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Clinical Trials in the USA / NCT06986161
Active, not recruiting Not applicable

Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals

NCT06986161 · tracked via the Priya Life Science USA tracker
Sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Phase
Not applicable
Started
2025-04-14
Last updated
2026-08-28

Condition(s) studied

Pre Diabetes

Investigational drug(s) / intervention(s)

MangoControl Beverage

Mango: Mango beverage

Control Beverage: Italian Ice beverage

Study summary

The purpose of this study is to investigate the effect of mango intake on metabolic and inflammatory responses relative to meals in individuals at risk of developing diabetes, as well as to understand how the beneficial compounds found in mangoes are absorbed and processed in the body.

Eligibility

Sex
ALL
Min age
20 Years
Max age
60 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Be between 20-60 years old. * Have a BMI of 25-35 kilograms per square meter. * Have fasting blood glucose between 100-125 milligrams per deciliter or Glycated hemoglobin (HbA1c) between 5.7-6.4%. * Be non-smokers for at least 12 months. * Be generally healthy, with no major organ-related diseases. * Not take medications or supplements that could interfere with the study. * Be able to follow study procedures, including dietary restrictions and scheduled visits. Exclusion Criteria: * Smoke, vape, or use marijuana. * Have allergies or intolerance to mangoes or study foods. * Have blood pressure above 160/100 millimeters of Mercury. * Have fasting blood glucose above 125 milligrams per deciliter. * Have a history of major heart disease, stroke, or cancer in the past five years. * Be pregnant, planning to become pregnant, or breastfeeding. * Take anti-inflammatory drugs or certain dietary supplements. * Have had major surgery or trauma in the past two months. * Follow extreme diets (e.g., vegan, Atkins). * Have used antibiotics in the last six weeks. * Have a history of eating disorders or substance abuse in the past two years. * Drink more than three cups of coffee or tea per day. * Have donated blood in the last three months. * Be professional athletes or do excessive exercise. * Have had weight changes of more than 11 pounds in the past two months. * Work overnight shifts.

Primary outcome measure(s)

  • Change in postprandial glucose — 7 hours
    Change in postprandial glucose as measured by absolute values and calculated insulin sensitivity using homeostasis model assessment of fasting insulin sensitivity (HOMA-%S) and B-cell function (HOMA-%).
  • Change in postprandial glucose through peripheral insulin sensitivity — 7 hours
    Change in postprandial glucose as measured by assessment of peripheral insulin sensitivity using Matsuda index.
  • Change in postprandial insulin — 7 hours
    Change in postprandial insulin as measured by absolute values and calculated insulin sensitivity using homeostasis model assessment of fasting insulin sensitivity (HOMA-%S) and B-cell function (HOMA-%).
  • Change in postprandial insulin through peripheral insulin sensitivity — 7 hours
    Change in postprandial insulin as measured by assessment of peripheral insulin sensitivity using Matsuda index.
  • Evaluate Interleukin-6 (IL-6) as an index of systemic inflammatory response — 7 hours
    Assessments to address this aim will include analysis of systemic markers of inflammation (IL-6) in plasma using ELISA method
  • Evaluate Tumor Necrosis Factor-alpha (TNF-α) as an index of systemic inflammatory response — 7 hours
    Assessments to address this aim will include analysis of systemic markers of inflammation (TNF-α) in plasma using ELISA method

Trial sites (1)

FacilityCityRegionStatus
Clinical Nutrition Research Center Chicago Illinois

More Clinical Nutrition Research Center, Illinois Institute of Technology trials in the USA

Differential Absorption Kinetics of Grape Seed Extract Polyphenols Starting soon
Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes Recruiting
Berries, Inflammation, and Gut Microbiome Active, not recruiting
Food and Metabolism Study Recruiting
Effects of Mango on Insulin Sensitivity in Prediabetes Starting soon

Other trials for the same condition

Effects of Mango on Insulin Sensitivity in Prediabetes Starting soon
Glycemic Metrics and Patterns in People With and Without Prediabetes Recruiting
MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors Recruiting
Efficacy of Viome's Precision Nutrition Program Towards Reducing HbA1c Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06986161 on ClinicalTrials.gov ↗ ← All trials in the USA