Folinic acid clinical trials
Folinic acid is named as an intervention in 14 current clinical trials in our USA, Germany, Japan, France, Spain, South Korea, China, Italy, Belgium, Taiwan, Israel, Canada, Mexico, UK, Poland, Brazil, Australia, Sweden and Singapore registers. 8 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Astellas Pharma Global Development, Inc (3). The most-studied condition is Autism Spectrum Disorder. The EU clinical trials register (CTIS) separately lists 5 authorised or ongoing trials, 1 with a site in Ireland.
How Folinic acid works
All drug targets →- Down syndromePhase 3
- Colon carcinomaPhase 3
- Colorectal cancerPhase 3
- Exocrine pancreatic carcinomaPhase 3
- Gastric cancerPhase 3
- Gastroesophageal junction adenocarcinomaPhase 3
- Malignant colon neoplasmPhase 3
- Metastatic colorectal cancerPhase 3
- Pancreatic adenocarcinomaPhase 3
- Psychotic disorderPhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL1232801, CC BY-SA 3.0. The Guide to Pharmacology has no record of this medicine, so its targets rest on ChEMBL alone. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Folinic acid
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 2 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Folinic acid
- ChEMBL
- CHEMBL1232801
- DrugBank
- DB03256
- PubChem CID
- 135484651
- CAS number
- 73951-54-9
- FDA UNII
- VR9EYV4XBE
- Wikidata
- Q27094183
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Folinic acid
14 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Folinic acid in the EU trials register (CTIS)
5 trials · 1 in IrelandAuthorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Folinic acid. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.
Folinic acid across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
2 single-substance products containing Folinic acid on the HPRA medicines list.
- Folinic acid (as calcium folinate) 10 mg/ml solution for injection or infusionFresenius Kabi Deutschland GmbH · PA2059/001/001 · Marketed
- Leucovorin-Teva 10mg/ml Concentrate for Solution for InfusionTeva Pharma B.V. · PA0749/001/001 · Marketed
Supply shortages
No entry for Folinic acid in the EMA, FDA or German BfArM shortage lists we track.
Conditions studied with Folinic acid
24 conditionsAll 24 conditions
| Condition (as registered) | Trials |
|---|---|
| Autism Spectrum Disorder | 2 |
| Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | 1 |
| Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer | 1 |
| Metastatic Gastric Adenocarcinoma or Cancer | 1 |
| Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma | 1 |
| Unresectable Metastatic Colorectal Cancer | 1 |
| Gastric Adenocarcinoma | 1 |
| Gastroesophageal Junction (GEJ) Adenocarcinoma | 1 |
| Colorectal Cancer | 1 |
| Pharmacokinetics of Zolbetuximab | 1 |
| Gastric Cancer | 1 |
| Gastro-esophageal Junction (GEJ) Cancer | 1 |
| Pharmacokinetics of Oxaliplatin | 1 |
| Locally Recurrent Rectal Cancer | 1 |
| Colon Cancer Stage II | 1 |
| Colon Cancer Stage III | 1 |
| Pancreatic Ductal Adenocarcinoma | 1 |
| Rectal Cancer Stage III | 1 |
| Metastatic Colorectal Carcinoma (mCRC) | 1 |
| Colorectal Neoplasms | 1 |
| Ampulla of Vater Carcinoma | 1 |
| Appendix Carcinoma | 1 |
| Carcinoma of Unknown Primary With Gastrointestinal Profile | 1 |
| Colon Carcinoma | 1 |
Sponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| Astellas Pharma Global Development, Inc | 3 |
| Federation Francophone de Cancerologie Digestive | 2 |
| AbbVie | 1 |
| EMD Serono Research & Development Institute, Inc | 1 |
| Fudan University | 1 |
| IFOM ETS - The AIRC Institute of Molecular Oncology | 1 |
| John Neoptolemos | 1 |
| Prof. Dr. med. Claus Rödel | 1 |
| Alliance for Clinical Trials in Oncology | 1 |
| KK Women's and Children's Hospital | 1 |
| Prof. Adi Aran | 1 |
By country register
A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.
Related compounds
Questions about Folinic acid trials
How many clinical trials are testing Folinic acid?
14 current trials in our USA, Germany, Japan, France, Spain, South Korea, China, Italy, Belgium, Taiwan, Israel, Canada, Mexico, UK, Poland, Brazil, Australia, Sweden and Singapore registers name Folinic acid as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.
Are Folinic acid trials recruiting patients?
Yes. 8 of the 14 trials are recruiting: 1 with sites in USA, 2 with sites in Germany, 1 with sites in Japan, 1 with sites in France, 1 with sites in Spain, 2 with sites in China, 1 with sites in Italy, 1 with sites in Belgium, 1 with sites in Israel, 1 with sites in Mexico, 1 with sites in Sweden and 1 with sites in Singapore. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Folinic acid clinical trials?
Astellas Pharma Global Development, Inc (3), Federation Francophone de Cancerologie Digestive (2), AbbVie (1) and EMD Serono Research & Development Institute, Inc (1), among 11 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Are there Folinic acid clinical trials in Ireland?
Yes. 1 trial in the EU register (CTIS) list a site in Ireland. Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.
Is Folinic acid licensed in Ireland?
Yes. The HPRA medicines list includes 2 single-substance products containing Folinic acid, for example Folinic acid (as calcium folinate) 10 mg/ml solution for injection or infusion (Fresenius Kabi Deutschland GmbH). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Folinic acid shortage?
Not in the lists we track: Folinic acid has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Folinic acid works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Folinic acid works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Folinic acid (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.