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Clinical Trials in the USA / NCT06818643
Recruiting Phase 1/2

A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

NCT06818643 · tracked via the Priya Life Science USA tracker
Sponsor
Merck Sharp & Dohme LLC
Phase
Phase 1/2
Started
2025-03-25
Last updated
2026-09-10

Condition(s) studied

Advanced Solid TumorsMalignant Neoplasm

Investigational drug(s) / intervention(s)

MK-3120

MK-3120: IV infusion

Study summary

Researchers are looking for new ways to treat people with certain advanced solid tumors. Advanced means the cancer has spread to other parts of the body and cannot be removed with surgery. Solid tumors are cancers mostly in body organs and tissues, not in the blood or other body liquids. The main goal of this study is to learn about the safety of MK-3120 and if people tolerate it.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Has a confirmed advanced (unresectable and/or metastatic) solid tumor and has received or been intolerant to all available treatments * If human immunodeficiency virus (HIV) positive, has well controlled HIV on antiretroviral therapy (ART) * If hepatitis B surface antigen (HBsAg) positive, must have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV viral load * If hepatitis C virus (HCV) infected, must have undetectable HCV viral load Exclusion Criteria: * Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease * Has uncontrolled significant cardiovascular disease or cerebrovascular disease * Has history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing * Has pleural effusion, ascites, and/or pericardial effusion that are symptomatic or require repeated drainage * Is HIV-positive and has a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease * Known additional malignancy that is progressing or has required active treatment within the past 2 years * Known active central nervous system (CNS) metastases and/or carcinomatous meningitis * Active infection requiring systemic therapy, with exceptions * History of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease * Has HBV or HCV infection

Primary outcome measure(s)

Trial sites (49)

FacilityCityRegionStatus
The University of Alabama at Birmingham ( Site 1005) Birmingham Alabama Recruiting
University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 1003) Miami Florida Recruiting
John Theurer Cancer Center at Hackensack University Medical Center ( Site 1009) Hackensack New Jersey Recruiting
NEXT Oncology ( Site 1010) Austin Texas Recruiting
NEXT Oncology ( Site 1011) Houston Texas Recruiting
NEXT Oncology ( Site 1012) Irving Texas Recruiting
Virginia Commonwealth University ( Site 1008) Richmond Virginia Recruiting
Centro de Estudios Clínicos SAGA ( Site 0033) Santiago Region M. de Santiago Recruiting
FALP ( Site 0031) Santiago Region M. de Santiago Recruiting
Pontificia Universidad Catolica de Chile ( Site 0032) Santiago Region M. de Santiago Recruiting
Bradford Hill Centro de Investigaciones Clinicas ( Site 0030) Santiago Region M. de Santiago Recruiting
Peking University First Hospital ( Site 0180) Beijing Beijing Municipality Recruiting
Chongqing Cancer Hospital ( Site 0186) Chongqing Chongqing Municipality Recruiting
Hunan Cancer Hospital ( Site 0181) Changsha Hunan Recruiting
The First Hospital of Jilin University ( Site 0185) Changchun Jilin Recruiting
West China Hospital Sichuan University ( Site 0187) Chengdu Sichuan Recruiting
Institut Paoli Calmettes ( Site 0053) Marseille Bouches-du-Rhone Recruiting
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer-Medical Oncology ( Site 0054) Rennes Ille-et-Vilaine Recruiting
Centre Oscar Lambret ( Site 0051) Lille Nord Recruiting
Gustave Roussy ( Site 0050) Villejuif Val-de-Marne Recruiting
Rambam Health Care Campus ( Site 0082) Haifa Israel Recruiting
Rabin Medical Center ( Site 0081) Petah Tikva Israel Recruiting
Sheba Medical Center ( Site 0080) Ramat Gan Israel Recruiting
National Cancer Center Hospital East ( Site 0190) Kashiwa Chiba Recruiting
Cancer Institute Hospital of JFCR ( Site 0192) Koto Tokyo Recruiting
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 0191) Osaka Japan Recruiting
Radboudumc ( Site 0091) Nijmegen Gelderland Recruiting
Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 0090) Amsterdam North Holland Recruiting
Amsterdam UMC, locatie VUmc ( Site 0093) Amsterdam North Holland Recruiting
Erasmus Medisch Centrum ( Site 0092) Rotterdam South Holland Recruiting
Pratia Poznan ( Site 0105) Poznan Greater Poland Voivodeship Recruiting
Pratia MCM Krakow ( Site 0106) Krakow Lesser Poland Voivodeship Recruiting
Narodowy Instytut Onkologii ( Site 0100) Warsaw Masovian Voivodeship Recruiting
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie ( Site 0104) Koszalin West Pomeranian Voivodeship Recruiting
Seoul National University Hospital ( Site 0150) Seoul South Korea Recruiting
Severance Hospital Yonsei University Health System ( Site 0151) Seoul South Korea Recruiting
Asan Medical Center ( Site 0153) Seoul South Korea Recruiting
Samsung Medical Center ( Site 0152) Seoul South Korea Recruiting
Institut Català d'Oncologia - L'Hospitalet ( Site 0113) L'Hospitalet de Llobregat Barcelona Recruiting
HOSPITAL CLÍNIC DE BARCELONA ( Site 0112) Barcelona Catalonia Recruiting

+ 9 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06818643 on ClinicalTrials.gov ↗ ← All trials in the USA