Clinical Trials in the USA / NCT05904691
Active, not recruiting
Phase 1
Safety and Tolerability of OCU-10-C-110 for Injection in Subjects With Neovascular Age-related Macular Degeneration
NCT05904691 · tracked via the Priya Life Science USA tracker
Condition(s) studied
Neovascular Age-related Macular Degeneration (nAMD)
Investigational drug(s) / intervention(s)
OCU-10-C-110 for Injection
OCU-10-C-110 for Injection: OCU-10-C-110 for Injection in one of 3 doses
Study summary
Multi-center, open-label, two-part safety assessment following administration of single ascending doses and repeat administration of the HTD of OCU-10-C-110 for Injection in the study eye of participants with nAMD
Eligibility
Inclusion Criteria:
1. Angiographically documented active choroidal neovascular (CNV) lesion (i.e., leakage on fluorescein angiography or subretinal, intraretinal, or sub-retinal pigment epithelium \[sub-RPE\] fluid on spectral domain optical coherence tomography \[SD-OCT\]) secondary to age-related macular degeneration (AMD), within the previous 10 weeks
2. Subjects must have received, 7 to 14 days prior to the Baseline Visit, an intravitreal injection in the study eye of an anti-vascular endothelial growth factor (VEGF) ocular therapeutic approved for use in the United States
Exclusion Criteria:
1. History or current evidence of a medical condition (systemic or ophthalmic disease, metabolic dysfunction, physical examination finding or clinical laboratory finding) that may, in the opinion of the investigator, preclude the safe administration of the study medication, adherence to the scheduled study visits, or safe participation in the study or affect the results of the study (e.g., unstable or progressive cardiovascular, cerebral vascular, pulmonary, Parkinson's, liver or renal disease, depression, cancer, or dementia)
2. History or evidence of the following surgeries/procedures in the study eye:
1. Submacular surgery
2. Vitrectomy
3. Retinal detachment or retinal tear
4. Incisional glaucoma surgery
Primary outcome measure(s)
- Ocular safety - AE — Cohort A - 8 weeks; Cohort B - 12 weeks
Number of Adverse events
Trial sites (3)
| Facility | City | Region | Status |
|---|---|---|---|
| Raj K. Maturi, M.D., P.C. | Carmel | Indiana | |
| Retina Research Institute of Texas | Abilene | Texas | |
| Strategic Clinical Research Group LLC | Willow Park | Texas |
Other trials for the same condition
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration
Active, not recruiting
Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD
Enrolling by invitation
A Long-term Follow up Study of EXG102-031 in Patients With wAMD (Everest LTFU)
Active, not recruiting
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05904691 on ClinicalTrials.gov ↗ ← All trials in the USA