Clinical trial register · Poland

Clinical Trials in Poland

Every study on the ClinicalTrials.gov registry that lists a site in Poland and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 2709 matching records held by the registry are in this view. Synced 12 Nov 2026, 03:19 UTC

2709

Studies in scope

all four open statuses

1380

Recruiting now

open to new participants

510

Lead sponsors

across recruiting studies

Top sites

Warsaw 1318 Krakow 881 Poznan 697 Gdansk 663 Lodz 618

Trials in this register

Status

Study

Lead sponsor

Phase

Enrol

Sites in Poland

Start

Recruiting

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

NCT05509777Crohn's Disease

DrugMirikizumab

Eli Lilly and Company

Phase 3

Rzeszów, Warsaw

2024-03-13

Recruiting

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

NCT05923073Crohn's Disease

DrugsTremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

120

Rzeszów, Warsaw

2024-03-13

Recruiting

The NEU-STIM Trial

NCT05942924Infant, Premature, Diseases, Birth, Preterm

Leiden University Medical Center

Not applicable

3,280

Bydgoszcz, Gdansk, Katowice, Poznan, Rzeszów, Wroclaw

2024-03-11

Active, closed

A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)

NCT06220604Plaque Psoriasis

DrugsIcotrokinra·Deucravacitinib

Janssen Research & Development, LLC

Phase 3

731

Bialystok, Katowice, Kielce, Krakow, Olsztyn, Warsaw, Wroclaw

2024-03-09

Recruiting

Clinical Application of the J-PET Scanner Prototype

NCT06242119Prostate Cancer, Prostatic Hyperplasia, Prostatic Neoplasms, Prostate Cancer Metastatic

Jagiellonian University

Observational

Krakow

2024-03-07

Active, closed

The Hyalex First-in-Human Study

NCT06344481Cartilage Injury

Hyalex Orthopaedics, Inc.

Not applicable

Lodz, Warsaw

2024-03-07

By invitation

The Influence of Modifying Highly Calcified Coronary Lesions on Coronary Microcirculation

NCT06507449Coronary Artery Calcification, Ischemic Heart Disease, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Coronary Artery Disease

Medical University of Silesia

Not applicable

Katowice

2024-03-07

Active, closed

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

NCT06292013Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)

DrugLepodisiran

Eli Lilly and Company

Phase 3

17,300

Bialystok, Bydgoszcz, Chrzanów, Dąbrowa Górnicza, Elblag, Gdansk, Grudziądz, Katowice

2024-03-05

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

NCT06233461Crohn's Disease

DrugZasocitinib

Takeda

Phase 2

268

Torun, Wroclaw, Warsaw, Szczecin, Bydgoszcz, Lodz, Lublin, Poznan

2024-03-05

Recruiting

A Study of Sepiapterin in Participants With Phenylketonuria (PKU)

NCT06302348Phenylketonuria

PTC Therapeutics

Phase 3

Szczecin, Warsaw

2024-03-04

Recruiting

H. Pylori Screen-and-treat Study in a Population of Young Adults

NCT06275204Gastric Cancer, H Pylori Infection, H Pylori Eradication, H-pylori

University of Latvia

Observational

6,800

Wroclaw

2024-03-04

Active, closed

AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2

NCT06346392Gastric Cancer, Gastroesophageal Junction Cancer

DrugsSonesitatug Vedotin·Ramucirumab·Trifluridine/Tipiracil·Apatinib

AstraZeneca

Phase 3

594

Bielsko-Biala, Gdansk, Katowice, Krakow, Lublin, Słupsk, Warsaw

2024-03-04

Recruiting

The STOP-MED CTRCD Trial

NCT06183437Heart Failure, Cardiotoxicity, Cardiac Toxicity, Antineoplastics Toxicity

Dinesh Thavendiranathan

Phase 4

335

Warsaw

2024-03-04

Recruiting

Effectiveness and Safety of Knee Cartilage Lesion Treatment Using CartiONE: 1-to-13 Year Follow-up.

NCT06809231Knee Cartilage Lesion

Cartilage Repair Systems BV

Observational

100

Warsaw

2024-03-01

Recruiting

STICH3C Cardiac Magnetic Resonance Observational Study

NCT07133984Ischemic Left Ventricle Systolic Dysfunction, Multivessel Coronary Artery Disease

Weill Medical College of Cornell University

Observational

230

Wroclaw

2024-03-01

Recruiting

Bedside Ultrasound on the Effectiveness of Lumbar Puncture in Children.

NCT06584864Meningitis, Pediatric Disorder

Medical University of Warsaw

Not applicable

120

Warsaw

2024-03-01

Recruiting

Ocular Manifestations of Granulomatosis With Polyangiitis.

NCT07664709GPA, Vasculitis, Microscopic Polyangiitis (MPA), Churg-Strauss Syndrome (CSS)

Military Institute od Medicine National Research Institute

Observational

Warsaw

2024-03-01

Recruiting

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

NCT06165341Alpha1-Antitrypsin Deficiency

DrugFazirsiran

Takeda

Phase 3

Mysłowice

2024-03-01

Active, closed

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor

NCT06241118Dermatitis Atopic

DrugsPimecrolimus·Amlitelimab·Tacrolimus

Sanofi

Phase 3

464

Warsaw, Gdansk

2024-02-29

Recruiting

Physiologic Cardiac Pacing to Prevent Left Ventricular Dysfunction Post TAVI

NCT05966675Atrioventricular Block, Second and Third Degree

Medical University of Silesia

Not applicable

500

Katowice

2024-02-27

Recruiting

Efficacy and Safety of Methotrexate Versus Placebo in Adults With Atopic Dermatitis.

NCT06239311Moderate to Severe Atopic Dermatitis

DrugMethotrexate

medac GmbH

Phase 3

277

Częstochowa, Gdansk, Katowice, Lodz, Lublin, Mikołów, Poznan, Szczecin

2024-02-27

Recruiting

A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

NCT06161025Solid Cancer

DrugsR-DXd·Topotecan·Paclitaxel

Daiichi Sankyo

Phase 2/3

860

Bialystok, Gdansk, Poznan, Siedlce

2024-02-27

Active, closed

A Phase 2 Study to Evaluate DNTH103 in Adults With Generalized Myasthenia Gravis (MAGIC)

NCT06282159Myasthenia Gravis, Generalized

DrugClaseprubart

Dianthus Therapeutics

Phase 2

Bydgoszcz, Katowice, Krakow, Lublin, Warsaw

2024-02-23

Active, closed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy

NCT05979311HIV, HIV Infections

DrugsBictegravir·Dolutegravir·Emtricitabine·Lamivudine

ViiV Healthcare

Phase 3

463

Bydgoszcz, Lodz, Wroclaw

2024-02-21

Active, closed

A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer

NCT06012435Carcinoma, Non-Small-Cell Lung

DrugsSigvotatug vedotin·Docetaxel

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

762

Gdansk, Lodz, Lublin, Poznan

2024-02-21

Recruiting

A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

NCT06283966COPD (Chronic Obstructive Pulmonary Disease)

AstraZeneca

Phase 3

5,250

Bialystok, Bydgoszcz, Chęciny, Chojnice, Częstochowa, Inowrocław, Karczew, Katowice

2024-02-21

Active, closed

Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)

NCT06117774Limited Stage Small Cell Lung Cancer, Small Cell Lung Cancer

DrugTarlatamab

Amgen

Phase 3

404

Bialystok, Bystra, Gdansk, Lublin, Poznan, Prabuty, Przemyśl, Warsaw

2024-02-20

Recruiting

Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy

NCT05933057Duchenne Muscular Dystrophy

DrugHydroxyurea

Italfarmaco

Phase 3

138

Gdansk, Warsaw

2024-02-19

Recruiting

A Global Prospective Observational Registry of Patients With Pompe Disease

NCT06121011Pompe Disease

DrugsAlglucosidase alfa·Cipaglucosidase alfa·Miglustat·Avalglucosidase alfa

Amicus Therapeutics

Observational

500

Rzeszów

2024-02-16

Active, closed

DAREON™-9: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With Small Cell Lung Cancer When Taken Together With a Single Agent Chemotherapy

NCT05990738Small Cell Lung Carcinoma (SCLC)

DrugsObrixtamig·Topotecan

Boehringer Ingelheim

Phase 1

Lodz

2024-02-14

Active, closed

DAREONᵀᴹ-8: A Study to Test How Well Different Doses of BI 764532 in Addition to Standard of Care Are Tolerated by People With Advanced Small Cell Lung Cancer

NCT06077500Small Cell Lung Carcinoma (SCLC)

DrugsObrixtamig·Etoposide·Atezolizumab·Carboplatin

Boehringer Ingelheim

Phase 1

Gdansk, Lodz, Poznan

2024-02-14

Active, closed

A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4

NCT06078553Congenital Myasthenic Syndrome

argenx

Observational

152

Bydgoszcz, Katowice, Warsaw

2024-02-13

Active, closed

Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

NCT06151574Lung Cancer, Non-squamous, Non-small Cell

DrugsZongertinib·Pemetrexed·Keytruda·Cisplatin

Boehringer Ingelheim

Phase 3

428

Lodz, Poznan, Warsaw

2024-02-09

Recruiting

A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

NCT06072482Antineutrophil Cytoplasmic Antibody-associated Vasculitis

DrugAvacopan

Amgen

Phase 4

300

Lodz, Warsaw

2024-02-07

Active, closed

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

NCT06191744Follicular Lymphoma (FL)

DrugsEpcoritamab·Bendamustine·Obinutuzumab·Vincristine

Genmab

Phase 3

1,095

Poznan, Krakow, Warsaw, Lodz, Kielce

2024-02-05

Recruiting

Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes

NCT05957055Attention Deficit Disorder with Hyperactivity, Diabetes Mellitus, Type 1

DrugsLisdexamfetamine·Methylphenidate

Medical University of Lodz

Phase 2

150

Lodz

2024-02-05

Recruiting

Study of Olverembatinib (HQP1351) in Patients With CML-CP

NCT06423911Chronic Myeloid Leukemia, CML, CML, Chronic Phase

DrugsBosutinib·Olverembatinib

Ascentage Pharma Group Inc.

Phase 3

333

Gdansk, Katowice, Krakow, Lodz, Torun, Warsaw, Wałbrzych

2024-02-05

Active, closed

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

NCT05853575Advanced Cancer, Metastatic Cancer, Malignant Neoplasm of Lung

DrugAdagrasib

Mirati Therapeutics Inc.

Phase 2

200

Krakow, Gdynia, Lublin

2024-02-01

Active, closed

A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa

NCT06212999Hidradenitis Suppurativa (HS)

DrugPovorcitinib

Incyte Corporation

Phase 3

617

Lublin, Ostrowiec Świętokrzyski, Rzeszów, Warsaw, Wroclaw

2024-01-30

Recruiting

Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)

NCT06003387Hemophilia B

CSL Behring

Phase 3

Warsaw

2024-01-30

Active, closed

Anti-inflammatory Probiotics in Cognitive Functioning

NCT07165977Memory Decline, Cognitive Decline, Cognitive Aging

University of Social Sciences and Humanities, Warsaw

Not applicable

110

Warsaw

2024-01-25

Recruiting

A Phase 3 Study of Efepoetin Alfa for Treatment of Anemia in Patients With Chronic Kidney Disease on Dialysis

NCT06466785Anemia of Chronic Kidney Disease

DrugDarbepoetin Alfa

Genexine, Inc.

Phase 3

429

Bialystok, Brodnica, Lodz, Pszczyna, Wadowice, Warsaw, Żyrardów

2024-01-25

Active, closed

Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)

NCT06225596Metastatic Urothelial Cancer

DrugsZelenectide pevedotin·Avelumab·Gemcitabine·Cisplatin

BicycleTx Limited

Phase 2

375

Gdansk, Wieliszew

2024-01-24

Active, closed

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

NCT06143891Chronic Graft Versus Host Disease

DrugsBelumosudil·Prednisolone·Prednisone

Sanofi

Phase 3

260

Gdansk, Szczecin

2024-01-23

Active, closed

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

NCT06208150Multiple Myeloma

DrugsElotuzumab·Talquetamab·Velcade·Teclistamab

Janssen Research & Development, LLC

Phase 3

838

Biała Podlaska, Brzozów, Kielce, Lublin, Szczecin, Wroclaw

2024-01-22

Active, closed

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis

NCT06260163Colitis, Ulcerative

DrugsTremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

112

Gdansk, Rzeszów, Warsaw

2024-01-19

Active, closed

A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo

NCT06163326Vitiligo

DrugRitlecitinib

Pfizer

Phase 3

394

Osielsko, Warsaw, Szczecin, Lodz, Ostrowiec Świętokrzyski

2024-01-19

Active, closed

A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)

NCT06018337Metastatic Breast Cancer

DrugsDB-1303/BNT323·Nab-paclitaxel·Capecitabine·Paclitaxel

DualityBio Inc.

Phase 3

541

Rzeszów, Torun, Krakow, Poznan, Warsaw, Wroclaw, Lodz

2024-01-18

Active, closed

A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

NCT06143878Plaque Psoriasis

DrugsIcotrokinra·Deucravacitinib

Janssen Research & Development, LLC

Phase 3

774

Bialystok, Elblag, Krakow, Lodz, Osielsko, Poznan, Warsaw, Wroclaw

2024-01-17

Recruiting

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

NCT06008197Heart Failure, Acute Heart Failure

DrugsKerendia·Finerenone

Colorado Prevention Center

Phase 3

5,200

Katowice, Krakow, Lodz, Lublin, Oświęcim, Tychy

2024-01-17

Active, closed

A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease

NCT05970172Chronic Kidney Disease, Renal Anemia

DrugRoxadustat

Astellas Pharma Global Development, Inc.

Phase 3

Krakow, Warsaw

2024-01-16

Active, closed

A Study to Compare the Pharmacokinetics, Efficacy, Safety, and Immunogenicity of Pembrolizumab (SB27, EU Sourced Keytruda, and US Sourced Keytruda) in Subjects With Stage II-IIIA NSCLC Following Complete Resection and Adjuvant Platinum-based Chemotherapy

NCT06268613Non-small Cell Lung Cancer Stage II, Non-small Cell Lung Cancer Stage IIIA

DrugsEU-sourced Keytruda·US-sourced Keytruda·Pembrolizumab

Samsung Bioepis Co., Ltd.

Phase 1

163

Gdansk, Otwock

2024-01-16

Recruiting

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

NCT06064877Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

DrugsErbitux·Cetuximab

AVEO Pharmaceuticals, Inc.

Phase 3

410

Bydgoszcz, Gliwice

2024-01-11

Active, closed

Study of ALXN2220 Versus Placebo in Adults With ATTR-CM

NCT06183931Transthyretin Amyloid Cardiomyopathy

DrugCliramitug

Alexion Pharmaceuticals, Inc.

Phase 3

1,182

Gdansk, Poznan, Warsaw

2024-01-11

Recruiting

A Study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics and Safety of CT-P53 and Ocrevus in Patients With Relapsing-remitting Multiple Sclerosis

NCT05906992Relapsing-remitting Multiple Sclerosis

DrugOcrelizumab

Celltrion

Phase 3

512

Poznan

2024-01-11

Recruiting

Dietary Salicylates and Preeclampsia

NCT06239363Pregnancy Disease, Preeclampsia, Diet Habit

Poznan University of Life Sciences

Observational

500

Poznan

2024-01-08

Recruiting

Safety and Efficacy of RVU120 Combined With Venetoclax for Treatment of Relapsed/Refractory AML

NCT06191263Acute Myeloid Leukemia

DrugsRVU120·Venetoclax

Ryvu Therapeutics SA

Phase 2

Warsaw, Biała Podlaska, Gdansk, Katowice, Torun, Wałbrzych, Wroclaw, Zielona Góra

2024-01-05

Active, closed

Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa

NCT06079281Hypophosphatasia

DrugALXN1850

Alexion Pharmaceuticals, Inc.

Phase 3

124

Lodz

2024-01-03

Active, closed

A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC

NCT05849298Prostatic Neoplasm

DrugsARPI·Pylarify·Illuccix·Lu-PSMA

Novartis Pharmaceuticals

Phase 2

Kielce

2024-01-03

By invitation

Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)

NCT06191315Wheezing, Asthma

DrugDupilumab

Sanofi

Phase 3

Tarnów, Lodz, Warsaw

2024-01-03

Recruiting

The MAGiC™ Cardiac Ablation European Study

NCT06019845Arrhythmias, Cardiac

Stereotaxis

Not applicable

150

Warsaw

2024-01-02

Recruiting

Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine

NCT07159750Migraine, Episodic Migraine, Chronic Migraine, Headache

Hospital Universitari Vall d'Hebron Research Institute

Observational

700

Wroclaw

2024-01-02

Recruiting

Multimodal Cardiac Imaging Registry in Patients with Atrial Fibrillation

NCT06584266Atrial Fibrillation and Flutter, Heart Failure, Artificial Intelligence (AI), Echocardiography

University in Zielona Góra

Observational

3,000

Nowa Sól, Katowice, Krakow, Warsaw, Zielona Góra

2024-01-01

Active, closed

Predicting Operational Difficulties and Outcomes of RARP Based on Preoperative Assessment - Introducing the PIODO Questionnaire

NCT06985004Prostate Cancer, Robot-Assisted Laparoscopic Radical Prostatectomy

Pomeranian Medical University Szczecin

Observational

288

Szczecin

2024-01-01

By invitation

Cerebrolysin in Critically Ill Patients With Delirium

NCT06677502Cognitive Impairment

DrugCerebrolysin

Medical University of Lublin

Not applicable

500

Lubin

2024-01-01

Recruiting

NanoTherm In Adjuvant Therapy of Glioblastoma Multiforme

NCT06271421Glioblastoma Multiforme

Poznan University of Medical Sciences

Not applicable

100

Poznan

2024-01-01

Recruiting

Comparison of Three Types of Distal Arteriovenous Fistulas: SBAVF, RCAVF, and RCAVF With Venous Branch Patch.

NCT06550479Dialysis; Complications, Vascular Access Complication

Wroclaw Medical University

Not applicable

180

Wroclaw

2024-01-01

Active, closed

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

NCT06079879Essential Thrombocythemia

DrugsAnagrelide·Bomedemstat·Busulfan·Ruxolitinib

Merck Sharp & Dohme LLC

Phase 3

340

Katowice, Kielce

2023-12-31

Recruiting

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

NCT06136624Prostate Cancer Metastatic

DrugsFludrocortisone acetate·Opevesostat·Zytiga·Hydrocortisone

Merck Sharp & Dohme LLC

Phase 3

1,310

Bydgoszcz, Grudziądz, Torun, Siedlce, Koszalin, Szczecin, Kielce

2023-12-31

Recruiting

Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment

NCT06247085Homocystinuria

DrugPegtibatinase

Travere Therapeutics, Inc.

Phase 3

Krakow, Warsaw

2023-12-28

Recruiting

A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone Lymphoma

NCT06149286Relapsed/Refractory Follicular Lymphoma, Relapsed/Refractory Marginal Zone Lymphoma (R/R MZL)

DrugsOdronextamab·Lenalidomide·Rituximab

Regeneron Pharmaceuticals

Phase 3

580

Bydgoszcz, Wałbrzych, Wroclaw, Lublin, Krakow, Gdansk, Poznan, Skorzewo

2023-12-28

Active, closed

Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis

NCT06141486Multiple Sclerosis

DrugFrexalimab

Sanofi

Phase 3

943

Poznan, Bydgoszcz, Krakow, Rzeszów, Bialystok, Katowice, Zabrze

2023-12-27

Recruiting

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

NCT06059638Hypertension, Hypertension, Systolic, Hypertension, Essential

Orchestra BioMed, Inc

Not applicable

316

Katowice, Krakow, Lodz, Lublin, Poznan, Szczecin, Warsaw, Wroclaw

2023-12-27

Active, closed

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)

NCT06099782Non-Small Cell Lung Cancer, Renal Cell Carcinoma, Melanoma

Drugs) Berahyaluronidase alfa·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 2

147

Bydgoszcz, Warsaw, Koszalin, Szczecin

2023-12-26

Recruiting

Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections

NCT06936969Prolonged Air Leak, Persistent Air Leak

Wielkopolskie Centrum Pulmonologii i Torakochirurgii

Not applicable

200

Poznan

2023-12-22

Recruiting

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

NCT06119581Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

DrugsOlomorasib·Pemetrexed·Cisplatin·Carboplatin

Eli Lilly and Company

Phase 3

1,264

Kielce, Szczecin, Torun

2023-12-21

Active, closed

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

NCT06140836Carcinoma, Non-Small-Cell Lung

DrugsRepotrectinib·Crizotinib

Bristol-Myers Squibb

Phase 3

190

Lublin, Olsztyn

2023-12-21

Recruiting

A Head-to-head Study Comparing the Functional Value of Two Models of Robotically Assisted Rehabilitation in SMA (Spinal Muscular Atrophy) Patients

NCT06322654SMA

Wiktor Dega University Orthopedic and Rehabilitation Hospital

Not applicable

200

Poznan

2023-12-21

Recruiting

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)

NCT05912517Hemolytic Disease of the Fetus and Newborn

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

120

Lodz, Warsaw

2023-12-20

Active, closed

Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma

NCT05948475Cholangiocarcinoma

DrugTinengotinib

TransThera Sciences (Nanjing), Inc.

Phase 3

200

Warsaw

2023-12-20

Recruiting

Global Trial in APG2575 for Patients With CLL/SLL

NCT06104566CLL/SLL

DrugLisaftoclax

Ascentage Pharma Group Inc.

Phase 3

400

Bydgoszcz, Krakow, Lodz, Skorzewo

2023-12-20

Recruiting

Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma

NCT06016920HPV Positive Oropharyngeal Squamous Cell Carcinoma, HNSCC

DrugsKeytruda·Pembrolizumab

Nykode Therapeutics ASA

Phase 1/2

110

Gdansk, Gliwice

2023-12-19

Recruiting

Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.

NCT06174610Acute Kidney Injury

Uniwersytecki Szpital Kliniczny w Opolu

Observational

Opole

2023-12-19

Active, closed

A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo

NCT06118411Vitiligo

DrugUpadacitinib

AbbVie

Phase 3

614

Osielsko, Krakow, Warsaw, Bialystok, Katowice, Szczecin

2023-12-19

Active, closed

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)

NCT05973773Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation

DrugZipalertinib

Taiho Oncology, Inc.

Phase 3

285

Pozna?, Lublin, Lodz

2023-12-18

Recruiting

Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation

NCT05955365Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor

DrugsDOAC·Aspirin

Insel Gruppe AG, University Hospital Bern

Phase 4

3,010

Poznan

2023-12-18

Active, closed

A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus

NCT05835986Systemic Lupus Erythematosus

DrugTocilizumab

Hoffmann-La Roche

Phase 1

Warsaw

2023-12-18

Recruiting

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

NCT06170788Non-small Cell Lung Cancer (NSCLC)

DrugsSacituzumab tirumotecan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

614

Bydgoszcz, Grudziądz, Torun, Krakow, Warsaw, Przemyśl, Olsztyn, Lodz

2023-12-15

Recruiting

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

NCT06129864Locally Advanced Head and Neck Squamous Cell Carcinoma

DrugVolrustomig

AstraZeneca

Phase 3

1,145

Bialystok, Bielsko-Biala, Bydgoszcz, Gliwice, Olsztyn, Piotrkow Trybunalski, Siedlce, Tomaszów Mazowiecki

2023-12-14

Recruiting

A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

NCT06091865Diffuse Large B-cell Lymphoma (DLBCL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

904

Krakow, Wroclaw, Poznan, Skorzewo, Bydgoszcz, Gdansk, Lublin, Warsaw

2023-12-13

Recruiting

AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

NCT06219941Gastric Cancer, Gastroesophageal Junction Cancer, Biliary Tract Cancer, Pancreatic Ductal Adenocarcinoma

DrugsL-leucovorin·Nanoliposomal Irinotecan·Onivyde·Sonesitatug Vedotin

AstraZeneca

Phase 2

226

Krakow, Warsaw

2023-12-13

Active, closed

Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis

NCT06141473Multiple Sclerosis

DrugsCholestyramine·Activated Charcoal·Teriflunomide·Frexalimab

Sanofi

Phase 3

1,655

Plewiska, Bydgoszcz, Krakow, Lublin, Lodz, Warsaw, Rzeszów, Katowice

2023-12-13

Active, closed

A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment Naïve Mantle Cell Lymphoma

NCT05951959Mantle Cell Lymphoma (MCL)

DrugsAcalabrutinib·Venetoclax·Rituximab

AstraZeneca

Phase 2

108

Gdynia, Krakow, Warsaw

2023-12-13

Active, closed

A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib

NCT05734105GIST

DrugsRipretinib·Sunitinib

Deciphera Pharmaceuticals, LLC

Phase 3

Warsaw

2023-12-13

Recruiting

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

NCT06136559Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsNemtabrutinib·Ibrutinib·Acalabrutinib

Merck Sharp & Dohme LLC

Phase 3

1,200

Krakow, Lublin, Warsaw, Gdansk, Słupsk, Gliwice, Katowice, Olsztyn

2023-12-13

Recruiting

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

NCT06091254Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Bendamustine

Regeneron Pharmaceuticals

Phase 3

822

Wałbrzych, Wroclaw, Krakow, Gdansk, Skorzewo, Katowice, Lodz, Lublin

2023-12-12

Active, closed

MAXPIRe: Study to Evaluate Axatilimab in Participants With Idiopathic Pulmonary Fibrosis (IPF)

NCT06132256Idiopathic Pulmonary Fibrosis

DrugAxatilimab

Syndax Pharmaceuticals

Phase 2

145

Bydgoszcz, Maków Podhalański, Olsztyn

2023-12-11

Active, closed

Frexalimab in Preservation of Endogenous Insulin Secretion Compared to Placebo in Adults and Adolescents on Top of Insulin Therapy (FABULINUS)

NCT06111586Type 1 Diabetes Mellitus

DrugFrexalimab

Sanofi

Phase 2

197

Lodz, Warsaw, Bialystok, Katowice, Szczecin

2023-12-11

Recruiting

A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

NCT05995353Crohn's Disease

DrugsSkyrizi·Risankizumab

AbbVie

Phase 3

110

Torun, Warsaw

2023-12-11

Active, closed

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

NCT06065748Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

DrugsGiredestrant·Ribociclib·Abemaciclib·Palbociclib

Hoffmann-La Roche

Phase 3

1,050

?ód?, Bydgoszcz, Gdynia, Gliwice, Kielce, Konin, Koszalin, Lublin

2023-12-11

Active, closed

A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines

NCT05976243Chronic Inducible Urticaria

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

362

Bydgoszcz, Warsaw

2023-12-07

Active, closed

Assessing the Safety, Immune Response, and Early Efficacy of a Candida Vaccine in Women With Recurrent Vulvovaginal Candidiasis: A Randomized Controlled Study

NCT06190509Recurrent Vulvovaginal Candidiasis

LimmaTech Biologics AG

Phase 1/2

251

Skórzewo, Bydgoszcz, Katowice, Lublin, Warsaw

2023-12-06

Active, closed

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

NCT06132958Endometrial Cancer

DrugsAbraxane·Adriamycin·Sacituzumab tirumotecan·Taxol

Merck Sharp & Dohme LLC

Phase 3

710

Poznan, Siedlce, Warsaw, Bialystok

2023-12-06

Active, closed

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

NCT06077760Non-small Cell Lung Cancer

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

868

Poznan, Bydgoszcz, Krakow, Warsaw, Przemyśl, Bialystok, Gdansk, Olsztyn

2023-12-06

Recruiting

Initial Triple Therapy Including Parenteral Treprostinil vs Initial Double Oral Therapy in PAH Group I Patients

NCT06317805Pulmonary Arterial Hypertension

AOP Orphan Pharmaceuticals AG

Phase 4

110

Krakow, Otwock

2023-12-06

Active, closed

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06029972Ulcerative Colitis

Gilead Sciences

Phase 2

176

Krakow, Lublin, Poznan, Rzeszów, Sopot, Warsaw, Wroclaw

2023-12-05

Active, closed

Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)

NCT06109779Biliary Tract Cancer

DrugsGemcitabine/Cisplatin·Rilvegostomig·Teysuno·Capecitabine

AstraZeneca

Phase 3

760

Bydgoszcz, Krakow, Lublin, Przemyśl, Warsaw

2023-12-04

Active, closed

A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patients

NCT06514807Essential Thrombocythaemia

DrugBesremi

AOP Orphan Pharmaceuticals AG

Phase 3

117

Gdansk, Katowice, Krakow, Lodz

2023-12-04

Active, closed

A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)

NCT06127043Ulcerative Colitis

DrugRosnilimab

AnaptysBio, Inc.

Phase 2

132

Bydgoszcz, Częstochowa, Elblag, Katowice, Krakow, Lodz, Lublin, Poznan

2023-12-04

Recruiting

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NCT06215716NASH With Fibrosis, MASH With Fibrosis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

1,650

Poznan, Krakow, Wroclaw, Warsaw, Gdansk, Gdynia, Częstochowa, Katowice

2023-12-01

Recruiting

Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease

NCT06293157Metastatic Spinal Cord Compression, Metastasis Spine

Copernicus Memorial Hospital

Not applicable

226

Bydgoszcz, Wroclaw, Lodz

2023-12-01

Active, closed

The Effect of Probiotic Supplementation on the Exercise Performance of Long-distance Runners.

NCT07411482Intestinal Microbiome, Probiotic, Runners

Medical University of Gdansk

Not applicable

Gdansk

2023-12-01

Recruiting

LN-RADS, RECIST 1.1 and Node-RADS Classification in the Assessment of Lymph Nodes

NCT06527027Lymph Node Neoplasm, Lymph Node Metastasis

Copernicus Memorial Hospital

Not applicable

1,000

Krakow, Lodz, Warsaw

2023-12-01

Active, closed

Renal Colic and Urolithiasis in Poland

NCT06176469Renal Colic, Urolithiasis

Mikolaj Przydacz

Observational

10,000

Krakow

2023-12-01

Recruiting

Cardiovascular Disease in Patients With Chronic Kidney Disease: Polish Kidney- Heart Project

NCT06083168Chronic Kidney Disease, Cardiovascular Diseases

Medical University of Silesia

Observational

6,000

Olsztyn, Zabrze

2023-12-01

Recruiting

The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)

NCT06408441Epithelioid Hemangioendothelioma, Sarcoma,Soft Tissue

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

100

Warsaw

2023-12-01

Recruiting

Remote ECG Monitoring Post TAVI

NCT07521800TAVI(Transcatheter Aortic Valve Implantation), Remote Monitoring, Arrythmia, Atrial Fibrillation (AF)

Medical University of Silesia

Not applicable

250

Bialystok, Katowice

2023-12-01

Recruiting

The Fourth Left Atrial Appendage Occlusion Study

NCT05963698Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism

Hamilton Health Sciences Corporation

Not applicable

4,000

Warsaw, Ustroń

2023-11-30

Active, closed

A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy

NCT05988073Multifocal Motor Neuropathy

argenx

Observational

413

Bydgoszcz, Katowice, Krakow, Lublin, Warsaw

2023-11-29

Active, closed

A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1)

NCT06113445NonSegmental Vitiligo

DrugPovorcitinib

Incyte Corporation

Phase 3

467

Chorzów, Częstochowa, Gdansk, Katowice, Lodz, Osielsko, Ostrowiec Świętokrzyski, Rzeszów

2023-11-29

Active, closed

A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)

NCT06113471NonSegmental Vitiligo

DrugPovorcitinib

Incyte Corporation

Phase 3

450

Gdansk, Gdynia, Katowice, Kielce, Lodz, Skierniewice, Szczecin, Tarnów

2023-11-27

Recruiting

Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

NCT05866419Spinal Muscular Atrophy, Spine Deformity, Scoliosis

Alcyone Therapeutics, Inc

Not applicable

Krakow, Lodz

2023-11-27

Recruiting

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

NCT06103864Breast Cancer

DrugsDato-DXd·Durvalumab·Nab-paclitaxel·Gemcitabine

AstraZeneca

Phase 3

625

Bialystok, Bydgoszcz, Gdansk, Gdynia, Konin, Krakow, Legnica, Lodz

2023-11-23

Recruiting

A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts

NCT06094010Influenza

DrugBaloxavir Marboxil

Hoffmann-La Roche

Phase 3

1,100

Bydgoszcz, Częstochowa, Grójec, Katowice, Lodz, Siemianowice Śląskie, Warsaw, Wo?omin

2023-11-22

Active, closed

Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents

NCT06120491Metastatic Castration-Sensitive Prostate Cancer

DrugsSaruparib·Zytiga·Xtandi·Abiraterone acetate

AstraZeneca

Phase 3

1,898

Bydgoszcz, Koszalin, Poznan, Rzeszów, Warsaw, Wroclaw

2023-11-21

Active, closed

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

NCT06016738Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer

DrugsPalazestrant·Exemestane·Anastrozole·Letrozole

Olema Pharmaceuticals, Inc.

Phase 3

510

Lublin, Lodz, Otwock, Brzozów, Rzeszów, Gdynia, Gdansk, Krakow

2023-11-16

Recruiting

Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation

NCT05665608Sudden Cardiac Death, Myocardial Infarction

Charite University, Berlin, Germany

Not applicable

3,595

Rzeszów, Warsaw, Zabrze

2023-11-16

Recruiting

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

NCT05920356Non-Small Cell Lung Cancer (NSCLC)

DrugsSotorasib·Pembrolizumab

Amgen

Phase 3

750

Bialystok, Bystra, Gdynia, Gliwice, Krakow, Lodz, Lublin, Poznan

2023-11-16

Active, closed

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis

NCT06136741Moderate to Severe Atopic Dermatitis

DrugRezpegaldesleukin

Nektar Therapeutics

Phase 2

396

Wroclaw, Warsaw, Rzeszów, Gdansk, Gdynia, Częstochowa, Iława, Katowice

2023-11-15

Active, closed

Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.

NCT06042478Chronic Spontaneous Urticaria

DrugsOmalizumab·Remibrutinib

Novartis Pharmaceuticals

Phase 3

470

Krosno, Gdansk

2023-11-15

Active, closed

A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease.

NCT06063967Crohn's Disease

DrugsSkyrizi·Risankizumab

AbbVie

Phase 3

289

Krakow, Warsaw

2023-11-15

Recruiting

Functional Links Between the Temporomandibular Joint and the Pelvis in Gynecology

NCT05978414Prolapse; Female, Endometriosis-related Pain

Poznan University of Physical Education

Not applicable

200

Poznan

2023-11-14

Recruiting

ChAracterization of Patients and Treatment OUtcomes in Severe Tricuspid Regurgitation

NCT06838611Tricuspid Regurgitation, Heart Failure, Valve Heart Disease

Medical University of Warsaw

Observational

300

Warsaw

2023-11-14

Active, closed

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

NCT06112379Breast Cancer

DrugsDato-DXd·Epirubicin·Xeloda·Olaparib

AstraZeneca

Phase 3

1,902

Bialystok, Bydgoszcz, Gdynia, Krakow, Lodz, Warsaw

2023-11-14

Active, closed

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

NCT06062420Neoplasms, Head and Neck

DrugsRemzistotug·Nelistotug·Belrestotug·Dostarlimab

GlaxoSmithKline

Phase 2

316

Bielsko-Biala, Katowice, Krakow, Przemyśl, Siedlce, Warsaw

2023-11-14

Active, closed

A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma

NCT06097364Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

733

Krakow, Skorzewo, Bydgoszcz, Gdansk, Katowice, Lodz, Lublin, Warsaw

2023-11-14

Recruiting

A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma

NCT05583617Multiple Myeloma

DrugsCevostamab·Iberdomide·Tocilizumab·Lenalidomide

Hoffmann-La Roche

Phase 1/2

200

Gda?sk, Olsztyn, Późna

2023-11-14

Active, closed

[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

NCT05870579Breast Cancer

DrugsGa-NeoB·Lu-NeoB·Ribociclib·Fulvestrant

Novartis Pharmaceuticals

Phase 1

Gliwice

2023-11-13

Active, closed

Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease

NCT06075706Steroid-refractory Acute Graft-versus-host Disease

DrugMC0518

medac GmbH

Phase 2

Wroclaw, Lublin, Poznan

2023-11-13

Active, closed

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

NCT06074588Non-small Cell Lung Cancer (NSCLC)

DrugsTaxotere·Sacituzumab tirumotecan·Pemetrexed·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

556

Bydgoszcz, Torun, Warsaw, Przemyśl, Gliwice, Kielce

2023-11-12

Active, closed

Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)

NCT06073821CLL

DrugsSonrotoclax·Zanubrutinib·Obinutuzumab·Venetoclax

BeOne Medicines

Phase 3

652

Lodz, Lublin, Poznan, Warsaw, Wroclaw

2023-11-11

Active, closed

Study of Multiple-Ascending-Dose Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extrapulmonary Manifestations

NCT05890729Pulmonary Sarcoidosis

Xentria, Inc.

Phase 1/2

Bielsk Podlaski, Lodz

2023-11-10

Active, closed

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma

NCT06097728Unresectable Pleural Mesothelioma

DrugsVolrustomig·Yervoy·Paraplatin·Ipilimumab

AstraZeneca

Phase 3

863

Bystra, Olsztyn, Poznan, Warsaw

2023-11-09

Active, closed

Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)

NCT05925803Systemic Sclerosis, Scleroderma

AstraZeneca

Phase 3

314

Bydgoszcz, Krakow, Lodz, Sosnowiec, Warsaw

2023-11-08

Active, closed

Effects of a Widely Used Vaccine Adjuvant in Subjects With Early Alzheimer's Disease Double-blind Study to Assess the Safety and Efficacy of AD04 in Patients With Early Alzheimer's Disease - ADVANCE

NCT07107074Alzheimer Disease, Early Onset

ADvantage Therapeutics

Phase 2

122

Bialystok, Bydgoszcz

2023-11-08

Active, closed

A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2

NCT06072183Stable Nonsegmental Vitiligo, Active Nonsegmental Vitiligo

DrugRitlecitinib

Pfizer

Phase 3

1,571

Bydgoszcz, Krakow, Warsaw, Bialystok, Katowice, Szczecin, Lodz

2023-11-08

Active, closed

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

NCT06122779Heart Failure

DrugBMS-986435

Bristol-Myers Squibb

Phase 2

227

Lódz, Bialystok

2023-11-07

Active, closed

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

NCT06087835Chronic Kidney Disease With High Proteinuria

DrugDapagliflozin

AstraZeneca

Phase 3

1,835

Chrzanów, Krakow, Lodz, Poznan, Radom, Rzeszów, Szczecin, Warsaw

2023-11-07

Active, closed

Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.

NCT05782907Ulcerative Colitis

DrugUpadacitinib

AbbVie

Phase 3

122

Torun, Warsaw

2023-11-06

Recruiting

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

NCT05696626Metastatic Breast Cancer

DrugsAbemaciclib·Fulvestrant

LeonaBio

Phase 3

600

Biała Podlaska, Gliwice, Krakow, Lodz, Poznan, Wieliszew

2023-10-31

Active, closed

IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

NCT05987332Metastatic Uveal Melanoma

DrugsDarovasertib·Crizotinib·Dacarbazine·Yervoy

IDEAYA Biosciences

Phase 2/3

420

Gdansk, Warsaw

2023-10-31

Active, closed

A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.

NCT05985915Sjogrens Syndrome

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

612

Poznan, Krakow, Wroclaw, Bydgoszcz, Warsaw

2023-10-27

Recruiting

Surgery Versus Endoscopic Resection for Incompletely Removed Early Colon CAnceR

NCT06057350Treatment Side Effects, Colorectal Cancer

Norwegian Department of Health and Social Affairs

Not applicable

304

Warsaw

2023-10-27

Active, closed

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

NCT05899608Non-Small Cell Lung Cancer

DrugsIvonescimab·Pembrolizumab

Summit Therapeutics

Phase 3

1,600

Bydgoszcz, Lodz, Poznan, Prabuty, Warsaw

2023-10-26

Active, closed

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

NCT06025578Progressive Pulmonary Fibrosis

DrugAdmilparant

Bristol-Myers Squibb

Phase 3

1,057

Bydgoszcz, Krakow, Bialystok, Gdansk, Olsztyn, Będzin, Katowice, Lodz

2023-10-25

Active, closed

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

NCT06052059Ulcerative Colitis

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 3

1,109

Poznan, Torun, Krakow, Nowy Targ, Wadowice, Wroclaw, Warsaw, Chorzów

2023-10-25

Recruiting

To Evaluate the Efficacy and Safety of Naxitamab in Patients With Refractory Ewing's Sarcoma (Butterfly)

NCT05968768Ewing Sarcoma

DrugNaxitamab

Anna Raciborska

Phase 2

Warsaw, Wroclaw

2023-10-24

Active, closed

A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.

NCT05984277Metastatic Non-small Cell Lung Cancer

DrugsVolrustomig·Pemetrexed·Paclitaxel·Carboplatin

AstraZeneca

Phase 3

895

Lublin, Poznan, Przemyśl, Radom, Warsaw

2023-10-24

Active, closed

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

NCT05949684Myelodysplastic Syndromes

DrugsEpoetin Alfa·Reblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

402

Wałbrzych, Gdansk, Katowice, Warsaw

2023-10-24

Active, closed

Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure

NCT05598333Congestive Heart Failure

AskBio Inc

Phase 2

150

Chrzanów, Lublin

2023-10-20

Recruiting

Real-world Usage of HyQvia in Multiple Myeloma Adults With Secondary Immunodeficiency

NCT05879757Multiple Myeloma, Secondary Immunodeficiency (SID)

Takeda

Observational

Szczecin

2023-10-17

Active, closed

A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

NCT06075667Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

160

Warsaw, Zabrze, Lodz

2023-10-16

Active, closed

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation

NCT06045806Multiple Myeloma

DrugsIdecabtagene vicleucel·Endoxan·Fludara·Cytoxan

Celgene

Phase 3

Lublin, Warsaw, Gliwice, Gdansk, Poznan

2023-10-16

Active, closed

A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults

NCT06047444Chronic Migraine

DrugsDysport·Botulinum toxin type A

Ipsen

Phase 3

759

Bydgoszcz, Gdynia, Katowice, Krakow, Lublin, Oświęcim

2023-10-12

Active, closed

A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)

NCT06095102Plaque Psoriasis

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

311

Bialystok, Krakow, Lodz, Osielsko, Poznan, Warsaw, Wroclaw

2023-10-12

Active, closed

A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis

NCT06095115Plaque Psoriasis

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

684

Bialystok, Elblag, Krakow, Lodz, Osielsko, Poznan, Warsaw, Wroclaw

2023-10-12

Recruiting

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

NCT06012240Alopecia Areata

DrugUpadacitinib

AbbVie

Phase 3

1,500

Osielsko, Torun, Krakow, Wroclaw, Warsaw, Bialystok, Katowice, Elblag

2023-10-11

Active, closed

Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

NCT06008756Arteriosclerosis, Hypercholesterolaemia

DrugEnlicitide Decanoate

Merck Sharp & Dohme LLC

Phase 3

14,550

Poznan, Bydgoszcz, Torun, Chrzanów, Krakow, Tarnów, Legnica, Lublin

2023-10-09

Active, closed

A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants

NCT06045689Myelodysplastic Syndromes

DrugsReblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

106

Lódz, Warsaw, Katowice, Wałbrzych

2023-10-05

Active, closed

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

NCT05952557Breast Cancer, Early Breast Cancer

DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole

AstraZeneca

Phase 3

5,511

Bialystok, Biała Podlaska, Bydgoszcz, Gdansk, Gdynia, Koszalin, Krakow, Lodz

2023-10-05

Active, closed

To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL

NCT06072131Peripheral T Cell Lymphoma

DrugsBelinostat·Pralatrexate·CHOP·Prednisone

Acrotech Biopharma Inc.

Phase 3

504

Wroclaw, Krakow, Warsaw, Lodz

2023-10-04

By invitation

A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

NCT06044337Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus

DrugLitifilimab

Biogen

Phase 3

306

Warsaw, Rzeszów

2023-10-03

Recruiting

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

NCT05755386IC-MPGN

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

106

Poznan, Bialystok, Krakow, Olsztyn, Warsaw, Wroclaw

2023-10-02

Active, closed

A Phase III Trial Comparing Tisagenlecleucel to Standard of Care (SoC) in Adult Participants With r/r Follicular Lymphoma

NCT05888493Follicular Lymphoma (FL)

DrugTisagenlecleucel

Novartis Pharmaceuticals

Phase 3

109

Poznan, Gliwice, Gdansk, Lodz

2023-10-02

Recruiting

Effects of β-alanine and Sodium Bicarbonate Supplementation on Physical Capacity and Biochemical Markers Concentrations

NCT07092930Supplementation, Sports, Female Athletes

Poznan University of Physical Education

Phase 3

100

Poznan

2023-10-01

Recruiting

Telemedical Algorithm-Supported Care for Hypertension

NCT06722625Arterial Hypertension, Cardiovascular Diseases

Poznan University of Medical Sciences

Not applicable

200

Poznan

2023-10-01

By invitation

Effects of Transcranial Direct Current Stimulation on Cognitive Rehabilitation in Schizophrenia

NCT07273175Cognitive Impairments, Schizophrenia

Medical University of Lodz

Not applicable

120

Lodz

2023-10-01

Active, closed

Empagliflozin in the Prevention of Cardiotoxicity in Cancer Patients Undergoing Chemotherapy Based on Anthracyclines

NCT05271162Cardiotoxicity

DrugDapagliflozin

Maria Sklodowska-Curie National Research Institute of Oncology

Phase 3

220

Warsaw

2023-09-30

Active, closed

A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults

NCT06047457Episodic Migraine

DrugsDysport·Botulinum toxin type A

Ipsen

Phase 3

751

Bydgoszcz, Gdynia, Katowice, Krakow, Lublin, Oświęcim

2023-09-29

Active, closed

A Long-term Study of STAR-0215 in Participants With Hereditary Angioedema

NCT06007677Hereditary Angioedema

DrugNavenibart

Astria Therapeutics, Inc.

Phase 2

Krakow

2023-09-26

Active, closed

A Study of Obexelimab in Patients With Warm Autoimmune Hemolytic Anemia (SApHiAre)

NCT05786573Warm Autoimmune Hemolytic Anemia

DrugObexelimab

Zenas BioPharma (USA), LLC

Phase 3

134

Gdansk

2023-09-25

Recruiting

Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)

NCT06079671Locally Advanced Cervical Cancer

DrugVolrustomig

AstraZeneca

Phase 3

800

Bialystok, Gdansk, Gliwice, Krakow, Lodz, Poznan, Warsaw, Wroclaw

2023-09-22

Active, closed

Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)

NCT06088290Leiomyosarcoma

DrugsLurbinectedin·Doxorubicin

PharmaMar

Phase 3

469

Warsaw, Gdynia

2023-09-21

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A

NCT05987449Hemophilia A

Hoffmann-La Roche

Phase 1/2

Gda?sk, Warsaw

2023-09-21

Active, closed

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

NCT06047080Large B-Cell Lymphoma

DrugsPolatuzumab Vedotin·Glofitamab·Doxorubicin·Prednisone

Hoffmann-La Roche

Phase 3

1,130

Brzozów, Gda?sk, Katowice, Kielce, Krakow, Wroc?aw

2023-09-18

Recruiting

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05730036Relapsed Refractory Multiple Myeloma (RRMM)

DrugsElotuzumab·Linvoseltamab·Pomalidomide·Dexamethasone

Regeneron Pharmaceuticals

Phase 3

410

Gdansk, Bydgoszcz, Katowice, Lublin, Lodz

2023-09-18

Active, closed

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis

NCT06003426Idiopathic Pulmonary Fibrosis

DrugAdmilparant

Bristol-Myers Squibb

Phase 3

1,255

Bydgoszcz, Bialystok, Gdansk, Olsztyn, Lodz

2023-09-14

Active, closed

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

NCT05904886Hepatocellular Carcinoma

DrugsTiragolumab·Tecentriq·Avastin·Atezolizumab

Hoffmann-La Roche

Phase 3

687

Mysłowice, Warsaw

2023-09-14

By invitation

A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy

NCT05979441Myositis, Active Idiopathic Inflammatory Myopathy, Dermatomyositis, Polymyositis

DrugEfgartigimod PH20

argenx

Phase 3

240

Lodz, Szczecin

2023-09-12

Recruiting

International Prospective REgistry on Pre-pectorAl Breast REconstruction

NCT05817175Breast Cancer

European Breast Cancer Research Association of Surgical Trialists

Observational

1,236

Zielona Góra

2023-09-12

Active, closed

A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome

NCT05946941Sjögren's Syndrome

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

774

Krakow, Warsaw, Bydgoszcz, Lublin, Poznan, Wroclaw

2023-09-11

Recruiting

A Study to Investigate PK, Safety, Tolerability of Cefepime-enmetazobactam in Pediatric Participants With cUTI

NCT05826990Complicated Urinary Tract Infection

Orchid Pharma Europe GmbH

Phase 2

Łomianki

2023-09-11

Recruiting

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

NCT05894239Metastatic Breast Cancer

DrugsPhesgo·Inavolisib

Hoffmann-La Roche

Phase 3

230

Bydgoszcz, Gda?sk, Gdynia, Gliwice, Konin, Koszalin, Późna, Warsaw

2023-09-08

Active, closed

Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine

NCT05846230Bronchiectasis

DrugVerducatib

Boehringer Ingelheim

Phase 2

268

Bialystok, Piaseczno, Świdnik, Warsaw, Wroclaw

2023-09-08

Recruiting

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

NCT06051617Primary Biliary Cholangitis

DrugSeladelpar

Gilead Sciences

Phase 3

402

Mysłowice, Wroclaw

2023-09-07

Recruiting

The ReTAVI Prospective Observational Registry

NCT05601453Structural Valve Deterioration, Structural Valve Degeneration, Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction

Institut für Pharmakologie und Präventive Medizin

Observational

250

Bialystok, Gdansk, Katowice, Krakow, Warsaw, Wroclaw

2023-09-05

Recruiting

The Effect of Allopurinol on the Risk of Cardiovascular Events in Patients with Cardiovascular Risk

NCT05943821Cardiovascular Diseases, Uric Acid

DrugAllopurinol

Poznan University of Medical Sciences

Phase 3

1,116

Poznan

2023-09-01

Recruiting

Pacemaker Implantation Versus Cardioneuroablation for Functional Atrioventricular Block

NCT05774262Atrioventricular Block

American Heart of Poland

Not applicable

300

Dąbrowa Górnicza, Mielec

2023-09-01

Active, closed

Enlighten Study: The EV-ICD Post Approval Registry

NCT06048731Ventricular Arrhythmia, Tachycardia

Medtronic

Observational

1,000

Poznan, Warsaw, Zabrze

2023-09-01

By invitation

Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain

NCT05676827TMD, Masticatory Muscle Pain

Wroclaw Medical University

Observational

102

Wroclaw

2023-09-01

Active, closed

A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)

NCT06081894Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy

DrugAficamten

Cytokinetics

Phase 3

500

Katowice

2023-08-31

Active, closed

A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)

NCT06041269Rheumatoid Arthritis

DrugRosnilimab

AnaptysBio, Inc.

Phase 2

420

Poznan, Torun, Nowa Sól, Warsaw, Opole, Bytom, Bialystok, Bydgoszcz

2023-08-31

Active, closed

A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC

NCT05884398Metastatic Castrate-sensitive Prostate Cancer

DrugApalutamide

Janssen Research & Development, LLC

Phase 3

420

Bydgoszcz, Koszalin, Warsaw, Wroclaw

2023-08-31

Recruiting

A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis

NCT06016842Primary Biliary Cholangitis (PBC)

DrugElafibranor

Ipsen

Phase 3

276

Elblag, Katowice, Krakow, Lodz, Lublin, Małogoskie, Rzeszów, Sosnowiec

2023-08-31

Active, closed

A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations

NCT06052267Asthma

DrugAlbuterol Sulfate

Teva Branded Pharmaceutical Products R&D LLC

Phase 3

2,769

Bialystok, Bydgoszcz, Elblag, Gdansk, Krakow, Lodz, Lublin, Maków Podhalański

2023-08-30

Recruiting

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)

NCT06064890Frontotemporal Dementia, FTD, FTD-GRN, Dementia, Frontotemporal

AviadoBio Ltd

Phase 1/2

Katowice, Szczecin, Warsaw

2023-08-30

Recruiting

A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)

NCT06126224Psychosis Associated With Alzheimer's Disease

DrugKarXT

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 3

500

Lublin, Lodz, Sopot, Katowice, Bydgoszcz, Siemianowice Śląskie, Ścinawa

2023-08-28

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

NCT06023589Asthma

DrugTezepelumab

AstraZeneca

Phase 3

231

Lodz, Tarnów

2023-08-24

Active, closed

A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis

NCT05995964Atopic Dermatitis

DrugTilrekimig

Pfizer

Phase 2

507

Poznan, Krakow, Wroclaw, Katowice, Ostrowiec Świętokrzyski

2023-08-22

Active, closed

A Study of Ianalumab (VAY736) in Patients With Primary Immune Thrombocytopenia (ITP) Previously Treated With at Least Two Lines of Therapies

NCT05885555Primary Immune Thrombocytopenia (ITP)

DrugIanalumab

Novartis Pharmaceuticals

Phase 2

Katowice

2023-08-16

Active, closed

A Study to Evaluate Long-term Safety of Ecopipam Tablets in Children, Adolescents and Adults With Tourette's Disorder

NCT06021522Tourette Syndrome

Emalex Biosciences Inc.

Phase 3

150

Katowice, Gdansk, Poznan, Krakow

2023-08-16

Recruiting

Study of the Effectiveness of Treatment of Sarcopenia With the Use of a Medicinal Product (Nandrolone), Comprehensive Physiotherapy and Diet

NCT05978206Sarcopenia

National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland

Phase 2

168

Warsaw

2023-08-10

Active, closed

Comparing Decision on Aesthetics After Breast Cancer Locoregional Treatment.

NCT05196269Breast Cancer

Fundacao Champalimaud

Not applicable

1,030

Gdansk

2023-08-08

Active, closed

A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

NCT05797610Primary IgA Nephropathy

Hoffmann-La Roche

Phase 3

459

Krakow, Lodz, Opole, Poznan, Warsaw

2023-08-08

Active, closed

Cladribine Tablets Level of Response Predictors in Clinical Practice (CLODINA)

NCT05797740Multiple Sclerosis

DrugsMavenclad·Cladribine

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Observational

366

Krakow, Poznan, Szczecin

2023-08-03

Recruiting

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

NCT05855200Colonic Neoplasms, Neoplasms, Colon

DrugsCapeox·Dostarlimab·Folfox

GlaxoSmithKline

Phase 3

892

Bydgoszcz, Warsaw

2023-08-01

Recruiting

Stereotactic Re-irradiation of Local Recurrences of Prostate Cancer After Radiotherapy

NCT06201078Local Recurrence of Malignant Tumor of Prostate, Radiotherapy

Maria Sklodowska-Curie National Research Institute of Oncology

Phase 2

Gliwice

2023-07-31

Active, closed

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

NCT05843643Systemic Lupus Erythematosus

DrugUpadacitinib

AbbVie

Phase 3

1,014

Poznan, Bydgoszcz, Warsaw, Olsztyn

2023-07-25

Active, closed

Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease

NCT05910528Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 2

Szczecin, Warsaw

2023-07-24

Active, closed

A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

NCT05933577Melanoma

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

1,089

Poznan, Bydgoszcz, Siedlce, Warsaw, Bialystok, Gdansk, Gliwice, Szczecin

2023-07-19

Recruiting

Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

NCT05639933Acneiform Eruption Due to Chemical, Xerosis Cutis, Paronychia

Hoth Therapeutics, Inc.

Phase 2

152

Krakow, Lublin

2023-07-19

Recruiting

Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

NCT05797831Endometrial Cancer

DrugNavtemadlin

Kartos Therapeutics, Inc.

Phase 2/3

268

Bialystok, Gdansk, Gliwice, Krakow, Olsztyn, Poznan, Warsaw, Wroclaw

2023-07-17

Active, closed

Pembrolizumab in Combination With Eftilagimod Alpha and Radiotherapy in Neoadjuvant Treatment of Patients With Soft Tissue Sarcoma - EFTISARC-NEO Trial

NCT06128863Neoadjuvant, Immunotherapy, Sarcoma,Soft Tissue, Radiation Therapy

DrugsEfti·Keytruda

Maria Sklodowska-Curie National Research Institute of Oncology

Phase 2

Warsaw

2023-07-17

Active, closed

Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension

NCT05968430Hypertension

Mineralys Therapeutics Inc.

Phase 3

1,076

Katowice, Lodz, Olsztyn, Skierniewice, Warsaw

2023-07-14

Recruiting

The Effect of Sacubitril/Valsartan Versus Ramipril on Left Ventricular Function and Remodeling in Patients With Ischemic Heart Failure With Mid-range Ejection Fraction

NCT05508035Heart Failure With Moderately Reduced Ejection Fraction

DrugsRamipril·Sacubitril / Valsartan

John Paul II Hospital, Krakow

Phase 3

488

Krakow

2023-07-13

Recruiting

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

NCT05980949Psychosis Associated With Alzheimer's Disease

DrugKarXT

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 3

1,000

Poznan, Lodz, Lódz, Gdansk, Iława, Bydgoszcz, Katowice, Kielce

2023-07-11

Active, closed

24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 - <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up

NCT05677451Chronic Spontaneous Urticaria

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

100

Lodz

2023-07-11

Active, closed

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma

NCT05851443Moderate to Severe Asthma

DrugsICS/LABA·Povorcitinib

Incyte Corporation

Phase 2

247

Bialystok, Gdansk, Krakow, Lubin, Ostrowiec Świętokrzyski, Warsaw

2023-07-11

Active, closed

Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)

NCT05853367Metastatic Solid Tumors, Advanced Solid Tumors

DrugsCalderasib·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 1

Warsaw, Gdansk

2023-07-06

Recruiting

Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement

NCT05727176Advanced Cholangiocarcinoma, FGFR2 Fusions, Gene Rearrangement

DrugFutibatinib

Taiho Oncology, Inc.

Phase 2

120

Koszalin, Lublin, Otwock, Warsaw

2023-07-05

Recruiting

Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

NCT05549258Neuromyelitis Optica Spectrum Disorder

DrugInebilizumab

Amgen

Phase 2

Gdansk

2023-07-03

Recruiting

Cognitive Functioning in Adults With Somatic Diseases and General Population From a Biopsychosocial Perspective

NCT06365658Aphasia, Development, Human, Neuropathology

Bartosz M. Radtke

Observational

600

Gdansk

2023-07-03

Recruiting

Angio-based Final Functional Effect of PCI

NCT06255678Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome, Chronic Coronary Syndrome

Medical University of Warsaw

Observational

2,005

Warsaw

2023-07-03

Active, closed

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

NCT05878769Chronic Obstructive Pulmonary Disease

Hoffmann-La Roche

Phase 3

2,000

Trzebnica, Wroclaw, Lodz, Bia?ystok, Bydgoszcz, Chojnice, Gdynia, Grudzadz

2023-06-28

Active, closed

Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy

NCT05696717Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy

Theravance Biopharma

Phase 3

102

Gdansk, Katowice, Krakow, Oświęcim

2023-06-27

Active, closed

Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus

NCT05966480SLE

DrugEnvudeucitinib

Alumis Inc

Phase 2

408

Bytom, Bialystok, Bydgoszcz, Częstochowa, Krakow, Nadarzyn, Poznan, Sosnowiec

2023-06-26

Active, closed

A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus

NCT05672576Lupus Erythematosus, Systemic

DrugCenerimod

Viatris Innovation GmbH

Phase 3

451

Bydgoszcz, Lodz, Poznan, Szczecin, Warsaw

2023-06-26

Active, closed

A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT05776472Paroxysmal Nocturnal Hemoglobinuria

DrugPegcetacoplan

Swedish Orphan Biovitrum

Observational

165

Bialystok, Bydgoszcz, Gdansk, Krakow, Lodz, Lublin, Warsaw

2023-06-26

Recruiting

IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

NCT05742607Non Small Cell Lung Cancer

DrugDurvalumab

Innate Pharma

Phase 2

Bialystok, Krąków, Lublin, Poznan, Prabuty, Warsaw

2023-06-23

Active, closed

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

NCT05827016Multiple Myeloma

DrugsIberdomide·Lenalidomide

Bristol-Myers Squibb

Phase 3

1,230

Bydgoszcz, Gdansk, Gliwice, Katowice, Lublin, Warsaw, Lodz

2023-06-22

Recruiting

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

NCT05427370Coronary Artery Disease, Heart Failure Systolic

Sunnybrook Health Sciences Centre

Not applicable

754

Bialystok, Katowice

2023-06-22

Active, closed

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358Acute Myocardial Infarction, Coronary Artery Disease

Population Health Research Institute

Not applicable

5,100

Legnica, Lubin, Warsaw, Wroclaw

2023-06-22

Recruiting

Novel Setup Algorithm for Cardiac Neuromodulation Therapy

NCT05719454Hypertension, Bradycardia

BackBeat Medical Inc

Not applicable

Krakow, Poznan, Szczecin, Warsaw, Zabrze

2023-06-21

Recruiting

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

NCT05789082Non-Small Cell Lung Cancer

DrugsDivarasib·Pemetrexed·Cisplatin·Carboplatin

Hoffmann-La Roche

Phase 1/2

320

Gda?sk, Krakow, Olsztyn

2023-06-20

Recruiting

Change History and Adopt a Robotic SolutioN for anGioplasty procedurE

NCT05853419Coronary Disease

Robocath

Observational

500

Warsaw

2023-06-20

Active, closed

Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta

NCT05768854Osteogenesis Imperfecta

DrugSetrusumab

Ultragenyx Pharmaceutical Inc

Phase 3

Lodz

2023-06-14

Recruiting

A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments

NCT05714839Multiple Myeloma

DrugsBelantamab mafodotin·Pomalidomide·Dexamethasone

GlaxoSmithKline

Phase 1/2

123

Gdansk, Lublin

2023-06-14

Recruiting

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

NCT05877963Relapsing Multiple Sclerosis

DrugUblituximab

TG Therapeutics, Inc.

Phase 3

800

Bydgoszcz, Katowice, Kielce, Krakow, Lodz, Olsztyn, Poznan, Warsaw

2023-06-13

Active, closed

Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Epidermolysis Bullosa (Phase III, Cross-over)

NCT05464381Epidermolysis Bullosa

DrugAllo-APZ2-OTS

RHEACELL GmbH & Co. KG

Phase 3

Warsaw

2023-06-13

Recruiting

A Study of Eptinezumab in Pediatric Participants With Episodic Migraine

NCT05897320Episodic Migraine

DrugEptinezumab

H. Lundbeck A/S

Phase 3

315

Krakow, Oświęcim, Lublin, Warsaw

2023-06-08

Active, closed

Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism

NCT05778071Chronic Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases

Alexion Pharmaceuticals, Inc.

Phase 3

165

Krakow, Lodz, Warsaw

2023-06-07

Recruiting

A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

NCT05646862Breast Cancer

DrugsBupropion·Omeprazole·Alpelisib·Inavolisib

Hoffmann-La Roche

Phase 3

420

Bydgoszcz, Gdynia, Gliwice, Konin, Koszalin, Krakow, Rzeszów, Warsaw

2023-06-07

By invitation

Long-term Extension Study to Assess Adverse Events of Oral Atogepant Tablets in Pediatric Participants (6 to 17 Years of Age) With Migraine

NCT05707949Migraine Prophylaxis

DrugAtogepant

AbbVie

Phase 3

650

Poznan, Bydgoszcz, Krakow, Lublin, Warsaw, Wroclaw

2023-06-05

Recruiting

A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study

NCT05862285Cancer

DrugsTiragolumab and Atezolizumab·Divarasib·Tiragolumab·Ipatasertib

Hoffmann-La Roche

Phase 3

200

Gda?sk, Koszalin, Warsaw

2023-06-01

By invitation

The Meaning of Dopaminergic Pathway in Sleep Breathing Disorders.

NCT05890911Sleep Apnea, Sleep-Disordered Breathing

Wroclaw Medical University

Observational

100

Wroclaw

2023-06-01

Recruiting

Effectiveness of Low-dose Naltrexone in Patients With Different Types of Vulvodynia

NCT05955313Vulvodynia, Naltrexone, Quality of Life

DrugNaltrexone

Medical University of Lublin

Phase 2

300

Lublin

2023-05-31

Recruiting

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

NCT05714085Heart Failure, Left Ventricular Systolic Dysfunction

DrugVericiguat

Merck Sharp & Dohme LLC

Phase 2/3

342

Gdansk

2023-05-31

Active, closed

Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer

NCT05740566Small Cell Lung Cancer (SCLC)

DrugsAmrubicin·Lurbinectedin·Tarlatamab·Topotecan

Amgen

Phase 3

509

Bystra, Krakow, Poznan

2023-05-31

Active, closed

A Study of Brigatinib as Preferred First Therapy for Adults With Non-Small Cell Lung Cancer (NSCLC) ENTIRETY

NCT05735327Non-small Cell Lung Cancer (NSCLC)

Takeda

Observational

Wroclaw, Poznan, Bydgoszcz, Krakow, Lublin, Warsaw, Rzeszów, Bystra

2023-05-22

Recruiting

A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

NCT05895786Myositis

Pfizer

Phase 3

318

Poznan, Krakow, Warsaw, Bialystok

2023-05-20

Active, closed

A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer

NCT05908734Carcinoma, Non-Small-Cell Lung

DrugsCetrelimab·Amivantamab

Janssen Research & Development, LLC

Phase 1/2

Lublin, Poznan, Warsaw

2023-05-18

Recruiting

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

NCT05442567Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

240

Krakow, Wroclaw, Warsaw, Rzeszów, Gdansk, Katowice, Szczecin, Lodz

2023-05-16

Recruiting

A Phase 2/3,PSMA-T4, Prostate Cancer

NCT05847166Prostate Cancer

NCBJ Polatom: Narodowe Centrum Badań Jądrowych Polatom

Not applicable

Bydgoszcz, Lodz, Warsaw, Wroclaw

2023-05-10

Recruiting

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

NCT05716100Focal Onset Seizures

DrugAzetukalner

Xenon Pharmaceuticals Inc.

Phase 3

360

Gdansk, Lublin, Nowa Sól, Warsaw

2023-05-09

Recruiting

Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction

NCT07595809Heart Failure With Reduced Ejection Fraction

Medical University of Silesia

Not applicable

100

Zabrze

2023-05-08

Active, closed

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

NCT05840211Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast Cancer

DrugsAbraxane·Xeloda·Sacituzumab Govitecan·Taxol

Gilead Sciences

Phase 3

654

Gdansk, Krakow, Lodz, Lublin, Warsaw

2023-05-08

Active, closed

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)

NCT05629234Cancer

DrugsTagrisso·Osimertinib

AstraZeneca

Phase 3

Szczecin

2023-05-08

Active, closed

Cardioneuroablation for Reflex Syncope and Exercise Capacity

NCT06440291Syncope, Vasovagal

Centre of Postgraduate Medical Education

Not applicable

100

Warsaw

2023-05-02

Recruiting

Automated Fetal Cardiac Function in Babies Affected by Heart Diseases

NCT05698277Congenital Heart Defect, Cardiac Function

Anna Erenbourg

Observational

495

Krakow

2023-05-01

Recruiting

Safety and Performance of ENDOMATIC SEPIOLA Left Atrial Appendage (LAA) Closure Device

NCT06099106Atrial Fibrillation

Endomatic Ltd.

Not applicable

Poznan

2023-05-01

Recruiting

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

NCT05711394Episodic Migraine

DrugAtogepant

AbbVie

Phase 3

450

Poznan, Bydgoszcz, Krakow, Lublin, Warsaw, Wroclaw

2023-05-01

Recruiting

Endometriosis and Peritoneal Dysbiosis

NCT05824819Endometriosis, Infertility Unexplained

Jagiellonian University

Not applicable

100

Krakow

2023-05-01

Active, closed

Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)

NCT05804045Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath

DrugPimicotinib

Abbisko Therapeutics Co, Ltd

Phase 3

Warsaw

2023-04-27

By invitation

An Open-label Study of XEN1101 in Epilepsy

NCT05718817Focal Epilepsy, Tonic-Clonic Seizures

DrugAzetukalner

Xenon Pharmaceuticals Inc.

Phase 3

880

Bydgoszcz, Gdansk, Lublin, Nowa Sól, Warsaw

2023-04-25

Active, closed

Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System in Complex PCI Patients

NCT05705973Cardiovascular Disease, Coronary Artery Occlusion, Ischemic Heart Disease

Terumo Europe N.V.

Observational

3,000

Poznan

2023-04-25

Recruiting

Monitoring of Venous Ulcers Using a Bioimpedance Measurement Based Method and System

NCT05805137Venous Ulcer

CutoSense Oy

Not applicable

Gdansk

2023-04-20

Recruiting

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

NCT04124120Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting

Weill Medical College of Cornell University

Not applicable

2,300

Gdansk, Katowice, Zabrze

2023-04-17

Active, closed

Clinical Significance of Adherent Perinephric Fat in Patients Undergoing Partial Nephrectomy

NCT05887245Renal Cell Carcinoma, Kidney Neoplasm, Urologic Neoplasms, Urogenital Neoplasms

Centre of Postgraduate Medical Education

Observational

200

Otwock

2023-04-17

Active, closed

Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab

NCT05626855Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type 2, SMA

DrugApitegromab

Scholar Rock, Inc.

Phase 3

238

Gdansk, Poznan, Warsaw

2023-04-17

Active, closed

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

NCT05645692Urothelial Cancer

DrugsTobemstomig·Tiragolumab·Atezolizumab

Hoffmann-La Roche

Phase 2

204

Koszalin, Krakow, Późna, Warsaw

2023-04-13

Active, closed

A Multifaceted Assessment of Eating Behaviors, Anthropometric Measurements and Body Composition in Pediatric Patients With Drug-resistant Epilepsy on a Ketogenic Diet and Healthy Children

NCT07714226Epilepsy Intractable

Wroclaw Medical University

Observational

150

Wroclaw

2023-04-12

Active, closed

TrEatment Approach in the Multimodal Era Registry

NCT05629052Chronic Thromboembolic Pulmonary Hypertension, CTEPH

International CTEPH Association

Observational

1,000

Krakow, Otwock

2023-04-12

Active, closed

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

NCT05757869Atrial Fibrillation

DrugsMilvexian·Apixaban

Janssen Research & Development, LLC

Phase 3

20,284

Biała Podlaska, Bydgoszcz, Chojnice, Chorzów, Chrzanów, Elblag, Gdansk, Gdynia

2023-04-11

Recruiting

Study of SGR-1505 in Mature B-Cell Neoplasms

NCT05544019Mature B-Cell Neoplasm, Non Hodgkin Lymphoma, DLBCL, Waldenstrom Macroglobulinemia

Schrödinger, Inc.

Phase 1

Gdansk, Lodz, Warsaw

2023-04-10

Active, closed

A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma

NCT05692180Asthma

DrugBenralizumab

AstraZeneca

Phase 3

Bialystok, Krakow, Lodz, Skarżysko-Kamienna, Tarnów

2023-04-05

Active, closed

Comparative Efficacy, Safety, PK, and Immunogenicity Study

NCT05853354Osteoporosis, Postmenopausal

DrugDenosumab

Luye Pharma Group Ltd.

Phase 3

392

Skórzewo, Katowice, Częstochowa, Gdansk, Gdynia, Jelenia Góra, Krakow, Lodz

2023-04-05

Active, closed

A Study Evaluating the Effect of Filgotinib in Participants With Active Axial Spondyloarthritis

NCT05785611Axial Spondyloarthritis

DrugFilgotinib

Alfasigma S.p.A.

Phase 3

495

Bialystok, Elblag, Katowice, Lubin, Lublin, Nowa Sól, Olsztyn, Opole

2023-04-05

Active, closed

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

NCT05794906Biochemically Recurrent Prostate Cancer

DrugDarolutamide

Bayer

Phase 3

985

Bydgoszcz, Kielce, Krakow, Lublin, Warsaw, Wroclaw

2023-04-03

Active, closed

Open Label, Long-term Study Evaluating Safety and Efficacy of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis

NCT05769777Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2

999

Lublin, Lodz, Warsaw, Gdansk, Chorzów, Katowice

2023-04-03

Recruiting

Psychological Factors and Pain in Orthopedic Surgery Patients

NCT06707363Orthopedic Surgical Procedures

Jagiellonian University

Observational

170

Krakow

2023-04-03

Recruiting

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

NCT05774951Breast Cancer, Early Breast Cancer

DrugsCamizestrant·Tamoxifen·Exemestane·Anastrozole

AstraZeneca

Phase 3

4,300

Bialystok, Grudziądz, Koszalin, Lodz, Lublin, Opole, Poznan, Racibórz

2023-03-31

Active, closed

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05572515Multiple Myeloma

DrugsTeclistamab·Carfilzomib·Pomalidomide·Bortezomib

Janssen Research & Development, LLC

Phase 3

614

Gdansk, Katowice, Kielce, Lublin

2023-03-29

Active, closed

A Study of Secukinumab to Evaluate Maintenance of Response in Participants With Non-radiographic Axial Spondyloarthritis Who Achieved Remission

NCT05622708Non-radiographic Axial Spondyloarthritis

DrugSecukinumab

Novartis Pharmaceuticals

Phase 4

240

Krakow, Warsaw, Bydgoszcz, Sochaczew, Torun

2023-03-28

Active, closed

Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System

NCT05501873Atrial Fibrillation

Boston Scientific Corporation

Observational

1,173

Warsaw

2023-03-24

By invitation

Induction of Sustained Unresponsiveness to Sesame Using High- and Low-dose Sesame Oral Immunotherapy

NCT05923216Food Allergy

Medical University of Warsaw

Not applicable

Warsaw

2023-03-24

Active, closed

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

NCT05714202Bladder Cancer

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 3

1,135

Bialystok, Bydgoszcz, Lublin, Piotrkow Trybunalski, Poznan, Słupsk, Warsaw, Wroclaw

2023-03-23

Active, closed

A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)

NCT05624554Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsNemtabrutinib·Riabni·Ruxience·Truxima

Merck Sharp & Dohme LLC

Phase 3

300

Lublin, Warsaw, Gdansk, Katowice, Olsztyn, Kielce

2023-03-16

Recruiting

Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis

NCT05201404Hepatocellular Carcinoma, Cirrhosis

DrugNamodenoson

Can-Fite BioPharma

Phase 3

471

Koszalin, Krakow, Mysłowice, Przemyśl, Warsaw, Wroclaw

2023-03-15

Active, closed

Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer

NCT05445778Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer

DrugsMirvetuximab Soravtansine·Bevacizumab

AbbVie

Phase 3

520

Poznan, Krakow, Siedlce, Gdynia

2023-03-15

By invitation

A Study to Assess the Long-Term Safety and Efficacy of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis

NCT05735483Atopic Dermatitis, Eczema

DrugLebrikizumab

Eli Lilly and Company

Phase 3

338

Warsaw, Krakow, Gdansk, Lodz

2023-03-09

Active, closed

A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

NCT05739383Primary Prevention of Atherosclerotic Cardiovascular Disease

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

14,012

Krakow, Bialystok, Bydgoszcz, Bygdoszcz, Chorzów, Elblag, Gdynia, Grudziądz

2023-03-09

Recruiting

A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works

NCT05744921Paroxysmal Nocturnal Hemoglobinuria

DrugsCemdisiran·Pozelimab

Regeneron Pharmaceuticals

Phase 3

202

Bydgoszcz, Gdansk

2023-03-07

Active, closed

A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma

NCT05625399Melanoma

DrugsPhesgo·Relatlimab·Nivolumab

Bristol-Myers Squibb

Phase 3

579

Bydgoszcz, Krakow, Opole, Poznan, Warsaw

2023-03-06

Recruiting

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

NCT05677971Alpha1-Antitrypsin Deficiency

DrugFazirsiran

Takeda

Phase 3

160

Śląskie, Warsaw

2023-03-06

Active, closed

A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer

NCT05654623Advanced Breast Cancer

DrugsVepdegestrant·Fulvestrant

Pfizer

Phase 3

624

Krakow, Warsaw, Gdansk, Lodz

2023-03-03

Active, closed

Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1)

NCT05639114Systemic Lupus Erythematosus

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

436

Wroclaw, Bydgoszcz, Bytom, Lodz, Warsaw

2023-03-02

Active, closed

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

NCT05669755Cardiovascular Disease

DrugsCagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

7,101

Ruda Śląska, Dąbrówka, Bygdoszcz, Chrzanów, Krakow, Wroclaw, Lublin, Poniatowa

2023-03-01

Active, closed

A Study to Determine the Effect of Triheptanoin Compared With Even-Chain MCT on MCEs in Pediatric Patients With LC-FAOD

NCT05933200Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)

Ultragenyx Pharmaceutical Inc

Phase 3

Warsaw, Gdansk

2023-02-28

Recruiting

The Safety and Feasibility of the eLym™ System

NCT05747196Heart; Decompensation, Congestive

WhiteSwell, Limited

Not applicable

Wroclaw

2023-02-28

Active, closed

Efficacy and Safety of ATX01 in Adult Patients With CIPN (Chemotherapy-induced Peripheral Neuropathy)

NCT05593614Chemotherapy-induced Peripheral Neuropathy

AlgoTherapeutix

Phase 2

276

Konin, Lodz, Tychy, Zabrze

2023-02-28

Recruiting

A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata

NCT05723198Areata Alopecia, Alopecia, Hypotrichosis, Hair Diseases

DrugBaricitinib

Eli Lilly and Company

Phase 3

595

Gdansk, Katowice, Kielce, Krakow, Lodz, Rzeszów, Swietokrzyski, Warsaw

2023-02-27

By invitation

Observation of Clozapine Treatment Safety in Bipolar Disorder.

NCT06011460Bipolar Disorder

DrugClozapine

Medical University of Gdansk

Observational

Gdansk

2023-02-23

By invitation

An Extension Study of JR-141 to Evaluate the Long-term Safety and Efficacy in MPS II (Hunter Syndrome) Subjects

NCT05594992Mucopolysaccharidosis II

DrugJR-141

JCR Pharmaceuticals Co., Ltd.

Phase 3

Krakow

2023-02-22

Active, closed

Telemonitoring of HFrEF Patients

NCT07835490Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)

Medical University of Lodz

Not applicable

Lodz

2023-02-21

Active, closed

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

NCT05676931Advanced Non-Small Cell Lung Cancer

DrugsQuemliclustat·Domvanalimab·Zimberelimab·Docetaxel

Gilead Sciences

Phase 2

400

Gdynia, Katowice, Poznan, Warsaw

2023-02-21

Recruiting

Randomized, Double-blind, Placebo-controlled Trial of the Efficacy and Safety of Tianeptine in the Treatment of Covid Fog Symptoms in Patients After COVID-19.

NCT06012552Nervous System Diseases

Military Institute od Medicine National Research Institute

Phase 2

140

Warsaw

2023-02-17

Recruiting

Lesser Poland Cracovian Heart Failure Registry

NCT05746923Heart Failure, Heart Failure Acute

Jagiellonian University

Observational

2,500

Krakow

2023-02-15

Active, closed

A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

NCT05702034Ischemic Stroke; Ischemic Attack, Transient

DrugMilvexian

Janssen Research & Development, LLC

Phase 3

12,523

Bialystok, Bolesławiec, Bydgoszcz, Chelmie, Działdowo, Grodzisk Mazowiecki, Gryfice, Katowice

2023-02-15

Recruiting

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

NCT05667142Primary Generalized Tonic-Clonic Seizures

DrugAzetukalner

Xenon Pharmaceuticals Inc.

Phase 3

160

Bydgoszcz, Gdansk, Katowice, Lublin, Nowa Sól

2023-02-14

Active, closed

A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)

NCT05722015Metastatic Non-small Cell Lung Cancer

DrugsPegylated filgrastim·Pembrolizumab Formulated with Berahyaluronidase Alfa·Filgrastim·Taxol

Merck Sharp & Dohme LLC

Phase 3

377

Warsaw, Olsztyn, Koszalin

2023-02-14

Active, closed

Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

NCT05711940Treatment Resistant Depression

DrugPsilocybin

COMPASS Pathways

Phase 3

572

Bydgoszcz, Gdansk

2023-02-14

Active, closed

A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A

NCT05685238Haemophilia A, Haemophilia A With Inhibitors

Novo Nordisk A/S

Phase 3

451

Poznan, Wroclaw, Warsaw, Krakow, Lublin

2023-02-13

Recruiting

Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies

NCT05682378Heterozygous or Homozygous Familial Hypercholesterolemia

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

195

Gdansk, Lodz

2023-02-10

Recruiting

Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression

NCT05660798Coronary Artery Disease, Coronary Atherosclerosis, Nicotine Dependence

National Institute of Cardiology, Warsaw, Poland

Not applicable

180

Warsaw

2023-02-09

Active, closed

A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

NCT05578976Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone

Genmab

Phase 3

900

Piła, Skórzewo, Słupsk, Olsztyn, Kielce

2023-02-08

Active, closed

Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)

NCT05609968Carcinoma, Non-Small-Cell Lung

DrugsSacituzumab Govitecan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

614

Poznan, Bydgoszcz, Siedlce, Warsaw, Przemyśl, Prabuty, Racibórz

2023-02-06

Active, closed

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

NCT05686551Huntington Disease

Hoffmann-La Roche

Phase 2

301

Gdansk, Krakow, Warsaw

2023-02-03

Recruiting

Clinical Value and Cost-effectiveness of a Personalized Prevention Program (PPP) in Patients With High Risk Stable CHD

NCT04433052Coronary Heart Disease

Tampere University

Not applicable

12,000

Bialystok, Katowice, Krakow, Lublin, Toruniak, Warsaw

2023-02-01

Recruiting

The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males

NCT06204731Hypoxia, Altitude

University School of Physical Education, Krakow, Poland

Not applicable

Krakow

2023-02-01

Active, closed

Dynamics of Psychotherapy and Treatment Outcomes

NCT07017543Mental Disorders, Neurotic Disorders, Personality Disorders

University Hospital in Krakow

Not applicable

Krakow

2023-02-01

Active, closed

A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adolescent or Adult Participants With Severe Hemophilia

NCT05662319Hemophilia

DrugsAntithrombin·Clotting factor concentrates·Fitusiran

Sanofi

Phase 3

Krakow, Lodz, Warsaw

2023-02-01

Active, closed

A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9

NCT05723835SGA, Turner Syndrome, Noonan Syndrome, ISS

DrugSomapacitan

Novo Nordisk A/S

Phase 3

Rzeszów, Gdansk, Lodz, Zabrze

2023-02-01

Active, closed

Pembrolizumab in the Treatment of Advanced, Progressive Adrenocortical Carcinoma.

NCT05563467Adrenocortical Carcinoma

DrugsKeytruda·Pembrolizumab

Maria Sklodowska-Curie National Research Institute of Oncology

Phase 2

Gliwice, Krakow, Poznan, Warsaw

2023-01-31

Active, closed

A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Eosinophilic Asthma

NCT05748600Eosinophilic Asthma, Asthma; Eosinophilic, Asthma Attack

DrugDexpramipexole Dihydrochloride

Areteia Therapeutics

Phase 3

600

Będzin, Bialystok, Gdansk, Giżycko, Katowice, Krakow, Lodz, Lublin

2023-01-30

Recruiting

First-in-human Phase I Study to Evaluate Safety, Tolerability and Antineoplastic Activity of OATD-02 in Patients With Selected Advanced and/or Metastatic Solid Tumours

NCT05759923Advanced Ovarian Carcinoma, Advanced Renal Cell Carcinoma, Advanced Pancreatic Carcinoma, Advanced Colorectal Carcinoma

Molecure S.A.

Phase 1

Bydgoszcz, Otwock, Warsaw

2023-01-26

Active, closed

Study to Assess SLN124 in Patients With Polycythemia Vera

NCT05499013Polycythemia Vera

Silence Therapeutics plc

Phase 1/2

Gdansk, Katowice, Lublin

2023-01-26

Recruiting

Placebo Controlled Study to Assess the Efficacy and Safety of Rapamycin in Drug Resistant Epilepsy Associated With Tuberous Sclerosis Complex

NCT05534672Tuberous Sclerosis Complex

Katarzyna Kotulska

Phase 3

200

Lodz, Warsaw

2023-01-23

Recruiting

A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

NCT04782258Autosomal Recessive Polycystic Kidney (ARPKD)

DrugTolvaptan

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 3

Warsaw, Bialystok

2023-01-23

Recruiting

Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)

NCT05587712Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

Warsaw, Gdansk

2023-01-19

Active, closed

A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy

NCT05405361Multifocal Motor Neuropathy (MMN)

DrugEmpasiprubart

argenx

Phase 2

Krakow, Warsaw

2023-01-18

Active, closed

SKB264 in Combination With Pembrolizumab in Subjects With Selected Solid Tumors

NCT05642780Solid Tumor

DrugsSacituzumab tirumotecan·Keytruda·Pembrolizumab

Klus Pharma Inc.

Phase 2

240

Gdynia, Krakow, Warsaw

2023-01-17

Active, closed

A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery

NCT05608291Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,564

Siedlce, Gdansk, Słupsk, Poznan

2023-01-16

Active, closed

ABTECT - Maintenance

NCT05535946Ulcerative Colitis

DrugObefazimod

Abivax S.A.

Phase 3

1,116

Bialystok, Bydgoszcz, Kalisz, Kielce, Knurów, Krakow, Lodz, Lublin

2023-01-16

Active, closed

Physical Activity, Posture and Body Composition in Ontogeny

NCT06419829Pediatric Obesity, Postural Balance, Physical Activity

Wroclaw University of Health and Sport Sciences

Observational

1,000

Wroclaw

2023-01-15

Recruiting

Determining the Frequency of Occurrence and Defining the Most Appropriate Screening Test for Anal Intraepithelial Neoplasia (AIN) in Patients With Human Papillomavirus (HPV) Related Gynecological Diseases.

NCT06574087HPV-Related Carcinoma, HPV Infection

PCK Marine Hospital in Gdynia

Not applicable

248

Gdynia

2023-01-13

Active, closed

A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)

NCT05617677Systemic Lupus Erythematosus

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

516

Poznan, Bydgoszcz, Krakow, Nadarzyn, Warsaw, Katowice, Bialystok, Lublin

2023-01-12

Active, closed

A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus

NCT05620407Systemic Lupus Erythematosus

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

513

Poznan, Krakow, Lublin, Warsaw, Chorzów, Elblag, Szczecin, Wroclaw

2023-01-12

Active, closed

Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

NCT05555732Metastatic Non Small Cell Lung Cancer

DrugsDato-DXd·Pemetrexed·Keytruda·Cisplatin

Daiichi Sankyo

Phase 3

1,233

Bialystok, Lodz, Lublin, Poznan, Warsaw

2023-01-11

Active, closed

A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease

NCT05668013Crohn Disease, Colitis, Ulcerative

DrugDuvakitug

Teva Branded Pharmaceutical Products R&D LLC

Phase 2

247

Bydgoszcz, Częstochowa, Elblag, Gdansk, Katowice, Krakow, Kłodzko, Lodz

2023-01-11

Recruiting

Multicenter Assessment of Clinical Utility PET / MR With the Use of the Radiotracer 68Ga-PSMA-11 in Therapy Planning Personalized in Patients With Prostate Cancer

NCT05582876Prostate Cancer

Medical University of Bialystok

Not applicable

366

Bialystok, Bydgoszcz, Lodz, Lublin

2023-01-10

Recruiting

Alleviant ALLAY-HF Study

NCT05685303Heart Failure

Alleviant Medical, Inc.

Not applicable

700

Opole, Poznan, Wejherowo, Wroclaw, Zabrze

2023-01-10

Active, closed

A Phase 3 Study of Obexelimab in Patients With IgG4-Related Disease

NCT05662241IgG4 Related Disease

DrugObexelimab

Zenas BioPharma (USA), LLC

Phase 3

194

Warsaw, Bydgoszcz

2023-01-09

Recruiting

Xanthohumol as an Adjuvant in the Treatment of Septic Shock

NCT06225258Septic Shock, Pneumonia, ARDS

Medical University of Lublin

Phase 2

Lublin

2023-01-09

Recruiting

Ketoanalogues for Muscle Mass Loss in Nephrotic Syndrome

NCT05716880Nephrotic Syndrome

Military Institute od Medicine National Research Institute

Phase 3

150

Warsaw

2023-01-03

Recruiting

Neoadjuvant Endocrine Therapy +/- the PI3K Inhibitor Inavolisib in HER2+, HR+, PIK3CA Mutant Early Breast Cancer

NCT05306041HER2-positive Breast Cancer

DrugsPhesgo·Inavolisib

GBG Forschungs GmbH

Phase 2

170

Warsaw

2023-01-02

Active, closed

Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma

NCT05678673Non-Clear Cell Renal Cell Carcinoma

DrugsSunitinib Malate·Zanzalintinib·Sunitinib·Opdivo

Exelixis

Phase 3

317

Bydgoszcz, Gdansk, Otwock, Poznan, Rzeszów

2023-01-01

Active, closed

Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)

NCT05024773Bladder Carcinoma in Situ (CIS)

Fidia Farmaceutici s.p.a.

Phase 3

130

Przemyśl, Warsaw, Lublin

2022-12-29

Active, closed

Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations

NCT05687266NSCLC

DrugsDato-DXd·Durvalumab·Pemetrexed·Paclitaxel

AstraZeneca

Phase 3

1,350

Bydgoszcz, Bystra, Grudziądz, Kielce, Koszalin, Olsztyn, Poznan, Przemyśl

2022-12-29

By invitation

Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema

NCT05396105Hereditary Angioedema, Hereditary Angioedema Type I, Hereditary Angioedema Type II, Hereditary Angioedema Types I and II

DrugDeucrictibant

Pharvaris Netherlands B.V.

Phase 2/3

150

Krakow

2022-12-28

Recruiting

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

NCT05712200Atrial Fibrillation (AF)

DrugAbelacimab

Anthos Therapeutics, Inc.

Phase 3

2,500

Bialystok, Czeladź, Elblag, Gdynia, Katowice, Krakow, Legnica, Lodz

2022-12-27

Recruiting

A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

NCT05645107Hypogammaglobulinemia, Bacterial Infections, B-cell Chronic Lymphocytic Leukemia, Multiple Myleoma

DrugXembify

Grifols Therapeutics LLC

Phase 3

386

Torun, Krakow, Legnica, Wałbrzych, Słupsk, Bydgoszcz, Olsztyn

2022-12-26

Active, closed

Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)

NCT05531526Alzheimer Disease

AriBio Co., Ltd.

Phase 3

1,535

Bialystok, Katowice, Ścinawa, Warsaw, Wroclaw

2022-12-23

Active, closed

Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)

NCT05429268Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma

DrugsTafasitamab·Lenalidomide

Incyte Corporation

Phase 3

Bydgoszcz, Gdansk, Gdynia, Lublin, Olsztyn, Skórzewo, Warsaw, Wroclaw

2022-12-23

Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

NCT04953910Acute Myeloid Leukemia, Myelodysplastic Syndromes

DrugDecitabine

Taiho Oncology, Inc.

Phase 1

Wroclaw

2022-12-23

Recruiting

MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatment

NCT05723718Gastric Cancer, Gastric Adenocarcinoma, Malnutrition, Cachexia

Medical University of Lublin

Observational

125

Lublin

2022-12-20

Recruiting

Assessment of Outcomes of Double-bundle Posterior Cruciate Ligament Reconstruction (DB-PCLR)

NCT05701592Posterior Cruciate Ligament Tear

Konrad Malinowski MD

Observational

Bełchatów

2022-12-20

Recruiting

A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia

NCT05669950Congenital Adrenal Hyperplasia

DrugLu AG13909

H. Lundbeck A/S

Phase 1/2

Dobry Lekarz

2022-12-19

Recruiting

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

NCT05549297Advanced Melanoma

DrugTebentafusp

Immunocore Ltd

Phase 3

540

Bydgoszcz, Gdansk, Poznan, Warsaw

2022-12-19

Recruiting

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

NCT05287126Ulcerative Colitis

DrugEtrasimod

Pfizer

Phase 2

Warsaw, Katowice, Krakow, Szczecin, Wroclaw

2022-12-16

Recruiting

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

NCT05232916Breast Cancer

Greenwich LifeSciences, Inc.

Phase 3

2,250

Gdansk, Konin, Krakow, Opole, Poznan, Rzeszów, Słupsk, Warsaw

2022-12-16

Active, closed

A Study of Daratumumab

NCT05438043Multiple Myeloma

DrugsCarfilzomib·Pomalidomide·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

214

Legnica, Poznan

2022-12-15

Active, closed

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)

NCT05469737Myelodysplastic Syndromes

DrugAzacitidine

Bristol-Myers Squibb

Phase 2/3

230

Olsztyn

2022-12-14

Active, closed

Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial

NCT05581303Atherosclerotic Cardiovascular Disease

DrugOlpasiran

Amgen

Phase 3

7,297

Bełchatów, Bielsko-Biala, Chrzanów, Dąbrowa Górnicza, Dębica, Gdansk, Giżycko, Kędzierzyn-Koźle

2022-12-14

Active, closed

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

NCT05488314Carcinoma, Non-Small-Cell Lung

DrugsCapmatinib·Amivantamab

Janssen Research & Development, LLC

Phase 1/2

Gdansk, Lublin, Warsaw

2022-12-13

Active, closed

A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus

NCT05648500Lupus Erythematosus, Systemic

DrugCenerimod

Viatris Innovation GmbH

Phase 3

470

Bialystok, Częstochowa, Katowice, Krakow, Lublin, Wroclaw

2022-12-13

Active, closed

A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)

NCT05668988Non-small Cell Lung Cancer

DrugsSunvozertinib·Pemetrexed·Carboplatin

Dizal Pharmaceuticals

Phase 3

324

Gdansk, Poznan, Przemyśl, Warsaw

2022-12-13

Active, closed

CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

NCT05681351Severe Hypertriglyceridemia

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

885

Gdansk, Józefów, Katowice, Lodz, Lublin, Poznan, Tarnów, Warsaw

2022-12-13

Recruiting

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

NCT05624450Viral Lung Infection and Acute Respiratory Failure

DrugTozorakimab

AstraZeneca

Phase 3

3,527

Chrzanów, Lodz, Rzeszów, Warsaw, Wroclaw, Łańcut, Łęczna

2022-12-13

Active, closed

An Extension Study of Long-term Efficacy, Safety and Tolerability of Remibrutinib in Chronic Spontaneous Urticaria Patients Who Completed Preceding Studies With Remibrutinib

NCT05513001Chronic Spontaneous Urticaria

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

696

Bialystok, Lodz, Poznan, Warsaw

2022-12-09

Active, closed

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

NCT05501886Breast Cancer

DrugsGedatolisib·Alpelisib·Palbociclib·Fulvestrant

Celcuity Inc

Phase 3

701

Bydgoszcz, Konin, Krakow, Lodz, Opole, Siedlce, Szczecin, Warsaw

2022-12-08

Active, closed

Study to Evaluate the Efficacy of Immunosuppression in Myocarditis or Inflammatory Cardiomyopathy.

NCT04654988Myocarditis, Heart Failure, Endomyocardial Biopsy, Cardiomyopathies, Secondary

DrugsAzathioprine·Prednisone

Medical University of Warsaw

Phase 4

100

Warsaw

2022-12-01

By invitation

An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

NCT05667493Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

DrugEplontersen

Ionis Pharmaceuticals, Inc.

Phase 3

1,400

Krakow

2022-11-30

Active, closed

Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis

NCT05588843Colitis Ulcerative

Sanofi

Phase 2

187

Włocławek, Wroclaw, Łęczna, Warsaw, Gdynia, Katowice, Tychy, Krakow

2022-11-25

Active, closed

Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and Efficacy in Subjects Without F508del

NCT05331183Cystic Fibrosis

DrugsELX/TEZ/IVA·Ivacaftor·Elexacaftor/Tezacaftor/Ivacaftor

Vertex Pharmaceuticals Incorporated

Phase 3

297

Gdansk, Łomianki

2022-11-23

Active, closed

Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation

NCT05609578Advanced NSCLC, Metastatic Lung Cancer

DrugAdagrasib

Mirati Therapeutics Inc.

Phase 2

Lodz, Poznan, Warsaw

2022-11-22

Active, closed

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Observational

6,000

Olsztyn, Poznan, Warsaw, Wałbrzych

2022-11-21

Active, closed

A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)

NCT05394116Fibrodysplasia Ossificans Progressiva

Regeneron Pharmaceuticals

Phase 3

Rzeszów

2022-11-21

Active, closed

Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis

NCT05556096Generalized Myasthenia Gravis

Alexion Pharmaceuticals, Inc.

Phase 3

260

Bydgoszcz, Katowice, Krakow, Lublin, Poznan

2022-11-21

Recruiting

A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma

NCT05533775Mature B-Cell Non-Hodgkin Lymphoma

DrugsIfosfamide·Glofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

Wroclaw

2022-11-16

Active, closed

Dazucorilant in Patients With Amyotrophic Lateral Sclerosis

NCT05407324Amyotrophic Lateral Sclerosis

Corcept Therapeutics

Phase 2

279

Bydgoszcz, Krakow, Warsaw

2022-11-15

Recruiting

A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant

NCT05623020Multiple Myeloma

DrugsElranatamab·Bortezomib·Daratumumab·Lenalidomide

Pfizer

Phase 3

1,060

Wroclaw, Gdansk, Katowice

2022-11-10

Recruiting

Further Evaluation of Safety and Performance of the NEXUS Aortic Arch Stent Graft System and the Custom-Made NEXUS Multibranch™ Aortic Arch Stent Graft System

NCT05636527AAT9

Endospan Ltd.

Observational

Warsaw

2022-11-09

Active, closed

A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy

NCT05444257Cystic Fibrosis

DrugVNZ/TEZ/D-IVA

Vertex Pharmaceuticals Incorporated

Phase 3

822

Gdansk, Łomianki

2022-11-08

Recruiting

A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria

NCT05457283Chronic Kidney Disease, Proteinuria, Children

DrugFinerenone

Bayer

Phase 3

100

Bialystok, Gdansk, Krakow, Lodz, Warsaw, Wroclaw

2022-11-08

Active, closed

A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)

NCT05490446Myelodysplastic Syndromes

DrugTebapivat

Agios Pharmaceuticals, Inc.

Phase 2

Warsaw, Katowice, Olsztyn

2022-11-07

Active, closed

Xeltis Hemodialysis Access Graft: aXess Pivotal Study

NCT05473299End-stage Renal Disease

Xeltis

Not applicable

120

Poznan, Wroclaw

2022-11-04

Recruiting

Bipolar Radio-frequency Ablation After Standard Unipolar Approach - Prospective Registry.

NCT05707637Ventricular Arrythmia

Centre of Postgraduate Medical Education

Observational

100

Warsaw

2022-11-02

Active, closed

A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)

NCT05170204Non-Small Cell Lung Cancer

DrugsEntrectinib·Alectinib·Durvalumab

Hoffmann-La Roche

Phase 3

Wroc?aw

2022-11-01

Recruiting

Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer

NCT05468554Thyroid Cancer

DrugMetformin

Medical University of Bialystok

Phase 3

160

Bialystok, Kielce

2022-11-01

Recruiting

Vitamin D in Dialysis Patients - Diagnostic and Therapeutic Management

NCT06571344Vitamin D Deficiency Due to Chronic Kidney Disease

DrugCholecalciferol

Medical University of Gdansk

Observational

160

Gdansk

2022-11-01

Recruiting

Evaluation of Clinical Efficacy and Safety of Aortal Stent-Graft Created Using 3D Printing Technology

NCT06969729Abdominal Aortic Aneurysm, Juxtarenal Abdominal Aortic Aneurysm, Pararenal Abdominal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm

Samodzielny Publiczny Szpital Kliniczny nr 2 PUM

Not applicable

100

Szczecin

2022-11-01

Active, closed

Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type

NCT05397639Agitation, Alzheimer's Type Dementia

Suven Life Sciences Limited

Phase 3

375

Lodz, Warsaw, Katowice, Zabrze

2022-11-01

Recruiting

Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS)

NCT07153211Neuropathic Pain, Chronic Pain, Spinal Cord Stimulation (SCS)

Pawel Sokal

Not applicable

Bydgoszcz

2022-11-01

Active, closed

A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight

NCT05567796Obesity

DrugsCagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

3,400

Bydgoszcz, Krakow, Legnica, Lublin, Warsaw, Bialystok, Gdansk, Katowice

2022-11-01

Active, closed

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

NCT05389449Paroxysmal Nocturnal Hemoglobinuria

DrugDanicopan

Alexion Pharmaceuticals, Inc.

Phase 3

Gdansk

2022-10-28

Recruiting

PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)

NCT04790253Limited Stage Small Cell Lung Cancer, Extensive-stage Small-cell Lung Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Not applicable

600

Gdansk, Olsztyn

2022-10-27

Recruiting

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

NCT05552222Multiple Myeloma

DrugsTalquetamab·Teclistamab·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,590

Biała Podlaska, Brzozów, Bydgoszcz, Katowice, Kielce, Lodz, Lublin, Poznan

2022-10-25

Active, closed

Berotralstat Treatment in Children With Hereditary Angioedema

NCT05453968Hereditary Angioedema, Pediatric

DrugBerotralstat

BioCryst Pharmaceuticals

Phase 3

Krakow

2022-10-25

Active, closed

A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp

NCT05387525Keratosis, Actinic

DrugDiclofenac Sodium

Almirall, S.A.

Phase 4

447

Lublin, Rzeszów, Warsaw, Wroclaw

2022-10-24

Recruiting

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

NCT05253651Colorectal Neoplasms

DrugsTucatinib·Herceptin·Erbitux·Avastin

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

400

Konin, Warsaw, Rzeszów, Gdansk, Lodz

2022-10-24

Active, closed

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05259839Relapsed/Refractory Multiple Myeloma

DrugsEtentamig·Pomalidomide·Daratumumab·Lenalidomide

AbbVie

Phase 1

283

Opole, Wroclaw, Lublin, Gdansk

2022-10-20

Active, closed

A Study of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis

NCT05559359Atopic Dermatitis, Eczema

DrugLebrikizumab

Eli Lilly and Company

Phase 3

377

Gdansk, Krakow, Lodz, Warsaw

2022-10-18

Active, closed

A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer

NCT05587296Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes

Bayer

Phase 3

474

Bialystok, Katowice, Krakow, Lodz, Skorzewo, Warsaw

2022-10-14

Active, closed

A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer

NCT05565378Lung Cancer, Non-Small Cell

DrugsNelistotug·Belrestotug·Dostarlimab·Pembrolizumab

GlaxoSmithKline

Phase 2

351

Lublin, Prabuty, Siedlce

2022-10-14

Active, closed

A Study About the Natural History in Adults With BAG3 Dilated Cardiomyopathy (a Type of Heart Disease) (BAG3 DCM)

NCT05981092Cardiomyopathy, Dilated, Bcl-2 Anathogene-3 (BAG3) Dilated Cardiomyopathy (DCM)

Alexion Pharmaceuticals, Inc.

Observational

Warsaw

2022-10-14

Active, closed

A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment

NCT05455320Multiple Myeloma

DrugsTalquetamab·Pomalidomide·Daratumumab·Dexamethasone

Janssen Research & Development, LLC

Phase 3

864

Brzozów, Gdansk, Katowice, Kielce, Krakow, Lublin, Olsztyn, Szczecin

2022-10-13

Recruiting

Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC

NCT05491525Neurogenic Detrusor Overactivity

DrugVibegron

Urovant Sciences GmbH

Phase 2/3

Bialystok, Gdansk, Warsaw

2022-10-12

Active, closed

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

NCT05556512Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

15,374

Bialystok, Bydgoszcz, Chorzów, Elblag, Gdansk, Krakow, Lodz, Lublin

2022-10-11

Active, closed

A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

NCT05508789Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases

DrugDonanemab

Eli Lilly and Company

Phase 3

1,500

Bialystok, Bydgoszcz, Gdansk, Katowice, Krakow, Poznan, Szczecin, Warsaw

2022-10-10

Active, closed

A Study to Learn About the Safety of BIIB115 Injections and How BIIB115 is Processed in the Bodies of Healthy Adult Male Volunteers and of Pediatric Participants With Spinal Muscular Atrophy Who Previously Took Onasemnogene Abeparvovec

NCT05575011Healthy Volunteer, Muscular Atrophy, Spinal

DrugSalanersen

Biogen

Phase 1

Lodz, Warsaw

2022-10-10

Active, closed

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

NCT05514054Breast Neoplasms

DrugsImlunestrant·Tamoxifen·Exemestane·Anastrozole

Eli Lilly and Company

Phase 3

8,000

Gdynia, Koszalin, Lodz, Opole, Oświęcim, Siedlce, Torun, Warsaw

2022-10-04

Recruiting

Cladribine vs Placebo for Non-active Progressive Multiple Sclerosis (CLASP-MS).

NCT05961644Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis

DrugsChloride Sodium·Cladribine

Institute of Psychiatry and Neurology, Warsaw

Phase 2/3

188

Warsaw

2022-10-03

Recruiting

Remodelling of the Lower Airways in Chronic Cough

NCT07659860Chronic Cough

Medical University of Warsaw

Observational

Warsaw

2022-10-01

Recruiting

A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies

NCT05443126NSCLC

DrugPemetrexed

Ellipses Pharma

Phase 1/2

265

Gdansk, Warsaw

2022-09-30

Active, closed

The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events

NCT05421286HIV-1-infection, Inflammation, AIDS

Copenhagen University Hospital, Rigshospitalet

Observational

991

Lodz

2022-09-28

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

NCT05503264NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis

DrugSatralizumab

Hoffmann-La Roche

Phase 3

122

Krakow, Zabrze

2022-09-27

Active, closed

A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease

NCT05347095Fistulizing Crohns Disease, Perianal Crohns Disease

DrugGuselkumab

Janssen-Cilag Ltd.

Phase 3

288

Bialystok, Krakow, Lodz, Rzeszów, Szczecin, Torun, Warsaw, Wroclaw

2022-09-27

Recruiting

Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT05327114Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

201

Chorzów, Krakow, Lublin, Poznan

2022-09-23

Recruiting

Effect of INtravenous FERRic Carboxymaltose Onmortality and Cardiovascular Morbidity, and Quality of Life in Iron Deficient Patients With Recent Myocardial infarCTion

NCT05759078Myocardial Infarction, Acute

DrugsSodium Chloride Inj·Ferinject

Wroclaw Medical University

Phase 4

1,000

Bydgoszcz, Grudziądz, Torun, Chrzanów, Gorlice, Krakow, Nowy Targ, Oświęcim

2022-09-22

Recruiting

INSIGHTFUL-FFR Clinical Trial

NCT05437900Coronary Artery Disease, Acute Coronary Syndrome

CoreAalst BV

Phase 4

2,500

Bydgoszcz, Krakow, Warsaw

2022-09-22

Recruiting

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT05519085Relapsed or Refractory Multiple Myeloma

DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib

Celgene

Phase 3

810

Skórzewo, Torun, Krakow, Warsaw, Słupsk, Katowice

2022-09-20

Active, closed

NCT05409066Follicular Lymphoma (FL)

DrugsEpcoritamab·Lenalidomide·Rituximab

Genmab

Phase 3

549

Piła, Skórzewo, Krakow, Gdynia, Kielce

2022-09-20

Active, closed

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis

NCT05242484Colitis, Ulcerative

DrugsJNJ-78934804·Golimumab·Guselkumab

Janssen Research & Development, LLC

Phase 2

577

Bydgoszcz, Krakow, Lodz, Lublin, Nowy Targ, Olsztyn, Poznan, Rzeszów

2022-09-19

Active, closed

Monitoring of Outcomes of Cellular and Exosome-based Therapies in Autoinflammatory and Post-infectious Neuroinflammatory Syndromes

NCT07145502Autoimmune Encephalitis, Early-stage Panencephalitis, Neuroinflammatory Demyelination

Biocells Medical

Observational

Warsaw

2022-09-19

Active, closed

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

NCT05462717Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma, Advanced Solid Tumor

DrugElironrasib

Revolution Medicines, Inc.

Phase 1

222

Lodz, Poznan, Warsaw

2022-09-19

Active, closed

The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)

NCT05540327Systemic Lupus Erythematosus

DrugEnpatoran

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Phase 2

381

Bialystok, Kościan, Krakow, Poznan, Szczecin, Warsaw

2022-09-16

Active, closed

A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy

NCT05450692Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsCeralasertib·Durvalumab·Docetaxel

AstraZeneca

Phase 3

594

Gdansk, Krakow, Poznan, Skórzewo

2022-09-15

Active, closed

A Study of Guselkumab Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

NCT05528510Colitis, Ulcerative

DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3

Janssen Research & Development, LLC

Phase 3

418

Bialystok, Bydgoszcz, Chojnice, Krakow, Lublin, Poznan, Rzeszów, Szczecin

2022-09-13

Active, closed

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

NCT05531565Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus

DrugLitifilimab

Biogen

Phase 2/3

450

Kielce, Krakow, Krosno, Lodz, Rzeszów, Warsaw, Wroclaw

2022-09-13

Active, closed

A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT05057494Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

DrugsAcalabrutinib·Obinutuzumab·Venetoclax

AstraZeneca

Phase 3

607

Bydgoszcz, Gdansk, Katowice, Krakow, Lódz, Lublin

2022-09-12

Active, closed

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

NCT05243797Multiple Myeloma

DrugsTeclistamab·Lenalidomide

European Myeloma Network B.V.

Phase 3

1,594

Gdansk, Poznan

2022-09-08

Recruiting

Observational Study on the Use of Ropeginterferon Alfa-2b in Polycythemia Vera (ROPEG-PV)

NCT06506084Polycythemia Vera

DrugBesremi

FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS

Observational

429

Gdansk, Katowice, Krakow, Lodz, Wroclaw

2022-09-08

Active, closed

Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of RXC007 in Idiopathic Pulmonary Fibrosis

NCT05570058IPF, Fibrosis

Redx Pharma Ltd

Phase 2

Gdansk, Lodz, Warsaw

2022-09-08

Active, closed

Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer

NCT05425940Colorectal Cancer

DrugsZanzalintinib·Regorafenib·Tecentriq·Atezolizumab

Exelixis

Phase 3

901

Bydgoszcz, Opole, Siedlce, Tomaszów Mazowiecki, Warsaw

2022-09-07

Active, closed

Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial

NCT05334368Hypereosinophilic Syndrome

DrugDepemokimab

GlaxoSmithKline

Phase 3

110

Chęciny, Lodz

2022-09-06

Recruiting

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

NCT05489211Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer, Ovarian Cancer

DrugsPrednisone/Prednisolone·Volrustomig·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

454

Gliwice, Krakow, Lodz, Poznan, Warsaw

2022-09-06

Active, closed

Study of Sonrotoclax (BGB-11417) Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma

NCT05471843Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma (MCL), Relapsed Mantle Cell Lymphoma

DrugSonrotoclax

BeOne Medicines

Phase 1/2

125

Gdansk, Krakow, Lublin

2022-09-05

Recruiting

Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia

NCT05303649Stroke, Ischemic, Aphasia Non Fluent

Institute of Psychiatry and Neurology, Warsaw

Not applicable

Warsaw

2022-09-02

Recruiting

Safety Outcomes Post Kidney Biopsy - Randomized Clinical Evaluation of Efficacy of Desmopressin

NCT05467033Kidney Biopsy

DrugsDesmopressin·NaCl

Medical University of Bialystok

Phase 3

424

Bialystok

2022-09-01

Recruiting

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

NCT05533697Advanced Solid Tumors

DrugsIpilimumab·Nivolumab·Pembrolizumab

ModernaTX, Inc.

Phase 1/2

361

Warsaw

2022-09-01

By invitation

Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)

NCT05565352Major Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder, Somatoform Disorders

DrugKetamine Hydrochloride

Medical University of Gdansk

Observational

140

Gdansk

2022-09-01

Active, closed

A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

NCT05378425Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer

DrugsKeytruda·Pembrolizumab

Nectin Therapeutics Ltd

Phase 1

Warsaw

2022-09-01

Recruiting

Genetics of the Acute Response to Oral Semaglutide

NCT05340868PreDiabetes, Prediabetic State, Obesity

DrugsSemaglutide Pill·Semaglutide

Medical University of Bialystok

Not applicable

1,000

Bialystok

2022-09-01

Active, closed

The Efficiency of Transcranial Direct Current Stimulation in the Treatment of Anorexia Nervosa

NCT05814458Anorexia Nervosa

Medical University of Lublin

Not applicable

Lublin

2022-09-01

Active, closed

Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With GEP-NETs and PPGLs

NCT04711135Gastroenteropancreatic Neuroendocrine Tumors, Pheochromocytoma, Paraganglioma

DrugsLutetium [177Lu] oxodotreotide/dotatate·Lutathera

Advanced Accelerator Applications

Phase 2

Gliwice

2022-08-31

Active, closed

Sub-study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Nirogacestat, Pomalidomide, and Dexamethasone in Participants With RRMM

NCT07150104Multiple Myeloma

DrugsNirogacestat·Belantamab mafodotin·Pomalidomide·Dexamethasone

GlaxoSmithKline

Phase 1/2

Lublin

2022-08-31

Recruiting

Asciminib Roll-over Study

NCT04877522Chronic Myelogenous Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive

DrugsAsciminib single agent·Bosutinib·ABL001·Nilotinib

Novartis Pharmaceuticals

Phase 4

347

Katowice, Krakow, Warsaw, Wroclaw

2022-08-30

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

NCT05271409Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

DrugSatralizumab

Hoffmann-La Roche

Phase 3

139

Katowice, Warsaw, Zabrze

2022-08-30

Recruiting

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Glycopyrronium (Bromide) in Children (6 to Less Than 12 Years) With Asthma

NCT05222529Asthma

Novartis Pharmaceuticals

Phase 2

Tarnów, Lodz

2022-08-29

Active, closed

A Study to Learn About the Safety of Diranersen (BIIB080) Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age

NCT05399888Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia

Biogen

Phase 2

416

Bialystok, Bydgoszcz, Katowice, Krakow, Lodz, Lublin, Sopot, Warsaw

2022-08-24

Recruiting

A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery

NCT05156983Coagulation Disorder

Takeda

Phase 3

440

Szczecin

2022-08-24

Active, closed

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

NCT05492578Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2/3

1,856

Torun, Krakow, Tarnów, Wroclaw, Lublin, Lodz, Warsaw, Rzeszów

2022-08-22

By invitation

Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis

NCT05374590Generalized Myasthenia Gravis, gMG

DrugsEfgartigimod PH20·Efgartigimod

argenx

Phase 2/3

Gdansk, Katowice, Warsaw

2022-08-18

Active, closed

A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

NCT05424822Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

DrugJNJ-80948543

Janssen Research & Development, LLC

Phase 1

167

Gdansk, Skorzewo

2022-08-18

Recruiting

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

NCT05489705Obstructive Hypertrophic Cardiomyopathy

DrugMavacamten

Bristol-Myers Squibb

Observational

1,700

Katowice, Warsaw

2022-08-16

Active, closed

A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition

NCT05061134Melanoma

DrugsCeralasertib·Durvalumab

AstraZeneca

Phase 2

194

Brzozów, Gdansk, Krakow, Lodz, Poznan, Warsaw

2022-08-11

Not yet open

Enteral Feeding in Infants With Duct Dependant Lesions.

NCT05117164Duct Dependent Lesions, Necrotising Enterocolitis, Death, Growth

Princess Anna Mazowiecka Hospital, Warsaw, Poland

Not applicable

384

Warsaw

2022-08-10

Active, closed

A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow

NCT05330325SGA, Turner Syndrome, Noonan Syndrome, ISS

DrugsNorditropin·Somapacitan

Novo Nordisk A/S

Phase 3

412

Rzeszów, Cracow, Gdansk, Katowice, Lodz, Szczecin, Zabrze

2022-08-10

Recruiting

Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome

NCT05492344ARDS, Human, Lung Ultrasound, Mechanical Ventilation

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Not applicable

538

Warsaw

2022-08-09

Active, closed

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

NCT05388669Advanced or Metastatic Non-small Cell Lung Cancer

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 3

418

Bydgoszcz, Krakow, Otwock, Poznan, Warsaw

2022-08-05

Active, closed

Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

NCT05349214Sjogren Syndrome

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

506

Poznan, Krakow, Wroclaw, Warsaw

2022-08-04

Active, closed

Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

NCT05261399Carcinoma, Non-Small-Cell Lung

DrugsSavolitinib·Tagrisso·Osimertinib·Pemetrexed

AstraZeneca

Phase 3

341

Lodz, Olsztyn

2022-08-03

Active, closed

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

NCT05382286Triple Negative Breast Cancer, PD-L1 Positive

DrugsAbraxane·Sacituzumab Govitecan·Taxol·Nab-paclitaxel

Gilead Sciences

Phase 3

443

Gdansk, Gliwice, Opole, Poznan, Siedlce, Warsaw

2022-07-25

Active, closed

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

NCT05242471Crohn's Disease

DrugsJNJ-78934804·Golimumab·Guselkumab

Janssen Research & Development, LLC

Phase 2

703

Bydgoszcz, Krakow, Lodz, Lublin, Olsztyn, Poznan, Rzeszów, Sopot

2022-07-22

Recruiting

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma

DrugsPirtobrutinib·Ibrutinib

Loxo Oncology, Inc.

Phase 3

737

Biała Podlaska, Bydgoszcz, Gdansk, Katowice, Krakow, Lublin, Skórzewo, Wroclaw

2022-07-22

Active, closed

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

NCT05458297Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma

DrugsNemtabrutinib·Zilovertamab vedotin

Merck Sharp & Dohme LLC

Phase 2

189

Krakow, Lublin, Warsaw, Olsztyn, Lodz, Kielce

2022-07-21

Recruiting

A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis

NCT05265273Myasthenia Gravis

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

Gdansk

2022-07-20

Active, closed

Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

NCT05382299Triple Negative Breast Cancer, PD-L1 Negative

DrugsAbraxane·Sacituzumab Govitecan·Nab-paclitaxel·Gemcitabine

Gilead Sciences

Phase 3

623

Gdansk, Gliwice, Opole, Siedlce, Warsaw

2022-07-20

Active, closed

Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients

NCT05222555Diffuse Large B Cell Lymphoma

DrugsTafasitamab·Lenalidomide

Incyte Corporation

Phase 1/2

Skórzewo, Krakow, Wroclaw, Warsaw, Opole, Gdynia, Lodz, Olsztyn

2022-07-19

Active, closed

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

NCT05296798Locally Advanced or Metastatic Breast Cancer

DrugsPhesgo·Giredestrant·Pertuzumab·Trastuzumab

Hoffmann-La Roche

Phase 3

922

Gdansk, Konin, Koszalin, Opole, Pi?a, Późna, Rzeszów, Warsaw

2022-07-18

Active, closed

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)

NCT05406401Lymphoma, Large B-Cell, Diffuse (DLBCL)

DrugsRituximab Biosimilar·Zilovertamab vedotin·Truxima·Adriamycin

Merck Sharp & Dohme LLC

Phase 2

Warsaw, Gdansk, Gliwice, Lodz

2022-07-14

Active, closed

Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)

NCT05263934Eosinophilic Granulomatosis With Polyangiitis

DrugsDepemokimab·Mepolizumab

GlaxoSmithKline

Phase 3

163

Gdansk, Lodz, Warsaw

2022-07-14

Active, closed

Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

NCT05352672Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,546

Siedlce, Gdansk, Słupsk, Poznan, Warsaw

2022-07-14

Active, closed

A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)

NCT05392114Hereditary Angioedema

DrugDonidalorsen

Ionis Pharmaceuticals, Inc.

Phase 3

154

Krakow

2022-07-13

Active, closed

A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer

NCT05217446Metastatic Colorectal Cancer

DrugsEncorafenib·Erbitux·Cetuximab·Keytruda

Pfizer

Phase 2

108

Konin, Brzozów

2022-07-11

Active, closed

HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy

NCT05338970Nonsquamous Non-small Cell Lung Cancer, EGFR L858R, EGFR Exon 19 Deletion

DrugPatritumab deruxtecan

Daiichi Sankyo

Phase 3

586

Bialystok, Lublin, Poznan

2022-07-08

Active, closed

Roll-over Study to Allow Continued Access to Ribociclib

NCT05161195Metastatic Breast Cancer

DrugsGoserelin·Tamoxifen·Anastrozole·Ribociclib

Novartis Pharmaceuticals

Phase 4

134

Gdansk

2022-07-07

Active, closed

A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy

NCT05337553Spinal Muscular Atrophy, Neuromuscular Diseases, SMA

DrugTaldefgrobep alfa

Biohaven Pharmaceuticals, Inc.

Phase 3

269

Gdansk, Poznan, Warsaw, Wroclaw

2022-07-06

Active, closed

An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of Odevixibat in Children With Biliary Atresia

NCT05426733Biliary Atresia

DrugOdevixibat

Albireo, an Ipsen Company

Phase 3

180

Warsaw

2022-07-05

Recruiting

Assessment of Anterior Cruciate Ligament (ACL) Degeneratio Mucosa Treatment

NCT05701579Anterior Cruciate Ligament Injuries

Artromedical Konrad Malinowski Clinic

Observational

Bełchatów

2022-07-01

Active, closed

Long Term Evaluation of Safety and Efficacy of Tildrakizumab in Patients With Psoriatic Arthritis

NCT04991116Psoriatic Arthritis

Sun Pharmaceutical Industries Limited

Phase 3

529

Bialystok, Krakow, Lublin, Nadarzyn, Olsztyn, Poznan, Torun, Warsaw

2022-06-30

Active, closed

Relacorilant in Combination With Nab-Paclitaxel in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer

NCT05257408Ovarian Neoplasm, Fallopian Tube Neoplasms, Peritoneal Neoplasms

DrugsNab-paclitaxel /m^2·Relacorilant

Corcept Therapeutics

Phase 3

381

Gdynia, Poznan, Siedlce

2022-06-29

Recruiting

International Wilson's Disease Patient Registry (iWilson Registry)

NCT05239858Wilson's Disease

Orphalan

Observational

500

Warsaw

2022-06-29

Active, closed

(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis

NCT05186753SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis

DrugBezuclastinib

Cogent Biosciences, Inc.

Phase 2

237

Gdansk, Lublin

2022-06-27

Active, closed

SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM

NCT05405166Plasma Cell Myeloma Recurrent

DrugsParacetamol / Acetaminophen·Montelukast·Diphenhydramine·Isatuximab

Sanofi

Phase 3

531

Krakow, Wroclaw, Lublin

2022-06-23

Active, closed

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT04975997Multiple Myeloma

DrugsIberdomide·Bortezomib·Daratumumab·Dexamethasone

Celgene

Phase 3

939

Bialystok, Krakow, Nowy Sącz, Poznan, Warsaw, Wałbrzych

2022-06-23

Recruiting

CytOSorb TreatMent Of Critically Ill PatientS Registry

NCT05146336Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis

CytoSorbents, Inc

Observational

3,000

Krakow, Wroclaw

2022-06-22

Recruiting

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

NCT05142189Non-Small Cell Lung Cancer

DrugsBNT116·Gotistobart·Cemiplimab·Osimertinib

BioNTech SE

Phase 1

320

Gdansk, Olsztyn, Poznan, Warsaw

2022-06-17

Active, closed

A Feasibility Study of the CroíValve DUO System for Tricuspid Regurgitation

NCT05296148Tricuspid Regurgitation

CroiValve Limited

Not applicable

Gdansk, Katowice, Warsaw

2022-06-17

Recruiting

Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT

NCT05429632Adult Acute Myeloid Leukemia

Priothera SAS

Phase 3

366

Krakow, Katowice, Gdansk, Warsaw

2022-06-16

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Polish investigative site. Derived from ClinicalTrials.gov. Retrieved 13 November 2026. https://priyalifescience.com/clinical-trials-poland?page=4

Query this register directly

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Poland and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 2,709 studies in total at the last sync on 12 Nov 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in Poland?

1,380 of the 2,709 studies in this register are recruiting new participants as of the 12 Nov 2026, 03:19 UTC sync. A further 131 have not yet opened recruitment, 1,087 are active but closed to new participants, and 111 are enrolling by invitation only. Eligibility for any study is decided by its study team.

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Browse trials by condition

Obesity (43) Multiple Myeloma (41) Breast Cancer (41) Heart Failure (40) Ulcerative Colitis (34) Carcinoma, Non-Small-Cell Lung (29) Coronary Artery Disease (27) Non-Small Cell Lung Cancer (26) Crohn's Disease (26) Chronic Lymphocytic Leukemia (25) Non-small Cell Lung Cancer (23) Overweight (22) Prostate Cancer (22) Systemic Lupus Erythematosus (21) Atopic Dermatitis (21)

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Browse trials by site location

Warsaw (1318) Krakow (881) Poznan (697) Gdansk (663) Lodz (618) Wroclaw (526) Bydgoszcz (525) Lublin (525) Katowice (510) Bialystok (388) Olsztyn (190) Rzeszów (183) Szczecin (183) Gdynia (167) Gliwice (121)

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.