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Compound · clinical trials

Xtandi clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 17 trials in our Canada, Spain, South Korea, USA, Poland, Japan, Australia, UK, China, Germany, France, Brazil, Taiwan, Italy, Netherlands, Sweden, Czechia, Turkey, Israel, Switzerland, Belgium, Egypt, Austria, Norway, Denmark, India, Portugal, Mexico and Singapore registers that name Xtandi as an intervention. Synced 26 Sep 2026
17Current trials
8Recruiting now
14Lead sponsors
29Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov registry records · Last verified · Editorial standards
At a glance

Xtandi is named as an intervention in 17 current clinical trials in our Canada, Spain, South Korea, USA, Poland, Japan, Australia, UK, China, Germany, France, Brazil, Taiwan, Italy, Netherlands, Sweden, Czechia, Turkey, Israel, Switzerland, Belgium, Egypt, Austria, Norway, Denmark, India, Portugal, Mexico and Singapore registers. 8 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Pfizer (4). The most-studied condition is Prostate Cancer.

Trials by status

  • Recruiting847%
  • Not yet open16%
  • Active, closed847%

Trials by phase

  • Phase 3635%
  • Phase 2529%
  • Phase 1212%
  • Phase 2/3212%
  • Phase 1/216%
  • Phase EARLY_PHASE116%
01

Clinical trials of Xtandi

17 trials
StudyPhaseStatusLead sponsorRegisters
ProBio: A Biomarker Driven Study in Patients With Metastatic Prostate Cancer
NCT03903835 · ClinicalTrials.gov ↗ · Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Phase 3 Recruiting Karolinska Institutet Belgium, Sweden, Switzerland, Norway
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
NCT06629779 · Metastatic Castration-Resistant Prostate Cancer
Phase 3 Recruiting Pfizer UK, USA, China, Germany, France, Spain, Italy, Netherlands, Sweden, Denmark, Poland, Czechia, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Egypt
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
NCT07028853 · ClinicalTrials.gov ↗ · Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer
Phase 3 Recruiting Pfizer UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Czechia, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel, Egypt
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
NCT07611110 · Metastatic Castration-resistant Prostate Cancer
Phase 3 Recruiting AstraZeneca UK, USA, India, China, Germany, France, Spain, Sweden, Poland, Austria, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel
Phase II Randomised Controlled Trial of Patient-specific Adaptive vs. Continuous Abiraterone or eNZalutamide in mCRPC
NCT05393791 · ClinicalTrials.gov ↗ · Prostatic Neoplasms, Castration-Resistant
Phase 2 Recruiting Leiden University Medical Center Netherlands, Australia
Fractionated Stereotactic Radiotherapy Plus Second-generation Antiandrogen for Oligometastatic Castration-resistant Prostate Cancer Patients.
NCT07717268 · ClinicalTrials.gov ↗ · Prostatic Neoplasms, Castration-Resistant
Phase 2 Recruiting Instituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología Radioterápic Spain
Combination Study of Antibiotics With Enzalutamide (PROMIZE)
NCT06126731 · ClinicalTrials.gov ↗ · Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Phase 1/2 Recruiting Institute of Cancer Research, United Kingdom Switzerland
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977 · ClinicalTrials.gov ↗ · Metastatic Castration Resistant Prostate Cancer (mCRPC), Small Cell Lung Cancer (SCLC), Follicular Lymphoma (FL)
Phase 1 Recruiting Pfizer USA, China, Spain, Poland, Japan, South Korea
Safety, Tolerability, and Efficacy of CP-PCA07 in Combination With Enzalutamide in Patients With Castration-Resistant Prostate Cancer
NCT07683013 · ClinicalTrials.gov ↗ · Castration-Resistant Prostate Cancer (CRPC)
Phase 1 Not yet open Hyundai Bioscience Co., Ltd South Korea
Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression
NCT05683964 · ClinicalTrials.gov ↗ · Prostate Adenocarcinoma, Prostate Cancer, Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Phase EARLY_PHASE1 Active, closed Beth Israel Deaconess Medical Center Israel
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
NCT04446117 · ClinicalTrials.gov ↗ · Metastatic Prostate Cancer, Prostate Adenocarcinoma
Phase 3 Active, closed Exelixis UK, USA, Germany, France, Spain, Italy, Belgium, Poland, Austria, Czechia, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Singapore, Australia, Israel
A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
NCT06551324 · ClinicalTrials.gov ↗ · Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Phase 3 Active, closed Pfizer UK, USA, China, Germany, France, Spain, Italy, Netherlands, Sweden, Poland, Czechia, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
NCT00268476 · ClinicalTrials.gov ↗ · Prostate Cancer
Phase 2/3 Active, closed Medical Research Council Switzerland
Management of Castration-Resistant Prostate Cancer with Oligometastases
NCT02685397 · ClinicalTrials.gov ↗ · Castration-resistant Prostate Cancer Patients with Oligometastases
Phase 2/3 Active, closed Sir Mortimer B. Davis - Jewish General Hospital Canada
A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery
NCT03809000 · ClinicalTrials.gov ↗ · Prostate Cancer
Phase 2 Active, closed RTOG Foundation, Inc Norway, Canada
PROstate Cancer TReatment Optimization Via Analysis of Circulating Tumour DNA
NCT04015622 · ClinicalTrials.gov ↗ · Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Phase 2 Active, closed British Columbia Cancer Agency Canada
Enzalutamide With Lu PSMA-617 Versus Enzalutamide Alone in Men With Metastatic Castration-resistant Prostate Cancer
NCT04419402 · ClinicalTrials.gov ↗ · Metastatic Castration-Resistant Prostate Cancer
Phase 2 Active, closed Australian and New Zealand Urogenital and Prostate Cancer Trials Group Australia

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Xtandi

18 conditions
Prostate Cancer4Metastatic Castration-Resistant Prostate Cancer2Prostate Adenocarcinoma2Prostatic Neoplasms, Castration-Resistant2Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)2Metastatic Castration-Resistant Prostate Cancer (mCRPC)2Metastatic Castration-resistant Prostate Cancer1Metastatic Castrate Resistant Prostate Cancer (mCRPC)1Metastatic Prostate Cancer1Metastatic Castration Sensitive Prostate Cancer (mCSPC)1Hormone Sensitive Prostate Cancer1Cancer of the Prostate1
All 18 conditions
Condition (as registered)Trials
Prostate Cancer4
Metastatic Castration-Resistant Prostate Cancer2
Prostate Adenocarcinoma2
Prostatic Neoplasms, Castration-Resistant2
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)2
Metastatic Castration-Resistant Prostate Cancer (mCRPC)2
Metastatic Castration-resistant Prostate Cancer1
Metastatic Castrate Resistant Prostate Cancer (mCRPC)1
Metastatic Prostate Cancer1
Metastatic Castration Sensitive Prostate Cancer (mCSPC)1
Hormone Sensitive Prostate Cancer1
Cancer of the Prostate1
Metastatic Castration Resistant Prostate Cancer (mCRPC)1
Small Cell Lung Cancer (SCLC)1
Follicular Lymphoma (FL)1
Metastatic Castration-resistant Prostate Cancer (mCRPC)1
Castration-resistant Prostate Cancer Patients with Oligometastases1
Castration-Resistant Prostate Cancer (CRPC)1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Pfizer4
AstraZeneca1
Exelixis1
Instituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología Radioterápic1
Leiden University Medical Center1
Karolinska Institutet1
Institute of Cancer Research, United Kingdom1
Medical Research Council1
RTOG Foundation, Inc1
British Columbia Cancer Agency1
Sir Mortimer B. Davis - Jewish General Hospital1
Hyundai Bioscience Co., Ltd1
Australian and New Zealand Urogenital and Prostate Cancer Trials Group1
Beth Israel Deaconess Medical Center1
04

By country register

RegisterTrialsRecruiting
Clinical trials in Canada83
Clinical trials in Spain75
Clinical trials in South Korea74
Clinical trials in USA64
Clinical trials in Poland64
Clinical trials in Japan64
Clinical trials in Australia63
Clinical trials in UK53
Clinical trials in China54
Clinical trials in Germany53
Clinical trials in France53
Clinical trials in Brazil53
Clinical trials in Taiwan53
Clinical trials in Italy42
Clinical trials in Netherlands43
Clinical trials in Sweden43
Clinical trials in Czechia42
Clinical trials in Turkey43
Clinical trials in Israel42
Clinical trials in Switzerland43
Clinical trials in Belgium32
Clinical trials in Egypt22
Clinical trials in Austria21
Clinical trials in Norway21
Clinical trials in Denmark11
Clinical trials in India11
Clinical trials in Portugal10
Clinical trials in Mexico10
Clinical trials in Singapore10

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Xtandi trials

How many clinical trials are testing Xtandi?

17 current trials in our Canada, Spain, South Korea, USA, Poland, Japan, Australia, UK, China, Germany, France, Brazil, Taiwan, Italy, Netherlands, Sweden, Czechia, Turkey, Israel, Switzerland, Belgium, Egypt, Austria, Norway, Denmark, India, Portugal, Mexico and Singapore registers name Xtandi as a drug or biological intervention, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Xtandi trials recruiting patients?

Yes. 8 of the 17 trials are recruiting: 3 with sites in Canada, 5 with sites in Spain, 4 with sites in South Korea, 4 with sites in USA, 4 with sites in Poland, 4 with sites in Japan, 3 with sites in Australia, 3 with sites in UK, 4 with sites in China, 3 with sites in Germany, 3 with sites in France, 3 with sites in Brazil, 3 with sites in Taiwan, 2 with sites in Italy, 3 with sites in Netherlands, 3 with sites in Sweden, 2 with sites in Czechia, 3 with sites in Turkey, 2 with sites in Israel, 3 with sites in Switzerland, 2 with sites in Belgium, 2 with sites in Egypt, 1 with sites in Austria, 1 with sites in Norway, 1 with sites in Denmark and 1 with sites in India. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Xtandi clinical trials?

Pfizer (4), AstraZeneca (1), Exelixis (1) and Instituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología Radioterápic (1), among 14 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Xtandi works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Xtandi works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Xtandi (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.