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Priya Life Science Compound trial record
Compound · clinical trials

TNO155 clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 3 trials in our Spain, Italy, Belgium, Canada, Japan, South Korea, USA, Germany, Netherlands, Taiwan, Australia, China, France, Denmark, UK, Austria and Singapore registers that name TNO155 as an intervention. Synced 10 Nov 2026
3Current trials
0Recruiting now
2Lead sponsors
17Country registers
At a glance

TNO155 is named as an intervention in 3 current clinical trials in our Spain, Italy, Belgium, Canada, Japan, South Korea, USA, Germany, Netherlands, Taiwan, Australia, China, France, Denmark, UK, Austria and Singapore registers. None are recruiting at the moment. The most common phase is Phase 1/2. The sponsor with the most trials is Novartis Pharmaceuticals (2). The most-studied condition is Advanced Solid Tumors.

How TNO155 works

All drug targets →
  • Protein-tyrosine phosphatase 2C inhibitor Inhibitor
    Target: PTPN11 protein tyrosine phosphatase non-receptor type 11
    ✓ In ChEMBL and the Guide to Pharmacology
Diseases it has been tested for in clinical trials, by furthest phase
  • Lung cancerPhase 1/2
  • Colorectal cancerPhase 1

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL4650521, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 12068, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for TNO155

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Reference identifiers for TNO155

ChEMBL
CHEMBL4650521
DrugBank
DB19137
PubChem CID
118238370
CAS number
1801765-04-7
FDA UNII
FPJWORQEGI
Wikidata
Q133821370
Wikipedia
Batoprotafib

Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.

Trials by status

  • Active, closed3100%

Trials by phase

  • Phase 1/2267%
  • Phase 1133%
01

Clinical trials of TNO155

3 trials
StudyPhaseStatusLead sponsorRegisters
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
NCT04699188 · KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal
Phase 1/2 Active, closed Novartis Pharmaceuticals USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Canada, Japan, South Korea, Taiwan, Singapore, Australia
Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments
NCT07468071 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer, Advanced Solid Tumors Harboring the KRAS G12C Mutation
Phase 1/2 Active, closed Novartis Pharmaceuticals China, France, Spain, Italy, Belgium, Denmark, Canada, Japan, South Korea
Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
NCT04185883 · Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation
Phase 1 Active, closed Amgen UK, USA, Germany, Spain, Italy, Netherlands, Belgium, Austria, Canada, Japan, South Korea, Taiwan, Australia

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with TNO155

8 conditions
Advanced Solid Tumors1Kirsten Rat Sarcoma (KRAS) pG12C Mutation1KRAS G12C Mutant Solid Tumors1Carcinoma, Non-Small-Cell Lung1Carcinoma, Colorectal1Cancer of Lung1Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer1Advanced Solid Tumors Harboring the KRAS G12C Mutation1
05

Related compounds

06

Questions about TNO155 trials

How many clinical trials are testing TNO155?

3 current trials in our Spain, Italy, Belgium, Canada, Japan, South Korea, USA, Germany, Netherlands, Taiwan, Australia, China, France, Denmark, UK, Austria and Singapore registers name TNO155 as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are TNO155 trials recruiting patients?

Not at the moment. None of the 3 trials in our registers is recruiting; they are active but closed to enrolment, not yet open, or enrolling by invitation. Only the study team can confirm whether a patient is eligible.

Who sponsors TNO155 clinical trials?

Novartis Pharmaceuticals (2) and Amgen (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how TNO155 works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how TNO155 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists TNO155 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.