Pivotal U.S. Clinical Validation of AI-COA® for Depression and Anxiety

Inclusion Criteria: * English fluency * 18 to 65 years of age. * Diagnosed with MDD or MDE (Includes Remission, HAM-D \<= 7) * Starting, or has started, a new treatment for depression or anxiety within 2-3 weeks of enrollment * Access to a laptop or other computer with a well functioning microphone and webcam, and a stable Internet connection * Stated willingness to comply with all study procedures and availability for the duration of the study * Resides in the United States at the time of consent and during completion of study Exclusion Criteria: * Any cognitive impairment that limits ability to provide informed consent or authorization * Vulnerable or protected populations (e.g. prisoners) * Impairment that would prevent participants from completing an online survey and/or engaging in clinician assessment interviews (e.g., visual impairment, motor impairment, hearing impairment) * Acute intoxication at the time of the assessments * Concurrent medication/treatment: * Receiving any fast-acting treatment for depression or anxiety (e.g. ketamine, psychedelics, deep brain stimulation, etc.) in between initial baseline assessment (A1) and Restest (A2) , or in between Follow up assessment (B1) and Retest (B2) * Anxiolytics: Use of benzodiazepines or other anxiety-reducing medications that could affect speech or motor activity, within the past 4 weeks. * Antipsychotics and Mood Stabilizers: Medications that can alter cognitive and motor functions, within the past 6 weeks. * Stimulants: Use of medications like methylphenidate or amphetamines that affect energy levels and behavior, within the past 2 weeks * Epilepsy medication: seizure activity or medication side effects that may alter behavior, within the past 4 weeks. * Any history or evidence of any of the following conditions: * Neurodevelopmental, Neurocognitive, Neurodegenerative or movement disorders including, but not limited to: * Tourette's syndrome * Multiple Sclerosis * Amyotrophic Lateral Sclerosis * Parkinson's Disease * Stroke * Traumatic Brain Injury * Facial paralysis. * Conditions with vocal cord impact: * Vocal cord injury or cerebrovascular accident or head trauma with residual dysarthria in the past year * Disorders that may impact vocal cords such as acute or chronic laryngitis, vocal cord paresis or paralysis, or spasmodic dysphonia * Past or active heavy smokers (an average of \>20 cigarettes per day) * Schizophrenia Spectrum and Other Psychotic Disorders: * Individuals with a current or past diagnosis of Schizophrenia, Schizoaffective Disorder, or other psychotic disorders, including Delusional Disorder and Brief Psychotic Disorder. * Current hypomanic episode as defined by DSM-5 criteria. This includes those with Bipolar I Disorder, Bipolar II Disorder, or Cyclothymic Disorder who are not in a stable mood state at the time of assessment. * Chronic Pain Conditions: Such as fibromyalgia, which may affect facial expressions and vocal tone. * Prosthetic Facial Devices: Could affect facial recognition algorithms. Cosmetic Procedures: Such as Botox injections or facelifts that can impact facial expressions. * Dental Work: Major procedures that might affect speech. * Participants who have previously participated in another research project by Deliberate.