Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction

NCT07595809 · tracked via the Priya Life Science Poland tracker

Sponsor

Medical University of Silesia

Phase

Not applicable

Started

2023-05-08

Last updated

2026-05-19

Condition(s) studied

Heart Failure With Reduced Ejection Fraction

Investigational drug(s) / intervention(s)

Resistance ExerciseDietary Intervention

Resistance Exercise: The exercise intervention includes resistance training using elastic bands, with instruction and follow-up provided by a medical rehabilitation specialist.

Dietary Intervention: Individualized 14-day meal plan based on the DASH diet with high-protein components.

Study summary

Heart failure with reduced ejection fraction (HFrEF) is frequently associated with abnormalities in body composition, including reduced skeletal muscle mass and sarcopenia, which are independent predictors of reduced exercise tolerance, impaired quality of life, and increased mortality. Despite advances in pharmacological therapy, evidence-based non-pharmacological strategies aimed at preventing muscle mass loss remain limited.

This randomized controlled trial aims to evaluate the effects of dietary intervention based on the DASH diet with high-protein elements, resistance exercise training, and their combination on skeletal muscle mass, functional capacity, echocardiographic parameters, biochemical markers, and quality of life in patients with HFrEF.

Eligibility

Sex

ALL

Min age

30 Years

Max age

—

Healthy volunteers

Inclusion Criteria: Written informed consent obtained prior to participation Age \>30 years Diagnosis of chronic heart failure, NYHA functional class I-III Left ventricular ejection fraction \<40% Exclusion Criteria: NYHA functional class IV heart failure Potentially reversible cause of heart failure Estimated glomerular filtration rate \<30 mL/min Severe anemia (hemoglobin \<9 g/dL) Uncontrolled thyroid disease Severe hepatic dysfunction History of hyperkalemia or hyperkalemia at baseline Epilepsy Presence of joint endoprostheses Gastrointestinal disorders limiting adherence to the DASH diet Physical limitations precluding participation in structured exercis

Primary outcome measure(s)

Change in skeletal muscle mass — Baseline to 6 months
Quantitative assessment of skeletal muscle mass change over the study period.

Trial sites (1)

Facility	City	Region	Status
2nd Department and Clinical Ward of Cardiology Specialist Hospital in Zabrze, Poland	Zabrze	Silesian Voivodeship	Recruiting

More Medical University of Silesia trials in Poland

Minimally Invasive Surgery Versus Open Radical Hysterectomy in Presumably Early Stage Cervical Cancer: a Retrospective Multicenter Non-inferiority Study Comparing Overall and Progression-free Survival. Recruiting

Stereotactic Radiosurgery as Second-line Therapy for Ventricular Tachycardia Starting soon

Prehabilitation in Ovarian Cancer Patients During Chemiotherapy Before Cytoreductive Surgery. Enrolling by invitation

Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain in Nephrology and Transplantation Department Recruiting

Oritavancin for CIED Infections With MDR Gram-positive Cocci Starting soon

Other trials for the same condition

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction Recruiting

Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07595809 on ClinicalTrials.gov ↗ ← All trials in Poland