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Clinical Trials in Spain / NCT05763641
Recruiting Observational

TAD After Chemotherapy in Locally Advanced Breast Cancer

NCT05763641 · tracked via the Priya Life Science Spain tracker
Sponsor
Hospital Universitari de Bellvitge
Phase
Observational
Started
2021-02-01
Last updated
2026-09-17

Condition(s) studied

Sentinel Lymph NodeBreast CancerLocally Advanced

Investigational drug(s) / intervention(s)

Target Axillary Dissection

Target Axillary Dissection: TAD after neoadjuvant chemotherapy and subsequent axillary lymph node dissection

Study summary

This is an observational study to validate target axillary dissection (TAD) in locally advanced tumors (cN2 and/or cT4).

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Axillary lymph node metastasis proven by cytology * Clinical or radiological N2a (at least 4 suspicious lymph nodes on axillary ultrasound at diagnosis) * Extensive T4 subsidiary to axillary lymphadenectomy according to current clinical criteria * Neoadjuvant chemotherapy Exclusion Criteria: * cN3 verified by imaging tests * N2 due to internal mammary involvement (N2b). * Tumors whose surrogate molecular subtype is luminal A. * Patients undergoing neoadjuvant endocrine therapy * Patients with local recurrences and metastatic tumors.

Primary outcome measure(s)

  • TAD validation in locally advanced breast cancer — 3 years
    False negative rate when performing TAD after NAC

Trial sites (2)

FacilityCityRegionStatus
Hospital de Bellvitge L'Hospitalet de Llobregat Barcelona Recruiting
Hospital Clínico y Provincial de Barcelona Barcelona Spain Recruiting

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Other trials for the same condition

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A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor. Active, not recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05763641 on ClinicalTrials.gov ↗ ← All trials in Spain