This is a 4-part study that includes a Part A, Part B, Part C, and Part D. Parts A and D will study the safety and tolerability of the study drug known as LY3537031 in participants who are overweight and obese. Part B and Part C will study the safety and tolerability of LY3537031 in healthy participants. Part C will contain only Japanese and Chinese healthy participants.
Blood tests will be performed to check how much LY3537031 gets into the bloodstream and how long it takes the body to eliminate it. Body weight will be measured. The study will last approximately 49 weeks excluding a screening period.
Eligibility
Sex
ALL
Min age
22 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Have a BMI within the range of:
* Parts A and D: 27.0 to 45.0 kilogram per square meter (kg/m²)
* Parts B and C: 22.0 to 26.9 kg/m²
* Parts B and C: Weigh 60 kg (80 pounds (lbs)) or more at screening
* Have no significant (not more than 5%) self-reported weight gain or loss in the past 3 months prior to screening
* Have a thyroid stimulating hormone (TSH) value within normal local laboratory ranges.
Exclusion Criteria:
* Have undergone any form of bariatric surgery
* Participants who are lactating
* Have taken medications that promote weight loss within 90 days before screening
* Have a serum calcitonin level (at screening) of greater than or equal to 35 nanograms per liter (ng/L) (35 picograms per milliliter (pg/mL), 10.2 picomoles per liter (pmol/L))
Primary outcome measure(s)
Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs), Serious Adverse Event(s) (SAEs), and Adverse Event(s) (AEs) Considered by the Investigator to be Related to Study Drug Administration — Baseline to Study Completion (Up to 56 Weeks) A summary of TEAEs, SAEs, and AEs regardless of causality, will be reported in the Reported Adverse Events module
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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