North Carolina Recruiting
Accellacare of Raleigh Raleigh North Carolina Recruiting
Accellacare-Salisbury PMG Res Salisbury North Carolina Recruiting
Accellacare and KDCILM, LLC Wilmington North Carolina Recruiting
Lynn Institute of Norman Norman Oklahoma Recruiting
Clinical Res Collaborative Cumberland Rhode Island Recruiting
Medical Uni of SC Charleston Charleston South Carolina Recruiting
Coastal Carolina Research Ctr North Charleston South Carolina Recruiting
Hillcrest Clinical Research Simpsonville South Carolina Recruiting
Spartanburg Medical Research Spartanburg South Carolina Recruiting
Amarillo Medical Specialists Amarillo Texas Recruiting
North Texas Endocrine Center Dallas Texas Recruiting
Washington Cntr Weight Mgmt Arlington Virginia Not Yet Recruiting
Health Res of Hampton Roads Newport News Virginia Recruiting

+ 1 more sites — see the full list on the official registry below.

More Novo Nordisk A/S trials in the USA

A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight Recruiting
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation Active, not recruiting
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy Recruiting
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) Active, not recruiting
A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9 Active, not recruiting

Other trials for the same condition

A Study to Learn How Different Amounts of the Study Medicine Called PF-08642534 Are Tolerated and Act in the Body of People Who Have Obesity Recruiting
A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight Recruiting
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight Active, not recruiting
A Study of LY3537031 in Overweight, Obese, and Healthy Participants Active, not recruiting
First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671 Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07720271 on ClinicalTrials.gov ↗ ← All trials in the USA