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Compound · clinical trials

Andamertinib clinical trials

Also listed in trial records as PLB1004
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 9 trials in our China and USA registers that name Andamertinib as an intervention. Synced 28 Sep 2026
9Current trials
4Recruiting now
4Lead sponsors
2Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Andamertinib is named as an intervention in 9 current clinical trials in our China and USA registers. 4 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Avistone Biotechnology Co., Ltd (6). The most-studied condition is Non-Small-Cell Lung Cancer.

Trials by status

  • Recruiting444%
  • Not yet open333%
  • Active, closed111%
  • By invitation111%

Trials by phase

  • Phase 2444%
  • Phase 1/2333%
  • Phase 1111%
  • Phase 3111%
01

Clinical trials of Andamertinib

9 trials
StudyPhaseStatusLead sponsorRegisters
Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic NSCLC.
NCT06574347 · ClinicalTrials.gov ↗ · Non-Small-Cell Lung Cancer
Phase 2 Recruiting Avistone Biotechnology Co., Ltd China
Andamertinib With or Without Platinum-doublet Chemotherapy Versus Platinum-doublet Chemotherapy in Patients With NSCLC Harboring Atypical EGFR Mutations
NCT07336732 · ClinicalTrials.gov ↗ · Non-Small-Cell Lung Cancer
Phase 2 Recruiting Avistone Biotechnology Co., Ltd China
Vebreltinib Plus PLB1004 in EGFR-mutated, Advanced NSCLC With MET Amplification or MET Overexpression Following EGFR-TKI
NCT06343064 · ClinicalTrials.gov ↗ · Non-Small-Cell Lung Cancer
Phase 1/2 Recruiting Avistone Biotechnology Co., Ltd China
A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer
NCT06046495 · Non-Small Cell Lung Cancer
Phase 1 Recruiting Avistone Biotechnology Co., Ltd USA
The Study Of Andamertinib Plus Anlotinib In Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT07780578 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line
Phase 2 Not yet open Fudan University China
Phase I/II Study of PLB1004 Combined With Platinum-based Doublet Chemotherapy in Patients With EGFR Mutation-positive
NCT07063329 · ClinicalTrials.gov ↗ · NSCLC (Non-small Cell Lung Cancer)
Phase 1/2 Not yet open Avistone Pharmaceutical๏ผˆNingbo๏ผ‰Co., LTD China
A Study to Evaluate ANS014004 in Combination With EGFR-TKI in Non-Small Cell Lung Cancer
NCT07285148 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer, EGFR Mutation, Metastatic Lung Cancer
Phase 1/2 Not yet open Beijing Pearl Biotechnology Limited Liability Company USA
Efficacy and Safety Evaluation of PLB1004 in Patients With Non-squamous NSCLC Harboring EGFR Exon 20 Insertion.
NCT06281964 · ClinicalTrials.gov ↗ · Non-Small-Cell Lung Cancer
Phase 3 By invitation Avistone Biotechnology Co., Ltd China
A Phase โ…ก Study Assessing the Safety and Efficacy of PLB1004 in EGFR ex20ins Mutation Patients With Advanced and Metastatic Non-small Cell Lung Cancer(NSCLC)
NCT06015503 · ClinicalTrials.gov ↗ · NSCLC (Non-small Cell Lung Cancer)
Phase 2 Active, closed Avistone Biotechnology Co., Ltd China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Andamertinib

7 conditions
Non-Small-Cell Lung Cancer4Non-Small Cell Lung Cancer2NSCLC (Non-small Cell Lung Cancer)2EGFR Mutation1Metastatic Lung Cancer1MET Alteration1Non-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Avistone Biotechnology Co., Ltd6
Beijing Pearl Biotechnology Limited Liability Company1
Avistone Pharmaceutical๏ผˆNingbo๏ผ‰Co., LTD1
Fudan University1
04

By country register

RegisterTrialsRecruiting
Clinical trials in China73
Clinical trials in USA21

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Andamertinib trials

How many clinical trials are testing Andamertinib?

9 current trials in our China and USA registers name Andamertinib (also registered as PLB1004) as a drug or biological intervention, as of the registry sync on 28 September 2026. Completed and withdrawn studies are not counted.

Are Andamertinib trials recruiting patients?

Yes. 4 of the 9 trials are recruiting: 3 with sites in China and 1 with sites in USA. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Andamertinib clinical trials?

Avistone Biotechnology Co., Ltd (6), Beijing Pearl Biotechnology Limited Liability Company (1), Avistone Pharmaceutical๏ผˆNingbo๏ผ‰Co., LTD (1) and Fudan University (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Andamertinib works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Andamertinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Andamertinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 28 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.