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Clinical Trials in the USA / NCT07886372
Starting soon Not applicable

Effects of Mango on Insulin Sensitivity in Prediabetes

NCT07886372 · tracked via the Priya Life Science USA tracker
Sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Phase
Not applicable
Started
2026-10-28
Last updated
2026-10-21

Condition(s) studied

Pre Diabetes

Investigational drug(s) / intervention(s)

Mango juiceControl Beverage

Mango juice: Mango beverage

Control Beverage: Italian Ice beverage

Study summary

The purpose of this study is to determine whether daily mango consumption for 6 weeks can improve glucose utilization in individuals with prediabetes. The findings from this research may help explore the potential role of mangoes in a healthy diet for people at risk of developing type 2 diabetes

Eligibility

Sex
ALL
Min age
25 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria: * Be between 25-60 years old. * Have a BMI of 25-35 kilograms per square meter. * Have fasting blood glucose between 100-125 milligrams per deciliter or Glycated hemoglobin (HbA1c) between 5.7-6.4%. * Be non-smokers for at least 12 months. * Be generally healthy, with no major organ-related diseases. * Not take medications or supplements that could interfere with the study. * Be able to follow study procedures, including dietary restrictions and scheduled visits. Exclusion Criteria: * Smoke, vape, or use marijuana. * Have allergies or intolerance to mangoes or study foods. * Have blood pressure above 160/100 millimeters of Mercury. * Have fasting blood glucose above 125 milligrams per deciliter. * Have a history of major heart disease, stroke, or cancer in the past five years. * Be pregnant, planning to become pregnant, or breastfeeding. * Take anti-inflammatory drugs or certain dietary supplements. * Have had major surgery or trauma in the past two months. * Follow extreme diets (e.g., vegan, Atkins). * Have used antibiotics in the last six weeks. * Have a history of eating disorders or substance abuse in the past two years. * Drink more than three cups of coffee or tea per day. * Have donated blood in the last three months. * Be professional athletes or do excessive exercise. * Have had weight changes of more than 11 pounds in the past two months. * Work overnight shifts.

Primary outcome measure(s)

  • Fasting Plasma Glucose Concentration — Baseline and Week 6
    Fasting plasma glucose concentration will be measured in plasma samples using a Randox automated clinical analyzer.
  • Fasting Plasma Insulin Concentration — Baseline and Week 6
    Fasting plasma insulin concentration will be measured in plasma samples using a Randox automated clinical analyzer.
  • Insulin Sensitivity — Baseline and Week 6
    The Matsuda index for insulin sensitivity will be calculated using validated equations based on paired glucose and insulin values obtained during the Liquid Meal Tolerance Test (LMTT).

Trial sites (1)

FacilityCityRegionStatus
Clinical Nutrition Research Center Chicago Illinois

More Clinical Nutrition Research Center, Illinois Institute of Technology trials in the USA

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Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human Active, not recruiting
Differential Absorption Kinetics of Grape Seed Extract Polyphenols Starting soon

Other trials for the same condition

Efficacy of Viome's Precision Nutrition Program Towards Reducing HbA1c Recruiting
Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals Active, not recruiting
MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors Recruiting
Glycemic Metrics and Patterns in People With and Without Prediabetes Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07886372 on ClinicalTrials.gov ↗ ← All trials in the USA