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Starting soon Phase 3

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk

NCT07900633 · tracked via the Priya Life Science USA tracker
Phase
Phase 3
Started
2026-12
Last updated
2026-10-28

Condition(s) studied

ObesityOverweightCardiovascular DiseasesDiabetes Mellitus, Type 2

Investigational drug(s) / intervention(s)

Eloralintide →Placebo

Eloralintide: Administered SC

Placebo: Administered SC

Study summary

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk.

Eligibility

Sex
ALL
Min age
45 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Have type 2 diabetes * Have a HbA1c value between ≥ 6.5% and ≤ 9.5% at screening * Are on stable treatment with an unchanged dose of at least 1 and no more than 4 antihyperglycemic therapies for at least 90 days before screening * Have an increased risk of cardiovascular events * Have a BMI ≥ 25.0 kg/m2 at screening * Have a stable body weight (\<5% body weight change) for 90 days prior to screening * Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have a history or diagnosis of New York Heart Association Functional Classification IV congestive heart failure * Have had within 60 days prior to screening: * acute myocardial infarction * stroke * hospitalization for congestive heart failure, or * coronary, peripheral, or carotid artery revascularization procedure * Have received treatment combining sulfonylurea and insulin within 90 days prior to screening

Primary outcome measure(s)

  • Percent Change from Baseline in Body Weight — Baseline, Week 64
  • Change from Baseline in Hemoglobin A1c (HbA1c) — Baseline, Week 36

Trial sites (309)

FacilityCityRegionStatus
Central Research Associates Birmingham Alabama
University of Alabama - Department of Nutrition Sciences Birmingham Alabama
Nephrology Consultants Huntsville Alabama
Smiths Medical Center Apache Junction Arizona
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC Gilbert Arizona
Elite Clinical Studies, LLC Phoenix Arizona
Southwest Kidney Institute - Surprise Surprise Arizona
Valley Clinical Trials, Inc. Covina California
Neighborhood Healthcare Institute of Health Escondido California
First Valley Medical Group Lancaster California
Ark Clinical Research Long Beach California
Valley Clinical Trials, LLC dba Flourish Research Northridge California
FOMAT Medical Research Oxnard California
Acclaim Clinical Research San Diego California
Care Access - Santa Clarita Santa Clarita California
Millennium Clinical Trials Westlake Village California
Chase Medical Research, LLC Waterbury Connecticut
Omega Research Orlando Altamonte Springs Florida
Care Access - Brandon Brandon Florida
American Research Institute Cutler Bay Florida
Fleming Island Center for Clinical Research Fleming Island Florida
Northeast Research Institute - Downtown Office Jacksonville Florida
Lakeview Institute of Clinical Research Leesburg Florida
Millennium Medical Research - Miami Miami Florida
Onhealth Research Center Miami Florida
Center for Diabetes, Obesity, and Metabolism Pembroke Pines Florida
Peace River Cardiovascular Center Port Charlotte Florida
Southeastern Clinical Research Institute Augusta Georgia
East-West Medical Research Institute Honolulu Hawaii
Care Access - Arlington Heights Arlington Heights Illinois
Healthcare Research Network - Chicago Tinley Park Illinois
American Health Network of Indiana, LLC - Franklin Franklin Indiana
American Health Network of Indiana, LLC - Greenfield Greenfield Indiana
Care Access - Baltimore Baltimore Maryland
Ascension Saint Agnes Heart Care Baltimore Maryland
Lucida Clinical Trials New Bedford Massachusetts
Lake Michigan Nephrology Saint Joseph Michigan
Revive Research Institute, Inc. Southfield Michigan
SKY Integrative Medical Center/SKYCRNG Ridgeland Mississippi
Clinvest Headlands Llc Springfield Missouri

+ 269 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07900633 on ClinicalTrials.gov ↗ ← All trials in the USA