🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in the USA / NCT05904691
Active, not recruiting Phase 1

Safety and Tolerability of OCU-10-C-110 for Injection in Subjects With Neovascular Age-related Macular Degeneration

NCT05904691 · tracked via the Priya Life Science USA tracker
Sponsor
Ocugenix Corporation
Phase
Phase 1
Started
2023-11-01
Last updated
2026-05-01

Condition(s) studied

Neovascular Age-related Macular Degeneration (nAMD)

Investigational drug(s) / intervention(s)

OCU-10-C-110 for Injection

OCU-10-C-110 for Injection: OCU-10-C-110 for Injection in one of 3 doses

Study summary

Multi-center, open-label, two-part safety assessment following administration of single ascending doses and repeat administration of the HTD of OCU-10-C-110 for Injection in the study eye of participants with nAMD

Eligibility

Sex
ALL
Min age
50 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Angiographically documented active choroidal neovascular (CNV) lesion (i.e., leakage on fluorescein angiography or subretinal, intraretinal, or sub-retinal pigment epithelium \[sub-RPE\] fluid on spectral domain optical coherence tomography \[SD-OCT\]) secondary to age-related macular degeneration (AMD), within the previous 10 weeks 2. Subjects must have received, 7 to 14 days prior to the Baseline Visit, an intravitreal injection in the study eye of an anti-vascular endothelial growth factor (VEGF) ocular therapeutic approved for use in the United States Exclusion Criteria: 1. History or current evidence of a medical condition (systemic or ophthalmic disease, metabolic dysfunction, physical examination finding or clinical laboratory finding) that may, in the opinion of the investigator, preclude the safe administration of the study medication, adherence to the scheduled study visits, or safe participation in the study or affect the results of the study (e.g., unstable or progressive cardiovascular, cerebral vascular, pulmonary, Parkinson's, liver or renal disease, depression, cancer, or dementia) 2. History or evidence of the following surgeries/procedures in the study eye: 1. Submacular surgery 2. Vitrectomy 3. Retinal detachment or retinal tear 4. Incisional glaucoma surgery

Primary outcome measure(s)

Trial sites (3)

FacilityCityRegionStatus
Raj K. Maturi, M.D., P.C. Carmel Indiana
Retina Research Institute of Texas Abilene Texas
Strategic Clinical Research Group LLC Willow Park Texas

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05904691 on ClinicalTrials.gov ↗ ← All trials in the USA