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Compound · clinical trials

Entrectinib

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 8 trials in our China, USA, UK and India registers that name Entrectinib as an intervention. Synced 24 Sep 2026
8Trials tracked
2Recruiting now
2Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Entrectinib is named as a drug or biological intervention in 8 clinical trials in our China, USA, UK and India trial registers, 2 of which are recruiting. Lead sponsors include Hoffmann-La Roche (7) and Genentech, Inc. (1). Registered phases: Phase 2, Phase 3, Phase 1/2 and Phase 2/3. Conditions studied include Solid Tumors; Non-Small Cell Lung Cancer; Cancer.

01

Clinical trials of Entrectinib

8 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT05862285 A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
Cancer
Phase 3 Recruiting Hoffmann-La Roche UK, China
NCT04302025 A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC) (ClinicalTrials.gov ↗)
Non-small Cell Lung Cancer
Phase 2 Recruiting Genentech, Inc. USA
NCT04603807 A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases
Carcinoma, Non-Small-Cell Lung
Phase 3 Active, closed Hoffmann-La Roche India, China
NCT05170204 A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC) (ClinicalTrials.gov ↗)
Non-Small Cell Lung Cancer
Phase 3 Active, closed Hoffmann-La Roche UK, USA, China
NCT03178552 A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer
Phase 2/3 Active, closed Hoffmann-La Roche USA, China
NCT02568267 Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) (ClinicalTrials.gov ↗)
Breast Cancer, Cholangiocarcinoma, Colorectal Cancer
Phase 2 Active, closed Hoffmann-La Roche UK, USA, China
NCT04589845 Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
Solid Tumors
Phase 2 Active, closed Hoffmann-La Roche UK, USA, China
NCT02650401 Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options
Solid Tumors, CNS Tumors
Phase 1/2 Active, closed Hoffmann-La Roche UK, USA, China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

10 conditions
Condition (as registered)Trials
Solid Tumors2
Non-Small Cell Lung Cancer2
Cancer1
CNS Tumors1
Breast Cancer1
Cholangiocarcinoma1
Colorectal Cancer1
Head and Neck Neoplasms1
Non-small Cell Lung Cancer1
Carcinoma, Non-Small-Cell Lung1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Hoffmann-La Roche7
Genentech, Inc.1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Entrectinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Entrectinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.