Clinical trial register · Spain

Clinical Trials in Barcelona, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Spain and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 5875 matching records held by the registry are in this view. Synced 11 Oct 2026, 03:18 UTC

5875

Studies in scope

all four open statuses

3096

Recruiting now

open to new participants

1137

Lead sponsors

across recruiting studies

Top sites

Barcelona 3238 Madrid 3046 Valencia 1215 Seville 1054 Málaga 746

Trials with a site in Barcelona

Status

Study

Lead sponsor

Phase

Enrol

Sites in Spain

Start

Active, closed

Chemotherapy-Free pCR-Guided Strategy With Trastuzumab-pertuzumab and T-DM1 in HER2-positive Early Breast Cancer

NCT04733118Early Breast Cancer

MedSIR

Phase 2

393

L'Hospitalet de Llobregat, Córdoba, Reus, A Coruña, Alicante, Badalona, Barcelona, Bilbao

2021-08-05

Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

NCT04913285Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma

Pierre Fabre Medicament

Phase 1

400

Barcelona, Madrid, Málaga, Seville, Valencia, Las Palmas de Gran Canaria

2021-08-04

Active, closed

Pulmonary Embolism International THrOmbolysis Study-3

NCT04430569Pulmonary Embolism

DrugAlteplase

Assistance Publique - Hôpitaux de Paris

Phase 3

800

Badalona, Barcelona, Cartagena, Galdakao, Madrid, Seville, Valencia

2021-08-04

Active, closed

The CROCO Study: CROhn's Disease COhort Study

NCT05420233Crohn Disease

GLSMED Learning Health S.A.

Not applicable

533

Barcelona, Galdakao, Vigo

2021-08-01

Recruiting

Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.

NCT04817618C3G

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

Barcelona, Port de Sagunt, Madrid, Málaga, Seville

2021-07-28

Active, closed

Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria

NCT04747613Paroxysmal Nocturnal Hemoglobinuria

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

208

Santiago Compostela, Donostia / San Sebastian, Barcelona

2021-07-27

By invitation

A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus

NCT04976322Systemic Lupus Erythematosus

UCB Biopharma SRL

Phase 3

760

Barcelona, Málaga, Sabadell, Vigo

2021-07-27

Recruiting

Spanish Natural History Study for LAMA2 Muscular Dystrophy

NCT06924125LAMA2-MD (Merosin Deficient Congenital Muscular Dystrophy, MDC1A), Merosin Deficient CMD (Full or Partial), Merosin Deficient Congenital Muscular Dystrophy, Muscular Dystrophies

Hospital Universitari Vall d'Hebron Research Institute

Observational

100

Barcelona

2021-07-27

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04910568Multiple Myeloma

DrugsCevostamab·Pomalidomide·Tocilizumab·Daratumumab

Genentech, Inc.

Phase 1

186

Barcelona, Madrid

2021-07-26

Recruiting

A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications

NCT04877288Renal Allograft Recipients

DrugsCyclosporine A·Belatacept·Mycophenolate Mofetil·Tacrolimus

Bristol-Myers Squibb

Phase 3

102

Barcelona, Rivas-Vaciamadrid, Seville

2021-07-21

Active, closed

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

NCT05101148Neurofibromatosis Type 1

DrugSelumetinib

AstraZeneca

Phase 1

Barcelona, Madrid

2021-07-21

Active, closed

Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing

NCT04798768Tachycardia, Ventricular, Arrhythmia, Ventricular

Boston Scientific Corporation

Not applicable

297

Barcelona

2021-07-20

Recruiting

A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

NCT04951622Myasthenia Gravis

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

199

Alicante, Barcelona, Bilbao, Seville, Valencia

2021-07-15

Active, closed

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

NCT04908189Psoriatic Arthritis

DrugsApremilast·Deucravacitinib

Bristol-Myers Squibb

Phase 3

729

Barcelona, Madrid, Santander, Valencia

2021-07-15

Active, closed

A Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Velodrome)

NCT04657289Neovascular Age-related Macular Degeneration (nAMD)

DrugRanibizumab

Hoffmann-La Roche

Phase 3

451

L'Hospitalet de Llobregat, San Cugat Del Valles, Majadahonda, Pamplona, Oviedo, Barcelona, Córdoba, Madrid

2021-07-14

Active, closed

A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases

NCT04554914Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)

DrugTabelecleucel

Pierre Fabre Medicament

Phase 2

190

Barcelona, Madrid, Seville

2021-07-14

Active, closed

Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation

NCT04788888Symptomatic Severe Aortic Stenosis

Abbott Medical Devices

Not applicable

434

Madrid, Alicante, Barcelona, Seville

2021-07-13

Recruiting

European and North Indian Cohort of KaWasaki dIsease

NCT06305611Kawasaki Disease

Meyer Children's Hospital IRCCS

Observational

103

Barcelona

2021-07-13

Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

NCT04613921Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications

European Foundation for Study of Chronic Liver Failure

Observational

3,000

Barcelona, Madrid, Santander, Seville, Valencia

2021-07-08

Recruiting

The ABC-HCC Trial: Atezolizumab Plus Bevacizumab vs. Transarterial Chemoembolization (TACE) in Intermediate-stage HepatoCellular Carcinoma

NCT04803994Hepatocellular Carcinoma

DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab

Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

Phase 3

434

Alicante, Badajoz, Badalona, Barcelona, Cadiz, Jaén, Madrid, Málaga

2021-07-06

Active, closed

Long-Term Observational Study on Effectiveness and Safety of Lecigon in Patients With Advanced Parkinson's Disease

NCT05043103Advanced Parkinson Disease

Britannia Pharmaceuticals Ltd.

Observational

312

Barcelona, Madrid, Seville

2021-07-06

Recruiting

A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma

NCT04669171Follicular Lymphoma, Marginal Zone Lymphoma

DrugsLenalidomide·Rituximab

Enterome

Phase 1/2

Barcelona, Madrid, Pamplona, Salamanca

2021-07-05

Active, closed

Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)

NCT04886804Neoplasm Metastasis, Non-Small Cell Lung Cancer

DrugZongertinib

Boehringer Ingelheim

Phase 1

554

Barcelona, L'Hospitalet de Llobregat, Madrid, Málaga, Valencia

2021-07-02

Active, closed

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

NCT04964934ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Anastrozole·Abemaciclib·Ribociclib

AstraZeneca

Phase 3

315

A Coruña, Badalona, Barcelona, L'Hospitalet de Llobregat, Madrid, Málaga, Murcia, Sant Joan Despí

2021-06-30

Recruiting

A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

NCT04965675Chronic Migraine in Children

DrugEptinezumab

H. Lundbeck A/S

Phase 3

285

Barcelona, Seville, Sevilla, Madrid

2021-06-30

Active, closed

Chemoembolization (Lifepearls-Irinotecan) in Patients With Colorectal Cancer and Metastatic Disease

NCT04595266Colorectal Cancer Metastatic, Liver Metastasis Colon Cancer

DrugsFolfox·Bevacizumab

Grupo Espanol Multidisciplinario del Cancer Digestivo

Phase 2

Barcelona, Sabadell, Madrid, Pamplona, Valencia

2021-06-29

Active, closed

Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease

NCT04915755Neoplasms, Breast

DrugNiraparib

GlaxoSmithKline

Phase 3

Barcelona, Cáceres, Córdoba, Granada, Madrid, Málaga, Santiago de Compostela, Valencia

2021-06-28

Active, closed

A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

NCT04629248Primary Membranous Nephropathy

DrugsDiphenhydramine·Acetaminophen·Tacrolimus·Methylprednisolone

Hoffmann-La Roche

Phase 3

142

L'Hospitalet de Llobregat, Barcelona, Madrid, Seville

2021-06-25

Active, closed

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).

NCT04895722Colorectal Cancer

DrugsPembrolizumab/Vibostolimab·MK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab

Merck Sharp & Dohme LLC

Phase 2

302

Santander, Barcelona, Madrid, Málaga, Pamplona, Oviedo, Valencia

2021-06-25

Active, closed

Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)

NCT04806451Congenital Adrenal Hyperplasia

DrugCrinecerfont

Neurocrine Biosciences

Phase 3

103

Barcelona, Seville

2021-06-25

Active, closed

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

NCT04793958Advanced Colorectal Cancer, Metastatic Colorectal Cancer

DrugsAdagrasib·MFOLFOX6·Erbitux·Folfox

Mirati Therapeutics Inc.

Phase 3

461

A Coruña, Badalona, Barcelona, Córdoba, LHospitalet de Llobregat, Madrid, Pamplona, Sabadell

2021-06-24

Recruiting

WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)

NCT04701684Stroke, Acute

Philips Clinical & Medical Affairs Global

Not applicable

594

Madrid, Barcelona, Girona, Seville

2021-06-23

Recruiting

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

NCT04802759Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

DrugsSamuraciclib·Ipatasertib·Giredestrant·Phesgo

Hoffmann-La Roche

Phase 1/2

316

Barcelona, Madrid, Valencia

2021-06-22

Active, closed

A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer

NCT04739761Breast Cancer

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 3

506

Barcelona, Bilbao (Vizcaya), Granada, Madrid, Salamanca, Santander, Santiago de Compostela-Coruña, Seville

2021-06-22

Recruiting

DPX-Survivac and Pembrolizumab With and Without Intermittent Low-Dose Cyclophosphamide, in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

NCT04920617Relapsed Diffuse Large B-cell Lymphoma, Refractory Diffuse Large B-cell Lymphoma

DrugsDPX-Survivac·Procytox·Cytoxan·Keytruda

ImmunoVaccine Technologies, Inc. (IMV Inc.)

Phase 2

102

Barcelona, Burgos, Seville

2021-06-18

Active, closed

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

NCT04895358Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol

Merck Sharp & Dohme LLC

Phase 3

342

Barcelona, Pozuelo de Alarcón, Madrid, Valencia

2021-06-18

Active, closed

177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer

NCT04689828Prostatic Neoplasms

DrugsARDT·Illuccix·Lu-PSMA

Novartis Pharmaceuticals

Phase 3

469

Santiago Compostela, L'Hospitalet de Llobregat, El Palmar, Pamplona, Valencia, Barcelona, Madrid, Málaga

2021-06-15

Active, closed

FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)

NCT04768972Amyotrophic Lateral Sclerosis

Ionis Pharmaceuticals, Inc.

Phase 3

Barcelona

2021-06-14

Recruiting

Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study

NCT04657822Sickle Cell Disease

DrugCrizanlizumab

Novartis Pharmaceuticals

Phase 4

130

Barcelona, Madrid

2021-06-10

Recruiting

PEEP in Patients With Acute Respiratory Failure

NCT04912960Acute Respiratory Failure With Hypoxia

Jesus Villar

Observational

Las Palmas de Gran Canaria, Barcelona, Madrid

2021-06-10

Active, closed

An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)

NCT04720157Prostatic Neoplasms

DrugsARDT·Illuccix·Lu-PSMA

Novartis Pharmaceuticals

Phase 3

1,140

L'Hospitalet de Llobregat, Sabadell, Majadahonda, El Palmar, Barcelona, Madrid, Valencia

2021-06-09

Active, closed

Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus

NCT04877691Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

367

Barcelona, Madrid, Santiago de Compostela, Seville, Valencia

2021-06-08

Active, closed

Proof-of-concept Study for SAR441344 (Frexalimab) in Relapsing Multiple Sclerosis

NCT04879628Multiple Sclerosis

DrugsMRI contrast-enhancing preparations·Frexalimab

Sanofi

Phase 2

129

Barcelona, Vigo

2021-06-07

Recruiting

Trial-Ready Cohort-Down Syndrome (TRC-DS)

NCT04165109Down Syndrome, Alzheimer Disease, Dementia

University of Southern California

Observational

550

Barcelona

2021-06-07

Active, closed

The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy (#HOPE4LIVER EU/UK)

NCT04573881Liver Neoplasms, Hepatocellular Carcinoma, Liver Metastases

HistoSonics, Inc.

Not applicable

Barcelona

2021-06-04

Active, closed

Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)

NCT04703192Relapsed/Refractory Peripheral T-Cell Lymphoma, Adult T Cell Leukemia/Lymphoma

DrugValemetostat Tosylate

Daiichi Sankyo

Phase 2

155

Barcelona, Madrid, Seville

2021-06-03

Active, closed

STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation

NCT04428944Atrial Fibrillation

McGill University Health Centre/Research Institute of the McGill University Health Centre

Not applicable

617

Barcelona

2021-06-01

Recruiting

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

NCT04895709Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer

DrugsImzokitug·Pumitamig·Docetaxel·Nivolumab

Bristol-Myers Squibb

Phase 1/2

1,109

Málaga, Badalona, Barcelona, Madrid, Pamplona

2021-05-27

Active, closed

Multicenter Clinical Trial Comparing Treatment with Allogeneic Mesenchymal Cells Versus Autologous Mesenchymal Cells and Versus Active Control with Hyaluronic Acid in Patients with Knee Osteoarthritis.

NCT05086939Knee Osteoarthritis

DrugHyaluronic Acid

Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León

Phase 3

124

Barcelona, Madrid, Málaga, Murcia, Pamplona, Salamanca

2021-05-26

Active, closed

A Clinical Study on Implants With TiUltra Technology and Associated Prosthetic Components

NCT04737421Marginal Bone Level Change

Nobel Biocare

Observational

1,000

Barcelona, Málaga, Palma de Mallorca

2021-05-26

Active, closed

β-AARC: Cohort Study for the Identification of Blood-based Biomarkers in a Population With Subjective Cognitive Decline

NCT04935372Alzheimer Disease, Preclinical Alzheimer, Mild Cognitive Impairment

Barcelonabeta Brain Research Center, Pasqual Maragall Foundation

Observational

200

Barcelona

2021-05-25

Active, closed

A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

NCT04895241Lupus Erythematosus, Systemic

DrugLitifilimab

Biogen

Phase 3

548

Santander, Valladolid, Barcelona, Granada, Seville, Valencia

2021-05-25

Recruiting

A Study of BGB-11417 in Participants With Myeloid Malignancies

NCT04771130Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm

DrugsPosaconazole·Sonrotoclax·Azacitidine

BeOne Medicines

Phase 1/2

260

Barcelona, Salamanca, Seville, Valencia

2021-05-24

Active, closed

Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)

NCT04704934Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsRamucirumab·Trastuzumab deruxtecan·Paclitaxel

Daiichi Sankyo

Phase 3

490

Barcelona, Madrid, Pamplona, Santiago de Compostela, Valencia

2021-05-21

Active, closed

A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread

NCT04810078Clear Cell Renal Cell Carcinoma

DrugsNivolumab and rHuPH20·Opdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

681

Barcelona, Madrid, Sabadell, Santander, Seville

2021-05-21

Active, closed

Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)

NCT04544293Autoimmune Pulmonary Alveolar Proteinosis

DrugMolgramostim

Savara Inc.

Phase 3

164

Barcelona

2021-05-19

Active, closed

RISE - Study of the AGN1 LOEP SV Kit in Patients With Vertebral Compression Fractures

NCT04821739Vertebral Compression Fracture, Vertebral Compression, Vertebral Fracture

AgNovos Healthcare, LLC

Not applicable

100

Valladolid, Barcelona

2021-05-19

Recruiting

A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)

NCT04811560Acute Leukemia

DrugBleximenib

Janssen Research & Development, LLC

Phase 1/2

420

Barcelona, Madrid, Pamplona, Salamanca, Seville, Valencia

2021-05-19

Active, closed

The SELUTION DeNovo Study

NCT04859985Coronary Artery Disease

M.A. Med Alliance S.A.

Not applicable

3,326

Barcelona, Madrid, Vigo

2021-05-15

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

NCT07218029Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 3

815

Palma de Mallorca, Santander, Barcelona, Majadahonda, Madrid, Toledo

2021-05-12

Active, closed

Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients

NCT04824092Diffuse Large B-cell Lymphoma

DrugsTafasitamab·Vincristine·Doxorubicin·Prednisone

Incyte Corporation

Phase 3

899

Badalona, Barcelona, Girona, Jerez de la Frontera, Lugo, Madrid, Pamplona, Salamanca

2021-05-11

Active, closed

Prospective Observational Study of Filgotinib in Subjects With Rheumatoid Arthritis

NCT04871919Rheumatoid Arthritis

DrugFilgotinib

Alfasigma S.p.A.

Observational

1,304

A Coruña, Barcelona, Córdoba, Mérida, Murcia, Palma, Pontevedra, Santa Cruz de Tenerife

2021-05-11

Active, closed

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Abemaciclib·Ribociclib·Palbociclib

AstraZeneca

Phase 3

893

Barcelona, Granada, Lleida, Madrid, Málaga, Pamplona, Santiago de Compostela

2021-05-10

Active, closed

Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)

NCT04675333Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma

DrugsEvorpacept·Cisplatin/Carboplatin·Fluorouracil·Keytruda

ALX Oncology Inc.

Phase 2

172

Barcelona, Badalona, L'Hospitalet de Llobregat, Leganés, Madrid, Málaga, Pamplona

2021-05-10

Recruiting

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

NCT04614103Metastatic Non Small Cell Lung Cancer

DrugLifileucel

Iovance Biotherapeutics, Inc.

Phase 2

170

A Coruña, Barcelona, Córdoba, Madrid, Málaga, Pamplona, Salamanca, Seville

2021-05-07

By invitation

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

NCT04848506Symptomatic Hypertrophic Cardiomyopathy (HCM)

DrugAficamten

Cytokinetics

Phase 2/3

900

A Coruña, Barcelona, Madrid, Málaga, Palma, Pontevedra, Salamanca, Seville

2021-05-06

Recruiting

Intraoperative Radiotherapy in Patients With Brain Metastases

NCT04847284Brain Metastases

Parc de Salut Mar

Not applicable

Barcelona

2021-05-05

Active, closed

Safety & Effectiveness Evaluation of Seraph 100 in Treatment of Pts With COVID-19

NCT04547257COVID-19

ExThera Medical Corporation

Not applicable

Barcelona, Madrid

2021-05-04

Active, closed

A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy

NCT04660344Muscle-invasive Bladder Cancer

DrugsTecentriq·Atezolizumab

Hoffmann-La Roche

Phase 3

761

Sabadell, Santander, Córdoba, Donostia / San Sebastian, Barcelona, Madrid, Seville, Valencia

2021-05-03

Recruiting

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

NCT04752774Spasticity

DrugsDysport·Corabotase

Ipsen

Phase 1/2

240

A Coruña, Barcelona, Huelva, Madrid, Santiago de Compostela, Seville, Vigo

2021-04-29

Recruiting

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

NCT04743141Acute Treatment of Migraine

DrugRimegepant

Pfizer

Phase 3

600

Balenya, Barcelona, Valladolid

2021-04-28

Active, closed

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

NCT04868877Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma

DrugsBispecific·Tagrisso·Osimertinib

Merus B.V.

Phase 1/2

194

Barcelona, Madrid, Pamplona, Valencia

2021-04-28

Active, closed

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

NCT04784715Breast Cancer; HER2-positive; Metastatic

DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab

AstraZeneca

Phase 3

1,157

Alicante, Barcelona, Madrid, Majadahonda, Seville

2021-04-26

Recruiting

RESTORE - Study of AGN1 LOEP to Prevent Secondary Hip Fractures

NCT04796350Fragility Fracture, Hip Fractures, Osteoporosis

AgNovos Healthcare, LLC

Not applicable

2,400

Barcelona, Valladolid, Bilbao, Galdakao, Jaén, Madrid, Manresa, Sabadell

2021-04-24

Active, closed

DiamondTemp Global Registry

NCT04735016Arrhythmia

Medtronic Cardiac Ablation Solutions

Observational

545

Barcelona, Madrid

2021-04-22

Active, closed

A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice

NCT04475926Limb-girdle Muscular Dystrophy

Sarepta Therapeutics, Inc.

Observational

205

Barcelona

2021-04-22

Recruiting

Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics

NCT05761080Laparoscopic Appendectomy, Complicated Appendicitis, Periappendicular Abscess

DrugMaximum

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Phase 4

772

Barcelona, Córdoba, Lleida, Madrid, Seville, Badalona, Esplugues de Llobregat, Girona

2021-04-22

Recruiting

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

NCT04752722Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Non-muscle Invasive Bladder Cancer

DrugPhase 2

enGene, Inc.

Phase 1/2

350

Barbera Del Valles, Barcelona, L'Hospitalet de Llobregat, Madrid, Murcia, Santander

2021-04-22

Active, closed

Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)

NCT04700124Bladder Cancer

DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

808

Badalona, Manresa, Girona, Santiago de Compostela, Las Palmas de Gran Canaria, Oviedo, Valencia, Barcelona

2021-04-21

Active, closed

Rectal Tumor Resection Using the UNI-VEC Multichannel Transanal Access Device

NCT06286956Rectal Polyp, Rectal Polyps, Rectal Lesion, Sessile Colonic Polyp

Vecmedical Spain, S.L.

Not applicable

Barcelona, Terrassa, A Coruña, Lugo, Vigo, Madrid, Murcia, Gijón

2021-04-19

Recruiting

Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).

NCT04663750Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage

King's College Hospital NHS Trust

Phase 3

210

Barcelona

2021-04-16

Recruiting

Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD

NCT04580420Primary Hyperoxaluria Type 1, End Stage Renal Disease

DrugDcr-Phxc

Dicerna Pharmaceuticals, Inc., a Novo Nordisk company

Phase 2

Barcelona, Santa Cruz de Tenerife

2021-04-15

Active, closed

A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

NCT04680052Follicular Lymphoma, Marginal Zone Lymphoma

DrugsTafasitamab·Lenalidomide·Rituximab

Incyte Corporation

Phase 3

654

A Coruña, Alicante, Badalona, Barcelona, Burgos, Gijón, L'Hospitalet de Llobregat, Madrid

2021-04-15

Active, closed

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

NCT04736706Carcinoma, Renal Cell

DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda

Merck Sharp & Dohme LLC

Phase 3

1,688

Santander, Barcelona, Girona, Madrid, Málaga

2021-04-14

Recruiting

Safety and Preliminary Efficacy of MBS8(1V270) in Cancer Patients With Advanced Solid Tumours

NCT04855435Advanced Solid Tumor, Uveal Melanoma, Metastatic, Cutaneous Melanoma

MonTa Biosciences ApS

Phase 1

106

Barcelona, Madrid, Valencia

2021-04-12

Active, closed

Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors

NCT04802876MSI-H Colorectal Cancer, Melanoma, Anal Carcinoma, Mesothelioma

DrugsSpartalizumab·Tislelizumab

SOLTI Breast Cancer Research Group

Phase 2

184

Barcelona

2021-04-12

Active, closed

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis

DrugsPelabresib·Ruxolitinib

Novartis Pharmaceuticals

Phase 3

430

Oviedo, Badalona, Barcelona, Cáceres, Las Palmas de Gran Canaria, Madrid, Murcia, Salamanca

2021-04-09

Active, closed

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

NCT04662255Lymphoma, Mantle-Cell

DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib

Loxo Oncology, Inc.

Phase 3

500

Málaga, Barcelona, L'Hospitalet de Llobregat, Pamplona, Palma de Mallorca, Madrid, Valencia

2021-04-08

Recruiting

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

NCT04617522Advanced or Metastatic Solid Tumor, Liver Failure

DrugSacituzumab Govitecan

Gilead Sciences

Phase 1

Barcelona, Seville

2021-04-06

Recruiting

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia

DrugNemtabrutinib

Merck Sharp & Dohme LLC

Phase 2

490

L'Hospitalet de Llobregat, Salamanca, A Coruña, Alicante, Barcelona, Madrid

2021-04-05

Active, closed

SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial

NCT04722250Symptomatic Aortic Stenosis, Aortic Valve Stenosis, Aortic Valve Replacement

Medtronic Cardiovascular

Not applicable

1,103

Barcelona

2021-04-02

Active, closed

Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)

NCT04675294Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma

DrugsEvorpacept·Keytruda·Pembrolizumab

ALX Oncology Inc.

Phase 2

189

Barcelona, Madrid, Málaga, Pamplona

2021-04-02

Active, closed

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

NCT04822181Non-alcoholic Steatohepatitis

DrugSemaglutide

Novo Nordisk A/S

Phase 3

1,205

Pontevedra, Barcelona, Majadahonda, Santander, Seville, Valencia, Valladolid

2021-04-01

By invitation

Characterization of Cerebral Tau Aggregates With 18F-RO6958948 PET in the ALFA Population

NCT04482660Healthy, Mild Cognitive Impairment

Barcelonabeta Brain Research Center, Pasqual Maragall Foundation

Not applicable

100

Barcelona

2021-03-29

Active, closed

Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

NCT04954001Neurofibromatosis 1, Plexiform Neurofibroma, NF1

DrugLuvometinib

Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.

Phase 1/2

160

Barcelona, Madrid

2021-03-26

Active, closed

Retention With Three Different Bonded Retainers a Multicenter, Randomized Controlled Trial With 5-year Follow-up

NCT04828096Dental Malocclusion, Stability

Region Örebro County

Not applicable

324

Barcelona

2021-03-25

Active, closed

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

NCT04620239Transitional Cell Cancer of Renal Pelvis and Ureter

Steba Biotech S.A.

Phase 3

A Coruña, Barcelona

2021-03-22

Active, closed

Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection

NCT04727788Kidney Transplant Rejection

Verici Dx

Observational

550

Barcelona

2021-03-21

Active, closed

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT04691804Metastatic Castration-Resistant Prostate Cancer (mCRPC)

DrugFluzoparib

Jiangsu HengRui Medicine Co., Ltd.

Phase 3

496

Castellon, Barcelona, Córdoba, Girona, Madrid, Málaga, Seville, Valencia

2021-03-18

Active, closed

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

NCT04586010Relapsing Multiple Sclerosis

DrugsFenebrutinib·Teriflunomide

Hoffmann-La Roche

Phase 3

746

L'Hospitalet de Llobregat, Pozuelo de Alarcón, EL Palmar (EL Palmar), Vigo, Barcelona, Madrid, Málaga, Seville

2021-03-17

Recruiting

DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.

NCT07717437Liver Cancer, Liver Metastases

Maastricht University Medical Center

Observational

350

Badalona, Barcelona

2021-03-16

Active, closed

Atrasentan in Patients With Proteinuric Glomerular Diseases

NCT04573920IgA Nephropathy, Focal Segmental Glomerulosclerosis, Alport Syndrome, Diabetic Kidney Disease

DrugAtrasentan

Novartis Pharmaceuticals

Phase 2

103

Port de Sagunt, Barcelona, Lugo, Madrid, Majadahonda

2021-03-15

By invitation

Digitally-enhanced, Decentralized, Multi-omics Observational Cohort

NCT04701177Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change

Greece 2021 Committee

Observational

100,000

Barcelona

2021-03-15

Active, closed

Study With Atezolizumab in Combination With Trastuzumab and Vinorelbine in HER2-positive Advanced/Metastatic Breast Cancer

NCT04759248Breast Cancer

DrugsVinorelbine·Trastuzumab·Atezolizumab

SOLTI Breast Cancer Research Group

Phase 2

Granada, Barcelona, L'Hospitalet de Llobregat, Santa Cruz de Tenerife, A Coruña, Alicante, Cáceres, León

2021-03-15

Active, closed

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

NCT04639050Alzheimers Disease

DrugTrontinemab

Hoffmann-La Roche

Phase 1/2

241

Sant Cugat del Vallès, Donostia / San Sebastian, Barcelona, Madrid, Valencia

2021-03-15

Active, closed

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

NCT04562389Myelofibrosis

DrugsSelinexor·Ruxolitinib

Karyopharm Therapeutics Inc

Phase 3

353

Cáceres, Oviedo, Zaragoza, Badalona, Barcelona, Girona, Las Palmas de Gran Canaria, Lugo

2021-03-11

Active, closed

A Study to Evaluate the Long-term Safety of Patients With Advanced Lymphoid Leukemia Who Have Been Previously Administered With UCART19

NCT02735083Advanced Lymphoid Leukemia

Institut de Recherches Internationales Servier

Phase 1

Barcelona

2021-03-10

Active, closed

Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT04666038Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsIdelalisib·Truxima·Pirtobrutinib·Bendamustine

Loxo Oncology, Inc.

Phase 3

238

L'Hospitalet de Llobregat, Toledo, Santiago de Compostela, Pozuelo de Alarcón, Madrid, Albacete, Barcelona, Cáceres

2021-03-09

Active, closed

A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer

NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III

DrugAutogene cevumeran

BioNTech SE

Phase 2

327

A Coruña, Ávila, Badalona, Barcelona, Córdoba, Madrid, Majadahonda, Málaga

2021-03-08

Recruiting

A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

NCT04710576Chronic Graft-versus-host-disease

DrugAxatilimab

Syndax Pharmaceuticals

Phase 2

296

Seville, Barcelona, Donostia / San Sebastian, Granada, Madrid, Majadahonda, Salamanca, Santander

2021-03-04

Recruiting

Conservative Management of HSIL in Patients With Future Pregnancy Aspiration

NCT04783805Cervical Intraepithelial Neoplasia, Squamous Intraepithelial Lesions of the Cervix, Uterine Cervical Dysplasia

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Observational

200

Barcelona

2021-03-03

Recruiting

sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.

NCT04766866Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Not applicable

9,132

Badalona, Las Palmas de Gran Canaria, El Palmar, Barcelona, Madrid, Palma de Mallorca, Valencia, Zaragoza

2021-03-02

Active, closed

Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)

NCT04608318Chronic Lymphoid Leukemia

DrugsVenclyxto·Ibrutinib·Obinutuzumab·Venetoclax

German CLL Study Group

Phase 3

897

Badalona, Barcelona, Madrid, Málaga, Oviedo, Salamanca, Santander, Seville

2021-03-01

Active, closed

An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis

DrugLuspatercept

Celgene

Phase 3

313

Barcelona, Granada, Las Palmas de Gran Canaria, Madrid, Palma de Mallorca, Salamanca, Santiago de Compostela, Seville

2021-02-25

Active, closed

A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

NCT04586231Carcinoma, Renal Cell

DrugsBelzutifan·Cabozantinib·Lenvatinib

Merck Sharp & Dohme LLC

Phase 3

747

A Coruña, Madrid, Barcelona, Seville

2021-02-25

Active, closed

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

NCT04699188KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung

DrugsTNO155·Opnurasib·Tislelizumab

Novartis Pharmaceuticals

Phase 1/2

344

Santiago Compostela, L'Hospitalet de Llobregat, Barcelona, Madrid, Málaga, Valencia

2021-02-24

Active, closed

Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors

NCT04721015Advanced Solid Tumors Cancer, Non Small Cell Lung Cancer (NSCLC)

DrugsOsimertinib·Docetaxel

AbbVie

Phase 1

Barcelona, Madrid, Majadahonda, Málaga

2021-02-23

Active, closed

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer

DrugsAdagrasib·Taxotere·Docetaxel

Mirati Therapeutics Inc.

Phase 3

453

Pamplona, A Coruña, Alicante, Badalona, Barakaldo, Barcelona, Córdoba, Girona

2021-02-23

Active, closed

A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

NCT04408638Diffuse Large B-cell Lymphoma

DrugsRituxumab·Glofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 3

270

Barcelona, Madrid, Seville, Valencia

2021-02-23

Recruiting

Comparison of Nutritional Screening Tools in Liver Cirrhosis Patients

NCT04502719Malnutrition, Cirrhosis, Liver

Hospital Clinic of Barcelona

Observational

Barcelona

2021-02-22

Active, closed

Monolithic Zirconia Posterior Single Crowns: a Randomized Clinical Trial.

NCT06865209Posterior Single Edentulous Sites

University of Barcelona

Not applicable

Barcelona

2021-02-19

Active, closed

Maternal Betaine Supplementation During Breastfeeding

NCT04633044Overweight and Obesity

Fundació Sant Joan de Déu

Phase 1/2

Barcelona

2021-02-11

Active, closed

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

NCT05388708Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation

University of Michigan

Observational

550

Barcelona, Madrid

2021-02-04

Recruiting

A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT04901936Paroxysmal Nocturnal Hemoglobinuria (PNH), Paroxysmal Hemoglobinuria

DrugPegcetacoplan

Apellis Pharmaceuticals, Inc.

Phase 2

Barcelona, Madrid

2021-02-04

Recruiting

PErsonalized Addition of Recombinant LH in Ovarian Stimulation

NCT04719000Infertility

Fundación Santiago Dexeus Font

Phase 4

120

Barcelona

2021-02-04

Recruiting

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

NCT03127267Amyotrophic Lateral Sclerosis

DrugsMasitinib·Riluzole

AB Science

Phase 3

495

Alicante, Barcelona, Madrid, Santiago de Compostela, Valencia

2021-02-02

Active, closed

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

NCT04619004Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor

DrugPatritumab deruxtecan

Daiichi Sankyo

Phase 2

277

Seville, Badalona, Majadahonda, Barcelona, Madrid, Málaga, Zaragoza

2021-02-02

Active, closed

Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04612751Advanced or Metastatic NSCLC

DrugsSabestomig·Volrustomig·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 1

155

A Coruña, Badalona, Barcelona, Madrid, Seville

2021-02-02

Active, closed

Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project

NCT04879563Breast Cancer, Prostate Cancer, Quality of Life, Survivorship

Region Örebro County

Phase 2

500

Barcelona

2021-02-01

Recruiting

First-In-Human Clinical Study for Treatment of Severe Mitral Valve INsufficiency With Epygon™ TRanscatheter Mitral VAlve System

NCT04775108Mitral Valve Regurgitation

Epygon

Not applicable

Badalona, Barcelona, Madrid, Murcia, Seville

2021-02-01

Recruiting

TAD After Chemotherapy in Locally Advanced Breast Cancer

NCT05763641Sentinel Lymph Node, Breast Cancer, Locally Advanced

Hospital Universitari de Bellvitge

Observational

162

L'Hospitalet de Llobregat, Barcelona

2021-02-01

Recruiting

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04634552Hematological Malignancies

DrugTalquetamab

Janssen Research & Development, LLC

Phase 2

510

Badalona, Barcelona, Madrid, Murcia, Pamplona, Pozuelo de Alarcón, Salamanca, Santander

2021-02-01

Active, closed

A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)

NCT04624659Sickle Cell Disease

DrugEtavopivat

Forma Therapeutics, Inc.

Phase 3

450

A Coruña, Badalona, Barakaldo, Barcelona, Madrid, Seville

2021-01-29

Active, closed

A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease

NCT04711252ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Anastrozole·Palbociclib

AstraZeneca

Phase 3

1,371

Barcelona, Jaén, Lleida, Madrid, Málaga, Pamplona, Santander, Seville

2021-01-28

Recruiting

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

NCT04657068Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer

DrugsIrinotecan·Gemcitabine

Artios Pharma Ltd

Phase 1/2

542

Elche, Sabadell, Santander, Barcelona, Lleida, Madrid, Pozuelo de Alarcón, El Palmar

2021-01-27

Recruiting

BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

NCT04752826Advanced Malignancies, Ovarian Cancer, T-cell Lymphoma, Melanoma

DrugsPembrolizumab KEYTRUDA·Paclitaxel

BioInvent International AB

Phase 1/2

250

Barcelona, Madrid

2021-01-25

Recruiting

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

NCT04031677Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

250

Barcelona, Madrid

2021-01-20

Recruiting

Prophylactic Cholecystectomy in Midgut NETs Patients Who Require Primary Tumor Surgery.

NCT04735198Midgut Carcinoid Tumor, Biliary Stones

Hospital Universitari de Bellvitge

Not applicable

100

Badalona, Barcelona, L'Hospitalet de Llobregat, Madrid

2021-01-20

Active, closed

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

NCT04589845Solid Tumors

DrugsCamonsertib·Belvarafenib·Pralsetinib·Divarasib

Hoffmann-La Roche

Phase 2

920

Esplugues de Llobregas, Barcelona, Madrid, Valencia

2021-01-18

Active, closed

BIOMIGA: Results From Magnetic Resonance Imaging

NCT06633484Migraine

Universitätsklinikum Hamburg-Eppendorf

Observational

219

Barcelona

2021-01-15

Active, closed

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

NCT04657991Melanoma

DrugsBinimetinib·Encorafenib·Keytruda·Pembrolizumab

Pfizer

Phase 3

257

Badalona, Santander, Majadahonda, El Palmar, A Coruña, Barcelona, Córdoba, Jaén

2021-01-15

Recruiting

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

NCT04649242Pediatric Migraine

Pfizer

Phase 3

2,100

Santander, Barcelona, Madrid, Seville, Valladolid

2021-01-15

Active, closed

New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy

NCT04564157Non-Small Cell Lung Cancer, Adjuvant Chemotherapy

DrugsParaplatin·Taxol·Opdivo·Nivolumab

Fundación GECP

Phase 3

210

Alicante, Badalona, Barcelona, L'Hospitalet de Llobregat, Bilbao, Cáceres, El Palmar, Girona

2021-01-13

Active, closed

A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)

NCT04628494Diffuse Large B-cell Lymphoma

DrugEpcoritamab

Genmab

Phase 3

483

Badalona, Barcelona, Cadiz, Cáceres, Córdoba, Lleida, Madrid, Salamanca

2021-01-13

Active, closed

A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

NCT04204616Prurigo Nodularis

DrugNemolizumab

Galderma R&D

Phase 3

500

Barcelona, Las Palmas de Gran Canaria

2021-01-11

Active, closed

Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

NCT04579380Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms

DrugsTucatinib·Herceptin·Fulvestrant·Trastuzumab

Seagen, a wholly owned subsidiary of Pfizer

Phase 2

217

L'Hospitalet de Llobregat, Barcelona, Valencia

2021-01-11

Active, closed

Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)

NCT04634877Endometrial Neoplasms

DrugsDocetaxel·Keytruda·Paclitaxel·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

990

Girona, Madrid, Barcelona, Córdoba

2021-01-10

Active, closed

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1

NCT04534205Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer

DrugPembrolizumab

BioNTech SE

Phase 2/3

358

Barcelona, Girona, Jaén, Madrid, Majadahonda, Málaga, Palma de Mallorca, Valencia

2021-01-07

Active, closed

A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL

NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia

DrugBlinatumomab

Amgen

Phase 1/2

181

Seville, Santander, Salamanca, Badalona, Barcelona, Esplugues de Llobregat, L'Hospitalet de Llobregat, Pamplona

2021-01-04

Recruiting

Peri-Implant and Peri-Prosthetic Fractures: Epidemiology, Morbidity, Mortality, Treatment and Outcome Analysis

NCT04663893Periprosthetic Fracture of the Upper or Lower Limb, Peri-implant Fracture of the Upper or Lower Limb, Periprosthetic Fractures, Peri-implant Fracture

Hospital Clínico Universitario de Valladolid

Observational

2,500

Barcelona, Gijón, Madrid, Valladolid

2021-01-01

Recruiting

Real-Life Chronic Rhinosinusitis Outcome Registry

NCT04670172Chronic Rhinosinusitis (Diagnosis)

Change Accelerator in Respiratory Care

Observational

4,550

Barcelona

2021-01-01

Recruiting

Survival Study of the Genutech® Total Knee Arthroplasty

NCT06899932Knee Osteoarthritis

Hospital de Sant Rafael

Observational

500

Barcelona

2021-01-01

Not yet open

Belimumab in Patients With Systemic Lupus Erythematosus

NCT04671706Systemic Lupus Erythematosus

Grupo de Trabajo de Enfermedades Autoinmunes Sistémicas (GEAS) de la Fundación Española de Medicina

Observational

3,000

Barcelona

2021-01

Active, closed

A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations

NCT04639219Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 2

102

Barcelona, Madrid, Pamplona, Seville

2020-12-30

Active, closed

Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours

NCT04735978Advanced Solid Tumor

DrugNivolumab

Replimune, Inc.

Phase 1

123

Barcelona, Madrid, Valencia

2020-12-29

Active, closed

A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer

NCT04538742Metastatic Breast Cancer

DrugsTucatinib·Pertuzumab·Trastuzumab deruxtecan·Durvalumab

AstraZeneca

Phase 1/2

245

Barcelona, L'Hospitalet de Llobregat, Madrid, Seville

2020-12-28

Active, closed

Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)

NCT04656652Non-small Cell Lung Cancer

DrugsDato-DXd·Docetaxel

Daiichi Sankyo

Phase 3

605

Barcelona, Madrid, Málaga, Ourense, Seville, Valencia, Zaragoza

2020-12-21

Active, closed

A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer

NCT04607421Neoplasms

DrugsEncorafenib·Zirabev·Erbitux·Xeloda

Pfizer

Phase 3

841

Santiago de Compostela, Elche, L'Hospitalet de Llobregat, Barcelona, Madrid, Seville, Valencia, Zaragoza

2020-12-21

Active, closed

A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers

NCT04626635Advanced Solid Tumors

DrugsMarlotamig·Trifluridine/Tipiracil·Cemiplimab·Bevacizumab

Regeneron Pharmaceuticals

Phase 1/2

548

Sant Cugat del Vallès, Pozuelo de Alarcón, Barcelona, Madrid, Valencia

2020-12-21

Active, closed

A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation

NCT04625270Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer

DrugsAvutometinib (VS-6766) and defactinib·Avutometinib·Lumakras

Verastem, Inc.

Phase 2

225

Barcelona, Córdoba, Madrid, Valencia

2020-12-21

Active, closed

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

NCT04640623Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 2

220

A Coruña, Badalona, Barcelona, Cadiz, Granada, Jerez de la Frontera, Madrid, Málaga

2020-12-18

Active, closed

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

NCT04663308Primary Sclerosing Cholangitis

DrugVolixibat

Mirum Pharmaceuticals, Inc.

Phase 2

182

Barcelona, Madrid

2020-12-18

Active, closed

A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

NCT04351555Non-Small Cell Lung Cancer

DrugsTagrisso·Osimertinib·Pemetrexed·Cisplatin

AstraZeneca

Phase 3

358

Barcelona, Madrid, Majadahonda, Málaga

2020-12-16

Active, closed

A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04586426Multiple Myeloma

DrugsTalquetamab·Teclistamab

Janssen Research & Development, LLC

Phase 1/2

228

Badalona, Barcelona, L'Hospitalet de Llobregat, Madrid, Pamplona, Salamanca, Santander

2020-12-15

Recruiting

FS222 First in Human Study in Patients With Advanced Malignancies

NCT04740424Advanced Cancer, Metastatic Cancer

invoX Pharma Limited

Phase 1

260

Pamplona, Barcelona, Las Palmas de Gran Canaria, Madrid, Majadahonda, Seville, Valencia

2020-12-14

Active, closed

Atrasentan in Patients With IgA Nephropathy

NCT04573478IgA Nephropathy, Immunoglobulin A Nephropathy

DrugsAtrasentan·Zigakibart

Novartis Pharmaceuticals

Phase 3

404

Barcelona, Madrid, Sagunto, Seville, Valencia

2020-12-11

Active, closed

AMEND-CRT: Mechanical Dyssynchrony as Selection Criterion for CRT

NCT04225520Left Ventricular Dyssynchrony, Heart Failure, Cardiomyopathy, Dilated, Cardiac Remodeling, Ventricular

Universitaire Ziekenhuizen KU Leuven

Not applicable

500

Barcelona

2020-12-10

Active, closed

First-in-Human Study of the GDF-15 Neutralizing Antibody Visugromab (CTL-002) in Patients With Advanced Cancer (GDFATHER)

NCT04725474Solid Tumor, Adult

DrugsVisugromab·Visugromab RDE·Nivolumab

CatalYm GmbH

Phase 1/2

199

Barcelona, Madrid, Pamplona

2020-12-09

Active, closed

Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy

NCT04655976Lung Cancer, Non-Small Cell

DrugsCobolimab·Dostarlimab·Docetaxel

GlaxoSmithKline

Phase 2/3

758

A Coruña, Badalona, Barcelona, Burgos, Córdoba, Las Palmas de Gran Canar, Madrid, Málaga

2020-12-08

Active, closed

Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)

NCT04624204Small Cell Lung Cancer

DrugsOlaparib·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

672

L'Hospitalet de Llobregat, Oviedo, Barcelona, Madrid, Málaga, Seville

2020-12-08

Active, closed

A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

NCT04658862Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab·Gemcitabine·Cisplatin

Janssen Research & Development, LLC

Phase 3

518

A Coruña, Badalona, Barcelona, Granada, Jerez de la Frontera, Madrid, Sabadell, Santander

2020-12-07

Active, closed

A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease

NCT04540497IgG4 Related Disease

DrugInebilizumab

Amgen

Phase 3

135

Barcelona, Madrid, Valencia

2020-12-04

Active, closed

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

NCT04622319HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer

DrugsTrastuzumab emtansine·Trastuzumab deruxtecan

Daiichi Sankyo

Phase 3

1,600

Bilbao, El Palmar, Reus, A Coruña, Alcorcón, Alicante, Badajoz, Barcelona

2020-12-04

Active, closed

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)

NCT04548999Multiple Sclerosis

DrugsOcrelizumab·Methylprednisolone

Hoffmann-La Roche

Phase 3

769

Pozuelo de Alarcón, Barcelona, Madrid, Murcia

2020-12-03

Recruiting

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer

DrugsAdagrasib·Pembrolizumab

Mirati Therapeutics Inc.

Phase 2/3

626

Pamplona, A Coruña, Badalona, Barcelona, Bilbao, Burgos, Jerez de la Frontera, Las Palmas de Gran Canaria

2020-12-02

Active, closed

Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)

NCT05649384Acute Chest Pain, NSTEMI - Non-ST Segment Elevation MI

University Hospital, Basel, Switzerland

Not applicable

64,374

Barcelona, Madrid, Valencia

2020-12-01

Active, closed

"Phase I / II Study on Infusion of Natural Killer Cells After Haploidentical Transplantation in Pediatric Patients"

NCT05304754High-risk Leukemias

Instituto de Investigación Hospital Universitario La Paz

Phase 1/2

Santiago de Compostela, Oviedo, Barcelona, Madrid, Málaga, Murcia, Seville, Valencia

2020-11-30

Active, closed

Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease

NCT04283864Crohn Disease

Weizmann Institute of Science

Observational

267

Barcelona

2020-11-29

Active, closed

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

NCT04544436Multiple Sclerosis

DrugsOcrelizumab·Methylprednisolone

Hoffmann-La Roche

Phase 3

864

A Coruña, Pozuelo de Alarcón, Vigo, Barcelona, Cadiz, Málaga

2020-11-26

Active, closed

A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine

NCT04616326Chronic Migraine

DrugGalcanezumab

Eli Lilly and Company

Phase 3

312

Barcelona, Seville, Valencia, Valladolid

2020-11-25

Active, closed

Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

NCT04623541Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Treatment-naïve High Risk Chronic Lymphocytic Leukemia

DrugsEpcoritamab·Pirtobrutinib·Lenalidomide·Venetoclax

Genmab

Phase 1/2

194

Barcelona, Coaña, Madrid, Seville, Valencia

2020-11-25

Active, closed

Restoration of Central Vision With the PRIMA System in Patients With Atrophic AMD

NCT04676854Geographic Atrophy

Science Corporation

Not applicable

Barcelona

2020-11-24

Recruiting

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

NCT04561518Transthyretin-Mediated Amyloidosis, ATTR Amyloidosis

Alnylam Pharmaceuticals

Observational

1,500

Barcelona, Madrid, Palma

2020-11-23

Recruiting

Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

NCT03963622ARDS

Unity Health Toronto

Not applicable

740

Barcelona

2020-11-23

Active, closed

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

NCT04603001Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), Myeloproliferative Neoplasms (MPNs)

DrugsLY3410738·Azacitidine·Venetoclax

Eli Lilly and Company

Phase 1

260

Barcelona, Madrid, Valencia

2020-11-19

Active, closed

FS120 Phase 1/1b Study in Patients With Advanced Malignancies

NCT04648202Advanced Cancer, Metastatic Cancer

invoX Pharma Limited

Phase 1

Barcelona, Madrid, Valencia

2020-11-18

Active, closed

Activity of Lorlatinib Based on ALK Resistance Mutations Detected on Blood in ALK Positive NSCLC Patients

NCT04127110Non Small Cell Lung Cancer

DrugLorlatinib

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

L'Hospitalet de Llobregat, Barcelona, Madrid, Palma de Mallorca, Pamplona, Seville

2020-11-17

Active, closed

Evaluation of Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk

NCT04829929Non-Valvular Atrial Fibrillation

Eclipse Medical Ltd.

Not applicable

200

Valladolid, Madrid, Salamanca, Barcelona

2020-11-17

Active, closed

Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer

NCT04592913Gastrointestinal Neoplasms, Esophagogastric Junction

DrugDurvalumab

AstraZeneca

Phase 3

957

Barcelona, Madrid, Málaga, Ourense, Santander, Seville, Valencia

2020-11-17

Active, closed

A Study to Test the Safety and Tolerability of Long-term UCB0107 Administration in Study Participants With Progressive Supranuclear Palsy

NCT04658199Progressive Supranuclear Palsy

UCB Biopharma SRL

Phase 1

Barcelona, Madrid, Pamplona

2020-11-16

Recruiting

Integrative Diagnosis for SCD and Other RADs

NCT07206095Sickle Cell Disease, Thalassaemia, Congenital Dyserythropoietic Anemia (CDA), Enzyme Disorder; Anemia

Hospital Universitari Vall d'Hebron Research Institute

Observational

200

Barcelona, Esplugues de Llobregat, Granollers, Mataró, Sabadell, Terrassa, Lleida

2020-11-13

Active, closed

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

NCT04644068Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer

DrugsSaruparib·Camizestrant·Dato-DXd·Trastuzumab deruxtecan

AstraZeneca

Phase 1/2

702

Barcelona, Madrid, Málaga, Pozuelo de Alarcón, Seville

2020-11-12

Active, closed

Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis

NCT04454658Myelofibrosis (MF)

DrugsNavitoclax·Ruxolitinib

AbbVie

Phase 1

Barcelona, Madrid

2020-11-11

Active, closed

RADIANT: A Study of Radium-223 Dichloride (Xofigo) vs Enzalutamide or Abiraterone (ARPIs, Androgen Receptor Pathway Inhibitors) in Patients With Prostate Cancer That Has Spread to the Bones (mCRPC, Metastatic Castration-Resistant Prostate Cancer)

NCT04597125Metastatic Castrate Resistant Prostate Cancer (mCRPC)

Bayer

Phase 4

654

Santiago de Compostela, Palma de Mallorca, Badalona, Castellon, Majadahonda, Oviedo, A Coruña, Barcelona

2020-11-09

Active, closed

Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)

NCT04408625Frontotemporal Dementia

DrugMethylprednisolone

Prevail Therapeutics

Phase 1/2

Barcelona, Donostia / San Sebastian

2020-11-09

Recruiting

Vyxeos® With Clofarabine for Pediatric AML

NCT07156435Relapsed Pediatric AML, Refractory Pediatric AML

DrugClofarabine

Princess Maxima Center for Pediatric Oncology

Phase 1

Barcelona, Madrid

2020-11-06

Recruiting

Guided Bone Regeneration Using Fixed vs Non-Fixed Resorbable Collagen Membranes

NCT06334159Bone Resorption

Universitat Internacional de Catalunya

Not applicable

Barcelona

2020-11-05

Active, closed

Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy

NCT04281485Duchenne Muscular Dystrophy

Pfizer

Phase 3

114

Esplugues de Llobregat, Barcelona, Valencia

2020-11-05

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)

NCT04512235AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and Dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

281

Barcelona, Gijón, Granada, Madrid, Majadahonda, Pamplona, Salamanca, Seville

2020-11-03

Active, closed

Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)

NCT04663347Diffuse Large B-Cell Lymphoma, Follicular Lymphoma

DrugsR-Ice·Rituximab and lenalidomide·Gemcitabine and oxaliplatin·Epcoritamab

Genmab

Phase 1/2

543

Barcelona, Madrid, Salamanca

2020-11-03

Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor

DrugsRezatapopt·Keytruda·Pembrolizumab

PMV Pharmaceuticals, Inc

Phase 1/2

300

Madrid, Barcelona, Rioja, Valencia

2020-10-29

Recruiting

A Retrospective Protocol Empowering Precision Research in Colorectal Cancer (ALFAOMEGA-RETRÒ)

NCT05101382Colorectal Cancer

IFOM ETS - The AIRC Institute of Molecular Oncology

Observational

500

L'Hospitalet de Llobregat, Barcelona, Valencia

2020-10-28

Active, closed

Sacituzumab Govitecan in Primary HER2-negative Breast Cancer

NCT04595565HER2-negative Breast Cancer, Triple Negative Breast Cancer

DrugsXeloda·Sacituzumab Govitecan·Paraplatin·Capecitabine

GBG Forschungs GmbH

Phase 3

1,332

Barakaldo, A Coruña, Albacete, Alcorcón, Alcoy, Alicante, Badalona, Barcelona

2020-10-28

Active, closed

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis

NCT04544449Multiple Sclerosis, Primary Progressive

DrugsFenebrutinib·Ocrelizumab

Hoffmann-La Roche

Phase 3

985

A Coruña, Lleida, Pozuelo de Alarcón, Vigo, Barcelona, Cadiz, Madrid, Málaga

2020-10-26

Recruiting

Abbott Vascular Medical Device Registry

NCT04573660Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism

Abbott Medical Devices

Observational

3,784

Barcelona, Madrid, Alicante

2020-10-25

Active, closed

Real World Study Using Comprehensive Genomic Data on the Next Treatment Decision Making in Metastatic Breast Cancer

NCT04497285Metastatic Breast Cancer

SOLTI Breast Cancer Research Group

Observational

600

Barcelona

2020-10-20

Active, closed

Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

NCT04464226Cancer

DrugDarolutamide

Bayer

Phase 3

402

Elche, Manacor, Palma de Mallorca, Sabadell, Alcorcón, Barcelona, Cáceres, Córdoba

2020-10-20

Active, closed

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

NCT04446117Metastatic Prostate Cancer, Prostate Adenocarcinoma

DrugsZytiga·Xtandi·Abiraterone·Abiraterone acetate

Exelixis

Phase 3

575

Elche, Palma de Mallorca, Manresa, Santiago de Compostela, Alcorcón, Oviedo, Badalona, Barcelona

2020-10-19

Active, closed

Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC

NCT04550260Esophageal Squamous Cell Carcinoma

DrugsFluorouracil·Durvalumab·Capecitabine·Cisplatin

AstraZeneca

Phase 3

640

Barcelona, Córdoba, Madrid, Pamplona, Santander, Zaragoza

2020-10-19

Active, closed

Myasthenia Gravis Inebilizumab Trial

NCT04524273Myasthenia Gravis

DrugInebilizumab

Amgen

Phase 3

238

Badalona, Barcelona, Córdoba

2020-10-15

Active, closed

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

NCT04538664Carcinoma, Non-Small-Cell Lung

DrugsAmivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 3

308

A Coruña, Badalona, Barcelona, Burgos, Madrid, Majadahonda, Málaga, Pamplona

2020-10-13

Active, closed

A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Palbociclib·Letrozole

Hoffmann-La Roche

Phase 3

992

L'Hospitalet de Llobregat, Donostia / San Sebastian, Pozuelo de Alarcón, A Coruña, Barcelona, Madrid, Seville, Valencia

2020-10-09

Active, closed

A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)

NCT04529772Diffuse Large B-Cell Lymphoma

DrugsAcalabrutinib·Vincristine·Doxorubicin·Prednisone

Acerta Pharma BV

Phase 3

611

Alcalá de Henares, Badalona, Barcelona, Gijón, L'Hospitalet de Llobregat, Madrid, Palma, Pamplona

2020-10-08

Active, closed

A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors

NCT04434092Paroxysmal Nocturnal Hemoglobinuria

DrugsCrovalimab·Eculizumab

Hoffmann-La Roche

Phase 3

210

Bilbao, Badalona, Las Palmas de Gran Canaria, Barcelona, Cáceres, Madrid, Salamanca

2020-10-08

Recruiting

Triple-A Barcelona Study

NCT06827652Abdominal Aortic Aneurysm

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Observational

800

Barcelona

2020-10-05

Active, closed

CARdiomyopathy in Type 2 DIAbetes Mellitus

NCT04303364Cardiomyopathy, Diabetic

Institut National de la Santé Et de la Recherche Médicale, France

Observational

1,256

Barcelona, Madrid

2020-10-02

Active, closed

Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

NCT04590963Squamous Cell Carcinoma of the Head and Neck

DrugsMonalizumab·Erbitux·Cetuximab

AstraZeneca

Phase 3

370

Barcelona, Madrid, Valencia

2020-10-02

Active, closed

Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma

NCT04484623Multiple Myeloma

DrugsBelantamab mafodotin·Pomalidomide·Bortezomib·Dexamethasone

GlaxoSmithKline

Phase 3

302

Barcelona, Gijón, L'Hospitalet de Llobrega, Madrid, MOstoles Madrid, Murcia, Palma de Mallorca, PamplonaNavarra

2020-10-01

Active, closed

Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

NCT04521686Cholangiocarcinoma, Chondrosarcoma, Glioma, Any Solid Tumor

DrugsLY3410738·Durvalumab·Gemcitabine·Cisplatin

Eli Lilly and Company

Phase 1

200

Barcelona, Madrid

2020-10-01

Active, closed

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

NCT04432584Paroxysmal Nocturnal Hemoglobinuria

DrugsCrovalimab·Eculizumab

Hoffmann-La Roche

Phase 3

190

Badalona, Santiago de Compostela, Asturias, Bilbao, Barcelona, Madrid, Málaga, Salamanca

2020-09-30

Active, closed

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04487080Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Osimertinib

Janssen Research & Development, LLC

Phase 3

1,074

A Coruña, Badalona, Barcelona, Burgos, Girona, Madrid, Majadahonda, Málaga

2020-09-30

By invitation

Follow-up Study of AAV-Mediated Gene Transfer (UX111; Previously Known as ABO-102) for MPS Type IIIA

NCT04360265Mucopolysaccharidosis IIIA, MPS IIIA, Sanfilippo Syndrome, Sanfilippo A

Ultragenyx Pharmaceutical Inc

Phase 3

Barcelona, Santiago de Compostela

2020-09-28

Active, closed

SPRINT: Signature for Pain Recovery IN Teens

NCT04285112Pain, Chronic, Pain, Joint Pain, Musculoskeletal Pain

Stanford University

Observational

275

Barcelona

2020-09-28

Active, closed

Isa-KRd vs KRd in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL)

NCT04483739Multiple Myeloma

European Myeloma Network B.V.

Phase 3

302

Badalona, Barcelona, Madrid, Pamplona, Salamanca, Santander

2020-09-25

Active, closed

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)

NCT04526665Primary Biliary Cirrhosis

DrugElafibranor

Ipsen

Phase 3

161

Barcelona, Madrid, Pontevedra, San Sebastián, Santander, Seville

2020-09-24

Active, closed

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)

NCT04497844Prostatic Neoplasms

DrugsAbiraterone acetate·Prednisone

Janssen Research & Development, LLC

Phase 3

696

A Coruña, Barcelona, Castellon, Girona, Jerez de la Frontera, Madrid, Málaga, Sabadell

2020-09-23

Active, closed

A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP, an Autoimmune Disorder That Affects the Peripheral Nerves)

NCT04280718Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

DrugEfgartigimod PH20

argenx

Phase 2

229

Badalona, Barcelona, Madrid

2020-09-18

Recruiting

Pancreatic Cancer Early Detection Consortium

NCT04970056Pancreas Cancer, Pancreas Cyst, Pancreatic Ductal Adenocarcinoma, Genetic Predisposition

Arbor Research Collaborative for Health

Observational

20,000

Barcelona, Lleida, Madrid

2020-09-18

Active, closed

A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04557098Hematological Malignancies

DrugTeclistamab

Janssen Research & Development, LLC

Phase 2

194

Badalona, Barcelona, Madrid, Pamplona, Pozuelo de Alarcón, Salamanca, Santander

2020-09-17

Recruiting

FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

NCT04625907Rhabdomyosarcoma

DrugsActinomycin-D·Dactinomycin·Ifosfamide·Vinorelbine

University of Birmingham

Phase 1/2

1,672

Barcelona, Bilbao, Madrid, Málaga, Seville, Valencia, Zaragoza

2020-09-17

Active, closed

Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

NCT04384484Relapsed Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma

DrugsLoncastuximab Tesirine·Rituximab·Oxaliplatin·Gemcitabine

ADC Therapeutics S.A.

Phase 3

440

Barcelona, Cáceres, Madrid, Santander, Seville, Valencia

2020-09-16

Active, closed

Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)

NCT04526691Advanced or Metastatic NSCLC

DrugsDato-DXd·Keytruda·Cisplatin·Carboplatin

Daiichi Sankyo

Phase 1

145

Barcelona, Madrid, Majadahonda

2020-09-15

Recruiting

A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

NCT04462770Dravet Syndrome

DrugClemizole HCl

Epygenix

Phase 3

150

Madrid, Barcelona

2020-09-15

Active, closed

Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome

NCT04401748Myelodysplastic Syndrome (MDS)

DrugsVenclexta·Azacitidine·Venetoclax

AbbVie

Phase 3

531

Badalona, Córdoba, Pozuelo de Alarcón, Barcelona, Madrid, Salamanca, Seville, Valencia

2020-09-10

Active, closed

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

NCT05593094Advanced Solid Tumors, HER2-positive Breast Cancer

DrugZN-A-1041

Hoffmann-La Roche

Phase 1/2

210

Argentona, Santiago de Compostela, A Gudiña, Las Cabezas de San Juan, Barcelona, Jaén, Madrid, Seville

2020-09-03

Active, closed

A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

NCT04442022Relapsed/Refractory Diffuse Large B-cell Lymphoma

DrugsSelinexor·Rituximab·Dexamethasone·Gemcitabine

Karyopharm Therapeutics Inc

Phase 2/3

501

Badalona, Barcelona, Madrid, Seville

2020-09-03

Active, closed

Adjuvant Therapy With Abemaciclib + SOC ET vs. SOC ET in Clinical or Genomic High Risk, HR+/HER2- EBC

NCT04565054Breast Cancer Female

DrugAbemaciclib

Women's Cancer Study Group GmbH

Phase 3

1,260

Palma, Barcelona, Cáceres, Elche, Madrid, Manresa, Málaga, Pamplona

2020-09-02

Active, closed

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

NCT04468984Myelofibrosis (MF)

DrugsNavitoclax·Ruxolitinib

AbbVie

Phase 3

330

A Coruña, Santiago de Compostela, Badalona, Las Palmas de Gran Canaria, Oviedo, Barcelona, Granada, Madrid

2020-08-31

Recruiting

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

NCT04421820Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma

DrugsFolfox·Oxaliplatin

Bold Therapeutics, Inc.

Phase 1/2

220

Barcelona, Madrid

2020-08-28

Active, closed

An Observational Real-world Study Evaluating Severe Tricuspid Regurgitation Patients Treated With the Abbott TriClip™ Device (bRIGHT)

NCT04483089Tricuspid Valve Regurgitation

Abbott Medical Devices

Observational

511

Barcelona, Vigo

2020-08-27

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)

NCT04504825AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and Dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

125

Barcelona, Gijón, Majadahonda, Pamplona, Seville

2020-08-25

Active, closed

Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

NCT04498117Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma

DrugsOregovomab·Paraplatin·Taxol·Paclitaxel

CanariaBio Inc.

Phase 3

615

Barcelona, L'Hospitalet de Llobregat, Valencia

2020-08-25

Active, closed

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

NCT04404283Diffuse Large B-cell Lymphoma

DrugsBrentuximab Vedotin·Lenalidomide·Rituximab

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

239

L'Hospitalet de Llobregat, Cáceres, Pozuelo de Alarcón, Marbella, Pamplona, Barcelona, Madrid, Pozuelo de Alarcon (madrid)

2020-08-20

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

NCT04419649Myelodysplastic Syndromes, Cytopenia

DrugElritercept

Takeda

Phase 2

160

Barcelona, Salamanca, Seville, Valencia

2020-08-19

Active, closed

Study to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults

NCT04370054Hemophilia A

Pfizer

Phase 3

Barcelona, Valladolid

2020-08-18

Active, closed

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

NCT04482309Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer, Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 2

477

Barcelona, Córdoba, Madrid, Valencia

2020-08-18

Active, closed

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis

NCT04221477Lupus Nephritis

DrugsDiphenhydramine·Acetaminophen·Methylprednisolone·Obinutuzumab

Hoffmann-La Roche

Phase 3

271

Barcelona, Madrid

2020-08-10

Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types

NCT04300556Solid Tumor

DrugsPrednisolone·Lenvatinib·Prednisone·Dexamethasone

Eisai Inc.

Phase 1/2

182

Badalona, Barcelona, Madrid, Toledo, Valencia

2020-08-06

Recruiting

AutoInflammatory Disease Alliance Registry (AIDA)

NCT05200715Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome

University of Siena

Observational

3,500

Barakaldo, Barcelona, Madrid, Santander, Valencia

2020-08-06

Active, closed

A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma

NCT04522323Advanced Renal Cell Carcinoma

DrugsVolrustomig·Axitinib·Lenvatinib

MedImmune LLC

Phase 1

Barcelona, Córdoba, Madrid, Sabadell, Seville, Valencia

2020-08-05

Active, closed

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib

NCT04421963Ovarian Cancer, Breast Cancer

DrugOlaparib

AstraZeneca

Phase 3

185

Badalona, Barcelona, Córdoba, Donostia / San Sebastian, Granada, Madrid, Pamplona, Valencia

2020-08-04

Active, closed

Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

NCT04509700B-Cell Malignancies

DrugsItacitinib·Parsaclisib·Ibrutinib·Ruxolitinib

Incyte Corporation

Phase 2

112

Alicante, Badalona, Barcelona, Boadilla del Monte, L'Hospitalet de Llobregat, Madrid, Pozuelo de Alarcón, Salamanca

2020-08-03

Active, closed

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

NCT04449874Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors

DrugsDivarasib·Erlotinib·Inavolisib·Cetuximab

Genentech, Inc.

Phase 1

498

Barcelona, Madrid, Málaga, Seville, Valencia

2020-07-29

Active, closed

A Study to Test Different Doses of Obrixtamig in Patients With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3

NCT04429087Small Cell Lung Carcinoma and Other Neuroendocrine Neoplasms Expressing DLL3

DrugObrixtamig

Boehringer Ingelheim

Phase 1

306

Barcelona, Pamplona, Valencia

2020-07-29

Active, closed

Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer

NCT04494425Advanced or Metastatic Breast Cancer

DrugsTrastuzumab deruxtecan·Nab-paclitaxel·Capecitabine·Paclitaxel

AstraZeneca

Phase 3

866

A Coruña, Barcelona, Córdoba, El Palmar, Madrid, San Sebastián, Seville, Valencia

2020-07-24

Active, closed

Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies

NCT04561362Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms

DrugsZelenectide pevedotin·Keytruda·Pembrolizumab

BicycleTx Limited

Phase 1/2

329

Barcelona, Madrid, Pozuelo de Alarcón, Santander

2020-07-17

Active, closed

AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

NCT04468659Preclinical Alzheimer's Disease, Early Preclinical Alzheimer's Disease

DrugLecanemab

Eisai Inc.

Phase 3

1,400

Barcelona, Donostia / San Sebastian, Madrid, Santander

2020-07-14

Active, closed

Linerixibat Long-term Safety, and Tolerability Study

NCT04167358Cholestasis

GlaxoSmithKline

Phase 3

242

Barcelona, Madrid, Seville, Valencia

2020-07-14

Active, closed

Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

NCT04493853Hormone-Sensitive Prostate Cancer

DrugsZytiga·Capivasertib·Abiraterone acetate

AstraZeneca

Phase 3

1,012

Badalona (Barcelona), Barcelona, Las Palmas de Gran Canaria, Madrid, Oviedo, Santander, Seville

2020-07-13

Active, closed

A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)

NCT03992430Muscular Dystrophy, Duchenne

DrugEteplirsen

Sarepta Therapeutics, Inc.

Phase 3

160

Barcelona, Valencia

2020-07-13

Recruiting

A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

NCT04307576Leukemia, Acute Lymphoblastic

DrugsInotuzumab Ozogamicin·Imatinib·Blinatumomab

Mats Heyman

Phase 3

6,430

Barakaldo, Barcelona, Esplugues de Llobregat, Madrid, Palma de Mallorca, Seville, Valencia, Zaragoza

2020-07-13

Active, closed

A Long-term Study of ADYNOVI/ADYNOVATE in Participants With Haemophilia A

NCT04158934Hemophilia A

Baxalta now part of Shire

Observational

207

Palma de Mallorca, Barcelona, Las Palmas, Madrid, Málaga

2020-07-09

Active, closed

Amplatzer Amulet LAAO vs. NOAC

NCT04226547Atrial Fibrillation, Stroke, Bleeding

DrugNOAC

Abbott Medical Devices

Not applicable

2,650

Madrid, Barcelona, Salamanca

2020-07-07

Active, closed

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

NCT04380636Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

DrugsParaplatin·Taxol·Olaparib·Etoposide

Merck Sharp & Dohme LLC

Phase 3

870

Majadahonda, Pozuelo de Alarcón, Málaga, Barcelona, Seville, Valencia

2020-07-06

Active, closed

Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia

NCT04258943Philadelphia Chromosome Positive CML, Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia, Chronic Phase Chronic Myelogenous Leukemia

DrugBosutinib

Children's Oncology Group

Phase 1/2

Barcelona, Madrid

2020-07-06

Recruiting

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

NCT04477785Parkinson Disease

Michael J. Fox Foundation for Parkinson's Research

Observational

4,500

Barcelona, Donostia / San Sebastian

2020-07-01

Active, closed

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

NCT04273945Pulmonary Arterial Hypertension

DrugMacitentan

Actelion

Phase 3

935

Barcelona, Madrid, Málaga, Salamanca

2020-06-30

Recruiting

A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

NCT04219254Solid Tumor, Adult

DrugKeytruda

BioInvent International AB

Phase 1/2

197

Barcelona, Majadahonda, Málaga, Pamplona, Seville

2020-06-29

Active, closed

Innoventric Trillium™ Stent Graft First-in-Human (FIH) Study

NCT04289870Tricuspid Regurgitation

Innoventric LTD

Not applicable

Barcelona, Salamanca, Vigo

2020-06-24

Active, closed

Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

NCT04270409Plasma Cell Myeloma

DrugsMontelukast·Diphenhydramine·Acetaminophen·Isatuximab

Sanofi

Phase 3

337

Barcelona, Pamplona, Valencia, Madrid, Salamanca, Zaragoza

2020-06-16

Not yet open

Omission of Surgery and Sentinel Lymph Node Dissection in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti- HER2-based Neoadjuvant Therapy (ELPIS Trial)

NCT04301375Mammary Cancer

DrugsTrastuzumab emtansine·Paclitaxel

David Garcia Cinca

Phase 2

Barcelona

2020-06-15

Active, closed

A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma

NCT04181827Multiple Myeloma

DrugsCilta-cel·Pomalidomide·Bortezomib·Daratumumab

Janssen Research & Development, LLC

Phase 3

419

Badalona, Barcelona, Madrid, Pamplona, Salamanca, Seville

2020-06-12

Active, closed

A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma

NCT04106219Neuroblastoma

DrugsTopotecan·Cyclophosphamide

Eli Lilly and Company

Phase 1

Barcelona, Madrid

2020-06-11

Active, closed

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma

DrugTazemetostat

Epizyme, Inc.

Phase 3

599

Barcelona, Marbella, El Palmar, Madrid, Pamplona, Salamanca, Seville

2020-06-11

Recruiting

RecruitmEnt Assessed by eleCtRical Impedance Tomography

NCT04460859Acute Respiratory Distress Syndrome (ARDS)

Unity Health Toronto

Observational

171

Barcelona

2020-06-09

Recruiting

International CIPN Assessment and Validation Study

NCT04633655Chemotherapy-induced Peripheral Neuropathy, Quality of Life

University of Milano Bicocca

Observational

1,000

Barcelona

2020-06-08

Recruiting

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

NCT04389632Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma

DrugsSigvotatug vedotin·Keytruda·Cisplatin·Carboplatin

Seagen, a wholly owned subsidiary of Pfizer

Phase 1

1,006

Madrid, Elche, Santander, Barcelona, Jerez de la Frontera, Málaga

2020-06-08

Active, closed

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

NCT04379596Gastric Cancer

DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Fluorouracil

AstraZeneca

Phase 2

452

Barcelona, Madrid, Santander, Seville

2020-06-03

Active, closed

A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

NCT04404660Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

DrugAUTO1

Autolus Limited

Phase 1/2

153

Barcelona, Seville, Valencia

2020-06-03

Recruiting

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

NCT04256317Myelodysplastic Syndromes, Acute Myeloid Leukemia, Myelodysplastic Syndrome/Neoplasm, Chronic Myelomonocytic Leukemia

DrugsVenclexta·Azacitidine·Venetoclax

Taiho Oncology, Inc.

Phase 2/3

316

Badalona, L'Hospitalet de Llobregat, Pamplona, Oviedo, Barcelona, Cáceres, Girona, Granada

2020-05-21

Active, closed

Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

NCT04246047Multiple Myeloma

DrugsBelantamab mafodotin·Bortezomib·Daratumumab·Dexamethasone

GlaxoSmithKline

Phase 3

494

Barcelona, Cáceres, Gijón, L'Hospitalet de Llobrega, Murcia, PamplonaNavarra, Salamanca

2020-05-07

Active, closed

Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

NCT04269200Endometrial Neoplasms

DrugsOlaparib·Durvalumab·Paclitaxel·Carboplatin

AstraZeneca

Phase 3

805

Barcelona, El Palmar, Girona, Jaén, Madrid, Mallorca

2020-05-05

Active, closed

Clinical Utility of Liquid Biopsy in Brigatinib ALK+ Patients

NCT04223596Lung Cancer, NSCLC, NSCLC Stage IIIB, NSCLC Stage IV

DrugBrigatinib

Fundación GECP

Phase 2

A Coruña, Alicante, Málaga, Palma de Mallorca, Badalona, L'Hospitalet de Llobregat, Barcelona, Las Palmas de Gran Canaria

2020-05-04

Active, closed

Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma

NCT04300244Cancer, Cancer, Lung, Cancer of Lung, Mesothelioma

DrugsLeukine·Yervoy·Ipilimumab·Opdivo

Åslaug Helland

Phase 2

118

Barcelona

2020-05-04

Recruiting

Spanish Registry of Esophagogastric Cancer

NCT04958720Esophageal Cancer, Gastric Cancer

Fundación Sociedad Española de Oncologia Médica

Observational

10,000

Alicante, Elche, Elda, Córdoba, Málaga, Seville, Palma de Mallorca, Barcelona

2020-04-27

Recruiting

Liver Transplant Combined With Neoadjuvant Chemo-radiotherapy in the Treatment of Unresectable Perihilar Cholangiocarcinoma. A Prospective Multicenter Study.

NCT04378023Unresectable Cholangiocarcinoma

Hospital Vall d'Hebron

Observational

Barcelona

2020-04-24

Active, closed

A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer

NCT04214288Advanced ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Fulvestrant

AstraZeneca

Phase 2

240

Barcelona, Madrid, Seville, Zaragoza

2020-04-22

Active, closed

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer

NCT04305496Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Fulvestrant

AstraZeneca

Phase 3

818

A Coruña, Barcelona, Córdoba, Hosp de Llobregat(Barcelona), Jaén, La Laguna (Tenerife), Lleida, Madrid

2020-04-16

Active, closed

Study of HPN217 in Participants With Relapsed/Refractory Multiple Myeloma MK-4002 (MK-4002-001)

NCT04184050Multiple Myeloma in Relapse, Multiple Myeloma, Multiple Myeloma of Bone, Multiple Myeloma With Failed Remission

Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 1

100

Barcelona, Madrid

2020-04-13

Active, closed

Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

NCT04162210Multiple Myeloma

DrugsBelantamab mafodotin·Dexamethasone

GlaxoSmithKline

Phase 3

325

Barcelona, L'Hospitalet de Llobrega, Málaga, PamplonaNavarra, Pozuelo de AlarcOn Madr, Santiago de Compostela

2020-04-02

By invitation

Use of Intraoperative Radiotherapy in Breast Cancer

NCT07030231Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Parc de Salut Mar

Observational

3,000

Barcelona

2020-04-01

Active, closed

Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer

NCT04223856Urothelial Cancer

DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin

Astellas Pharma Global Development, Inc.

Phase 3

886

Barcelona, Córdoba, Lugo, Madrid, Manresa, Pamplona, Sabadell, Santander

2020-03-30

Active, closed

Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies

NCT04277637Mature B-Cell Malignancies

DrugsSonrotoclax·Zanubrutinib·Obinutuzumab

BeOne Medicines

Phase 1

437

Barcelona, Madrid, Salamanca, Santander

2020-03-24

Recruiting

Randomised Evaluation of COVID-19 Therapy

NCT04381936Pneumonia

DrugsConvalescent plasma·Sotrovimab·Lopinavir / Ritonavir·Molnupiravir

University of Oxford

Phase 3

70,000

Barcelona

2020-03-19

By invitation

Breaking Bad News Skills of Doctors and Residents in the Surgical Setting

NCT04308707Communication Research, Patient Satisfaction, Communication Programs, Doctor Patient Relation

Hospital Clinic of Barcelona

Observational

Barcelona

2020-03-16

Recruiting

Early Detection of Advanced Adenomas and Colorectal Cancer

NCT06342440Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma

City of Hope Medical Center

Observational

2,000

Barcelona

2020-03-15

Recruiting

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

NCT04094610Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors

DrugRepotrectinib

Turning Point Therapeutics, Inc.

Phase 1/2

Esplugues de Llobregat, Pamplona, Barcelona, Madrid, Seville, Valencia

2020-03-12

Recruiting

The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study

NCT04204915Aortic Stenosis

University of Leicester

Not applicable

2,104

Barcelona, Pamplona

2020-03-10

Active, closed

First-in-Human Study of ICT01 in Patients With Advanced Cancer

NCT04243499Solid Tumor, Adult, Hematopoietic/Lymphoid Cancer

ImCheck Therapeutics, an Ipsen company

Phase 1/2

293

Barcelona, Madrid

2020-03-05

Recruiting

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

NCT04221542Prostate Cancer

DrugsXaluritamig·Abiraterone·Enzalutamide

Amgen

Phase 1

479

Barcelona, Pamplona, Madrid

2020-03-04

Recruiting

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

NCT04294927BRCA1 Gene Mutation, BRCA2 Gene Mutation, RAD51C Gene Mutation, RAD51D Gene Mutation

University Medical Center Nijmegen

Not applicable

3,000

Barcelona

2020-03-01

Active, closed

A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

NCT04195750Carcinoma, Renal Cell

DrugsBelzutifan·Everolimus

Merck Sharp & Dohme LLC

Phase 3

755

Barcelona, Valencia, Madrid

2020-02-27

Active, closed

Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer

NCT03937154Chemotherapy-induced Thrombocytopenia

DrugsNplate·Romiplostim

Amgen

Phase 3

145

Granada, Seville, Salamanca, Barcelona, Ourense, Fuenlabrada, Castellon, Madrid

2020-02-26

Active, closed

Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

NCT04262466Select Advanced Solid Tumors

DrugBrenetafusp

Immunocore Ltd

Phase 1/2

410

Pamplona, Barcelona, Madrid

2020-02-25

Active, closed

A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma

NCT04108195Multiple Myeloma

DrugsTalquetamab·Darzalex·Teclistamab·Pomalidomide

Janssen Research & Development, LLC

Phase 1

290

Barcelona, Madrid, Pamplona, Salamanca

2020-02-21

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

NCT04194944Non-Small Cell Lung Cancer

DrugsSelpercatinib·Pemetrexed·Cisplatin·Carboplatin

Eli Lilly and Company

Phase 3

261

Palma de Mallorca, Badalona, Santiago de Compostela, Las Palmas de Gran Canaria, Majadahonda, Pamplona, Alicante, Barcelona

2020-02-17

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

NCT04211337Medullary Thyroid Cancer

DrugsVandetanib·Selpercatinib·Cabozantinib

Loxo Oncology, Inc.

Phase 3

291

Barcelona, L'Hospitalet de Llobregat, Girona, Madrid, Málaga, Pamplona, Zaragoza

2020-02-11

Active, closed

DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer

NCT04042701Breast Cancer, Non-small Cell Lung Carcinoma

DrugsTrastuzumab deruxtecan·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 1

115

A Coruña, Barcelona, Las Palmas de Gran Canaria, Madrid, Seville, Zaragoza

2020-02-10

Recruiting

Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors

NCT03934372Acute Myeloid Leukemia, Accelerated Phase Chronic Myeloid Leukemia, Blast Phase Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia

DrugPonatinib

Incyte Biosciences International Sàrl

Phase 1/2

Barcelona, Madrid, Valencia

2020-01-29

Active, closed

A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer

NCT04191499Breast Cancer

DrugsInavolisib·Palbociclib·Fulvestrant

Hoffmann-La Roche

Phase 2/3

325

Badalona, Pamplona, San Cristóbal de La Laguna, Barcelona, Jaén, Madrid, Seville, Valencia

2020-01-29

Active, closed

Dendritic Cells Therapy Combined With Immunomodulatory Treatment in Multiple Sclerosis

NCT04530318Relapsing-Remitting Multiple Sclerosis

Judit Pich

Phase 2

L'Hospitalet de Llobregat, Barcelona

2020-01-27

Recruiting

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

NCT05999994Neoplasms, Child, Adolescent

DrugsRamucirumab·Vinorelbine·Abemaciclib·Temozolomide

Eli Lilly and Company

Phase 2

105

Barcelona, Esplugues de Llobregat, Madrid, San Cristóbal de La Laguna, Seville, Valencia

2020-01-22

Active, closed

MitraClip EXPAND G4 Study

NCT04177394Mitral Valve Regurgitation, Mitral Regurgitation

Abbott Medical Devices

Observational

1,164

Barcelona, Vigo

2020-01-17

Active, closed

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

NCT04170283B-cell Malignancies

DrugsZanubrutinib·Tislelizumab

BeOne Medicines

Phase 3

955

Barcelona, Girona, L'Hospitalet de Llobregat, Madrid, Salamanca, Toledo

2020-01-16

Active, closed

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

NCT04175600Hypertension, Pulmonary

DrugSelexipag

Actelion

Phase 3

138

A Coruña, Barcelona, Esplugues de Llobregat, Madrid, Seville

2020-01-16

Active, closed

A Study of Tildrakizumab in Pediatric Subjects With Chronic Plaque Psoriasis

NCT03997786Moderate-to-severe Chronic Plaque Psoriasis

DrugsTildrakizumab·Etanercept

Sun Pharmaceutical Industries Limited

Phase 2/3

135

Barcelona, Las Palmas de Gran Canaria

2020-01-15

Active, closed

TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

NCT04129502Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

DrugsMobocertinib·Pemetrexed·Cisplatin·Carboplatin

Takeda

Phase 3

354

L'Hospitalet de Llobregat, A Coruña, Alicante, Barcelona, Córdoba, Madrid, Valencia

2020-01-10

Recruiting

Medtronic SYMBIOSIS Post-Market Registry for Patients Undergoing Cardiac Surgery

NCT04241328Cardiovascular Diseases

Medtronic Cardiac Surgery

Observational

5,000

Barcelona

2020-01-09

Active, closed

Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET

NCT03972488Gastro-enteropancreatic Neuroendocrine Tumor

DrugsOctreotide LAR·Lutathera

Advanced Accelerator Applications

Phase 3

226

Barcelona, Madrid, Valencia

2020-01-08

Active, closed

Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

NCT04164901Grade 2 Glioma, Residual Glioma, Recurrent Glioma

DrugVorasidenib

Institut de Recherches Internationales Servier

Phase 3

331

Barcelona, Madrid

2020-01-05

Active, closed

Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors

NCT03967223Neoplasms

DrugsFludarabine·Cyclophosphamide

USWM CT, LLC

Phase 2

103

Barcelona, Hospitalet de Llobregat, Barcelona, Madrid, Seville

2019-12-31

Active, closed

A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer

NCT04165317Non-muscle Invasive Bladder Cancer

DrugsSasanlimab·Bacillus Calmette-Guerin

Pfizer

Phase 3

1,068

Badalona, Granollers, L'Hospitalet de Llobregat, Majadahonda, Pamplona, Reus, A Coruña, Barcelona

2019-12-30

Active, closed

Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis

NCT03989206Moderate-to-Severe Atopic Dermatitis

DrugNemolizumab

Galderma R&D

Phase 3

1,700

Alicante, Barcelona, L'Hospitalet de Llobregat, Las Palmas de Gran Canaria, Madrid, Pamplona

2019-12-30

Active, closed

Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

NCT04170153Metastatic or Locally Advanced Unresectable Solid Tumors

DrugsTuvusertib·Niraparib

EMD Serono Research & Development Institute, Inc.

Phase 1

161

Barcelona, Madrid, Valencia

2019-12-20

Recruiting

A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis

NCT03969329Secondary Hyperparathyroidism

DrugEtelcalcetide

Amgen

Phase 3

Seville, Barcelona

2019-12-20

Active, closed

A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy

NCT04027309Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2

DrugsMidostaurin·Gilteritinib

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

777

Barcelona, Girona, Lleida, Madrid, Palma, Tarragona, Valencia

2019-12-20

Recruiting

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

NCT04165798Carcinoma, Non-Small-Cell Lung

Merck Sharp & Dohme LLC

Observational

1,065

L'Hospitalet de Llobregat, Barcelona, Madrid

2019-12-19

Active, closed

Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma

NCT04091126Multiple Myeloma

DrugsBelantamab mafodotin·Bortezomib·Lenalidomide·Dexamethasone

GlaxoSmithKline

Phase 1

118

Badalona, Barcelona, Madrid, Málaga, PamplonaNavarra, Pozuelo de AlarcOn Madr, Santander

2019-12-18

Active, closed

Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

NCT04185883Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation

DrugsBI 1701963·TNO155·Sotorasib·Afatinib

Amgen

Phase 1

610

Barcelona, L'Hospitalet de Llobregat, Majadahonda, Madrid

2019-12-17

Recruiting

Terumo Aortic Global Endovascular Registry

NCT04246463Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery

Vascutek Ltd.

Observational

1,000

Badalona, Barcelona, Oviedo

2019-12-17

Recruiting

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

NCT04176198Myelofibrosis

DrugsMomelotinib·Ruxolitinib

Sumitomo Pharma America, Inc.

Phase 1/2

240

Barcelona, Salamanca

2019-12-16

Active, closed

A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma

NCT04194775Hepatocellular Carcinoma

DrugLenvatinib

CStone Pharmaceuticals

Phase 3

534

A Coruña, Ourense, Majadahonda, Oviedo, Ávila, Barcelona, Burgos, Girona

2019-12-13

Active, closed

HER2-PREDICT: Translational Study of Tumor Samples From Patients Treated With Trastuzumab Deruxtecan (T-DXd; DS-8201a)

NCT04257162Metastatic Cancer

SOLTI Breast Cancer Research Group

Not applicable

180

Badalona, Barcelona, Jerez de la Frontera, Santa Cruz de Tenerife, Lleida, Madrid, Seville, Valencia

2019-12-13

Active, closed

Cold Agglutinin Disease Real World Evidence Registry

NCT05791708Cold Agglutinin Disease (CAD), Cold Agglutinin Syndrome (CAS)

RECORDATI GROUP

Observational

429

Barcelona, Madrid

2019-12-12

Active, closed

A Clinical Trial Evaluating TG4050 in Head and Neck Cancer

NCT04183166Squamous Cell Carcinoma of Head and Neck

Transgene

Phase 1/2

Barcelona, Madrid, Málaga, Santiago de Compostela

2019-12-12

Active, closed

A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer

NCT04188548Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, Endometrial Cancer

DrugsImlunestrant·Alpelisib·Everolimus·Abemaciclib

Eli Lilly and Company

Phase 1

379

Barcelona, Madrid, Valencia

2019-12-10

Active, closed

LAM561 With RT and TMZ for Adults With Glioblastoma

NCT04250922Primary Glioblastoma, Glioblastoma Multiforme

DrugLAM561

Laminar Pharmaceuticals

Phase 2/3

144

Córdoba, Seville, Barcelona, Madrid, Valencia, Sabadell

2019-12-01

Recruiting

Clinical and Radiological Evaluation of Dental Autotransplantation in the Anterior Region in Young Patients

NCT07314580Tooth Loss, Tooth Injury

University of Barcelona

Observational

Barcelona

2019-12-01

Active, closed

Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE)

NCT04179032Systemic Lupus Erythematosus

GlaxoSmithKline

Phase 2

Barcelona, Madrid, Valencia

2019-11-28

Active, closed

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

NCT04153149Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

DrugVutrisiran

Alnylam Pharmaceuticals

Phase 3

655

L'Hospitalet de Llobregat, Majadahonda, Barcelona, Bilbao, Huelva, Málaga

2019-11-26

Recruiting

Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

NCT04179929Acute Lymphoblastic Leukemia

PETHEMA Foundation

Not applicable

300

Badalona, A Coruña, Albacete, Alicante, Ávila, Barcelona, Bellvitge, Bilbao

2019-11-25

Active, closed

Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance

NCT04150068HIV-1-infection

DrugLenacapavir

Gilead Sciences

Phase 2/3

Badalona, Barcelona, Madrid, Seville

2019-11-21

Active, closed

Surveillance AFter Extremity Tumor surgerY

NCT03944798Soft Tissue Sarcoma, Lung Metastases

McMaster University

Not applicable

310

Barcelona

2019-11-19

Active, closed

Immunotherapy, Chemotherapy, Radiotherapy and Surgery for Synchronous Oligo-metastatic NSCLC

NCT03965468Non-small Cell Lung Cancer, Stage IV, Oligometastasis

DrugsTremelimumab·Durvalumab·Paclitaxel·Carboplatin

ETOP IBCSG Partners Foundation

Phase 2

Barcelona, Granada, Madrid, Valencia

2019-11-19

Active, closed

NCT04232241Acute Myeloid Leukemia in Remission, Acute Lymphoblastic Leukemia in Remission, Myelodysplastic Syndromes

Universitätsklinikum Hamburg-Eppendorf

Phase 2

167

Badalona, Barcelona, Madrid, Salamanca, Seville, Valencia

2019-11-14

Active, closed

A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies

NCT03888105B-cell Non-Hodgkin Lymphoma (B-NHL)

DrugOdronextamab

Regeneron Pharmaceuticals

Phase 2

515

Palma, Barcelona, Pozuelo de Alarcón, Madrid, Salamanca, Valencia

2019-11-13

Active, closed

Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock

NCT04055909Shock, Septic

Inotrem

Phase 2

355

Barcelona, Madrid, Oviedo, Terrassa, Valencia

2019-11-13

Active, closed

Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors

NCT04140500Solid Tumors, Metastatic Melanoma, Non-small Cell Lung Cancer, Esophageal Squamous Cell Carcinoma

DrugTobemstomig

Hoffmann-La Roche

Phase 1/2

170

Pamplona, Barcelona, Madrid

2019-11-11

Active, closed

Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression

NCT04180371Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer

DrugsNuzefatide pevedotin·Opdivo·Nivolumab

BicycleTx Limited

Phase 1/2

288

Barcelona, Madrid

2019-11-07

Recruiting

High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

NCT04221035High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy

DrugsDinutuximab Beta·Vindesine·Cyclophosphamid·Thiotepa

Gustave Roussy, Cancer Campus, Grand Paris

Phase 3

800

Balea, Barcelona, Cruces, El Palmar, Madrid, Málaga, San Sebastián, Santiago de Compostela

2019-11-05

Active, closed

Orbital Fractures Registry

NCT03887988Orbital Fractures, Blow Out Fracture of Orbit

AO Innovation Translation Center

Observational

300

Barcelona, Madrid

2019-11-01

Active, closed

A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer

NCT04036682Non Small Cell Lung Cancer, EGFR Exon 20 Mutation

DrugZipalertinib

Cullinan Therapeutics Inc.

Phase 1/2

284

A Coruña, Barcelona, Las Palmas, Madrid, Málaga, Pamplona, Valencia

2019-10-31

By invitation

A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia

NCT04138927Warm Antibody Autoimmune Hemolytic Anemia

DrugFostamatinib

Rigel Pharmaceuticals

Phase 3

Barcelona

2019-10-30

Active, closed

Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

NCT04058756Advanced Solid Tumors

DrugSpartalizumab

Novartis Pharmaceuticals

Phase 1

120

L'Hospitalet de Llobregat, Barcelona, Madrid, Valencia

2019-10-30

Active, closed

Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma

NCT04099251Melanoma

DrugsOpdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

790

Barcelona, A Coruña, Badalona, Madrid, Málaga, Santander, Valencia

2019-10-28

Active, closed

Trimodality Therapy With/Out Durvalumab to Treat Patients With Muscle-Invasive Bladder Cancer

NCT03768570Bladder Cancer

DrugDurvalumab

Canadian Cancer Trials Group

Phase 2

Barcelona, Madrid, Santander, Valencia

2019-10-25

Recruiting

Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)

NCT04032470Essential Tremor

Boston Scientific Corporation

Observational

500

Barcelona, Oviedo

2019-10-23

Active, closed

Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors

NCT04041310Solid Tumor, Adult

DrugsKeytruda·Pembrolizumab

Nouscom SRL

Phase 1/2

115

A Coruña, Barcelona, Córdoba, Granada, Madrid, Pamplona, Salamanca, Santander

2019-10-21

Active, closed

Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors

NCT04083781Haemophilia A With Inhibitors, Haemophilia B With Inhibitors

DrugConcizumab

Novo Nordisk A/S

Phase 3

134

Barcelona, Madrid, Málaga, Oviedo, Seville

2019-10-21

Active, closed

Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors

NCT04336241Cancer

DrugsRP2·Opdivo·Nivolumab

Replimune, Inc.

Phase 1

Barcelona, Madrid, Valencia

2019-10-17

Active, closed

Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors

NCT03964727Metastatic Solid Tumor

DrugSacituzumab Govitecan

Gilead Sciences

Phase 2

227

Barcelona, Madrid, Valencia

2019-10-15

Recruiting

ALFAOMEGA Master Observational Trial

NCT04120935Colorectal Cancer

IFOM ETS - The AIRC Institute of Molecular Oncology

Observational

3,000

Barcelona, Valencia

2019-10-15

Active, closed

Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer

NCT04050436Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma

DrugsVusolimogene Oderparepvec·Cemiplimab

Replimune, Inc.

Phase 2

231

Barcelona, Madrid, Murcia, Pamplona, Valencia

2019-10-08

Active, closed

SyncAV Post-Market Trial

NCT04100148Congestive Heart Failure

Abbott Medical Devices

Not applicable

1,686

Badajoz, Barcelona, Madrid, Málaga, Salamanca

2019-10-03

Recruiting

Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN

NCT03955445C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

225

Pamplona, Barcelona, Madrid, Seville

2019-10-03

Active, closed

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

NCT03975647HER2-positive Breast Cancer

DrugsTucatinib·Trastuzumab emtansine

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

466

Palma de Mallorca, Barcelona, San Cristóbal de La Laguna, Córdoba, Madrid, Sant Joan Despí, Seville, Valencia

2019-10-02

Active, closed

Comprehensive Long-term Follow up of Adults With Arterial Switch Operation

NCT04335448Transposition of Great Vessels

University of Zurich

Observational

540

Barcelona, Seville, Valencia

2019-10-01

Active, closed

Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations

NCT04006210Parkinson's Disease

NeuroDerm Ltd.

Phase 3

381

Oviedo, Alicante, Barcelona, Burgos, Madrid, Seville, Valencia

2019-09-30

Active, closed

A Post-Authorisation Safety Study Patient Registry of Patients With Neuroblastoma Being Treated With Dinutuximab Beta

NCT04253015Neuroblastoma

RECORDATI GROUP

Observational

125

Barcelona, Valencia

2019-09-30

Active, closed

A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis

NCT04033445Ulcerative Colitis

DrugGuselkumab

Janssen Research & Development, LLC

Phase 2/3

1,064

Badalona, Barcelona, Girona, Madrid, Santander, Seville

2019-09-26

By invitation

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

NCT03683186PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension

United Therapeutics

Phase 3

1,000

Barcelona, Madrid, Valencia

2019-09-23

Active, closed

Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy

NCT04083339Diabetic Cardiomyopathies

Applied Therapeutics, Inc.

Phase 3

675

Badalona, El Palmar, A Coruña, Barcelona, Córdoba, Seville, Valencia

2019-09-20

Recruiting

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

NCT04104776Advanced Solid Tumor, Diffuse Large B Cell Lymphoma, Lymphoma, T-Cell, Mesothelioma, Malignant

DrugsTulmimetostat·Enzalutamide

Novartis Pharmaceuticals

Phase 1/2

300

Barcelona, Girona, L'Hospitalet de Llobregat, Madrid, Majadahonda, Palma, Pamplona, Sabadell

2019-09-18

Active, closed

GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors

NCT04083599Malignant Solid Tumor, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Melanoma

DrugsGEN1042·Adrucil·Nab-paclitaxel·Pemetrexed

Genmab

Phase 1/2

350

Barcelona, L'Hospitalet de Llobregat, Las Palmas de Gran Canaria, Lugo, Madrid, Málaga, Pamplona, Santiago de Compostela

2019-09-17

Active, closed

COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC

NCT04068610Metastatic Microsatellite-stable Colorectal Cancer

DrugsOleclumab·Folfox·Durvalumab·Bevacizumab

MedImmune LLC

Phase 1/2

Barcelona, Madrid

2019-09-13

Active, closed

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

NCT04067336Advanced Malignant Neoplasm, Acute Myeloid Leukemia, Mixed Lineage Leukemia, Mixed Lineage Acute Leukemia

DrugsZiftomenib·Itraconazole·Midazolam

Kura Oncology, Inc.

Phase 1/2

263

Barcelona, Madrid, Oviedo, Seville, Valencia

2019-09-12

Recruiting

Low INR to Minimize Bleeding With Mechanical Valves Trial

NCT03636295Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement

DrugWarfarin

Population Health Research Institute

Phase 3

2,625

Barcelona

2019-09-05

Recruiting

Spine Bone Cements Outcomes - Post Market Follow-up

NCT06367582Vertebral Fracture, Compression Fracture, Osteoporotic Fractures

Teknimed

Observational

500

Barcelona, Granada, Murcia, Terrassa, Zafra

2019-09-04

Active, closed

LITMUS Imaging Study

NCT05479721NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver

University of Oxford

Observational

450

Barcelona, Seville, Valladolid

2019-09-04

Active, closed

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

NCT04077463Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 1

701

Barcelona, Madrid, Seville

2019-09-04

Recruiting

A Treatment Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

NCT03911128Leukemia, Acute Lymphoblastic

Mats Heyman

Observational

500

Alicante, Barakaldo, Barcelona, Fuencarral-El Pardo, Madrid, Murcia, Palma de Mallorca, Santander

2019-08-29

Active, closed

Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast Cancer

NCT03820830Breast Cancer Recurrent

DrugPalbociclib

ETOP IBCSG Partners Foundation

Phase 3

405

San Cristóbal de La Laguna, A Coruña, Alicante, Barcelona, Bilbao, Girona, Madrid, Málaga

2019-08-27

Recruiting

Multivirus-specific T-cell Transfer Post SCT vs AdV, CMV and EBV Infections

NCT04832607AdV Infection, EBV Infection, CMV Infection, Stem Cell Transplant Complications

Tobias Feuchtinger

Phase 3

149

Barcelona, Madrid, Seville, Valencia

2019-08-27

Recruiting

International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

NCT04043494Lymphoblastic Lymphoma, Childhood

DrugsVindesine·Thioguanine·PEG-Asparaginase·Ifosfamide

University Hospital Muenster

Phase 3

683

Alicante, Almería, Badajoz, Barakaldo, Barcelona, Donostia / San Sebastian, Esplugues de Llobregat, Granada

2019-08-23

Active, closed

Phase II Study of Avelumab Plus Chemotherapy in the Peri-operative Treatment for Patients With Resectable Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC)

NCT03979131Gastroesophageal Junction Adenocarcinoma, Stomach Neoplasms

Vall d'Hebron Institute of Oncology

Phase 2

Barcelona

2019-08-22

Active, closed

TRILUMINATE Pivotal Trial

NCT03904147Tricuspid Regurgitation

Abbott Medical Devices

Not applicable

572

Barcelona

2019-08-21

Active, closed

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

NCT04044859Endometrial Cancer, Esophageal Cancer, Esophagogastric Junction (EGJ), Gastric (Stomach) Cancer

USWM CT, LLC

Phase 1

120

Madrid, Pío, Ibanez, Barcelona, Seville

2019-08-20

Active, closed

A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation

NCT04002297Mantle Cell Lymphoma; Non-Hodgkin Lymphoma

DrugsBendamustine·Zanubrutinib·Rituximab

BeOne Medicines

Phase 3

510

Barcelona, Girona, Madrid, Málaga, Seville

2019-08-20

Active, closed

Observational Evaluation of Atopic Dermatitis in Pediatric Patients

NCT03687359Dermatitis Atopic

Sanofi

Observational

1,860

Barcelona, Pozuelo de Alarcón, Mieres, Madrid

2019-08-15

Active, closed

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

NCT04119050Warm Autoimmune Hemolytic Anemia

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

118

Alcalá de Henares, Badalona, Barcelona, Burgos, Córdoba, Las Palmas de Gran Canaria, Madrid, Majadahonda

2019-08-15

Active, closed

Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

NCT04044768Synovial Sarcoma, Myxoid Liposarcoma

USWM CT, LLC

Phase 2

Barcelona, Madrid, Seville

2019-08-13

Active, closed

A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

NCT04077723Lymphoma, Non-Hodgkin

DrugsGlofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

498

Barcelona, Madrid, Málaga

2019-08-13

Recruiting

A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

NCT04064060Myelodysplastic Syndromes (MDS), Beta-thalassemia, Myeloproliferative Neoplasm(MPN)-Associated Myelofibrosis

DrugLuspatercept

Celgene

Phase 3

665

Barakaldo, Barcelona, Madrid, Oviedo, Salamanca, Seville, Valencia

2019-08-12

Active, closed

A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

NCT04035005Multiple Sclerosis, Primary Progressive

DrugOcrelizumab

Hoffmann-La Roche

Phase 3

1,013

Pozuelo de Alarcón, El Palmar, Vigo, Barcelona, Madrid, Salamanca, Seville, Valencia

2019-08-12

Recruiting

Pan Tumor Rollover Study

NCT03899155Cancer

DrugsRucaparib·Sunitinib·Trametinib·Relatlimab

Bristol-Myers Squibb

Phase 2

1,500

Donostia / San Sebastian, Majadahonda, Pamplona, A Coruña, Alicante, Badalona, Barcelona, Burgos

2019-08-09

Recruiting

Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies

NCT04068597Haematological Malignancy, Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma

DrugsIxazomib·Elranatamab·Teclistamab·Pomalidomide

CellCentric Ltd.

Phase 1/2

250

Badalona, Barcelona, Madrid, Pamplona, Valencia

2019-08-09

Active, closed

A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)

NCT04008030Metastatic Colorectal Cancer

DrugsFluorouracil·Leucovorin·Ipilimumab·Irinotecan

Bristol-Myers Squibb

Phase 3

839

Badalona, A Coruña, Barcelona, Madrid, Málaga, Seville, Valencia

2019-08-05

Recruiting

Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)

NCT03711110Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly, Antineoplastic Agents, Cardiotoxicity

Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León

Not applicable

514

Santiago de Compostela, Galdakao, Barcelona, Córdoba, Madrid, Málaga, Salamanca, Seville

2019-08-02

Active, closed

A Study of Cusatuzumab Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia Who Are Not Candidates for Intensive Chemotherapy

NCT04023526Leukemia, Myeloid, Acute

DrugsCusatuzumab·Azacitidine

OncoVerity, Inc.

Phase 2

103

Pozuelo de Alarcón, Barcelona, Córdoba, Madrid, Palma, Salamanca, Valencia

2019-07-29

Active, closed

A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B

NCT03861273Hemophilia B

Pfizer

Phase 3

El Palmar, Barcelona

2019-07-29

Active, closed

Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients

NCT03814746Sickle Cell Disease (SCD)

DrugCrizanlizumab

Novartis Pharmaceuticals

Phase 3

254

Barcelona, Madrid

2019-07-26

Recruiting

Safety and Preliminary Efficacy of OBT076 in Recurrent/Metastatic CD205+ Solid Tumors

NCT04064359Solid Tumor

Oxford BioTherapeutics Ltd

Phase 1

200

Barcelona, Madrid, Santander

2019-07-25

Active, closed

Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)

NCT03924895Urinary Bladder Cancer, Muscle-invasive

DrugsEnfortumab Vedotin·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

595

Badalona, Barcelona, Cáceres, Girona, Pozuelo de Alarcón, Valencia, Madrid, Seville

2019-07-24

Active, closed

Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine

NCT03836040Migraine

Amgen

Phase 3

457

Seville, Barcelona, Pamplona, Valencia

2019-07-19

Active, closed

A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer

NCT03981796Neoplasms

DrugsNiraparib·Dostarlimab·Paclitaxel·Carboplatin

Tesaro, Inc.

Phase 3

785

Barcelona, Donostia / San Sebastian, Madrid, Málaga, Murcia, Valencia

2019-07-18

Active, closed

My Personalized Breast Screening

NCT03672331Breast Screening

UNICANCER

Not applicable

53,142

Barcelona

2019-07-18

Active, closed

A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor

NCT04008797Endometrial Neoplasms, Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms

DrugsE7386·Doxorubicin·Lenvatinib·Paclitaxel

Eisai Inc.

Phase 1/2

301

A Coruña, Barcelona, Jaén, Madrid

2019-07-11

Active, closed

Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)

NCT03974022Non-Small Cell Lung Cancer

DrugSunvozertinib

Dizal Pharmaceuticals

Phase 1/2

315

Barcelona, Girona, Jerez de la Frontera, Madrid, Málaga, Seville, Valencia

2019-07-09

Active, closed

Long Term Extension Study in Patients With Primary Hyperoxaluria

NCT04042402Primary Hyperoxaluria Type 1 (PH1), Primary Hyperoxaluria Type 2 (PH2), Kidney Diseases, Urologic Diseases

DrugDcr-Phxc

Dicerna Pharmaceuticals, Inc., a Novo Nordisk company

Phase 3

Barcelona

2019-07-09

Active, closed

TSR-042 as Maintenance Therapy for Patients With High-risk Locally Advanced Cervical Cancer After Chemo-radiation

NCT03833479Cervical Cancer, Advanced Cancer

DrugDostarlimab

Grupo Español de Investigación en Cáncer de Ovario

Phase 2

134

Elche, Donostia / San Sebastian, Girona, Madrid, Vigo, Seville, Valencia, Barcelona

2019-06-28

Active, closed

Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL

NCT03960840Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia

DrugIbrutinib

Novartis Pharmaceuticals

Phase 1/2

217

Badalona, L'Hospitalet de Llobregat, Barcelona, Córdoba, Madrid, Salamanca, Seville, Valencia

2019-06-26

Active, closed

Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

NCT03944772Non-Small Cell Lung Cancer

DrugsNecitumumab·Gefitinib·Savolitinib·Selpercatinib

AstraZeneca

Phase 2

247

A Coruña, Barcelona, Madrid, Seville

2019-06-25

Active, closed

Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC

NCT03997123Triple Negative Breast Neoplasms

DrugsCapivasertib·Paclitaxel

AstraZeneca

Phase 3

923

Badalona, Barcelona, Hospitalet deLlobregat, Jaén, Madrid, Málaga, Seville, Valencia

2019-06-25

Active, closed

Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

NCT03937219Renal Cell Carcinoma

DrugsCabozantinib·Yervoy·Ipilimumab·Opdivo

Exelixis

Phase 3

855

Santiago de Compostela, Pamplona, Barcelona, Córdoba, Madrid, Oviedo, Valencia

2019-06-25

Recruiting

E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe

NCT03818503Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Observational

2,000

Badalona, Barcelona, Cartagena, Córdoba, Madrid, Pamplona, Salamanca, Terrassa

2019-06-24

Active, closed

A Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer

NCT03873402Renal Cell Carcinoma

DrugsYervoy·Ipilimumab·Opdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

437

Barcelona, Córdoba, Madrid, Pamplona, Sabadell, Santander, Santiago Compostela, Seville

2019-06-21

Recruiting

Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress

NCT03968393Stroke, Atrial Fibrillation

DrugsNon-Vitamin K Anticoagulant·NOAC·Dabigatran·Edoxaban

Population Health Research Institute

Phase 4

2,270

Barcelona, Madrid, Pamplona

2019-06-14

Active, closed

Adjuvant Palbociclib in Elderly Patients With Breast Cancer

NCT03609047Breast Cancer Stage II, Breast Cancer Stage III

DrugsDoxorubicin/cyclophosphamide·Palbociclib·Paclitaxel

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

366

Barcelona, Lleida, Madrid, Reus, Seville, Valencia

2019-06-14

Active, closed

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

NCT03899792Medullary Thyroid Cancer, Infantile Myofibromatosis, Infantile Fibrosarcoma, Papillary Thyroid Cancer

DrugSelpercatinib

Eli Lilly and Company

Phase 1/2

Barcelona

2019-06-13

Active, closed

Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)

NCT03992417Dermatitis Atopic

DrugDupilumab

Sanofi

Observational

955

Bilbao, Las Palmas de Gran Canaria, Majadahonda, Oviedo, Barakaldo, Barcelona, Madrid, Santiago de Compostela

2019-06-11

Active, closed

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

NCT03767244Prostatic Neoplasms

DrugApalutamide

Janssen Research & Development, LLC

Phase 3

2,517

A Coruña, Barcelona, Cadiz, Castellon, Jerez de la Frontera, Madrid, Manacor, Málaga

2019-06-11

Active, closed

Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

NCT03969004Cutaneous Squamous Cell Carcinoma

DrugCemiplimab

Regeneron Pharmaceuticals

Phase 3

415

Barcelona, Alcorcón, Torrejón de Ardoz, Badalona, Madrid, Majadahonda, Salamanca, Seville

2019-06-04

Recruiting

GETNE Registration of Thyroid Cancer

NCT03765333Thyroid Cancer

Grupo Espanol de Tumores Neuroendocrinos

Observational

Barcelona

2019-05-28

Active, closed

Childhood Obesity Risk Assessment Longitudinal Study

NCT06317883Child Obesity

Consorcio Centro de Investigación Biomédica en Red (CIBER)

Observational

1,508

Santiago de Compostela, Pamplona, Barcelona, Córdoba, Granada, Tarragona, Valencia, Zaragoza

2019-05-27

Active, closed

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

NCT03893955Cancer, Advanced Solid Tumors, Triple-Negative Breast Cancer (TNBC), Non-small-cell-lung-cancer (NSCLC)

DrugsABBV-927·Budigalimab·Nab-paclitaxel·Carboplatin

AbbVie

Phase 1

150

Barcelona, Madrid, Málaga

2019-05-21

Active, closed

A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)

NCT03930953Lymphoma, Non-Hodgkin

DrugsValemetostat·Tafasitamab·Golcadomide·Obinutuzumab

Celgene

Phase 1/2

438

Badalona (Barcelona), Barcelona, Madrid, Málaga, Salamanca

2019-05-20

Active, closed

NADIM II: Neo-Adjuvant Immunotherapy

NCT03838159Non Small Cell Lung Cancer

DrugsParaplatin·Taxol·Opdivo·Nivolumab

Fundación GECP

Phase 2

Alicante, Badalona, Barcelona, L'Hospitalet de Llobregat, Córdoba, Girona, Las Palmas de Gran Canaria, A Coruña

2019-05-15

Active, closed

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

NCT03811561Diabetes Mellitus, Type 2

DrugSemaglutide

Novo Nordisk A/S

Phase 3

1,500

A Coruña, Barcelona, L'Hospitalet de Llobregat, Pamplona, Seville, Valencia

2019-05-08

Active, closed

Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.

NCT03891953Carcinoma, Non-Small-Cell Lung, Melanoma, Nasopharyngeal Carcinoma, Microsatellite Stable Colorectal Cancer

DrugSpartalizumab

Novartis Pharmaceuticals

Phase 1

Barcelona

2019-05-07

Active, closed

(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis

NCT03731260Indolent Systemic Mastocytosis

DrugAvapritinib

Blueprint Medicines Corporation

Phase 2

251

Barcelona, Toledo

2019-04-16

By invitation

Zoledronate In the Prevention of Paget's Disease: Long Term Extension

NCT03859895Paget Disease

University of Edinburgh

Observational

287

Barcelona, Salamanca

2019-04-05

Active, closed

A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis

NCT03900429NASH - Nonalcoholic Steatohepatitis

DrugResmetirom

Madrigal Pharmaceuticals, Inc.

Phase 3

1,759

Majadahonda, Almería, Barcelona, Madrid, Pontevedra, Santander, Seville, Valencia

2019-03-28

Active, closed

Effectiveness of Treatments for Massive Rotator Cuff Tears: Mixed Methodology.

NCT05780229Massive Rotator Cuff Tears, Shoulder Disease

Parc de Salut Mar

Observational

200

Sabadell, Barcelona, Madrid

2019-03-27

Active, closed

A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease

NCT03887455Early Alzheimer's Disease

DrugLecanemab

Eisai Inc.

Phase 3

1,906

Sant Cugat del Vallès, Getxo, Donostia / San Sebastian, Barcelona, Córdoba, Madrid, Salamanca, Seville

2019-03-27

Active, closed

A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy

NCT03675308Psoriatic Arthritis

DrugsSkyrizi·Risankizumab

AbbVie

Phase 3

964

Badalona, Sabadell, A Coruña, Almería, Barcelona, Madrid, Valencia

2019-03-25

Active, closed

Avelumab Program Rollover Study

NCT03815643Solid Tumors

DrugAvelumab

EMD Serono Research & Development Institute, Inc.

Phase 3

205

Barcelona, Madrid, Mataró

2019-03-22

Active, closed

Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.

NCT03869892Metastatic Colorectal Cancer

DrugsTrifluridine/Tipiracil·Capecitabine

Institut de Recherches Internationales Servier

Phase 3

856

Alicante, Badalona, Barcelona, Córdoba, L'Hospitalet de Llobregat, Madrid, Santander, Seville

2019-03-21

Active, closed

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

NCT03845166Neoplasm Malignant, Renal Cell Carcinoma, Hormone Receptor Positive Breast Carcinoma, Metastatic Castration-resistant Prostate Cancer

DrugsZanzalintinib·Avelumab·Tecentriq·Atezolizumab

Exelixis

Phase 1

325

Sabadell, Santiago de Compostela, Barcelona, Madrid, Seville

2019-03-20

Active, closed

Left Atrial Appendage Closure by Surgery-2

NCT03724318Stroke, Ischemic, Atrial Fibrillation

Helena DOMINGUEZ

Not applicable

1,500

Barcelona

2019-03-17

Active, closed

A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer

NCT03816163Pancreatic Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma

DrugsZolbetuximab·Nab-paclitaxel·Gemcitabine

Astellas Pharma Global Development, Inc.

Phase 2

393

Llobregat, Pamplona, Barcelona, Cáceres, Córdoba, Lleida, Madrid, Málaga

2019-03-15

Recruiting

Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

NCT03850574Leukemia, Myeloid, Acute, Refractory AML, Relapsed Adult AML, Myelodysplastic Syndrome With Excess Blasts-2

DrugsAzacitidine·Venetoclax

Aptose Biosciences Inc.

Phase 1/2

240

Barcelona, Pozuelo de Alarcón, Oviedo, Valencia

2019-03-11

Active, closed

Durvalumab and Tremelimumab for Pediatric Malignancies

NCT03837899Pediatric Cancer, Solid Tumor Pediatric, Hematological Malignancies

DrugDurvalumab

AstraZeneca

Phase 1/2

Barcelona, Madrid

2019-03-07

Active, closed

Durvalumab With Stereotactic Body Radiation Therapy (SBRT) vs Placebo With SBRT in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients/ Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation

NCT03833154Carcinoma, Non-Small-Cell Lung

DrugDurvalumab

AstraZeneca

Phase 3

724

Badajoz, Barcelona, L'Hospitalet de Llobregat, Madrid, Málaga, San Sebastián, Santiago de Compostela, Seville

2019-03-06

Recruiting

Distribution of Lymph Node Metastases in Esophageal Carcinoma

NCT03222895Esophageal Neoplasms, Lymph Node Metastases

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Observational

5,000

Barcelona

2019-03-01

Active, closed

A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy

NCT03839771Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2

DrugsEnasidenib·Ivosidenib

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

968

Barcelona, Girona, Madrid, Palma, Tarragona, Valencia

2019-03-01

Active, closed

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

NCT03768063Cancer

DrugsEmactuzumab·Rucaparib·Cobimetinib·Vemurafenib

Hoffmann-La Roche

Phase 3

1,000

Barcelona, Madrid

2019-02-28

Active, closed

Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa

NCT03827798Hidradenitis Suppurativa

DrugsArumakimig·Ianalumab·Remibrutinib

Novartis Pharmaceuticals

Phase 2

248

Granada, Sabadell, Manises, Barcelona, Las Palmas GC, Valencia

2019-02-27

Active, closed

Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

NCT03836261Chronic Lymphocytic Leukemia

DrugsVenclyxto·Acalabrutinib·Venclexta·Obinutuzumab

Acerta Pharma BV

Phase 3

984

Badalona, Barcelona, Madrid, Majadahonda, Salamanca, Santander, Valencia

2019-02-25

Active, closed

Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors

NCT03821935Advanced Solid Tumors Cancer

DrugsLivmoniplimab·Budigalimab

AbbVie

Phase 1

364

Pamplona, Barcelona, Madrid, Valencia

2019-02-21

Active, closed

Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive

NCT03737461Recurrent Low Back Pain, Degenerative Disc Disease (DDD)

University Hospital, Montpellier

Phase 2/3

113

Barcelona, Pamplona, Valladolid

2019-02-18

Active, closed

A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

NCT03673501Gastrointestinal Stromal Tumors

DrugsRipretinib·Sunitinib

Deciphera Pharmaceuticals, LLC

Phase 3

453

Barcelona, Bilbao, Madrid, Málaga, Seville, Valencia, Vigo

2019-02-08

Active, closed

A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy

NCT03796962Focal Epilepsy

DrugAzetukalner

Xenon Pharmaceuticals Inc.

Phase 2

325

Seville, Badalona, Pamplona, Barcelona, Granada, Madrid, Málaga, Valencia

2019-01-30

Active, closed

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

NCT03748641Castration-Resistant Prostatic Cancer

DrugsAbiraterone acetate·Niraparib·Prednisone

Janssen Research & Development, LLC

Phase 3

765

A Coruña, Barcelona, Jerez de la Frontera, Madrid, Málaga, Pozuelo de Alarcón, Sabadell, Santander

2019-01-25

Recruiting

Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple Myeloma

NCT03761108Multiple Myeloma

DrugLinvoseltamab

Regeneron Pharmaceuticals

Phase 1/2

387

Barcelona, Pamplona, Madrid, Salamanca

2019-01-23

Active, closed

Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Preserve Femoral Stem

NCT03865667Joint Disease

MicroPort Orthopedics Inc.

Observational

Barcelona

2019-01-15

Recruiting

Natural History Study of Patients With Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency

NCT03758521Succinic Semialdehyde Dehydrogenase Deficiency

Boston Children's Hospital

Observational

Barcelona

2019-01-15

Recruiting

Understanding the Long-Term Management of Organic Acidemia Patients With CARBAGLU®: A Mixed Methods Approach

NCT04176523Methylmalonic Acidemia, Propionic Acidemia

DrugCarglumic Acid

RECORDATI GROUP

Observational

Barcelona, Bilbao, Madrid, Murcia, Palma de Mallorca, Seville, Zaragoza

2019-01-15

Active, closed

9-ING-41 in Patients With Advanced Cancers

NCT03678883Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer

DrugsCCNU·Lomustine·Abraxane·Adriamycin

Actuate Therapeutics Inc.

Phase 2

350

Barcelona, Madrid, Valencia

2019-01-04

Active, closed

A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve

NCT03682536Myelodysplastic Syndromes

DrugsEpoetin Alfa·Luspatercept

Celgene

Phase 3

363

Barcelona, Granada, Madrid, Málaga, Murcia, Ourense, Oviedo, Palma de Mallorca

2019-01-02

Recruiting

Spanish Academy of Dermatology and Venereology Registry of Atopic Dermatitis Therapy

NCT05674695Dermatitis, Atopic

DrugsCiclosporin·Omalizumab·Baricitinib·Upadacitinib

Fundación Academia Española de Dermatología

Observational

2,500

Badalona, Alicante, Barcelona, Las Palmas, Madrid, Pontevedra, Valencia, Zaragoza

2019-01-01

Active, closed

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

NCT03650114Relapsing Multiple Sclerosis

Drugs13-valent pneumococcal conjugate vaccine·23-valent pneumococcal polysaccharide vaccine·Ofatumumab

Novartis Pharmaceuticals

Phase 3

1,882

Cadiz, L'Hospitalet de Llobregat, Barcelona, Donostia / San Sebastian, Salt, Majadahonda, Pozuelo de Alarcón, El Palmar

2018-12-28

Active, closed

A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC

NCT03819465Metastatic Non-Small Cell Lung Cancer (NSCLC)

DrugsDanvatirsen·Oleclumab·Volrustomig·Rilvegostomig

AstraZeneca

Phase 1

175

Barcelona, Madrid, Seville

2018-12-27

Active, closed

Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)

NCT03725059Breast Cancer

DrugsEpirubicin·Adriamycin·Cytoxan·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,240

L'Hospitalet de Llobregat, A Coruña, Pozuelo de Alarcón, Madrid, Valencia, Barcelona, Jaén, Seville

2018-12-27

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)

NCT03711032High-risk Non-muscle Invasive Bladder Cancer

DrugsKeytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

1,397

Lugo, Pozuelo de Alarcón, Pamplona, Barcelona, Madrid, Valencia

2018-12-24

Active, closed

A Longitudinal Observational Study of Patients Undergoing Therapy for IMISC

NCT03661866Atopic Dermatitis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo

Target PharmaSolutions, Inc.

Observational

15,000

Barcelona, Madrid

2018-12-21

Active, closed

A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease

NCT03737214Fabry Disease

Idorsia Pharmaceuticals Ltd.

Phase 3

107

Barcelona, Madrid, Zaragoza

2018-12-18

Active, closed

Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)

NCT03765918Head and Neck Neoplasms

DrugsKeytruda·Cisplatin·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

714

Badalona, L'Hospitalet de Llobregat, Santiago de Compostela, Barcelona, Madrid, Seville

2018-12-17

Active, closed

Daratumumab, VELCADE (Bortezomib), Lenalidomide and Dexamethasone Compared to VELCADE, Lenalidomide and Dexamethasone in Subjects With Previously Untreated Multiple Myeloma

NCT03710603Multiple Myeloma

DrugsVelcade·Bortezomib·Daratumumab·Lenalidomide

Stichting European Myeloma Network

Phase 3

709

Barcelona

2018-12-14

Active, closed

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

NCT03742895Advanced Solid Neoplasms

DrugOlaparib

Merck Sharp & Dohme LLC

Phase 2

329

Pozuelo de Alarcón, Barcelona

2018-12-12

Active, closed

A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy

NCT03762850Immunoglobulin A Nephropathy

DrugsSparsentan·Irbesartan·Dapagliflozin

Travere Therapeutics, Inc.

Phase 3

406

Palma de Mallorca, Sagunto, Barcelona, Madrid, Seville, Valencia, Zaragoza

2018-12-11

Recruiting

A Modular Multi-Basket Trial to Improve Personalized Medicine in Cancer Patients (Basket of Baskets)

NCT03767075Advanced Solid Tumor

DrugsFutibatinib·Amivantamab·Atezolizumab

Vall d'Hebron Institute of Oncology

Phase 2

1,000

Barcelona

2018-12-10

Active, closed

A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer

NCT03800134Non-Small Cell Lung Cancer

DrugsDurvalumab·Pemetrexed·Gemcitabine·Paclitaxel

AstraZeneca

Phase 3

825

Alicante, Barcelona, Donostia / San Sebastian, Madrid, Málaga, Oviedo, Pamplona, Santiago de Compostela (A Coruña)

2018-12-06

Recruiting

Pulmonary Hemodynamics During Exercise - Research Network

NCT03954574Pulmonary Circulation Diseases

Medical University of Graz

Observational

1,500

Barcelona

2018-12-01

Active, closed

A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).

NCT03653507Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

DrugsZolbetuximab·Capecitabine·Oxaliplatin

Astellas Pharma Global Development, Inc.

Phase 3

507

A Coruña, Barcelona, Elche, Madrid, Málaga, Pamplona, Valencia

2018-11-28

Active, closed

A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer

NCT03706365Prostate Cancer

DrugsAbiraterone acetate·Abemaciclib·Prednisone

Eli Lilly and Company

Phase 2/3

393

Barcelona, Hospitalet, Madrid, Málaga

2018-11-26

Active, closed

Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC

NCT03732677Muscle Invasive Bladder Cancer

DrugsDurvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,063

Badalona, Barcelona, Córdoba, Las Palmas de Gran Canaria, Madrid, Santander, Seville

2018-11-16

Recruiting

ISCHEMIA-CTO Trial - Revascularisation or Optimal Medical Therapy of CTO

NCT03563417Ischemic Heart Disease, Chronic Total Occlusion of Coronary Artery

Aarhus University Hospital Skejby

Not applicable

1,560

Badalona, Galdakao, Barcelona, Madrid, Tarragona

2018-11-06

Active, closed

Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer

NCT03732820Metastatic Castration-resistant Prostate Cancer

DrugsZytiga·Abiraterone acetate·Olaparib

AstraZeneca

Phase 3

895

Barcelona, Girona, Madrid, Málaga, Seville

2018-10-31

Active, closed

Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)

NCT03707743Aortic Dissection

IRCCS San Raffaele

Observational

200

Barcelona

2018-10-30

Active, closed

Immunotherapy With Ipilimumab and Nivolumab Preceded or Not by a Targeted Therapy With Encorafenib and Binimetinib

NCT03235245Unresectable Stage III Melanoma, Stage IV Melanoma

DrugsBinimetinib·Encorafenib·Ipilimumab·Nivolumab

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

271

Badalona, Barcelona

2018-10-30

Active, closed

A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis

NCT03596645Colitis, Ulcerative

DrugsGolimumab·Infliximab

Janssen Research & Development, LLC

Phase 3

Barakaldo, Barcelona, Madrid, Málaga, Seville

2018-10-29

Active, closed

Treatment for Elderly Fit Newly Diagnosed Multiple Myeloma Patients Aged Between 65 and 80 Years

NCT03742297Newly Diagnosed Multiple Myeloma

DrugsMelphalan·Carfilzomib·Bortezomib·Daratumumab

PETHEMA Foundation

Phase 3

462

A Coruña, Albacete, Alicante, Badalona, Barcelona, Bilbao, Cáceres, Córdoba

2018-10-22

Active, closed

A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.

NCT03539744Multiple Myeloma

DrugsPomalidomide·Venetoclax·Dexamethasone

AbbVie

Phase 3

265

Palma de Mallorca, Marbella, Ourense, San Cristóbal de La Laguna, Barcelona, Girona, León, Madrid

2018-10-22

Active, closed

Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer.

NCT03616587ER+ HER2- Advanced Breast Cancer

DrugCamizestrant

AstraZeneca

Phase 1

396

Barcelona, Madrid, Seville, Valencia

2018-10-11

Active, closed

A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer

NCT03602859Ovarian Neoplasms, Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma

DrugsNiraparib·Dostarlimab

Tesaro, Inc.

Phase 3

1,400

Ávila, Badalona, Barcelona, Girona, Jaén, Madrid, Santiago de Compostela, Toledo

2018-10-11

Active, closed

Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

NCT03539536Non-small Cell Lung Cancer

DrugTelisotuzumab vedotin

AbbVie

Phase 2

270

Santiago de Compostela, Badalona, Las Palmas de Gran Canaria, Alcorcón, Ávila, Barcelona, Madrid, Málaga

2018-10-10

Recruiting

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

NCT03715933Ewing Sarcoma, Colorectal Adenocarcinoma

DrugsINBRX-109·Temozolomide·Fluorouracil·Leucovorin

Inhibrx Biosciences, Inc

Phase 1

411

Barcelona, Madrid

2018-10-08

Active, closed

A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

NCT03690388Differentiated Thyroid Cancer

DrugCabozantinib

Exelixis

Phase 3

187

Barcelona, Madrid, Málaga

2018-10-05

Active, closed

A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia

NCT03589326Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL)

DrugsPonatinib·Imatinib·Cytarabine·Vincristine

Takeda

Phase 3

245

Badalona, Barcelona, Salamanca, Valencia

2018-10-04

Active, closed

Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy

NCT03703297Small Cell Lung Cancer

DrugsTremelimumab·Durvalumab

AstraZeneca

Phase 3

730

Barcelona, Madrid, Oviedo, Seville, Valencia, Zaragoza

2018-09-27

Active, closed

Study of Durvalumab Given With Chemotherapy, Durvalumab in Combination With Tremelimumab Given With Chemotherapy, or Chemotherapy in Patients With Unresectable Urothelial Cancer

NCT03682068Unresectable Locally Advanced Urothelial Cancer, Metastatic Urothelial Cancer

DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,246

Barcelona, Lugo, Madrid, Málaga, Santander, Seville

2018-09-27

Active, closed

A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma

NCT03671018B-cell Non-Hodgkin Lymphoma

DrugsMosunetuzumab·Polatuzumab Vedotin·Tocilizumab·Rituximab

Hoffmann-La Roche

Phase 1/2

422

Barcelona, Cáceres, Madrid, Seville

2018-09-25

Recruiting

Extension Study for the Port Delivery System With Ranibizumab (Portal)

NCT03683251Neovascular Age-Related Macular Degeneration

DrugPDS Implant with Ranibizumab

Hoffmann-La Roche

Phase 3

1,000

L'Hospitalet de Llobregat, San Cugat Del Valles, Majadahonda, Pamplona, Oviedo, Burjassot, Barcelona, Córdoba

2018-09-20

Recruiting

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

NCT03567889Melanoma Stage IIIB, Melanoma Stage IIIC, Melanoma Stage IIID

DrugDaromun

Philogen S.p.A.

Phase 3

186

Badalona, Barcelona, Las Palmas de Gran Canaria, Donostia / San Sebastian, Madrid, Málaga, Murcia, Seville

2018-09-20

Active, closed

Reducing Lung CongestIon Symptoms in Advanced Heart Failure

NCT03499236Heart Failure

V-Wave Ltd

Not applicable

605

Barcelona, Madrid, Valencia, Valladolid

2018-09-19

Active, closed

Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)

NCT03553836Melanoma

DrugsKeytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

976

Donostia / San Sebastian, Valencia, Barcelona, Madrid, Seville

2018-09-12

Active, closed

Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer

NCT03595592Invasive Breast Cancer

DrugsPerjeta·Herceptin·Tecentriq·Pertuzumab

Fondazione Michelangelo

Phase 3

650

A Coruña, Alcoy, Alicante, Badajoz, Barcelona, Bilbao, Cáceres, Granada

2018-09-07

Active, closed

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis

NCT03398135Ulcerative Colitis (UC)

DrugsSkyrizi·Risankizumab

AbbVie

Phase 3

1,242

Ferrol, Sabadell, Majadahonda, Vigo, Gijón, Barcelona, Córdoba, Madrid

2018-08-28

Active, closed

Study of Abexinostat in Patients With Relapsed or Refractory Follicular Lymphoma

NCT03600441Follicular Lymphoma

DrugAbexinostat

Xynomic Pharmaceuticals, Inc.

Phase 2

139

Donostia / San Sebastian, Barcelona, Córdoba, Madrid

2018-08-27

Recruiting

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

NCT03486873Solid Tumors, Hematologic Malignancies

DrugsPembrolizumab/Favezelimab·) Berahyaluronidase alfa·Olaparib·Lenvatinib

Merck Sharp & Dohme LLC

Phase 3

3,500

Palma, Palma de Mallorca, L'Hospitalet de Llobregat, San Sebastian- Donostia, Santander, Badalona, Barcelona, Santiago de Compostela

2018-08-21

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Spanish investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 13 October 2026. https://priyalifescience.com/clinical-trials-spain/city/barcelona?page=6

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Spain and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 5,875 studies in total at the last sync on 11 Oct 2026, 03:18 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 3,238 of those studies with a site in Barcelona.

How many clinical trials are recruiting in Barcelona?

1,669 of the 3,238 studies on this page are recruiting new participants as of the 11 Oct 2026, 03:18 UTC sync. A further 132 have not yet opened recruitment, 1,365 are active but closed to new participants, and 72 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.