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Clinical Trials in the USA / NCT07600749
Recruiting Phase 1

Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

NCT07600749 · tracked via the Priya Life Science USA tracker
Sponsor
Merck Sharp & Dohme LLC
Phase
Phase 1
Started
2026-06-18
Last updated
2026-09-03

Condition(s) studied

Malignant Neoplasm

Investigational drug(s) / intervention(s)

MK-4884

MK-4884: Oral Administration

Study summary

Researchers are looking for new ways to treat certain types of advanced and/or metastatic solid tumors.

The main goal of this study is to learn about the safety of different doses of MK-4884 and if participants tolerate them.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Has a histologically or cytologically confirmed diagnosis of 1 of the following unresectable (locally advanced) and/or advanced (metastatic) solid tumors: * Colorectal carcinoma (CRC) * Renal cell carcinoma (RCC) that contains a clear cell component (with or without sarcomatoid and/or rhabdoid features) * Nonsquamous non-small cell lung cancer (NSCLC) * Biliary tract cancer (BTC) (intra-or extrahepatic cholangiocarcinoma (CCA)) or gallbladder cancer (GBC) * Has measurable disease by Response Evaluation Criteria In Solid Tumors 1.1 (RECIST 1.1) * Has adequate organ function * Participants with human immunodeficiency virus (HIV) infection must have well controlled HIV on stable antiretroviral therapy (ART) for at least 4 weeks * Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received Hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load * Participants with a history of Hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable Exclusion Criteria: * Has gastrointestinal malabsorption, a surgical procedure or a condition that could affect the absorption of the study drug * Has a history of clinically significant cardiac, cardiovascular and/or cerebrovascular disease * Has a serious nonhealing wound, ulcer, or bone fracture * Has an active infection(s) requiring systemic therapy * HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease * Known additional malignancy that is progressing or has required active treatment within the past 2 years * Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis * Has a history of stem cell/solid organ transplant * Has not adequately recovered from major surgery

Primary outcome measure(s)

Trial sites (8)

FacilityCityRegionStatus
NEXT Oncology ( Site 0151) San Antonio Texas Recruiting
Centre Hospitalier de l'Université de Montréal-Unit for Innovative Therapies ( Site 0002) Montreal Quebec Recruiting
Rambam Health Care Campus ( Site 0051) Haifa Israel Recruiting
Rabin Medical Center ( Site 0053) Petah Tikva Israel Recruiting
National Cancer Center Hospital ( Site 0201) Chūō Tokyo Recruiting
Cantonal Hospital St.Gallen ( Site 0101) Sankt Gallen Canton of St. Gallen Recruiting
CHUV (centre hospitalier universitaire vaudois) ( Site 0103) Lausanne Canton of Vaud Recruiting
Ospedale Regionale Bellinzona e Valli ( Site 0104) Bellinzona Canton Ticino Recruiting

More Merck Sharp & Dohme LLC trials in the USA

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07600749 on ClinicalTrials.gov ↗ ← All trials in the USA