A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
Condition(s) studied
Investigational drug(s) / intervention(s)
Talquetamab: Talquetamab will be administered as a SC injection.
Pomalidomide: Pomalidomide will be administered orally.
Teclistamab: Teclistamab will be administered as a SC injection.
Elotuzumab: Elotuzumab will be administered intravenously.
Dexamethasone: Dexamethasone will be administered either orally or intravenously.
Bortezomib: Bortezomib will be administered as a SC injection.
Study summary
The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd).
Eligibility
Primary outcome measure(s)
- Progression Free Survival (PFS) — Up to 3 years 5 months
PFS is defined as the duration from the date of randomization to either progressive disease or death, whichever comes first.
Trial sites (242)
| Facility | City | Region | Status |
|---|---|---|---|
| UCSF Fresno | Clovis | California | |
| UCLA | Santa Monica | California | |
| Yale University School Of Medicine | New Haven | Connecticut | |
| Medical Oncology Hematology Consultants, PA | Newark | Delaware | |
| Memorial Healthcare System | Hollywood | Florida | |
| Moffitt Cancer Center | Tampa | Florida | |
| Winship Cancer Institute Emory University | Atlanta | Georgia | |
| City of Hope Cancer Center | Newnan | Georgia | |
| Kootenai Health | Coeur d'Alene | Idaho | |
| Loyola University Medical Center | Maywood | Illinois | |
| University of Iowa Health Care | Waukee | Iowa | |
| Norton Cancer Institute | Louisville | Kentucky | |
| Our Lady of the Lake Hospital | Baton Rouge | Louisiana | |
| Luminis Health Center for Cancer and Blood Disorders | Annapolis | Maryland | |
| University of Maryland School of Medicine | Baltimore | Maryland | |
| The Sidney Kimmel Comprehensive Cancer Center at John Hopkins | Baltimore | Maryland | |
| University of Michigan | Ann Arbor | Michigan | |
| Henry Ford Cancer Institute | Detroit | Michigan | |
| Henry Ford Health Providence Southfield Hospital | Southfield | Michigan | |
| University Of Minnesota | Minneapolis | Minnesota | |
| Mayo Clinic Rochester | Rochester | Minnesota | |
| Regions Hospital | Saint Paul | Minnesota | |
| University of Nebraska | Omaha | Nebraska | |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | |
| Roswell Park Cancer Institute | Buffalo | New York | |
| Weill Cornell Medical College | New York | New York | |
| SUNY Upstate Medical University | Syracuse | New York | |
| Duke University Medical Center | Durham | North Carolina | |
| Gabrail Cancer Center | Canton | Ohio | |
| Louis Stokes Cleveland VA Med Ctr | Cleveland | Ohio | |
| Cleveland Clinic | Cleveland | Ohio | |
| Oregon Health And Science University | Portland | Oregon | |
| Penn State Milton S Hershey Medical Ctr | Hershey | Pennsylvania | |
| Thomas Jefferson University | Philadelphia | Pennsylvania | |
| West Penn Hospital | Pittsburgh | Pennsylvania | |
| University Of Pittsburgh Medical Center UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | |
| Medical University of South Carolina | Charleston | South Carolina | |
| Bon Secours Saint Francis Cancer Center | Greenville | South Carolina | |
| UT Southwestern Parkland Hospital | Dallas | Texas |
+ 202 more sites — see the full list on the official registry below.
More Janssen Research & Development, LLC trials in Poland
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06208150 on ClinicalTrials.gov ↗ ← All trials in Poland