The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males

Condition(s) studied

Investigational drug(s) / intervention(s)

Exercise and environmental conditions: Participants will engage in interval training and will reside and sleep at different altitudes for a period of 4 weeks. Aerobic and anaerobic capacity tests and an eccentric exercise test will be performed before and after the training intervention. Before and after the training program, somatic measurements will also be taken. Before and after the first and last workout, blood will be drawn for biochemical analysis.

Study summary

* Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males.
* Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.

Eligibility

Primary outcome measure(s)

• Measurement of aerobic capacity (endurance) — 7 days before training and 7-10 days after the training. Training will last 4 weeks.
  Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry)
• Measurement of anaerobic capacity — 7 days before training and 7-10 days after the training. Training will last 4 weeks
  Measurement of maximal anaerobic power (Wingate Anaerobic Test)
• Blood analysis — 7 days before training and 7- 10 days after the training. The training will last 4 weeks and will consist of 12 workouts.
  Indicators of prooxidant-antioxidant imbalance, markers of inflammatory status, markers of muscle damage, markers of intestinal damage, HIF (hypoxia-inducible factor), EPO (erythropoietin), markers of mitochondrial metabolism, morphology (including reticulocytes).
• Somatic indices — 7 days before training and 7-10 days after the training. Training will last 4 weeks.
  Body composition analysis ( body height \[m\], body mass \[kg\], Quetelet II Index \[kg/m\^2\], lean body mass \[kg\], fat mass \[kg\], fat percentage \[%\] and total water content \[kg\]

Trial sites (1)

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